Mice Protein Expression Analysis
Yilan Li
library(tidyverse)
data <- read.csv("data.csv")Data Description
This dataset comes from the UC Machine Learning Repository Mice Protein Expression. It consists of expression levels of 77 proteins modifications that produced signals in the nuclear fraction of the cortex. The dataset includes measurements from 38 control mice and 34 trisomic mice (Down syndrome).
dataWhat are the columns represent
Mouse ID: Unique identifier for each mouse, 15 measurements were taken for each protein per mouse.
Expression Levels: The dataset contains values for the expression levels of 77 proteins.
Genotype: The genotype of each mouse, either control (c) or trisomy (t).
Treatment Type: The treatment administered to the mouse, either memantine (m) or saline (s).
Behavior: Describes the behavioral context of each mouse, either context-shock (CS) or shock-context (SC).
Classes
The mice are classified into eight groups based on features such as genotype, behavior, and treatment. The genotypes can either be control or trisomic. In terms of behavior, some mice have been stimulated to learn (context-shock), while others have not (shock-context). Additionally, in order to assess the effect of the drug memantine on the ability to learn in trisomic mice, some mice were injected with the drug, and others were injected with saline as control.
blue_palette <- colorRampPalette(c("darkblue", "lightblue"))(8)
ggplot(data, aes(class)) +
geom_bar(aes(fill = class), alpha = 0.8) +
scale_fill_manual(values = blue_palette) +
labs(title = "Number of Classes", y = "Count", x="Class")
c-CS-s: Control mice, stimulated to learn, injected with saline (9 mice)
c-CS-m: Control mice, stimulated to learn, injected with memantine (10 mice)
c-SC-s: Control mice, not stimulated to learn, injected with saline (9 mice)
c-SC-m: Control mice, not stimulated to learn, injected with memantine (10 mice)
t-CS-s: Trisomic mice, stimulated to learn, injected with saline (7 mice)
t-CS-m: Trisomic mice, stimulated to learn, injected with memantine (9 mice)
t-SC-s: Trisomic mice, not stimulated to learn, injected with saline (9 mice)
t-SC-m: Trisomic mice, not stimulated to learn, injected with memantine (9 mice)
Data Cleaning and handle missing values
The dataset contains some missing values. In this case, we will handle the missing values by replacing them with the mean of the corresponding protein group.
missing_values <- data %>%
setNames(gsub("_N", "", names(.))) %>%
summarise(across(everything(), ~ sum(is.na(.)), .names = "{.col}")) %>%
pivot_longer(everything(), names_to = "key", values_to = "missing") %>%
mutate(
total = nrow(data),
pct = (missing / total) * 100,
isna = missing > 0
) %>%
filter(isna) %>%
arrange(desc(pct))
percentage.plot <- missing_values %>%
ggplot(aes(x = reorder(key, pct), y = pct)) +
geom_bar(stat = 'identity', fill = 'blue', alpha = 1) +
scale_x_discrete(limits = missing_values$key) +
coord_flip() +
labs(title = "Missing Values In the Dataset", x = 'Protein Name', y = "Percentage of Missing Values") +
theme(plot.title = element_text(hjust = 0.5)) +
guides(fill = "none")
percentage.plot
data <- data %>%
group_by(class) %>%
mutate(across(everything(), ~ replace(., is.na(.), mean(., na.rm = TRUE)))) %>%
as.data.frame()
names(data) <- gsub("_N", "", names(data))
proteins <- names(data[2:78])
classes <- as.vector(unique(as.character(data$class)))Data Visualization
Histogram for Expression Levels
for(i in 1:length(proteins)){
plot <- ggplot(data, aes(eval(parse(text = proteins[i])))) +
geom_histogram(aes(fill=..count..), color = "black", alpha = 0.5) +
scale_fill_gradient("Count", low="blue", high="darkblue") +
labs(title = proteins[i],
x = "Protein Expression Level",
y = "Frequency") +
theme_light()
cat("#### ", proteins[i], "\n")
print(plot)
cat('\n\n')
}DYRK1A
ITSN1
BDNF
NR1
NR2A
pAKT
pBRAF
pCAMKII
pCREB
pELK
pERK
pJNK
PKCA
pMEK
pNR1
pNR2A
pNR2B
pPKCAB
pRSK
AKT
BRAF
CAMKII
CREB
ELK
ERK
GSK3B
JNK
MEK
TRKA
RSK
APP
Bcatenin
SOD1
MTOR
P38
pMTOR
DSCR1
AMPKA
NR2B
pNUMB
RAPTOR
TIAM1
pP70S6
NUMB
P70S6
pGSK3B
pPKCG
CDK5
S6
ADARB1
AcetylH3K9
RRP1
BAX
ARC
ERBB4
nNOS
Tau
GFAP
GluR3
GluR4
IL1B
P3525
pCASP9
PSD95
SNCA
Ubiquitin
pGSK3B_Tyr216
SHH
BAD
BCL2
pS6
pCFOS
SYP
H3AcK18
EGR1
H3MeK4
CaNA
Boxplot for Distribution of Protein Expression Level by Class
for(i in 1:length(proteins)){
plot <- ggplot(data, aes(x = class, y = eval(parse(text = proteins[i])))) +
geom_boxplot(aes(fill = class), alpha = 0.8) +
stat_summary(fun.y=mean, colour="black", geom="point", size=1.5) +
labs(y = proteins[i]) +
scale_fill_manual(values = blue_palette)
cat("#### ", proteins[i], "\n")
print(plot)
cat('\n\n')
}DYRK1A
ITSN1
BDNF
NR1
NR2A
pAKT
pBRAF
pCAMKII
pCREB
pELK
pERK
pJNK
PKCA
pMEK
pNR1
pNR2A
pNR2B
pPKCAB
pRSK
AKT
BRAF
CAMKII
CREB
ELK
ERK
GSK3B
JNK
MEK
TRKA
RSK
APP
Bcatenin
SOD1
MTOR
P38
pMTOR
DSCR1
AMPKA
NR2B
pNUMB
RAPTOR
TIAM1
pP70S6
NUMB
P70S6
pGSK3B
pPKCG
CDK5
S6
ADARB1
AcetylH3K9
RRP1
BAX
ARC
ERBB4
nNOS
Tau
GFAP
GluR3
GluR4
IL1B
P3525
pCASP9
PSD95
SNCA
Ubiquitin
pGSK3B_Tyr216
SHH
BAD
BCL2
pS6
pCFOS
SYP
H3AcK18
EGR1
H3MeK4
CaNA
Anova and TukeyHSD Test
library(broom)
alpha <- 0.01
aov_test <- function(prot) {
aov_result <- aov(eval(parse(text = prot)) ~ class, data)
tidy(aov_result)
}
tukey_test <- function(aov_result) {
TukeyHSD(aov_result)$class
}
AOV_df <- data.frame(matrix(NA, nrow = length(proteins), ncol = 3))
names(AOV_df) <- c("Protein", "Var_expl", "p.value")
for (i in 1:length(proteins)) {
cat("#### ", proteins[i], "\n")
aov_result <- aov(eval(parse(text = proteins[i])) ~ class, data)
AOV <- tidy(aov_result)
AOV_df$Protein[i] <- proteins[i]
AOV_df$Var_expl[i] <- round(AOV$sumsq[1] / (AOV$sumsq[1] + AOV$sumsq[2]), 2)
AOV_df$p.value[i] <- AOV$p.value[1]
cat(paste0("Total variability: ", round(AOV$sumsq[1] + AOV$sumsq[2], 2)), "\n")
cat('\n\n')
cat(paste0("Percentage of explained variability for ", proteins[i], ": ", round(AOV$sumsq[1] * 100 / (AOV$sumsq[1] + AOV$sumsq[2]), 2), "%\n"))
cat('\n\n')
cat(paste0("P value for ", proteins[i], ": ", round(AOV$p.value[1], 5)), "\n\n")
cat('\n\n')
if (AOV$p.value[1] < alpha) {
cat("Significant ANOVA result; proceeding to Tukey HSD test for ", proteins[i], "\n")
tukey_result <- tukey_test(aov_result)
print(tukey_result)
} else {
cat("No significant ANOVA result; skipping Tukey HSD test for ", proteins[i], "\n")
}
cat('\n\n')
}DYRK1A
Total variability: 66.93
Percentage of explained variability for DYRK1A: 28.93%
P value for DYRK1A: 0
Significant ANOVA result; proceeding to Tukey HSD test for DYRK1A diff lwr upr p adj c-CS-s-c-CS-m 0.116291899 0.04039842 0.19218537 9.947272e-05 c-SC-m-c-CS-m -0.207253476 -0.28112276 -0.13338419 0.000000e+00 c-SC-s-c-CS-m -0.205633013 -0.28152649 -0.12973954 0.000000e+00 t-CS-m-c-CS-m 0.138837508 0.06294403 0.21473098 9.699904e-07 t-CS-s-c-CS-m 0.045278549 -0.03612144 0.12667854 6.943415e-01 t-SC-m-c-CS-m -0.150595735 -0.22648921 -0.07470226 6.438866e-08 t-SC-s-c-CS-m -0.142968422 -0.21886190 -0.06707495 3.826448e-07 c-SC-m-c-CS-s -0.323545375 -0.39943885 -0.24765190 0.000000e+00 c-SC-s-c-CS-s -0.321924912 -0.39978997 -0.24405985 0.000000e+00 t-CS-m-c-CS-s 0.022545609 -0.05531945 0.10041067 9.878641e-01 t-CS-s-c-CS-s -0.071013350 -0.15425460 0.01222790 1.602967e-01 t-SC-m-c-CS-s -0.266887634 -0.34475270 -0.18902257 0.000000e+00 t-SC-s-c-CS-s -0.259260321 -0.33712538 -0.18139526 0.000000e+00 c-SC-s-c-SC-m 0.001620463 -0.07427301 0.07751394 1.000000e+00 t-CS-m-c-SC-m 0.346090984 0.27019751 0.42198446 0.000000e+00 t-CS-s-c-SC-m 0.252532025 0.17113204 0.33393201 0.000000e+00 t-SC-m-c-SC-m 0.056657741 -0.01923573 0.13255122 3.128586e-01 t-SC-s-c-SC-m 0.064285054 -0.01160842 0.14017853 1.671956e-01 t-CS-m-c-SC-s 0.344470521 0.26660546 0.42233558 0.000000e+00 t-CS-s-c-SC-s 0.250911562 0.16767031 0.33415281 0.000000e+00 t-SC-m-c-SC-s 0.055037278 -0.02282778 0.13290234 3.855795e-01 t-SC-s-c-SC-s 0.062664591 -0.01520047 0.14052965 2.212756e-01 t-CS-s-t-CS-m -0.093558959 -0.17680021 -0.01031771 1.529981e-02 t-SC-m-t-CS-m -0.289433243 -0.36729831 -0.21156818 0.000000e+00 t-SC-s-t-CS-m -0.281805930 -0.35967099 -0.20394087 0.000000e+00 t-SC-m-t-CS-s -0.195874284 -0.27911554 -0.11263303 4.560252e-11 t-SC-s-t-CS-s -0.188246971 -0.27148822 -0.10500572 3.079893e-10 t-SC-s-t-SC-m 0.007627313 -0.07023775 0.08549238 9.999900e-01
ITSN1
Total variability: 68.15
Percentage of explained variability for ITSN1: 28.78%
P value for ITSN1: 0
Significant ANOVA result; proceeding to Tukey HSD test for ITSN1 diff lwr upr p adj c-CS-s-c-CS-m 0.11980786 0.04314464 0.196471068 6.410014e-05 c-SC-m-c-CS-m -0.21622649 -0.29084499 -0.141608004 0.000000e+00 c-SC-s-c-CS-m -0.20323362 -0.27989683 -0.126570404 0.000000e+00 t-CS-m-c-CS-m 0.14441918 0.06775597 0.221082394 3.825819e-07 t-CS-s-c-CS-m 0.10696915 0.02474358 0.189194725 2.112060e-03 t-SC-m-c-CS-m -0.08580384 -0.16246705 -0.009140624 1.605615e-02 t-SC-s-c-CS-m -0.10353107 -0.18019428 -0.026867860 1.146045e-03 c-SC-m-c-CS-s -0.33603435 -0.41269756 -0.259371139 0.000000e+00 c-SC-s-c-CS-s -0.32304147 -0.40169627 -0.244386676 0.000000e+00 t-CS-m-c-CS-s 0.02461133 -0.05404347 0.103266122 9.809073e-01 t-CS-s-c-CS-s -0.01283870 -0.09692422 0.071246810 9.997955e-01 t-SC-m-c-CS-s -0.20561169 -0.28426649 -0.126956897 0.000000e+00 t-SC-s-c-CS-s -0.22333893 -0.30199372 -0.144684132 0.000000e+00 c-SC-s-c-SC-m 0.01299288 -0.06367033 0.089656091 9.995905e-01 t-CS-m-c-SC-m 0.36064568 0.28398247 0.437308889 0.000000e+00 t-CS-s-c-SC-m 0.32319565 0.24097008 0.405421220 0.000000e+00 t-SC-m-c-SC-m 0.13042266 0.05375945 0.207085871 7.849435e-06 t-SC-s-c-SC-m 0.11269542 0.03603221 0.189358635 2.379151e-04 t-CS-m-c-SC-s 0.34765280 0.26899800 0.426307594 0.000000e+00 t-CS-s-c-SC-s 0.31020277 0.22611725 0.394288282 0.000000e+00 t-SC-m-c-SC-s 0.11742978 0.03877498 0.196084575 1.732111e-04 t-SC-s-c-SC-s 0.09970254 0.02104775 0.178357340 3.143161e-03 t-CS-s-t-CS-m -0.03745003 -0.12153554 0.046635483 8.781915e-01 t-SC-m-t-CS-m -0.23022302 -0.30887781 -0.151568223 0.000000e+00 t-SC-s-t-CS-m -0.24795025 -0.32660505 -0.169295459 0.000000e+00 t-SC-m-t-CS-s -0.19277299 -0.27685850 -0.108687475 1.624697e-10 t-SC-s-t-CS-s -0.21050022 -0.29458574 -0.126414711 1.263101e-12 t-SC-s-t-SC-m -0.01772724 -0.09638203 0.060927560 9.973967e-01
BDNF
Total variability: 2.62
Percentage of explained variability for BDNF: 10.97%
P value for BDNF: 0
Significant ANOVA result; proceeding to Tukey HSD test for BDNF diff lwr upr p adj c-CS-s-c-CS-m 0.0030979096 -0.013720984 0.0199168033 9.992916e-01 c-SC-m-c-CS-m -0.0482716607 -0.064641970 -0.0319013517 0.000000e+00 c-SC-s-c-CS-m -0.0258249025 -0.042643796 -0.0090060088 9.507174e-05 t-CS-m-c-CS-m -0.0264852092 -0.043304103 -0.0096663155 5.383381e-05 t-CS-s-c-CS-m -0.0337569838 -0.051796186 -0.0157177818 4.747394e-07 t-SC-m-c-CS-m -0.0181541101 -0.034973004 -0.0013352164 2.389551e-02 t-SC-s-c-CS-m -0.0136310252 -0.030449919 0.0031878685 2.134012e-01 c-SC-m-c-CS-s -0.0513695703 -0.068188464 -0.0345506766 0.000000e+00 c-SC-s-c-CS-s -0.0289228121 -0.046178633 -0.0116669913 1.163387e-05 t-CS-m-c-CS-s -0.0295831188 -0.046838940 -0.0123272979 6.375219e-06 t-CS-s-c-CS-s -0.0368548934 -0.055302142 -0.0184076449 5.031518e-08 t-SC-m-c-CS-s -0.0212520197 -0.038507841 -0.0039961989 4.769310e-03 t-SC-s-c-CS-s -0.0167289348 -0.033984756 0.0005268861 6.512007e-02 c-SC-s-c-SC-m 0.0224467582 0.005627864 0.0392656519 1.397275e-03 t-CS-m-c-SC-m 0.0217864515 0.004967558 0.0386053452 2.258840e-03 t-CS-s-c-SC-m 0.0145146769 -0.003524525 0.0325538789 2.215086e-01 t-SC-m-c-SC-m 0.0301175506 0.013298657 0.0469364443 1.850318e-06 t-SC-s-c-SC-m 0.0346406355 0.017821742 0.0514595292 1.603605e-08 t-CS-m-c-SC-s -0.0006603067 -0.017916128 0.0165955142 1.000000e+00 t-CS-s-c-SC-s -0.0079320813 -0.026379330 0.0105151672 8.967905e-01 t-SC-m-c-SC-s 0.0076707924 -0.009585028 0.0249266133 8.792631e-01 t-SC-s-c-SC-s 0.0121938774 -0.005061943 0.0294496982 3.859175e-01 t-CS-s-t-CS-m -0.0072717746 -0.025719023 0.0111754738 9.328307e-01 t-SC-m-t-CS-m 0.0083310991 -0.008924722 0.0255869199 8.253159e-01 t-SC-s-t-CS-m 0.0128541840 -0.004401637 0.0301100049 3.156819e-01 t-SC-m-t-CS-s 0.0156028737 -0.002844375 0.0340501221 1.686252e-01 t-SC-s-t-CS-s 0.0201259586 0.001678710 0.0385732071 2.131978e-02 t-SC-s-t-SC-m 0.0045230850 -0.012732736 0.0217789058 9.933333e-01
NR1
Total variability: 129.79
Percentage of explained variability for NR1: 9.23%
P value for NR1: 0
Significant ANOVA result; proceeding to Tukey HSD test for NR1 diff lwr upr p adj c-CS-s-c-CS-m 0.036060168 -0.08337399 0.155494324 9.844771e-01 c-SC-m-c-CS-m -0.236115640 -0.35236431 -0.119866968 2.728344e-08 c-SC-s-c-CS-m 0.023225272 -0.09620888 0.142659429 9.989906e-01 t-CS-m-c-CS-m -0.185207993 -0.30464215 -0.065773836 7.636077e-05 t-CS-s-c-CS-m -0.197142492 -0.32524229 -0.069042694 9.041452e-05 t-SC-m-c-CS-m -0.002303091 -0.12173725 0.117131065 1.000000e+00 t-SC-s-c-CS-m -0.133007368 -0.25244152 -0.013573211 1.699446e-02 c-SC-m-c-CS-s -0.272175807 -0.39160996 -0.152741651 2.155555e-10 c-SC-s-c-CS-s -0.012834896 -0.13537175 0.109701964 9.999841e-01 t-CS-m-c-CS-s -0.221268161 -0.34380502 -0.098731301 1.441784e-06 t-CS-s-c-CS-s -0.233202659 -0.36420007 -0.102205247 2.199728e-06 t-SC-m-c-CS-s -0.038363259 -0.16090012 0.084173600 9.808468e-01 t-SC-s-c-CS-s -0.169067536 -0.29160439 -0.046530676 7.897918e-04 c-SC-s-c-SC-m 0.259340912 0.13990676 0.378775069 1.871510e-09 t-CS-m-c-SC-m 0.050907647 -0.06852651 0.170341804 9.010342e-01 t-CS-s-c-SC-m 0.038973148 -0.08912665 0.167072945 9.837704e-01 t-SC-m-c-SC-m 0.233812549 0.11437839 0.353246705 1.041027e-07 t-SC-s-c-SC-m 0.103108272 -0.01632588 0.222542429 1.491539e-01 t-CS-m-c-SC-s -0.208433265 -0.33097012 -0.085896406 7.881380e-06 t-CS-s-c-SC-s -0.220367764 -0.35136518 -0.089370351 1.057735e-05 t-SC-m-c-SC-s -0.025528363 -0.14806522 0.097008496 9.984242e-01 t-SC-s-c-SC-s -0.156232640 -0.27876950 -0.033695781 2.880753e-03 t-CS-s-t-CS-m -0.011934499 -0.14293191 0.119062914 9.999939e-01 t-SC-m-t-CS-m 0.182904902 0.06036804 0.305441761 1.739957e-04 t-SC-s-t-CS-m 0.052200625 -0.07033623 0.174737484 9.013032e-01 t-SC-m-t-CS-s 0.194839400 0.06384199 0.325836813 1.872918e-04 t-SC-s-t-CS-s 0.064135124 -0.06686229 0.195132537 8.146058e-01 t-SC-s-t-SC-m -0.130704277 -0.25324114 -0.008167417 2.703197e-02
NR2A
Total variability: 937.08
Percentage of explained variability for NR2A: 12.73%
P value for NR2A: 0
Significant ANOVA result; proceeding to Tukey HSD test for NR2A diff lwr upr p adj c-CS-s-c-CS-m -0.0284633230 -0.3431444 0.28621776 9.999942e-01 c-SC-m-c-CS-m -0.8491246454 -1.1554127 -0.54283657 0.000000e+00 c-SC-s-c-CS-m -0.3954441305 -0.7101252 -0.08076305 3.572874e-03 t-CS-m-c-CS-m -0.7425806907 -1.0572618 -0.42789961 3.951872e-11 t-CS-s-c-CS-m -0.7937019653 -1.1312150 -0.45618895 4.705791e-11 t-SC-m-c-CS-m -0.2523174542 -0.5669985 0.06236363 2.254654e-01 t-SC-s-c-CS-m -0.7434475616 -1.0581286 -0.42876648 3.725142e-11 c-SC-m-c-CS-s -0.8206613224 -1.1353424 -0.50598024 0.000000e+00 c-SC-s-c-CS-s -0.3669808075 -0.6898368 -0.04412483 1.341726e-02 t-CS-m-c-CS-s -0.7141173677 -1.0369733 -0.39126139 8.388031e-10 t-CS-s-c-CS-s -0.7652386422 -1.1103862 -0.42009109 7.549793e-10 t-SC-m-c-CS-s -0.2238541312 -0.5467101 0.09900185 4.118121e-01 t-SC-s-c-CS-s -0.7149842385 -1.0378402 -0.39212826 7.949256e-10 c-SC-s-c-SC-m 0.4536805149 0.1389994 0.76836160 3.493741e-04 t-CS-m-c-SC-m 0.1065439547 -0.2081371 0.42122504 9.701694e-01 t-CS-s-c-SC-m 0.0554226802 -0.2820903 0.39293570 9.996679e-01 t-SC-m-c-SC-m 0.5968071912 0.2821261 0.91148827 3.066718e-07 t-SC-s-c-SC-m 0.1056770839 -0.2090040 0.42035816 9.714961e-01 t-CS-m-c-SC-s -0.3471365602 -0.6699925 -0.02428058 2.488823e-02 t-CS-s-c-SC-s -0.3982578348 -0.7434054 -0.05311028 1.120258e-02 t-SC-m-c-SC-s 0.1431266763 -0.1797293 0.46598265 8.807965e-01 t-SC-s-c-SC-s -0.3480034311 -0.6708594 -0.02514745 2.424682e-02 t-CS-s-t-CS-m -0.0511212745 -0.3962688 0.29402628 9.998332e-01 t-SC-m-t-CS-m 0.4902632365 0.1674073 0.81311921 1.210110e-04 t-SC-s-t-CS-m -0.0008668708 -0.3237228 0.32198911 1.000000e+00 t-SC-m-t-CS-s 0.5413845110 0.1962370 0.88653207 5.892094e-05 t-SC-s-t-CS-s 0.0502544037 -0.2948932 0.39540196 9.998513e-01 t-SC-s-t-SC-m -0.4911301073 -0.8139861 -0.16827413 1.164939e-04
pAKT
Total variability: 1.87
Percentage of explained variability for pAKT: 19.15%
P value for pAKT: 0
Significant ANOVA result; proceeding to Tukey HSD test for pAKT diff lwr upr p adj c-CS-s-c-CS-m -0.0175091451 -0.0310237229 -0.0039945674 2.252893e-03 c-SC-m-c-CS-m 0.0113209341 -0.0018331900 0.0244750582 1.520113e-01 c-SC-s-c-CS-m 0.0034360303 -0.0100785475 0.0169506080 9.944709e-01 t-CS-m-c-CS-m -0.0163106394 -0.0298252172 -0.0027960617 6.299223e-03 t-CS-s-c-CS-m -0.0154664111 -0.0299615499 -0.0009712724 2.694012e-02 t-SC-m-c-CS-m 0.0391985814 0.0256840037 0.0527131592 0.000000e+00 t-SC-s-c-CS-m 0.0168271454 0.0033125677 0.0303417232 4.084277e-03 c-SC-m-c-CS-s 0.0288300792 0.0153155015 0.0423446570 3.940553e-09 c-SC-s-c-CS-s 0.0209451754 0.0070795112 0.0348108396 1.353706e-04 t-CS-m-c-CS-s 0.0011985057 -0.0126671585 0.0150641699 9.999958e-01 t-CS-s-c-CS-s 0.0020427340 -0.0127802846 0.0168657526 9.998973e-01 t-SC-m-c-CS-s 0.0567077266 0.0428420623 0.0705733908 0.000000e+00 t-SC-s-c-CS-s 0.0343362906 0.0204706264 0.0482019548 2.714384e-12 c-SC-s-c-SC-m -0.0078849038 -0.0213994816 0.0056296739 6.394206e-01 t-CS-m-c-SC-m -0.0276315735 -0.0411461513 -0.0141169958 2.124900e-08 t-CS-s-c-SC-m -0.0267873452 -0.0412824840 -0.0122922065 7.072441e-07 t-SC-m-c-SC-m 0.0278776473 0.0143630696 0.0413922251 1.511311e-08 t-SC-s-c-SC-m 0.0055062113 -0.0080083664 0.0190207891 9.206677e-01 t-CS-m-c-SC-s -0.0197466697 -0.0336123339 -0.0058810055 4.418885e-04 t-CS-s-c-SC-s -0.0189024414 -0.0337254600 -0.0040794229 2.873132e-03 t-SC-m-c-SC-s 0.0357625511 0.0218968869 0.0496282154 0.000000e+00 t-SC-s-c-SC-s 0.0133911152 -0.0004745491 0.0272567794 6.718212e-02 t-CS-s-t-CS-m 0.0008442283 -0.0139787903 0.0156672469 9.999998e-01 t-SC-m-t-CS-m 0.0555092209 0.0416435566 0.0693748851 0.000000e+00 t-SC-s-t-CS-m 0.0331377849 0.0192721207 0.0470034491 2.057654e-11 t-SC-m-t-CS-s 0.0546649926 0.0398419740 0.0694880111 0.000000e+00 t-SC-s-t-CS-s 0.0322935566 0.0174705380 0.0471165752 1.624190e-09 t-SC-s-t-SC-m -0.0223714360 -0.0362371002 -0.0085057718 3.031522e-05
pBRAF
Total variability: 0.79
Percentage of explained variability for pBRAF: 15.88%
P value for pBRAF: 0
Significant ANOVA result; proceeding to Tukey HSD test for pBRAF diff lwr upr p adj c-CS-s-c-CS-m -0.0138554603 -0.022808263 -0.0049026580 7.985560e-05 c-SC-m-c-CS-m 0.0073355504 -0.001378468 0.0160495683 1.733240e-01 c-SC-s-c-CS-m 0.0027633489 -0.006189453 0.0117161512 9.823547e-01 t-CS-m-c-CS-m -0.0082554502 -0.017208253 0.0006973521 9.591841e-02 t-CS-s-c-CS-m -0.0174163703 -0.027018750 -0.0078139903 1.260921e-06 t-SC-m-c-CS-m 0.0187958007 0.009842998 0.0277486030 7.549982e-09 t-SC-s-c-CS-m 0.0031063863 -0.005846416 0.0120591887 9.658464e-01 c-SC-m-c-CS-s 0.0211910107 0.012238208 0.0301438130 3.386946e-11 c-SC-s-c-CS-s 0.0166188092 0.007433428 0.0258041906 1.359134e-06 t-CS-m-c-CS-s 0.0056000101 -0.003585371 0.0147853915 5.847826e-01 t-CS-s-c-CS-s -0.0035609100 -0.013380496 0.0062586757 9.565985e-01 t-SC-m-c-CS-s 0.0326512610 0.023465880 0.0418366424 0.000000e+00 t-SC-s-c-CS-s 0.0169618467 0.007776465 0.0261472280 7.244072e-07 c-SC-s-c-SC-m -0.0045722015 -0.013525004 0.0043806009 7.793107e-01 t-CS-m-c-SC-m -0.0155910006 -0.024543803 -0.0066381982 4.133452e-06 t-CS-s-c-SC-m -0.0247519207 -0.034354301 -0.0151495406 0.000000e+00 t-SC-m-c-SC-m 0.0114602503 0.002507448 0.0204130526 2.711991e-03 t-SC-s-c-SC-m -0.0042291640 -0.013181966 0.0047236383 8.410942e-01 t-CS-m-c-SC-s -0.0110187991 -0.020204180 -0.0018334177 6.830227e-03 t-CS-s-c-SC-s -0.0201797192 -0.029999305 -0.0103601335 1.747298e-08 t-SC-m-c-SC-s 0.0160324518 0.006847070 0.0252178332 3.877304e-06 t-SC-s-c-SC-s 0.0003430374 -0.008842344 0.0095284188 1.000000e+00 t-CS-s-t-CS-m -0.0091609201 -0.018980506 0.0006586656 8.801514e-02 t-SC-m-t-CS-m 0.0270512509 0.017865869 0.0362366323 0.000000e+00 t-SC-s-t-CS-m 0.0113618365 0.002176455 0.0205472179 4.485960e-03 t-SC-m-t-CS-s 0.0362121710 0.026392585 0.0460317567 0.000000e+00 t-SC-s-t-CS-s 0.0205227567 0.010703171 0.0303423424 9.038985e-09 t-SC-s-t-SC-m -0.0156894143 -0.024874796 -0.0065040329 7.044959e-06
pCAMKII
Total variability: 1806.17
Percentage of explained variability for pCAMKII: 32.91%
P value for pCAMKII: 0
Significant ANOVA result; proceeding to Tukey HSD test for pCAMKII diff lwr upr p adj c-CS-s-c-CS-m 0.01938951 -0.36366306 0.40244208 9.999999e-01 c-SC-m-c-CS-m 1.82014050 1.44730450 2.19297649 0.000000e+00 c-SC-s-c-CS-m 0.44510092 0.06204835 0.82815349 1.027839e-02 t-CS-m-c-CS-m 0.20561409 -0.17743848 0.58866666 7.319525e-01 t-CS-s-c-CS-m -0.42728473 -0.83812999 -0.01643947 3.477890e-02 t-SC-m-c-CS-m 1.36107046 0.97801789 1.74412304 0.000000e+00 t-SC-s-c-CS-m 1.26036848 0.87731591 1.64342105 0.000000e+00 c-SC-m-c-CS-s 1.80075099 1.41769841 2.18380356 0.000000e+00 c-SC-s-c-CS-s 0.42571141 0.03270776 0.81871506 2.301557e-02 t-CS-m-c-CS-s 0.18622458 -0.20677907 0.57922822 8.389228e-01 t-CS-s-c-CS-s -0.44667424 -0.86681281 -0.02653567 2.795314e-02 t-SC-m-c-CS-s 1.34168095 0.94867730 1.73468460 0.000000e+00 t-SC-s-c-CS-s 1.24097897 0.84797532 1.63398262 0.000000e+00 c-SC-s-c-SC-m -1.37503958 -1.75809215 -0.99198700 0.000000e+00 t-CS-m-c-SC-m -1.61452641 -1.99757898 -1.23147384 0.000000e+00 t-CS-s-c-SC-m -2.24742523 -2.65827048 -1.83657997 0.000000e+00 t-SC-m-c-SC-m -0.45907003 -0.84212261 -0.07601746 6.917624e-03 t-SC-s-c-SC-m -0.55977202 -0.94282459 -0.17671944 2.678253e-04 t-CS-m-c-SC-s -0.23948683 -0.63249048 0.15351682 5.853914e-01 t-CS-s-c-SC-s -0.87238565 -1.29252422 -0.45224708 1.168764e-08 t-SC-m-c-SC-s 0.91596954 0.52296590 1.30897319 7.332746e-11 t-SC-s-c-SC-s 0.81526756 0.42226391 1.20827121 1.213096e-08 t-CS-s-t-CS-m -0.63289882 -1.05303739 -0.21276025 1.435551e-04 t-SC-m-t-CS-m 1.15545637 0.76245273 1.54846002 0.000000e+00 t-SC-s-t-CS-m 1.05475439 0.66175074 1.44775804 0.000000e+00 t-SC-m-t-CS-s 1.78835519 1.36821662 2.20849376 0.000000e+00 t-SC-s-t-CS-s 1.68765321 1.26751464 2.10779178 0.000000e+00 t-SC-s-t-SC-m -0.10070198 -0.49370563 0.29230166 9.941991e-01
pCREB
Total variability: 1.14
Percentage of explained variability for pCREB: 11.06%
P value for pCREB: 0
Significant ANOVA result; proceeding to Tukey HSD test for pCREB diff lwr upr p adj c-CS-s-c-CS-m 0.0099551549 -0.0011409323 0.0210512421 1.162907e-01 c-SC-m-c-CS-m 0.0096646853 -0.0011354529 0.0204648236 1.183373e-01 c-SC-s-c-CS-m 0.0164647799 0.0053686927 0.0275608671 1.966433e-04 t-CS-m-c-CS-m 0.0049109630 -0.0061851243 0.0160070502 8.817079e-01 t-CS-s-c-CS-m 0.0115564533 -0.0003447194 0.0234576260 6.425975e-02 t-SC-m-c-CS-m 0.0333047725 0.0222086852 0.0444008597 0.000000e+00 t-SC-s-c-CS-m 0.0286807459 0.0175846587 0.0397768332 0.000000e+00 c-SC-m-c-CS-s -0.0002904696 -0.0113865568 0.0108056177 1.000000e+00 c-SC-s-c-CS-s 0.0065096250 -0.0048747203 0.0178939703 6.631984e-01 t-CS-m-c-CS-s -0.0050441919 -0.0164285372 0.0063401534 8.810880e-01 t-CS-s-c-CS-s 0.0016012984 -0.0105690787 0.0137716754 9.999249e-01 t-SC-m-c-CS-s 0.0233496176 0.0119652723 0.0347339629 1.883757e-08 t-SC-s-c-CS-s 0.0187255911 0.0073412458 0.0301099363 1.883932e-05 c-SC-s-c-SC-m 0.0068000946 -0.0042959927 0.0178961818 5.781178e-01 t-CS-m-c-SC-m -0.0047537224 -0.0158498096 0.0063423649 8.985855e-01 t-CS-s-c-SC-m 0.0018917680 -0.0100094047 0.0137929406 9.997325e-01 t-SC-m-c-SC-m 0.0236400872 0.0125439999 0.0347361744 4.157452e-09 t-SC-s-c-SC-m 0.0190160606 0.0079199734 0.0301121479 6.438526e-06 t-CS-m-c-SC-s -0.0115538169 -0.0229381622 -0.0001694716 4.377970e-02 t-CS-s-c-SC-s -0.0049083266 -0.0170787037 0.0072620504 9.246043e-01 t-SC-m-c-SC-s 0.0168399926 0.0054556473 0.0282243379 2.095862e-04 t-SC-s-c-SC-s 0.0122159660 0.0008316208 0.0236003113 2.541406e-02 t-CS-s-t-CS-m 0.0066454903 -0.0055248867 0.0188158674 7.142753e-01 t-SC-m-t-CS-m 0.0283938095 0.0170094642 0.0397781548 1.666112e-12 t-SC-s-t-CS-m 0.0237697830 0.0123854377 0.0351541283 9.397307e-09 t-SC-m-t-CS-s 0.0217483192 0.0095779422 0.0339186963 1.967244e-06 t-SC-s-t-CS-s 0.0171242927 0.0049539156 0.0292946697 5.537892e-04 t-SC-s-t-SC-m -0.0046240265 -0.0160083718 0.0067603188 9.218774e-01
pELK
Total variability: 234.72
Percentage of explained variability for pELK: 10.54%
P value for pELK: 0
Significant ANOVA result; proceeding to Tukey HSD test for pELK diff lwr upr p adj c-CS-s-c-CS-m 0.19452599 0.03507328 0.353978697 5.441052e-03 c-SC-m-c-CS-m -0.21375182 -0.36895169 -0.058551944 8.151609e-04 c-SC-s-c-CS-m -0.16460365 -0.32405636 -0.005150939 3.735306e-02 t-CS-m-c-CS-m 0.07158719 -0.08786552 0.231039903 8.736041e-01 t-CS-s-c-CS-m 0.02598379 -0.14503814 0.197005722 9.998022e-01 t-SC-m-c-CS-m -0.11080249 -0.27025520 0.048650221 4.087860e-01 t-SC-s-c-CS-m -0.28747859 -0.44693130 -0.128025875 1.511077e-06 c-SC-m-c-CS-s -0.40827780 -0.56773051 -0.248825091 9.992007e-16 c-SC-s-c-CS-s -0.35912964 -0.52272467 -0.195534607 1.168683e-09 t-CS-m-c-CS-s -0.12293879 -0.28653382 0.040656235 3.043579e-01 t-CS-s-c-CS-s -0.16854219 -0.34343264 0.006348249 6.836417e-02 t-SC-m-c-CS-s -0.30532848 -0.46892351 -0.141733447 5.168622e-07 t-SC-s-c-CS-s -0.48200457 -0.64559960 -0.318409543 0.000000e+00 c-SC-s-c-SC-m 0.04914817 -0.11030455 0.208600876 9.824955e-01 t-CS-m-c-SC-m 0.28533901 0.12588630 0.444791718 1.887625e-06 t-CS-s-c-SC-m 0.23973561 0.06871368 0.410757538 5.933230e-04 t-SC-m-c-SC-m 0.10294933 -0.05650338 0.262402036 5.091747e-01 t-SC-s-c-SC-m -0.07372677 -0.23317948 0.085725940 8.554994e-01 t-CS-m-c-SC-s 0.23619084 0.07259581 0.399785871 3.399215e-04 t-CS-s-c-SC-s 0.19058744 0.01569700 0.365477886 2.158412e-02 t-SC-m-c-SC-s 0.05380116 -0.10979387 0.217396190 9.746518e-01 t-SC-s-c-SC-s -0.12287494 -0.28646997 0.040720094 3.050250e-01 t-CS-s-t-CS-m -0.04560340 -0.22049384 0.129287044 9.935428e-01 t-SC-m-t-CS-m -0.18238968 -0.34598471 -0.018794652 1.678213e-02 t-SC-s-t-CS-m -0.35906578 -0.52266081 -0.195470748 1.177778e-09 t-SC-m-t-CS-s -0.13678628 -0.31167673 0.038104160 2.546059e-01 t-SC-s-t-CS-s -0.31346238 -0.48835282 -0.138571936 1.800849e-06 t-SC-s-t-SC-m -0.17667610 -0.34027113 -0.013081067 2.376245e-02
pERK
Total variability: 128.41
Percentage of explained variability for pERK: 35.97%
P value for pERK: 0
Significant ANOVA result; proceeding to Tukey HSD test for pERK diff lwr upr p adj c-CS-s-c-CS-m 0.130791433 0.031015877 0.230566989 0.001872032 c-SC-m-c-CS-m -0.336461844 -0.433576240 -0.239347449 0.000000000 c-SC-s-c-CS-m -0.365010844 -0.464786401 -0.265235288 0.000000000 t-CS-m-c-CS-m 0.109263057 0.009487501 0.209038613 0.020473393 t-CS-s-c-CS-m 0.004306835 -0.102708016 0.111321687 0.999999979 t-SC-m-c-CS-m -0.335295227 -0.435070784 -0.235519671 0.000000000 t-SC-s-c-CS-m -0.333116436 -0.432891992 -0.233340880 0.000000000 c-SC-m-c-CS-s -0.467253278 -0.567028834 -0.367477721 0.000000000 c-SC-s-c-CS-s -0.495802277 -0.598169838 -0.393434717 0.000000000 t-CS-m-c-CS-s -0.021528376 -0.123895937 0.080839185 0.998325860 t-CS-s-c-CS-s -0.126484598 -0.235920124 -0.017049072 0.010977855 t-SC-m-c-CS-s -0.466086661 -0.568454221 -0.363719100 0.000000000 t-SC-s-c-CS-s -0.463907869 -0.566275430 -0.361540308 0.000000000 c-SC-s-c-SC-m -0.028549000 -0.128324556 0.071226556 0.988689395 t-CS-m-c-SC-m 0.445724901 0.345949345 0.545500458 0.000000000 t-CS-s-c-SC-m 0.340768680 0.233753828 0.447783531 0.000000000 t-SC-m-c-SC-m 0.001166617 -0.098608939 0.100942173 1.000000000 t-SC-s-c-SC-m 0.003345408 -0.096430148 0.103120965 0.999999994 t-CS-m-c-SC-s 0.474273901 0.371906340 0.576641462 0.000000000 t-CS-s-c-SC-s 0.369317679 0.259882154 0.478753205 0.000000000 t-SC-m-c-SC-s 0.029715617 -0.072651944 0.132083178 0.987680220 t-SC-s-c-SC-s 0.031894408 -0.070473153 0.134261969 0.981371953 t-CS-s-t-CS-m -0.104956222 -0.214391748 0.004479304 0.071067023 t-SC-m-t-CS-m -0.444558284 -0.546925845 -0.342190723 0.000000000 t-SC-s-t-CS-m -0.442379493 -0.544747054 -0.340011932 0.000000000 t-SC-m-t-CS-s -0.339602062 -0.449037588 -0.230166537 0.000000000 t-SC-s-t-CS-s -0.337423271 -0.446858797 -0.227987745 0.000000000 t-SC-s-t-SC-m 0.002178791 -0.100188769 0.104546352 1.000000000
pJNK
Total variability: 2.91
Percentage of explained variability for pJNK: 20.98%
P value for pJNK: 0
Significant ANOVA result; proceeding to Tukey HSD test for pJNK diff lwr upr p adj c-CS-s-c-CS-m -0.036672776 -5.335039e-02 -0.019995166 1.086092e-09 c-SC-m-c-CS-m 0.017754794 1.522000e-03 0.033987587 2.074495e-02 c-SC-s-c-CS-m -0.011133623 -2.781123e-02 0.005543987 4.637147e-01 t-CS-m-c-CS-m -0.043901674 -6.057928e-02 -0.027224064 0.000000e+00 t-CS-s-c-CS-m -0.020775500 -3.866317e-02 -0.002887832 1.033788e-02 t-SC-m-c-CS-m 0.029875668 1.319806e-02 0.046553279 1.830037e-06 t-SC-s-c-CS-m -0.002572367 -1.924998e-02 0.014105243 9.997812e-01 c-SC-m-c-CS-s 0.054427569 3.774996e-02 0.071105180 0.000000e+00 c-SC-s-c-CS-s 0.025539152 8.428285e-03 0.042650019 1.741967e-04 t-CS-m-c-CS-s -0.007228898 -2.433977e-02 0.009881969 9.051877e-01 t-CS-s-c-CS-s 0.015897276 -2.395010e-03 0.034189562 1.431193e-01 t-SC-m-c-CS-s 0.066548444 4.943758e-02 0.083659311 0.000000e+00 t-SC-s-c-CS-s 0.034100408 1.698954e-02 0.051211275 5.506259e-08 c-SC-s-c-SC-m -0.028888417 -4.556603e-02 -0.012210807 4.799911e-06 t-CS-m-c-SC-m -0.061656468 -7.833408e-02 -0.044978857 0.000000e+00 t-CS-s-c-SC-m -0.038530293 -5.641796e-02 -0.020642626 2.631976e-09 t-SC-m-c-SC-m 0.012120875 -4.556735e-03 0.028798485 3.481262e-01 t-SC-s-c-SC-m -0.020327161 -3.700477e-02 -0.003649551 5.510843e-03 t-CS-m-c-SC-s -0.032768051 -4.987892e-02 -0.015657184 2.218693e-07 t-CS-s-c-SC-s -0.009641876 -2.793416e-02 0.008650410 7.499682e-01 t-SC-m-c-SC-s 0.041009292 2.389842e-02 0.058120159 1.773304e-11 t-SC-s-c-SC-s 0.008561256 -8.549611e-03 0.025672123 7.970007e-01 t-CS-s-t-CS-m 0.023126174 4.833888e-03 0.041418460 3.268847e-03 t-SC-m-t-CS-m 0.073777342 5.666648e-02 0.090888209 0.000000e+00 t-SC-s-t-CS-m 0.041329307 2.421844e-02 0.058440173 1.168876e-11 t-SC-m-t-CS-s 0.050651168 3.235888e-02 0.068943454 0.000000e+00 t-SC-s-t-CS-s 0.018203132 -8.915372e-05 0.036495419 5.219293e-02 t-SC-s-t-SC-m -0.032448036 -4.955890e-02 -0.015337169 3.077707e-07
PKCA
Total variability: 2.94
Percentage of explained variability for PKCA: 16.38%
P value for PKCA: 0
Significant ANOVA result; proceeding to Tukey HSD test for PKCA diff lwr upr p adj c-CS-s-c-CS-m 1.272407e-02 -0.004518478 0.029966623 3.279562e-01 c-SC-m-c-CS-m -5.036537e-02 -0.067148040 -0.033582707 0.000000e+00 c-SC-s-c-CS-m -5.032391e-02 -0.067566458 -0.033081357 0.000000e+00 t-CS-m-c-CS-m -1.980992e-02 -0.037052471 -0.002567370 1.180686e-02 t-CS-s-c-CS-m -3.031678e-02 -0.048810380 -0.011823185 2.050158e-05 t-SC-m-c-CS-m -2.436714e-02 -0.041609687 -0.007124585 5.107511e-04 t-SC-s-c-CS-m -1.440948e-02 -0.031652032 0.002833069 1.806900e-01 c-SC-m-c-CS-s -6.308945e-02 -0.080331997 -0.045846896 0.000000e+00 c-SC-s-c-CS-s -6.304798e-02 -0.080738464 -0.045357496 0.000000e+00 t-CS-m-c-CS-s -3.253399e-02 -0.050224477 -0.014843510 8.233960e-07 t-CS-s-c-CS-s -4.304086e-02 -0.061952778 -0.024128933 2.293562e-10 t-SC-m-c-CS-s -3.709121e-02 -0.054781692 -0.019400725 7.957549e-09 t-SC-s-c-CS-s -2.713355e-02 -0.044824038 -0.009443070 9.737815e-05 c-SC-s-c-SC-m 4.146619e-05 -0.017201084 0.017284017 1.000000e+00 t-CS-m-c-SC-m 3.055545e-02 0.013312902 0.047798003 2.512983e-06 t-CS-s-c-SC-m 2.004859e-02 0.001554993 0.038542189 2.282284e-02 t-SC-m-c-SC-m 2.599824e-02 0.008755687 0.043240788 1.407775e-04 t-SC-s-c-SC-m 3.595589e-02 0.018713342 0.053198443 9.879435e-09 t-CS-m-c-SC-s 3.051399e-02 0.012823503 0.048204470 5.393624e-06 t-CS-s-c-SC-s 2.000712e-02 0.001095202 0.038919047 2.938878e-02 t-SC-m-c-SC-s 2.595677e-02 0.008266288 0.043647255 2.469932e-04 t-SC-s-c-SC-s 3.591443e-02 0.018223942 0.053604910 2.777836e-08 t-CS-s-t-CS-m -1.050686e-02 -0.029418784 0.008405061 6.956816e-01 t-SC-m-t-CS-m -4.557215e-03 -0.022247699 0.013133269 9.940057e-01 t-SC-s-t-CS-m 5.400440e-03 -0.012290044 0.023090923 9.834473e-01 t-SC-m-t-CS-s 5.949647e-03 -0.012962276 0.024861569 9.803052e-01 t-SC-s-t-CS-s 1.590730e-02 -0.003004621 0.034819224 1.741377e-01 t-SC-s-t-SC-m 9.957655e-03 -0.007732829 0.027648138 6.811646e-01
pMEK
Total variability: 2.29
Percentage of explained variability for pMEK: 18.86%
P value for pMEK: 0
Significant ANOVA result; proceeding to Tukey HSD test for pMEK diff lwr upr p adj c-CS-s-c-CS-m -1.109995e-02 -0.026111763 0.0039118644 3.253511e-01 c-SC-m-c-CS-m 1.799575e-02 0.003384322 0.0326071756 4.767350e-03 c-SC-s-c-CS-m 8.288755e-03 -0.006723058 0.0233005691 7.023969e-01 t-CS-m-c-CS-m -1.634455e-02 -0.031356361 -0.0013327330 2.179265e-02 t-CS-s-c-CS-m -1.633464e-02 -0.032435646 -0.0002336302 4.392830e-02 t-SC-m-c-CS-m 4.549306e-02 0.030481243 0.0605048705 0.000000e+00 t-SC-s-c-CS-m 2.237013e-02 0.007358320 0.0373819479 1.801110e-04 c-SC-m-c-CS-s 2.909570e-02 0.014083885 0.0441075122 1.473923e-07 c-SC-s-c-CS-s 1.938870e-02 0.003986909 0.0347905007 3.481984e-03 t-CS-m-c-CS-s -5.244597e-03 -0.020646393 0.0101571985 9.692078e-01 t-CS-s-c-CS-s -5.234689e-03 -0.021699901 0.0112305237 9.790818e-01 t-SC-m-c-CS-s 5.659301e-02 0.041191210 0.0719948021 0.000000e+00 t-SC-s-c-CS-s 3.347008e-02 0.018068288 0.0488718795 1.809398e-09 c-SC-s-c-SC-m -9.706994e-03 -0.024718807 0.0053048201 5.071226e-01 t-CS-m-c-SC-m -3.434030e-02 -0.049352110 -0.0193284820 1.802746e-10 t-CS-s-c-SC-m -3.433039e-02 -0.050431395 -0.0182293793 4.022948e-09 t-SC-m-c-SC-m 2.749731e-02 0.012485494 0.0425091215 9.324778e-07 t-SC-s-c-SC-m 4.374385e-03 -0.010637429 0.0193861989 9.873983e-01 t-CS-m-c-SC-s -2.463330e-02 -0.040035098 -0.0092315062 3.740461e-05 t-CS-s-c-SC-s -2.462339e-02 -0.041088606 -0.0081581810 1.672735e-04 t-SC-m-c-SC-s 3.720430e-02 0.021802505 0.0526060974 1.163636e-11 t-SC-s-c-SC-s 1.408138e-02 -0.001320417 0.0294831748 1.019933e-01 t-CS-s-t-CS-m 9.908642e-06 -0.016455304 0.0164751211 1.000000e+00 t-SC-m-t-CS-m 6.183760e-02 0.046435808 0.0772393995 0.000000e+00 t-SC-s-t-CS-m 3.871468e-02 0.023312885 0.0541164769 9.011680e-13 t-SC-m-t-CS-s 6.182769e-02 0.045362482 0.0782929073 0.000000e+00 t-SC-s-t-CS-s 3.870477e-02 0.022239560 0.0551699847 4.798839e-11 t-SC-s-t-SC-m -2.312292e-02 -0.038524719 -0.0077211267 1.541795e-04
pNR1
Total variability: 14.98
Percentage of explained variability for pNR1: 11.39%
P value for pNR1: 0
Significant ANOVA result; proceeding to Tukey HSD test for pNR1 diff lwr upr p adj c-CS-s-c-CS-m -0.004068007 -0.044152403 0.03601639 9.999872e-01 c-SC-m-c-CS-m -0.059088473 -0.098103759 -0.02007319 1.280961e-04 c-SC-s-c-CS-m 0.010562449 -0.029521948 0.05064684 9.931152e-01 t-CS-m-c-CS-m -0.088918928 -0.129003324 -0.04883453 7.376542e-10 t-CS-s-c-CS-m -0.095850334 -0.138843086 -0.05285758 5.894381e-10 t-SC-m-c-CS-m 0.001624814 -0.038459582 0.04170921 1.000000e+00 t-SC-s-c-CS-m -0.056705802 -0.096790198 -0.01662141 5.009946e-04 c-SC-m-c-CS-s -0.055020466 -0.095104862 -0.01493607 8.652514e-04 c-SC-s-c-CS-s 0.014630455 -0.026495267 0.05575618 9.608599e-01 t-CS-m-c-CS-s -0.084850921 -0.125976643 -0.04372520 1.499302e-08 t-CS-s-c-CS-s -0.091782327 -0.135747574 -0.04781708 9.455491e-09 t-SC-m-c-CS-s 0.005692821 -0.035432901 0.04681854 9.998942e-01 t-SC-s-c-CS-s -0.052637795 -0.093763518 -0.01151207 2.716837e-03 c-SC-s-c-SC-m 0.069650921 0.029566525 0.10973532 4.398414e-06 t-CS-m-c-SC-m -0.029830455 -0.069914851 0.01025394 3.169510e-01 t-CS-s-c-SC-m -0.036761861 -0.079754613 0.00623089 1.581011e-01 t-SC-m-c-SC-m 0.060713287 0.020628891 0.10079768 1.278413e-04 t-SC-s-c-SC-m 0.002382670 -0.037701726 0.04246707 9.999997e-01 t-CS-m-c-SC-s -0.099481376 -0.140607099 -0.05835565 1.078237e-11 t-CS-s-c-SC-s -0.106412783 -0.150378029 -0.06244754 1.043932e-11 t-SC-m-c-SC-s -0.008937634 -0.050063357 0.03218809 9.979344e-01 t-SC-s-c-SC-s -0.067268251 -0.108393974 -0.02614253 2.166883e-05 t-CS-s-t-CS-m -0.006931406 -0.050896653 0.03703384 9.997467e-01 t-SC-m-t-CS-m 0.090543742 0.049418019 0.13166946 1.029057e-09 t-SC-s-t-CS-m 0.032213125 -0.008912597 0.07333885 2.528290e-01 t-SC-m-t-CS-s 0.097475148 0.053509901 0.14144040 7.555746e-10 t-SC-s-t-CS-s 0.039144532 -0.004820715 0.08310978 1.224177e-01 t-SC-s-t-SC-m -0.058330617 -0.099456339 -0.01720489 4.771633e-04
pNR2A
Total variability: 38.04
Percentage of explained variability for pNR2A: 30.98%
P value for pNR2A: 0
Significant ANOVA result; proceeding to Tukey HSD test for pNR2A diff lwr upr p adj c-CS-s-c-CS-m 0.02107107 -0.035316806 0.077458937 9.490882e-01 c-SC-m-c-CS-m 0.21982010 0.164936181 0.274704028 0.000000e+00 c-SC-s-c-CS-m 0.09470608 0.038318210 0.151093953 1.102928e-05 t-CS-m-c-CS-m -0.12039976 -0.176787631 -0.064011888 3.794592e-09 t-CS-s-c-CS-m -0.03786356 -0.098342694 0.022615583 5.502896e-01 t-SC-m-c-CS-m 0.15623982 0.099851947 0.212627690 0.000000e+00 t-SC-s-c-CS-m -0.00953174 -0.065919612 0.046856131 9.995975e-01 c-SC-m-c-CS-s 0.19874904 0.142361168 0.255136911 0.000000e+00 c-SC-s-c-CS-s 0.07363502 0.015782281 0.131487752 2.956120e-03 t-CS-m-c-CS-s -0.14147083 -0.199323561 -0.083618090 5.853651e-12 t-CS-s-c-CS-s -0.05893462 -0.120781797 0.002912555 7.479792e-02 t-SC-m-c-CS-s 0.13516875 0.077316017 0.193021488 6.496381e-11 t-SC-s-c-CS-s -0.03060281 -0.088455541 0.027249930 7.465124e-01 c-SC-s-c-SC-m -0.12511402 -0.181501894 -0.068726151 7.300300e-10 t-CS-m-c-SC-m -0.34021986 -0.396607736 -0.283831993 0.000000e+00 t-CS-s-c-SC-m -0.25768366 -0.318162798 -0.197204521 0.000000e+00 t-SC-m-c-SC-m -0.06358029 -0.119968158 -0.007192415 1.474392e-02 t-SC-s-c-SC-m -0.22935184 -0.285739716 -0.172963973 0.000000e+00 t-CS-m-c-SC-s -0.21510584 -0.272958577 -0.157253106 0.000000e+00 t-CS-s-c-SC-s -0.13256964 -0.194416813 -0.070722462 3.230197e-09 t-SC-m-c-SC-s 0.06153374 0.003681001 0.119386472 2.782822e-02 t-SC-s-c-SC-s -0.10423782 -0.162090557 -0.046385086 1.539735e-06 t-CS-s-t-CS-m 0.08253620 0.020689029 0.144383380 1.398962e-03 t-SC-m-t-CS-m 0.27663958 0.218786843 0.334492313 0.000000e+00 t-SC-s-t-CS-m 0.11086802 0.053015284 0.168720755 2.167029e-07 t-SC-m-t-CS-s 0.19410337 0.132256198 0.255950549 0.000000e+00 t-SC-s-t-CS-s 0.02833182 -0.033515360 0.090178991 8.614255e-01 t-SC-s-t-SC-m -0.16577156 -0.223624294 -0.107918823 0.000000e+00
pNR2B
Total variability: 78.92
Percentage of explained variability for pNR2B: 10.43%
P value for pNR2B: 0
Significant ANOVA result; proceeding to Tukey HSD test for pNR2B diff lwr upr p adj c-CS-s-c-CS-m 0.006862988 -0.08565196 0.099377932 9.999985e-01 c-SC-m-c-CS-m -0.046950090 -0.13699752 0.043097344 7.603575e-01 c-SC-s-c-CS-m 0.056261590 -0.03625335 0.148776534 5.879957e-01 t-CS-m-c-CS-m -0.144393545 -0.23690849 -0.051878601 6.601392e-05 t-CS-s-c-CS-m -0.072903906 -0.17213135 0.026323534 3.337270e-01 t-SC-m-c-CS-m 0.113034035 0.02051909 0.205548979 5.329735e-03 t-SC-s-c-CS-m -0.156024999 -0.24853994 -0.063510055 9.897084e-06 c-SC-m-c-CS-s -0.053813078 -0.14632802 0.038701866 6.430573e-01 c-SC-s-c-CS-s 0.049398602 -0.04551973 0.144316932 7.620871e-01 t-CS-m-c-CS-s -0.151256533 -0.24617486 -0.056338203 4.079127e-05 t-CS-s-c-CS-s -0.079766894 -0.18123886 0.021705069 2.485460e-01 t-SC-m-c-CS-s 0.106171047 0.01125272 0.201089377 1.616776e-02 t-SC-s-c-CS-s -0.162887987 -0.25780632 -0.067969657 6.205219e-06 c-SC-s-c-SC-m 0.103211680 0.01069674 0.195726624 1.665707e-02 t-CS-m-c-SC-m -0.097443455 -0.18995840 -0.004928511 3.071060e-02 t-CS-s-c-SC-m -0.025953815 -0.12518126 0.073273624 9.934200e-01 t-SC-m-c-SC-m 0.159984125 0.06746918 0.252499069 5.027338e-06 t-SC-s-c-SC-m -0.109074909 -0.20158985 -0.016559965 8.559660e-03 t-CS-m-c-SC-s -0.200655135 -0.29557346 -0.105736805 5.715001e-09 t-CS-s-c-SC-s -0.129165496 -0.23063746 -0.027693533 2.952032e-03 t-SC-m-c-SC-s 0.056772445 -0.03814589 0.151690775 6.089659e-01 t-SC-s-c-SC-s -0.212286589 -0.30720492 -0.117368259 5.111390e-10 t-CS-s-t-CS-m 0.071489639 -0.02998232 0.172961602 3.900134e-01 t-SC-m-t-CS-m 0.257427580 0.16250925 0.352345910 0.000000e+00 t-SC-s-t-CS-m -0.011631454 -0.10654978 0.083286876 9.999536e-01 t-SC-m-t-CS-s 0.185937941 0.08446598 0.287409904 9.215869e-07 t-SC-s-t-CS-s -0.083121094 -0.18459306 0.018350869 2.017062e-01 t-SC-s-t-SC-m -0.269059034 -0.36397736 -0.174140704 0.000000e+00
pPKCAB
Total variability: 249.75
Percentage of explained variability for pPKCAB: 38.58%
P value for pPKCAB: 0
Significant ANOVA result; proceeding to Tukey HSD test for pPKCAB diff lwr upr p adj c-CS-s-c-CS-m 0.333081925 0.19679965 0.46936420 6.036727e-12 c-SC-m-c-CS-m -0.539738074 -0.67238550 -0.40709065 0.000000e+00 c-SC-s-c-CS-m -0.492337023 -0.62861930 -0.35605475 0.000000e+00 t-CS-m-c-CS-m -0.005945668 -0.14222794 0.13033660 1.000000e+00 t-CS-s-c-CS-m 0.063666382 -0.08250396 0.20983672 8.902700e-01 t-SC-m-c-CS-m -0.491298156 -0.62758043 -0.35501588 0.000000e+00 t-SC-s-c-CS-m -0.155769812 -0.29205209 -0.01948754 1.256125e-02 c-SC-m-c-CS-s -0.872819999 -1.00910227 -0.73653773 0.000000e+00 c-SC-s-c-CS-s -0.825418948 -0.96524161 -0.68559629 0.000000e+00 t-CS-m-c-CS-s -0.339027593 -0.47885026 -0.19920493 9.463208e-12 t-CS-s-c-CS-s -0.269415542 -0.41889226 -0.11993883 1.524123e-06 t-SC-m-c-CS-s -0.824380081 -0.96420274 -0.68455742 0.000000e+00 t-SC-s-c-CS-s -0.488851737 -0.62867440 -0.34902907 0.000000e+00 c-SC-s-c-SC-m 0.047401051 -0.08888122 0.18368332 9.653893e-01 t-CS-m-c-SC-m 0.533792406 0.39751013 0.67007468 0.000000e+00 t-CS-s-c-SC-m 0.603404457 0.45723411 0.74957480 0.000000e+00 t-SC-m-c-SC-m 0.048439918 -0.08784235 0.18472219 9.610453e-01 t-SC-s-c-SC-m 0.383968262 0.24768599 0.52025054 0.000000e+00 t-CS-m-c-SC-s 0.486391355 0.34656869 0.62621402 0.000000e+00 t-CS-s-c-SC-s 0.556003405 0.40652669 0.70548012 0.000000e+00 t-SC-m-c-SC-s 0.001038867 -0.13878379 0.14086153 1.000000e+00 t-SC-s-c-SC-s 0.336567211 0.19674455 0.47638987 1.407352e-11 t-CS-s-t-CS-m 0.069612051 -0.07986466 0.21908876 8.507901e-01 t-SC-m-t-CS-m -0.485352488 -0.62517515 -0.34552983 0.000000e+00 t-SC-s-t-CS-m -0.149824144 -0.28964681 -0.01000148 2.579053e-02 t-SC-m-t-CS-s -0.554964538 -0.70444125 -0.40548783 0.000000e+00 t-SC-s-t-CS-s -0.219436195 -0.36891291 -0.06995948 2.444494e-04 t-SC-s-t-SC-m 0.335528344 0.19570568 0.47535101 1.659928e-11
pRSK
Total variability: 4.79
Percentage of explained variability for pRSK: 7.77%
P value for pRSK: 0
Significant ANOVA result; proceeding to Tukey HSD test for pRSK diff lwr upr p adj c-CS-s-c-CS-m -0.003444149 -0.0265661779 0.019677881 9.998267e-01 c-SC-m-c-CS-m -0.006230826 -0.0287361569 0.016274504 9.907118e-01 c-SC-s-c-CS-m -0.015792320 -0.0389143495 0.007329709 4.324229e-01 t-CS-m-c-CS-m 0.020685264 -0.0024367652 0.043807293 1.185640e-01 t-CS-s-c-CS-m -0.022415992 -0.0472156585 0.002383675 1.105056e-01 t-SC-m-c-CS-m 0.004849815 -0.0182722146 0.027971844 9.983541e-01 t-SC-s-c-CS-m 0.040919561 0.0177975316 0.064041590 2.612548e-06 c-SC-m-c-CS-s -0.002786678 -0.0259087068 0.020335352 9.999586e-01 c-SC-s-c-CS-s -0.012348172 -0.0360708731 0.011374530 7.619277e-01 t-CS-m-c-CS-s 0.024129413 0.0004067113 0.047852114 4.289648e-02 t-CS-s-c-CS-s -0.018971843 -0.0443324779 0.006388791 3.101956e-01 t-SC-m-c-CS-s 0.008293963 -0.0154287381 0.032016665 9.643934e-01 t-SC-s-c-CS-s 0.044363710 0.0206410081 0.068086411 4.847885e-07 c-SC-s-c-SC-m -0.009561494 -0.0326835233 0.013560535 9.146103e-01 t-CS-m-c-SC-m 0.026916090 0.0037940610 0.050038120 1.005003e-02 t-CS-s-c-SC-m -0.016185166 -0.0409848323 0.008614501 4.945862e-01 t-SC-m-c-SC-m 0.011080641 -0.0120413883 0.034202670 8.308211e-01 t-SC-s-c-SC-m 0.047150387 0.0240283578 0.070272416 2.348670e-08 t-CS-m-c-SC-s 0.036477584 0.0127548828 0.060200286 9.212869e-05 t-CS-s-c-SC-s -0.006623672 -0.0319843064 0.018736963 9.934782e-01 t-SC-m-c-SC-s 0.020642135 -0.0030805665 0.044364836 1.420166e-01 t-SC-s-c-SC-s 0.056711881 0.0329891796 0.080434583 2.026368e-11 t-CS-s-t-CS-m -0.043101256 -0.0684618907 -0.017740621 8.063641e-06 t-SC-m-t-CS-m -0.015835449 -0.0395581508 0.007887252 4.638295e-01 t-SC-s-t-CS-m 0.020234297 -0.0034884047 0.043956998 1.604672e-01 t-SC-m-t-CS-s 0.027265807 0.0019051720 0.052626441 2.490816e-02 t-SC-s-t-CS-s 0.063335553 0.0379749182 0.088696188 1.516565e-12 t-SC-s-t-SC-m 0.036069746 0.0123470447 0.059792448 1.177077e-04
AKT
Total variability: 17.47
Percentage of explained variability for AKT: 23.14%
P value for AKT: 0
Significant ANOVA result; proceeding to Tukey HSD test for AKT diff lwr upr p adj c-CS-s-c-CS-m -0.056301088 -0.0966270688 -0.01597511 6.385766e-04 c-SC-m-c-CS-m -0.050194737 -0.0894451648 -0.01094431 2.752281e-03 c-SC-s-c-CS-m 0.078827086 0.0385011058 0.11915307 1.096980e-07 t-CS-m-c-CS-m -0.115583586 -0.1559095670 -0.07525761 0.000000e+00 t-CS-s-c-CS-m -0.060162322 -0.1034141868 -0.01691046 6.829813e-04 t-SC-m-c-CS-m 0.063360206 0.0230342251 0.10368619 5.668944e-05 t-SC-s-c-CS-m -0.009368667 -0.0496946480 0.03095731 9.968470e-01 c-SC-m-c-CS-s 0.006106351 -0.0342196299 0.04643233 9.998066e-01 c-SC-s-c-CS-s 0.135128175 0.0937545914 0.17650176 0.000000e+00 t-CS-m-c-CS-s -0.059282498 -0.1006560814 -0.01790892 3.934266e-04 t-CS-s-c-CS-s -0.003861234 -0.0480914552 0.04036899 9.999955e-01 t-SC-m-c-CS-s 0.119661294 0.0782877108 0.16103488 0.000000e+00 t-SC-s-c-CS-s 0.046932421 0.0055588376 0.08830600 1.374326e-02 c-SC-s-c-SC-m 0.129021824 0.0886958432 0.16934780 0.000000e+00 t-CS-m-c-SC-m -0.065388849 -0.1057148296 -0.02506287 2.685197e-05 t-CS-s-c-SC-m -0.009967585 -0.0532194493 0.03328428 9.970034e-01 t-SC-m-c-SC-m 0.113554943 0.0732289626 0.15388092 0.000000e+00 t-SC-s-c-SC-m 0.040826070 0.0005000894 0.08115205 4.476970e-02 t-CS-m-c-SC-s -0.194410673 -0.2357842560 -0.15303709 0.000000e+00 t-CS-s-c-SC-s -0.138989409 -0.1832196297 -0.09475919 0.000000e+00 t-SC-m-c-SC-s -0.015466881 -0.0568404638 0.02590670 9.489776e-01 t-SC-s-c-SC-s -0.088195754 -0.1295693370 -0.04682217 4.061764e-09 t-CS-s-t-CS-m 0.055421264 0.0111910431 0.09965148 3.727082e-03 t-SC-m-t-CS-m 0.178943792 0.1375702090 0.22031738 0.000000e+00 t-SC-s-t-CS-m 0.106214919 0.0648413358 0.14758850 0.000000e+00 t-SC-m-t-CS-s 0.123522528 0.0792923074 0.16775275 0.000000e+00 t-SC-s-t-CS-s 0.050793655 0.0065634342 0.09502388 1.186974e-02 t-SC-s-t-SC-m -0.072728873 -0.1141024563 -0.03135529 3.170188e-06
BRAF
Total variability: 50.41
Percentage of explained variability for BRAF: 25.74%
P value for BRAF: 0
Significant ANOVA result; proceeding to Tukey HSD test for BRAF diff lwr upr p adj c-CS-s-c-CS-m 0.105757548 0.03843302 0.17308208 5.697090e-05 c-SC-m-c-CS-m -0.161484566 -0.22701345 -0.09595568 3.690381e-12 c-SC-s-c-CS-m -0.158289138 -0.22561367 -0.09096461 4.754452e-11 t-CS-m-c-CS-m 0.111968574 0.04464405 0.17929310 1.423088e-05 t-CS-s-c-CS-m 0.010770197 -0.06143912 0.08297951 9.998252e-01 t-SC-m-c-CS-m -0.130655793 -0.19798032 -0.06333126 1.409859e-07 t-SC-s-c-CS-m -0.139224748 -0.20654928 -0.07190022 1.370974e-08 c-SC-m-c-CS-s -0.267242114 -0.33456664 -0.19991759 0.000000e+00 c-SC-s-c-CS-s -0.264046685 -0.33312019 -0.19497318 0.000000e+00 t-CS-m-c-CS-s 0.006211026 -0.06286248 0.07528453 9.999944e-01 t-CS-s-c-CS-s -0.094987351 -0.16883004 -0.02114466 2.516604e-03 t-SC-m-c-CS-s -0.236413340 -0.30548685 -0.16733983 0.000000e+00 t-SC-s-c-CS-s -0.244982296 -0.31405580 -0.17590879 0.000000e+00 c-SC-s-c-SC-m 0.003195428 -0.06412910 0.07051996 9.999999e-01 t-CS-m-c-SC-m 0.273453140 0.20612861 0.34077767 0.000000e+00 t-CS-s-c-SC-m 0.172254763 0.10004545 0.24446408 2.266820e-11 t-SC-m-c-SC-m 0.030828773 -0.03649575 0.09815330 8.616730e-01 t-SC-s-c-SC-m 0.022259817 -0.04506471 0.08958435 9.738760e-01 t-CS-m-c-SC-s 0.270257711 0.20118420 0.33933122 0.000000e+00 t-CS-s-c-SC-s 0.169059334 0.09521665 0.24290202 1.733322e-10 t-SC-m-c-SC-s 0.027633345 -0.04144016 0.09670685 9.276070e-01 t-SC-s-c-SC-s 0.019064389 -0.05000912 0.08813790 9.908837e-01 t-CS-s-t-CS-m -0.101198377 -0.17504106 -0.02735569 8.894397e-04 t-SC-m-t-CS-m -0.242624367 -0.31169787 -0.17355086 0.000000e+00 t-SC-s-t-CS-m -0.251193322 -0.32026683 -0.18211981 0.000000e+00 t-SC-m-t-CS-s -0.141425990 -0.21526868 -0.06758330 2.211286e-07 t-SC-s-t-CS-s -0.149994945 -0.22383763 -0.07615226 2.720698e-08 t-SC-s-t-SC-m -0.008568956 -0.07764246 0.06050455 9.999496e-01
CAMKII
Total variability: 2.95
Percentage of explained variability for CAMKII: 14.76%
P value for CAMKII: 0
Significant ANOVA result; proceeding to Tukey HSD test for CAMKII diff lwr upr p adj c-CS-s-c-CS-m 0.0009424752 -0.0165043544 0.0183893048 9.999998e-01 c-SC-m-c-CS-m -0.0081085317 -0.0250900287 0.0088729652 8.334553e-01 c-SC-s-c-CS-m 0.0056703807 -0.0117764489 0.0231172103 9.762866e-01 t-CS-m-c-CS-m -0.0381089786 -0.0555558082 -0.0206621490 1.451723e-09 t-CS-s-c-CS-m -0.0193513616 -0.0380640598 -0.0006386633 3.672895e-02 t-SC-m-c-CS-m 0.0370547095 0.0196078799 0.0545015391 4.724721e-09 t-SC-s-c-CS-m -0.0102200004 -0.0276668300 0.0072268292 6.345898e-01 c-SC-m-c-CS-s -0.0090510069 -0.0264978365 0.0083958227 7.650577e-01 c-SC-s-c-CS-s 0.0047279055 -0.0131721640 0.0226279750 9.930154e-01 t-CS-m-c-CS-s -0.0390514538 -0.0569515233 -0.0211513844 1.529944e-09 t-CS-s-c-CS-s -0.0202938368 -0.0394298160 -0.0011578576 2.867080e-02 t-SC-m-c-CS-s 0.0361122343 0.0182121648 0.0540123038 3.513497e-08 t-SC-s-c-CS-s -0.0111624756 -0.0290625451 0.0067375938 5.554689e-01 c-SC-s-c-SC-m 0.0137789124 -0.0036679172 0.0312257420 2.430316e-01 t-CS-m-c-SC-m -0.0300004469 -0.0474472765 -0.0125536173 5.873720e-06 t-CS-s-c-SC-m -0.0112428299 -0.0299555281 0.0074698684 6.033377e-01 t-SC-m-c-SC-m 0.0451632412 0.0277164116 0.0626100708 0.000000e+00 t-SC-s-c-SC-m -0.0021114687 -0.0195582983 0.0153353609 9.999574e-01 t-CS-m-c-SC-s -0.0437793593 -0.0616794288 -0.0258792899 5.797918e-12 t-CS-s-c-SC-s -0.0250217423 -0.0441577215 -0.0058857631 1.948338e-03 t-SC-m-c-SC-s 0.0313843288 0.0134842593 0.0492843983 3.413267e-06 t-SC-s-c-SC-s -0.0158903812 -0.0337904506 0.0020096883 1.248386e-01 t-CS-s-t-CS-m 0.0187576171 -0.0003783621 0.0378935963 5.940597e-02 t-SC-m-t-CS-m 0.0751636881 0.0572636187 0.0930637576 0.000000e+00 t-SC-s-t-CS-m 0.0278889782 0.0099889087 0.0457890477 6.867592e-05 t-SC-m-t-CS-s 0.0564060711 0.0372700919 0.0755420503 0.000000e+00 t-SC-s-t-CS-s 0.0091313611 -0.0100046181 0.0282673403 8.339233e-01 t-SC-s-t-SC-m -0.0472747099 -0.0651747794 -0.0293746405 0.000000e+00
CREB
Total variability: 0.75
Percentage of explained variability for CREB: 8.96%
P value for CREB: 0
Significant ANOVA result; proceeding to Tukey HSD test for CREB diff lwr upr p adj c-CS-s-c-CS-m 4.622018e-04 -0.0086204748 0.009544878 9.999999e-01 c-SC-m-c-CS-m 6.954003e-03 -0.0018864254 0.015794431 2.477657e-01 c-SC-s-c-CS-m -5.926622e-05 -0.0091419428 0.009023410 1.000000e+00 t-CS-m-c-CS-m 7.143905e-04 -0.0083682861 0.009797067 9.999978e-01 t-CS-s-c-CS-m -1.229340e-02 -0.0220350790 -0.002551724 3.358896e-03 t-SC-m-c-CS-m 1.799864e-02 0.0089159612 0.027081314 6.757040e-08 t-SC-s-c-CS-m 9.508210e-03 0.0004255337 0.018590887 3.262606e-02 c-SC-m-c-CS-s 6.491801e-03 -0.0025908756 0.015574478 3.705054e-01 c-SC-s-c-CS-s -5.214680e-04 -0.0098400975 0.008797162 9.999998e-01 t-CS-m-c-CS-s 2.521887e-04 -0.0090664408 0.009570818 1.000000e+00 t-CS-s-c-CS-s -1.275560e-02 -0.0227176374 -0.002793569 2.700809e-03 t-SC-m-c-CS-s 1.753644e-02 0.0082178065 0.026855065 3.956795e-07 t-SC-s-c-CS-s 9.046008e-03 -0.0002726210 0.018364638 6.441826e-02 c-SC-s-c-SC-m -7.013269e-03 -0.0160959455 0.002069408 2.702099e-01 t-CS-m-c-SC-m -6.239612e-03 -0.0153222888 0.002843064 4.244592e-01 t-CS-s-c-SC-m -1.924740e-02 -0.0289890818 -0.009505727 7.513917e-08 t-SC-m-c-SC-m 1.104463e-02 0.0019619584 0.020127312 5.688346e-03 t-SC-s-c-SC-m 2.554208e-03 -0.0065284690 0.011636884 9.897999e-01 t-CS-m-c-SC-s 7.736567e-04 -0.0085449728 0.010092286 9.999968e-01 t-CS-s-c-SC-s -1.223414e-02 -0.0221961694 -0.002272101 4.963586e-03 t-SC-m-c-SC-s 1.805790e-02 0.0087392744 0.027376533 1.483340e-07 t-SC-s-c-SC-s 9.567476e-03 0.0002488469 0.018886106 3.932424e-02 t-CS-s-t-CS-m -1.300779e-02 -0.0229698261 -0.003045758 1.992375e-03 t-SC-m-t-CS-m 1.728425e-02 0.0079656177 0.026602877 6.300197e-07 t-SC-s-t-CS-m 8.793820e-03 -0.0005248097 0.018112449 8.068268e-02 t-SC-m-t-CS-s 3.029204e-02 0.0203300054 0.040254073 0.000000e+00 t-SC-s-t-CS-s 2.180161e-02 0.0118395779 0.031763646 1.336530e-09 t-SC-s-t-SC-m -8.490427e-03 -0.0178090570 0.000828202 1.045141e-01
ELK
Total variability: 119.84
Percentage of explained variability for ELK: 6.66%
P value for ELK: 0
Significant ANOVA result; proceeding to Tukey HSD test for ELK diff lwr upr p adj c-CS-s-c-CS-m 0.050182185 -0.066196910 0.16656128 8.953980e-01 c-SC-m-c-CS-m -0.205755775 -0.319030868 -0.09248068 1.205801e-06 c-SC-s-c-CS-m -0.012202350 -0.128581445 0.10417674 9.999840e-01 t-CS-m-c-CS-m -0.179942152 -0.296321247 -0.06356306 8.152920e-05 t-CS-s-c-CS-m -0.007058299 -0.131881372 0.11776477 9.999998e-01 t-SC-m-c-CS-m -0.084909525 -0.201288620 0.03146957 3.429789e-01 t-SC-s-c-CS-m -0.079558483 -0.195937578 0.03682061 4.311872e-01 c-SC-m-c-CS-s -0.255937960 -0.372317055 -0.13955887 1.080661e-09 c-SC-s-c-CS-s -0.062384536 -0.181786968 0.05701790 7.584057e-01 t-CS-m-c-CS-s -0.230124337 -0.349526769 -0.11072191 1.787585e-07 t-CS-s-c-CS-s -0.057240485 -0.184887054 0.07040608 8.742855e-01 t-SC-m-c-CS-s -0.135091711 -0.254494143 -0.01568928 1.417062e-02 t-SC-s-c-CS-s -0.129740669 -0.249143101 -0.01033824 2.226911e-02 c-SC-s-c-SC-m 0.193553424 0.077174329 0.30993252 1.422831e-05 t-CS-m-c-SC-m 0.025813623 -0.090565472 0.14219272 9.976478e-01 t-CS-s-c-SC-m 0.198697475 0.073874402 0.32352055 4.183901e-05 t-SC-m-c-SC-m 0.120846249 0.004467154 0.23722534 3.530969e-02 t-SC-s-c-SC-m 0.126197291 0.009818196 0.24257639 2.275998e-02 t-CS-m-c-SC-s -0.167739802 -0.287142234 -0.04833737 5.701454e-04 t-CS-s-c-SC-s 0.005144051 -0.122502518 0.13279062 1.000000e+00 t-SC-m-c-SC-s -0.072707175 -0.192109607 0.04669526 5.863367e-01 t-SC-s-c-SC-s -0.067356133 -0.186758565 0.05204630 6.787075e-01 t-CS-s-t-CS-m 0.172883853 0.045237284 0.30053042 1.090691e-03 t-SC-m-t-CS-m 0.095032626 -0.024369806 0.21443506 2.339828e-01 t-SC-s-t-CS-m 0.100383669 -0.019018763 0.21978610 1.746244e-01 t-SC-m-t-CS-s -0.077851226 -0.205497795 0.04979534 5.842969e-01 t-SC-s-t-CS-s -0.072500184 -0.200146753 0.05514639 6.709400e-01 t-SC-s-t-SC-m 0.005351042 -0.114051390 0.12475347 1.000000e+00
ERK
Total variability: 459.41
Percentage of explained variability for ERK: 18.63%
P value for ERK: 0
Significant ANOVA result; proceeding to Tukey HSD test for ERK diff lwr upr p adj c-CS-s-c-CS-m 0.0074006715 -0.20535786 0.22015921 1.000000e+00 c-SC-m-c-CS-m -0.8192690436 -1.02635299 -0.61218509 0.000000e+00 c-SC-s-c-CS-m -0.4964427910 -0.70920132 -0.28368426 6.930900e-11 t-CS-m-c-CS-m -0.5635592382 -0.77631777 -0.35080070 0.000000e+00 t-CS-s-c-CS-m -0.1591802852 -0.38737568 0.06901511 4.035501e-01 t-SC-m-c-CS-m -0.4891840092 -0.70194254 -0.27642548 1.415178e-10 t-SC-s-c-CS-m -0.4890135143 -0.70177205 -0.27625498 1.438908e-10 c-SC-m-c-CS-s -0.8266697151 -1.03942825 -0.61391118 0.000000e+00 c-SC-s-c-CS-s -0.5038434626 -0.72212911 -0.28555781 1.175097e-10 t-CS-m-c-CS-s -0.5709599098 -0.78924556 -0.35267426 0.000000e+00 t-CS-s-c-CS-s -0.1665809567 -0.39993813 0.06677622 3.722055e-01 t-SC-m-c-CS-s -0.4965846808 -0.71487033 -0.27829903 2.337680e-10 t-SC-s-c-CS-s -0.4964141858 -0.71469984 -0.27812854 2.375462e-10 c-SC-s-c-SC-m 0.3228262526 0.11006772 0.53558479 1.230549e-04 t-CS-m-c-SC-m 0.2557098054 0.04295127 0.46846834 6.660193e-03 t-CS-s-c-SC-m 0.6600887584 0.43189336 0.88828416 0.000000e+00 t-SC-m-c-SC-m 0.3300850344 0.11732650 0.54284357 7.554673e-05 t-SC-s-c-SC-m 0.3302555293 0.11749700 0.54301406 7.467654e-05 t-CS-m-c-SC-s -0.0671164472 -0.28540210 0.15116920 9.827439e-01 t-CS-s-c-SC-s 0.3372625059 0.10390533 0.57061968 3.330751e-04 t-SC-m-c-SC-s 0.0072587818 -0.21102687 0.22554443 1.000000e+00 t-SC-s-c-SC-s 0.0074292767 -0.21085637 0.22571493 1.000000e+00 t-CS-s-t-CS-m 0.4043789531 0.17102178 0.63773613 4.745716e-06 t-SC-m-t-CS-m 0.0743752290 -0.14391042 0.29266088 9.691045e-01 t-SC-s-t-CS-m 0.0745457239 -0.14373993 0.29283137 9.687103e-01 t-SC-m-t-CS-s -0.3300037241 -0.56336090 -0.09664655 5.043309e-04 t-SC-s-t-CS-s -0.3298332291 -0.56319040 -0.09647605 5.092137e-04 t-SC-s-t-SC-m 0.0001704949 -0.21811515 0.21845614 1.000000e+00
GSK3B
Total variability: 64.47
Percentage of explained variability for GSK3B: 25.78%
P value for GSK3B: 0
Significant ANOVA result; proceeding to Tukey HSD test for GSK3B diff lwr upr p adj c-CS-s-c-CS-m 0.066470266 -0.009644733 0.142585265 1.388207e-01 c-SC-m-c-CS-m -0.275125136 -0.349210036 -0.201040236 0.000000e+00 c-SC-s-c-CS-m -0.272903341 -0.349018340 -0.196788342 0.000000e+00 t-CS-m-c-CS-m -0.008004564 -0.084119563 0.068110436 9.999837e-01 t-CS-s-c-CS-m -0.053359874 -0.134997457 0.028277710 4.925430e-01 t-SC-m-c-CS-m -0.181319727 -0.257434727 -0.105204728 2.436595e-11 t-SC-s-c-CS-m -0.172086495 -0.248201494 -0.095971496 3.117049e-10 c-SC-m-c-CS-s -0.341595402 -0.417710401 -0.265480403 0.000000e+00 c-SC-s-c-CS-s -0.339373607 -0.417465949 -0.261281266 0.000000e+00 t-CS-m-c-CS-s -0.074474830 -0.152567171 0.003617512 7.432355e-02 t-CS-s-c-CS-s -0.119830140 -0.203314364 -0.036345915 3.804652e-04 t-SC-m-c-CS-s -0.247789994 -0.325882335 -0.169697652 0.000000e+00 t-SC-s-c-CS-s -0.238556761 -0.316649102 -0.160464419 0.000000e+00 c-SC-s-c-SC-m 0.002221795 -0.073893204 0.078336794 1.000000e+00 t-CS-m-c-SC-m 0.267120573 0.191005573 0.343235572 0.000000e+00 t-CS-s-c-SC-m 0.221765263 0.140127679 0.303402846 0.000000e+00 t-SC-m-c-SC-m 0.093805409 0.017690409 0.169920408 4.724328e-03 t-SC-s-c-SC-m 0.103038641 0.026923642 0.179153641 1.099973e-03 t-CS-m-c-SC-s 0.264898778 0.186806436 0.342991119 0.000000e+00 t-CS-s-c-SC-s 0.219543468 0.136059243 0.303027692 0.000000e+00 t-SC-m-c-SC-s 0.091583614 0.013491272 0.169675955 9.156828e-03 t-SC-s-c-SC-s 0.100816846 0.022724505 0.178909188 2.380376e-03 t-CS-s-t-CS-m -0.045355310 -0.128839535 0.038128915 7.195825e-01 t-SC-m-t-CS-m -0.173315164 -0.251407506 -0.095222822 7.220063e-10 t-SC-s-t-CS-m -0.164081931 -0.242174273 -0.085989590 7.309569e-09 t-SC-m-t-CS-s -0.127959854 -0.211444079 -0.044475629 9.885151e-05 t-SC-s-t-CS-s -0.118726621 -0.202210846 -0.035242397 4.537618e-04 t-SC-s-t-SC-m 0.009233233 -0.068859109 0.087325574 9.999637e-01
JNK
Total variability: 1.24
Percentage of explained variability for JNK: 5.52%
P value for JNK: 0
Significant ANOVA result; proceeding to Tukey HSD test for JNK diff lwr upr p adj c-CS-s-c-CS-m -0.015883445 -0.0277773238 -0.0039895660 1.383198e-03 c-SC-m-c-CS-m -0.023632947 -0.0352095983 -0.0120562950 2.253036e-08 c-SC-s-c-CS-m -0.013602452 -0.0254963305 -0.0017085727 1.247513e-02 t-CS-m-c-CS-m -0.012475656 -0.0243695352 -0.0005817774 3.199970e-02 t-CS-s-c-CS-m -0.021383193 -0.0341400417 -0.0086263442 1.161694e-05 t-SC-m-c-CS-m -0.001598405 -0.0134922835 0.0102954743 9.999133e-01 t-SC-s-c-CS-m -0.010870904 -0.0227647832 0.0010229746 1.022135e-01 c-SC-m-c-CS-s -0.007749502 -0.0196433806 0.0041443772 4.968394e-01 c-SC-s-c-CS-s 0.002280993 -0.0099218690 0.0144838556 9.992200e-01 t-CS-m-c-CS-s 0.003407789 -0.0087950737 0.0156106509 9.902175e-01 t-CS-s-c-CS-s -0.005499748 -0.0185451566 0.0075456604 9.061519e-01 t-SC-m-c-CS-s 0.014285040 0.0020821780 0.0264879025 9.369293e-03 t-SC-s-c-CS-s 0.005012541 -0.0071903217 0.0172154029 9.173845e-01 c-SC-s-c-SC-m 0.010030495 -0.0018633838 0.0219243740 1.715249e-01 t-CS-m-c-SC-m 0.011157290 -0.0007365885 0.0230511693 8.444293e-02 t-CS-s-c-SC-m 0.002249754 -0.0105070951 0.0150066025 9.994676e-01 t-SC-m-c-SC-m 0.022034542 0.0101406631 0.0339284209 6.542409e-07 t-SC-s-c-SC-m 0.012762042 0.0008681634 0.0246559212 2.542810e-02 t-CS-m-c-SC-s 0.001126795 -0.0110760670 0.0133296576 9.999933e-01 t-CS-s-c-SC-s -0.007780741 -0.0208261499 0.0052646671 6.124779e-01 t-SC-m-c-SC-s 0.012004047 -0.0001988153 0.0242069092 5.765051e-02 t-SC-s-c-SC-s 0.002731547 -0.0094713150 0.0149344095 9.975071e-01 t-CS-s-t-CS-m -0.008907537 -0.0219529452 0.0041378718 4.328019e-01 t-SC-m-t-CS-m 0.010877252 -0.0013256106 0.0230801139 1.214891e-01 t-SC-s-t-CS-m 0.001604752 -0.0105981103 0.0138076142 9.999252e-01 t-SC-m-t-CS-s 0.019784788 0.0067393798 0.0328301968 1.243266e-04 t-SC-s-t-CS-s 0.010512289 -0.0025331199 0.0235576972 2.198204e-01 t-SC-s-t-SC-m -0.009272500 -0.0214753619 0.0029303626 2.902342e-01
MEK
Total variability: 1.81
Percentage of explained variability for MEK: 7.17%
P value for MEK: 0
Significant ANOVA result; proceeding to Tukey HSD test for MEK diff lwr upr p adj c-CS-s-c-CS-m 0.006449933 -0.0078112465 0.0207111130 8.692595e-01 c-SC-m-c-CS-m -0.010163236 -0.0240440495 0.0037175767 3.382936e-01 c-SC-s-c-CS-m 0.001289523 -0.0129716570 0.0155507025 9.999942e-01 t-CS-m-c-CS-m -0.012230834 -0.0264920133 0.0020303462 1.552784e-01 t-CS-s-c-CS-m -0.008353993 -0.0236499044 0.0069419177 7.140427e-01 t-SC-m-c-CS-m 0.018538508 0.0042773284 0.0327996879 2.137625e-03 t-SC-s-c-CS-m 0.016627914 0.0023667344 0.0308890940 9.851225e-03 c-SC-m-c-CS-s -0.016613170 -0.0308743494 -0.0023519899 9.960823e-03 c-SC-s-c-CS-s -0.005160411 -0.0197920722 0.0094712512 9.626553e-01 t-CS-m-c-CS-s -0.018680767 -0.0333124286 -0.0040491051 2.821619e-03 t-CS-s-c-CS-s -0.014803927 -0.0304458310 0.0008379777 7.889311e-02 t-SC-m-c-CS-s 0.012088575 -0.0025430868 0.0267202366 1.925644e-01 t-SC-s-c-CS-s 0.010177981 -0.0044536808 0.0248096427 4.073689e-01 c-SC-s-c-SC-m 0.011452759 -0.0028084206 0.0257139389 2.236887e-01 t-CS-m-c-SC-m -0.002067597 -0.0163287770 0.0121935826 9.998555e-01 t-CS-s-c-SC-m 0.001809243 -0.0134866680 0.0171051541 9.999636e-01 t-SC-m-c-SC-m 0.028701745 0.0144405648 0.0429629243 3.841919e-08 t-SC-s-c-SC-m 0.026791151 0.0125299708 0.0410523304 4.186306e-07 t-CS-m-c-SC-s -0.013520356 -0.0281520181 0.0011113054 9.446052e-02 t-CS-s-c-SC-s -0.009643516 -0.0252854205 0.0059983882 5.703756e-01 t-SC-m-c-SC-s 0.017248985 0.0026173237 0.0318806471 8.570520e-03 t-SC-s-c-SC-s 0.015338391 0.0007067297 0.0299700532 3.218461e-02 t-CS-s-t-CS-m 0.003876840 -0.0117650641 0.0195187445 9.952765e-01 t-SC-m-t-CS-m 0.030769342 0.0161376800 0.0454010035 7.062225e-09 t-SC-s-t-CS-m 0.028858748 0.0142270861 0.0434904095 7.994176e-08 t-SC-m-t-CS-s 0.026892502 0.0112505972 0.0425344059 5.899565e-06 t-SC-s-t-CS-s 0.024981908 0.0093400032 0.0406238119 3.868559e-05 t-SC-s-t-SC-m -0.001910594 -0.0165422557 0.0127210678 9.999287e-01
TRKA
Total variability: 15.71
Percentage of explained variability for TRKA: 7.53%
P value for TRKA: 0
Significant ANOVA result; proceeding to Tukey HSD test for TRKA diff lwr upr p adj c-CS-s-c-CS-m -0.020444568 -0.062381945 0.0214928097 8.179340e-01 c-SC-m-c-CS-m -0.107354214 -0.148173060 -0.0665353686 0.000000e+00 c-SC-s-c-CS-m -0.042676179 -0.084613557 -0.0007388018 4.271365e-02 t-CS-m-c-CS-m -0.036760204 -0.078697581 0.0051771737 1.355626e-01 t-CS-s-c-CS-m -0.018498102 -0.063478280 0.0264820748 9.169030e-01 t-SC-m-c-CS-m -0.002329355 -0.044266733 0.0396080220 9.999998e-01 t-SC-s-c-CS-m -0.026379632 -0.068317010 0.0155577453 5.440499e-01 c-SC-m-c-CS-s -0.086909647 -0.128847024 -0.0449722692 1.261803e-08 c-SC-s-c-CS-s -0.022231612 -0.065258453 0.0207952299 7.687748e-01 t-CS-m-c-CS-s -0.016315636 -0.059342477 0.0267112054 9.450180e-01 t-CS-s-c-CS-s 0.001946465 -0.044051163 0.0479440935 1.000000e+00 t-SC-m-c-CS-s 0.018115212 -0.024911629 0.0611420537 9.067600e-01 t-SC-s-c-CS-s -0.005935064 -0.048961906 0.0370917770 9.998967e-01 c-SC-s-c-SC-m 0.064678035 0.022740658 0.1066154126 8.625955e-05 t-CS-m-c-SC-m 0.070594011 0.028656633 0.1125313881 1.039893e-05 t-CS-s-c-SC-m 0.088856112 0.043875935 0.1338362893 7.558711e-08 t-SC-m-c-SC-m 0.105024859 0.063087482 0.1469622365 1.227018e-12 t-SC-s-c-SC-m 0.080974582 0.039037205 0.1229119597 1.678915e-07 t-CS-m-c-SC-s 0.005915976 -0.037110866 0.0489428169 9.998989e-01 t-CS-s-c-SC-s 0.024178077 -0.021819551 0.0701757051 7.526488e-01 t-SC-m-c-SC-s 0.040346824 -0.002680018 0.0833736653 8.468691e-02 t-SC-s-c-SC-s 0.016296547 -0.026730294 0.0593233885 9.453534e-01 t-CS-s-t-CS-m 0.018262101 -0.027735527 0.0642597295 9.303426e-01 t-SC-m-t-CS-m 0.034430848 -0.008595993 0.0774576897 2.277504e-01 t-SC-s-t-CS-m 0.010380572 -0.032646270 0.0534074130 9.960057e-01 t-SC-m-t-CS-s 0.016168747 -0.029828881 0.0621663754 9.633285e-01 t-SC-s-t-CS-s -0.007881530 -0.053879158 0.0381160986 9.995598e-01 t-SC-s-t-SC-m -0.024050277 -0.067077118 0.0189765647 6.889746e-01
RSK
Total variability: 0.85
Percentage of explained variability for RSK: 5.18%
P value for RSK: 0
Significant ANOVA result; proceeding to Tukey HSD test for RSK diff lwr upr p adj c-CS-s-c-CS-m 0.0018248440 -0.0080650212 1.171471e-02 9.992834e-01 c-SC-m-c-CS-m 0.0027439149 -0.0068821729 1.237000e-02 9.889417e-01 c-SC-s-c-CS-m 0.0036499936 -0.0062398715 1.353986e-02 9.523295e-01 t-CS-m-c-CS-m -0.0050431291 -0.0149329942 4.846736e-03 7.806517e-01 t-CS-s-c-CS-m -0.0071646890 -0.0177721212 3.442743e-03 4.476787e-01 t-SC-m-c-CS-m 0.0161769525 0.0062870874 2.606682e-02 2.165674e-05 t-SC-s-c-CS-m 0.0039079849 -0.0059818802 1.379785e-02 9.319956e-01 c-SC-m-c-CS-s 0.0009190709 -0.0089707942 1.080894e-02 9.999930e-01 c-SC-s-c-CS-s 0.0018251497 -0.0083216378 1.197194e-02 9.993937e-01 t-CS-m-c-CS-s -0.0068679731 -0.0170147606 3.278814e-03 4.447971e-01 t-CS-s-c-CS-s -0.0089895330 -0.0198369051 1.857839e-03 1.893425e-01 t-SC-m-c-CS-s 0.0143521086 0.0042053211 2.449890e-02 5.023962e-04 t-SC-s-c-CS-s 0.0020831409 -0.0080636466 1.222993e-02 9.985661e-01 c-SC-s-c-SC-m 0.0009060788 -0.0089837864 1.079594e-02 9.999937e-01 t-CS-m-c-SC-m -0.0077870440 -0.0176769091 2.102821e-03 2.466154e-01 t-CS-s-c-SC-m -0.0099086039 -0.0205160361 6.988283e-04 8.717453e-02 t-SC-m-c-SC-m 0.0134330376 0.0035431725 2.332290e-02 1.038652e-03 t-SC-s-c-SC-m 0.0011640700 -0.0087257951 1.105394e-02 9.999648e-01 t-CS-m-c-SC-s -0.0086931227 -0.0188399103 1.453665e-03 1.562608e-01 t-CS-s-c-SC-s -0.0108146827 -0.0216620548 3.268947e-05 5.134652e-02 t-SC-m-c-SC-s 0.0125269589 0.0023801714 2.267375e-02 4.609429e-03 t-SC-s-c-SC-s 0.0002579912 -0.0098887963 1.040478e-02 1.000000e+00 t-CS-s-t-CS-m -0.0021215599 -0.0129689320 8.725812e-03 9.989522e-01 t-SC-m-t-CS-m 0.0212200816 0.0110732941 3.136687e-02 8.813526e-09 t-SC-s-t-CS-m 0.0089511140 -0.0011956735 1.909790e-02 1.300936e-01 t-SC-m-t-CS-s 0.0233416415 0.0124942694 3.418901e-02 2.746916e-09 t-SC-s-t-CS-s 0.0110726739 0.0002253018 2.192005e-02 4.151019e-02 t-SC-s-t-SC-m -0.0122689677 -0.0224157552 -2.122180e-03 6.142756e-03
APP
Total variability: 4.03
Percentage of explained variability for APP: 32.88%
P value for APP: 0
Significant ANOVA result; proceeding to Tukey HSD test for APP diff lwr upr p adj c-CS-s-c-CS-m -0.0067320974 -0.024829755 0.01136556 9.502946e-01 c-SC-m-c-CS-m -0.0457832199 -0.063398186 -0.02816825 0.000000e+00 c-SC-s-c-CS-m -0.0354673940 -0.053565052 -0.01736974 1.002380e-07 t-CS-m-c-CS-m 0.0376120935 0.019514436 0.05570975 1.128345e-08 t-CS-s-c-CS-m 0.0448638756 0.025453128 0.06427462 1.101382e-10 t-SC-m-c-CS-m 0.0431192100 0.025021552 0.06121687 2.415235e-11 t-SC-s-c-CS-m 0.0434798746 0.025382217 0.06157753 1.558542e-11 c-SC-m-c-CS-s -0.0390511225 -0.057148780 -0.02095346 2.444294e-09 c-SC-s-c-CS-s -0.0287352966 -0.047303102 -0.01016749 7.988370e-05 t-CS-m-c-CS-s 0.0443441909 0.025776386 0.06291200 2.135125e-11 t-CS-s-c-CS-s 0.0515959729 0.031746154 0.07144579 0.000000e+00 t-SC-m-c-CS-s 0.0498513074 0.031283502 0.06841911 0.000000e+00 t-SC-s-c-CS-s 0.0502119720 0.031644167 0.06877978 0.000000e+00 c-SC-s-c-SC-m 0.0103158259 -0.007781832 0.02841348 6.668355e-01 t-CS-m-c-SC-m 0.0833953133 0.065297656 0.10149297 0.000000e+00 t-CS-s-c-SC-m 0.0906470954 0.071236348 0.11005784 0.000000e+00 t-SC-m-c-SC-m 0.0889024299 0.070804772 0.10700009 0.000000e+00 t-SC-s-c-SC-m 0.0892630945 0.071165437 0.10736075 0.000000e+00 t-CS-m-c-SC-s 0.0730794874 0.054511682 0.09164729 0.000000e+00 t-CS-s-c-SC-s 0.0803312695 0.060481451 0.10018109 0.000000e+00 t-SC-m-c-SC-s 0.0785866039 0.060018799 0.09715441 0.000000e+00 t-SC-s-c-SC-s 0.0789472686 0.060379463 0.09751507 0.000000e+00 t-CS-s-t-CS-m 0.0072517821 -0.012598037 0.02710160 9.548412e-01 t-SC-m-t-CS-m 0.0055071165 -0.013060689 0.02407492 9.860143e-01 t-SC-s-t-CS-m 0.0058677812 -0.012700024 0.02443559 9.797892e-01 t-SC-m-t-CS-s -0.0017446656 -0.021594484 0.01810515 9.999952e-01 t-SC-s-t-CS-s -0.0013840009 -0.021233820 0.01846582 9.999990e-01 t-SC-s-t-SC-m 0.0003606647 -0.018207140 0.01892847 1.000000e+00
Bcatenin
Total variability: 201.65
Percentage of explained variability for Bcatenin: 7.56%
P value for Bcatenin: 0
Significant ANOVA result; proceeding to Tukey HSD test for Bcatenin diff lwr upr p adj c-CS-s-c-CS-m 0.078734926 -0.071505517 0.228975368 7.555265e-01 c-SC-m-c-CS-m -0.179207372 -0.325440680 -0.032974063 5.111409e-03 c-SC-s-c-CS-m 0.105545793 -0.044694650 0.255786236 3.939075e-01 t-CS-m-c-CS-m -0.112739980 -0.262980423 0.037500462 3.062148e-01 t-CS-s-c-CS-m -0.153105273 -0.314246531 0.008035985 7.653075e-02 t-SC-m-c-CS-m 0.146492489 -0.003747954 0.296732932 6.209870e-02 t-SC-s-c-CS-m 0.086318302 -0.063922141 0.236558745 6.576524e-01 c-SC-m-c-CS-s -0.257942297 -0.408182740 -0.107701854 6.128963e-06 c-SC-s-c-CS-s 0.026810868 -0.127332574 0.180954309 9.995140e-01 t-CS-m-c-CS-s -0.191474906 -0.345618348 -0.037331464 4.224189e-03 t-CS-s-c-CS-s -0.231840199 -0.396626469 -0.067053928 5.547529e-04 t-SC-m-c-CS-s 0.067757563 -0.086385878 0.221901005 8.854261e-01 t-SC-s-c-CS-s 0.007583376 -0.146560066 0.161726818 9.999999e-01 c-SC-s-c-SC-m 0.284753165 0.134512722 0.434993607 3.133117e-07 t-CS-m-c-SC-m 0.066467391 -0.083773052 0.216707834 8.819301e-01 t-CS-s-c-SC-m 0.026102098 -0.135039159 0.187243356 9.996967e-01 t-SC-m-c-SC-m 0.325699861 0.175459418 0.475940303 2.006985e-09 t-SC-s-c-SC-m 0.265525673 0.115285231 0.415766116 2.716358e-06 t-CS-m-c-SC-s -0.218285774 -0.372429215 -0.064142332 4.914248e-04 t-CS-s-c-SC-s -0.258651066 -0.423437337 -0.093864795 5.801894e-05 t-SC-m-c-SC-s 0.040946696 -0.113196746 0.195090138 9.927682e-01 t-SC-s-c-SC-s -0.019227491 -0.173370933 0.134915951 9.999477e-01 t-CS-s-t-CS-m -0.040365293 -0.205151563 0.124420978 9.956088e-01 t-SC-m-t-CS-m 0.259232470 0.105089028 0.413375911 1.065498e-05 t-SC-s-t-CS-m 0.199058282 0.044914841 0.353201724 2.369317e-03 t-SC-m-t-CS-s 0.299597762 0.134811491 0.464384033 1.172452e-06 t-SC-s-t-CS-s 0.239423575 0.074637304 0.404209846 3.002660e-04 t-SC-s-t-SC-m -0.060174187 -0.214317629 0.093969255 9.360894e-01
SOD1
Total variability: 84.8
Percentage of explained variability for SOD1: 65.8%
P value for SOD1: 0
Significant ANOVA result; proceeding to Tukey HSD test for SOD1 diff lwr upr p adj c-CS-s-c-CS-m -0.005945404 -0.06519928 0.05330847 9.999882e-01 c-SC-m-c-CS-m 0.290087365 0.23241388 0.34776085 0.000000e+00 c-SC-s-c-CS-m 0.525298263 0.46604439 0.58455213 0.000000e+00 t-CS-m-c-CS-m -0.022966264 -0.08222014 0.03628761 9.384011e-01 t-CS-s-c-CS-m -0.014990698 -0.07854378 0.04856239 9.965315e-01 t-SC-m-c-CS-m 0.501427053 0.44217318 0.56068092 0.000000e+00 t-SC-s-c-CS-m 0.390645082 0.33139121 0.44989895 0.000000e+00 c-SC-m-c-CS-s 0.296032769 0.23677890 0.35528664 0.000000e+00 c-SC-s-c-CS-s 0.531243667 0.47045048 0.59203686 0.000000e+00 t-CS-m-c-CS-s -0.017020860 -0.07781405 0.04377233 9.900657e-01 t-CS-s-c-CS-s -0.009045294 -0.07403595 0.05594536 9.998902e-01 t-SC-m-c-CS-s 0.507372457 0.44657927 0.56816565 0.000000e+00 t-SC-s-c-CS-s 0.396590486 0.33579730 0.45738368 0.000000e+00 c-SC-s-c-SC-m 0.235210898 0.17595703 0.29446477 0.000000e+00 t-CS-m-c-SC-m -0.313053629 -0.37230750 -0.25379976 0.000000e+00 t-CS-s-c-SC-m -0.305078063 -0.36863115 -0.24152498 0.000000e+00 t-SC-m-c-SC-m 0.211339688 0.15208582 0.27059356 0.000000e+00 t-SC-s-c-SC-m 0.100557717 0.04130384 0.15981159 8.383170e-06 t-CS-m-c-SC-s -0.548264527 -0.60905772 -0.48747134 0.000000e+00 t-CS-s-c-SC-s -0.540288961 -0.60527961 -0.47529831 0.000000e+00 t-SC-m-c-SC-s -0.023871210 -0.08466440 0.03692198 9.341510e-01 t-SC-s-c-SC-s -0.134653181 -0.19544637 -0.07385999 7.889380e-10 t-CS-s-t-CS-m 0.007975566 -0.05701509 0.07296622 9.999532e-01 t-SC-m-t-CS-m 0.524393317 0.46360013 0.58518651 0.000000e+00 t-SC-s-t-CS-m 0.413611346 0.35281816 0.47440454 0.000000e+00 t-SC-m-t-CS-s 0.516417751 0.45142710 0.58140840 0.000000e+00 t-SC-s-t-CS-s 0.405635779 0.34064513 0.47062643 0.000000e+00 t-SC-s-t-SC-m -0.110781971 -0.17157516 -0.04998878 1.093071e-06
MTOR
Total variability: 4.61
Percentage of explained variability for MTOR: 27.35%
P value for MTOR: 0
Significant ANOVA result; proceeding to Tukey HSD test for MTOR diff lwr upr p adj c-CS-s-c-CS-m -0.0333711243 -0.053519718 -0.0132225309 1.581926e-05 c-SC-m-c-CS-m -0.0165677598 -0.036178960 0.0030434410 1.697903e-01 c-SC-s-c-CS-m 0.0047095725 -0.015439021 0.0248581659 9.967239e-01 t-CS-m-c-CS-m -0.0794342510 -0.099582844 -0.0592856576 0.000000e+00 t-CS-s-c-CS-m -0.0893044815 -0.110914972 -0.0676939908 0.000000e+00 t-SC-m-c-CS-m 0.0120027520 -0.008145841 0.0321513454 6.139859e-01 t-SC-s-c-CS-m -0.0163747363 -0.036523330 0.0037738570 2.103458e-01 c-SC-m-c-CS-s 0.0168033645 -0.003345229 0.0369519579 1.828018e-01 c-SC-s-c-CS-s 0.0380806968 0.017408676 0.0587527174 7.816366e-07 t-CS-m-c-CS-s -0.0460631267 -0.066735147 -0.0253911061 6.034874e-10 t-CS-s-c-CS-s -0.0559333572 -0.078032677 -0.0338340376 4.523049e-13 t-SC-m-c-CS-s 0.0453738763 0.024701856 0.0660458969 1.175530e-09 t-SC-s-c-CS-s 0.0169963879 -0.003675633 0.0376684086 1.977231e-01 c-SC-s-c-SC-m 0.0212773322 0.001128739 0.0414259256 2.992128e-02 t-CS-m-c-SC-m -0.0628664912 -0.083015085 -0.0427178978 0.000000e+00 t-CS-s-c-SC-m -0.0727367217 -0.094347212 -0.0511262311 0.000000e+00 t-SC-m-c-SC-m 0.0285705117 0.008421918 0.0487191051 4.794307e-04 t-SC-s-c-SC-m 0.0001930234 -0.019955570 0.0203416168 1.000000e+00 t-CS-m-c-SC-s -0.0841438235 -0.104815844 -0.0634718028 0.000000e+00 t-CS-s-c-SC-s -0.0940140540 -0.116113374 -0.0719147343 0.000000e+00 t-SC-m-c-SC-s 0.0072931795 -0.013378841 0.0279652001 9.625881e-01 t-SC-s-c-SC-s -0.0210843088 -0.041756329 -0.0004122882 4.182254e-02 t-CS-s-t-CS-m -0.0098702305 -0.031969550 0.0122290891 8.765988e-01 t-SC-m-t-CS-m 0.0914370030 0.070764982 0.1121090236 0.000000e+00 t-SC-s-t-CS-m 0.0630595146 0.042387494 0.0837315353 0.000000e+00 t-SC-m-t-CS-s 0.1013072335 0.079207914 0.1234065531 0.000000e+00 t-SC-s-t-CS-s 0.0729297451 0.050830426 0.0950290648 0.000000e+00 t-SC-s-t-SC-m -0.0283774883 -0.049049509 -0.0077054677 8.637791e-04
P38
Total variability: 8.58
Percentage of explained variability for P38: 46.82%
P value for P38: 0
Significant ANOVA result; proceeding to Tukey HSD test for P38 diff lwr upr p adj c-CS-s-c-CS-m -0.03751654 -0.061020264 -0.014012813 3.921730e-05 c-SC-m-c-CS-m 0.07899054 0.056113695 0.101867388 0.000000e+00 c-SC-s-c-CS-m 0.05995953 0.036455807 0.083463257 1.113554e-13 t-CS-m-c-CS-m -0.05643761 -0.079941331 -0.032933881 1.603995e-11 t-CS-s-c-CS-m -0.09484918 -0.120058238 -0.069640124 0.000000e+00 t-SC-m-c-CS-m 0.09071735 0.067213622 0.114221073 0.000000e+00 t-SC-s-c-CS-m 0.02178110 -0.001722627 0.045284823 9.249004e-02 c-SC-m-c-CS-s 0.11650708 0.093003354 0.140010805 0.000000e+00 c-SC-s-c-CS-s 0.09747607 0.073361757 0.121590384 0.000000e+00 t-CS-m-c-CS-s -0.01892107 -0.043035381 0.005193246 2.507586e-01 t-CS-s-c-CS-s -0.05733264 -0.083111928 -0.031553358 6.580497e-10 t-SC-m-c-CS-s 0.12823389 0.104119572 0.152348199 0.000000e+00 t-SC-s-c-CS-s 0.05929764 0.035183323 0.083411950 4.209189e-12 c-SC-s-c-SC-m -0.01903101 -0.042534735 0.004472716 2.144410e-01 t-CS-m-c-SC-m -0.13542815 -0.158931873 -0.111924422 0.000000e+00 t-CS-s-c-SC-m -0.17383972 -0.199048780 -0.148630666 0.000000e+00 t-SC-m-c-SC-m 0.01172681 -0.011776920 0.035230531 7.993483e-01 t-SC-s-c-SC-m -0.05720944 -0.080713169 -0.033705718 7.629675e-12 t-CS-m-c-SC-s -0.11639714 -0.140511451 -0.092282825 0.000000e+00 t-CS-s-c-SC-s -0.15480871 -0.180587999 -0.129029428 0.000000e+00 t-SC-m-c-SC-s 0.03075782 0.006643502 0.054872128 2.863226e-03 t-SC-s-c-SC-s -0.03817843 -0.062292747 -0.014064121 4.751231e-05 t-CS-s-t-CS-m -0.03841158 -0.064190861 -0.012632290 1.804908e-04 t-SC-m-t-CS-m 0.14715495 0.123040640 0.171269266 0.000000e+00 t-SC-s-t-CS-m 0.07821870 0.054104391 0.102333017 0.000000e+00 t-SC-m-t-CS-s 0.18556653 0.159787243 0.211345814 0.000000e+00 t-SC-s-t-CS-s 0.11663028 0.090850994 0.142409565 0.000000e+00 t-SC-s-t-SC-m -0.06893625 -0.093050563 -0.044821936 0.000000e+00
pMTOR
Total variability: 16.13
Percentage of explained variability for pMTOR: 35.8%
P value for pMTOR: 0
Significant ANOVA result; proceeding to Tukey HSD test for pMTOR diff lwr upr p adj c-CS-s-c-CS-m -0.02635155 -0.061766004 0.009062898 3.171270e-01 c-SC-m-c-CS-m 0.06750119 0.033031291 0.101971082 1.029963e-07 c-SC-s-c-CS-m 0.02820844 -0.007206013 0.063622889 2.330787e-01 t-CS-m-c-CS-m -0.09746945 -0.132883899 -0.062054996 0.000000e+00 t-CS-s-c-CS-m -0.12123091 -0.159214881 -0.083246930 0.000000e+00 t-SC-m-c-CS-m 0.12166942 0.086254972 0.157083875 0.000000e+00 t-SC-s-c-CS-m -0.02301008 -0.058424535 0.012404368 5.006244e-01 c-SC-m-c-CS-s 0.09385274 0.058438288 0.129267191 0.000000e+00 c-SC-s-c-CS-s 0.05455999 0.018225531 0.090894451 1.535523e-04 t-CS-m-c-CS-s -0.07111789 -0.107452355 -0.034783434 1.047701e-07 t-CS-s-c-CS-s -0.09487935 -0.133722525 -0.056036181 6.244227e-12 t-SC-m-c-CS-s 0.14802098 0.111686516 0.184355437 0.000000e+00 t-SC-s-c-CS-s 0.00334147 -0.032992991 0.039675930 9.999935e-01 c-SC-s-c-SC-m -0.03929275 -0.074707200 -0.003878297 1.772025e-02 t-CS-m-c-SC-m -0.16497063 -0.200385085 -0.129556183 0.000000e+00 t-CS-s-c-SC-m -0.18873209 -0.226716067 -0.150748117 0.000000e+00 t-SC-m-c-SC-m 0.05416824 0.018753785 0.089582688 1.034573e-04 t-SC-s-c-SC-m -0.09051127 -0.125925721 -0.055096819 4.973799e-14 t-CS-m-c-SC-s -0.12567789 -0.162012346 -0.089343425 0.000000e+00 t-CS-s-c-SC-s -0.14943934 -0.188282516 -0.110596172 0.000000e+00 t-SC-m-c-SC-s 0.09346099 0.057126525 0.129795446 0.000000e+00 t-SC-s-c-SC-s -0.05121852 -0.087552982 -0.014884061 5.352414e-04 t-CS-s-t-CS-m -0.02376146 -0.062604630 0.015081714 5.804492e-01 t-SC-m-t-CS-m 0.21913887 0.182804411 0.255473331 0.000000e+00 t-SC-s-t-CS-m 0.07445936 0.038124904 0.110793824 1.946440e-08 t-SC-m-t-CS-s 0.24290033 0.204057157 0.281743501 0.000000e+00 t-SC-s-t-CS-s 0.09822082 0.059377650 0.137063994 5.043743e-13 t-SC-s-t-SC-m -0.14467951 -0.181013967 -0.108345046 0.000000e+00
DSCR1
Total variability: 10.89
Percentage of explained variability for DSCR1: 11.54%
P value for DSCR1: 0
Significant ANOVA result; proceeding to Tukey HSD test for DSCR1 diff lwr upr p adj c-CS-s-c-CS-m -0.0218913743 -0.056044521 0.0122617727 5.189403e-01 c-SC-m-c-CS-m 0.0004473917 -0.032794841 0.0336896240 1.000000e+00 c-SC-s-c-CS-m -0.0345936738 -0.068746821 -0.0004405267 4.457004e-02 t-CS-m-c-CS-m -0.0480886402 -0.082241787 -0.0139354932 5.466917e-04 t-CS-s-c-CS-m -0.0466905049 -0.083321661 -0.0100593491 2.893499e-03 t-SC-m-c-CS-m 0.0662664150 0.032113268 0.1004195620 1.420273e-07 t-SC-s-c-CS-m -0.0061790738 -0.040332221 0.0279740732 9.993701e-01 c-SC-m-c-CS-s 0.0223387660 -0.011814381 0.0564919130 4.915924e-01 c-SC-s-c-CS-s -0.0127022995 -0.047742689 0.0223380900 9.566812e-01 t-CS-m-c-CS-s -0.0261972659 -0.061237655 0.0088431236 3.109759e-01 t-CS-s-c-CS-s -0.0247991307 -0.062258883 0.0126606214 4.751442e-01 t-SC-m-c-CS-s 0.0881577893 0.053117400 0.1231981788 8.318901e-13 t-SC-s-c-CS-s 0.0157123005 -0.019328089 0.0507526900 8.743166e-01 c-SC-s-c-SC-m -0.0350410655 -0.069194212 -0.0008879184 3.957905e-02 t-CS-m-c-SC-m -0.0485360319 -0.082689179 -0.0143828848 4.599125e-04 t-CS-s-c-SC-m -0.0471378966 -0.083769052 -0.0105067408 2.502272e-03 t-SC-m-c-SC-m 0.0658190233 0.031665876 0.0999721703 1.791610e-07 t-SC-s-c-SC-m -0.0066264655 -0.040779613 0.0275266815 9.990054e-01 t-CS-m-c-SC-s -0.0134949664 -0.048535356 0.0215454231 9.403977e-01 t-CS-s-c-SC-s -0.0120968312 -0.049556583 0.0253629209 9.771347e-01 t-SC-m-c-SC-s 0.1008600888 0.065819699 0.1359004783 0.000000e+00 t-SC-s-c-SC-s 0.0284145999 -0.006625790 0.0634549894 2.127838e-01 t-CS-s-t-CS-m 0.0013981352 -0.036061617 0.0388578873 1.000000e+00 t-SC-m-t-CS-m 0.1143550552 0.079314666 0.1493954447 0.000000e+00 t-SC-s-t-CS-m 0.0419095663 0.006869177 0.0769499558 7.104567e-03 t-SC-m-t-CS-s 0.1129569199 0.075497168 0.1504166720 0.000000e+00 t-SC-s-t-CS-s 0.0405114311 0.003051679 0.0779711832 2.341545e-02 t-SC-s-t-SC-m -0.0724454888 -0.107485878 -0.0374050993 1.383406e-08
AMPKA
Total variability: 4.21
Percentage of explained variability for AMPKA: 14.51%
P value for AMPKA: 0
Significant ANOVA result; proceeding to Tukey HSD test for AMPKA diff lwr upr p adj c-CS-s-c-CS-m -0.0003345053 -0.021220852 0.020551841 1.000000e+00 c-SC-m-c-CS-m -0.0296262865 -0.049955563 -0.009297010 2.829059e-04 c-SC-s-c-CS-m -0.0276177285 -0.048504075 -0.006731382 1.627433e-03 t-CS-m-c-CS-m -0.0657155736 -0.086601920 -0.044829227 0.000000e+00 t-CS-s-c-CS-m -0.0615675632 -0.083969335 -0.039165791 0.000000e+00 t-SC-m-c-CS-m -0.0027817774 -0.023668124 0.018104569 9.999184e-01 t-SC-s-c-CS-m -0.0279642894 -0.048850636 -0.007077943 1.325053e-03 c-SC-m-c-CS-s -0.0292917812 -0.050178127 -0.008405435 5.882705e-04 c-SC-s-c-CS-s -0.0272832232 -0.048712162 -0.005854284 2.942379e-03 t-CS-m-c-CS-s -0.0653810682 -0.086810007 -0.043952129 0.000000e+00 t-CS-s-c-CS-s -0.0612330578 -0.084141557 -0.038324558 0.000000e+00 t-SC-m-c-CS-s -0.0024472720 -0.023876211 0.018981667 9.999713e-01 t-SC-s-c-CS-s -0.0276297840 -0.049058723 -0.006200845 2.427278e-03 c-SC-s-c-SC-m 0.0020085579 -0.018877788 0.022894904 9.999912e-01 t-CS-m-c-SC-m -0.0360892871 -0.056975633 -0.015202941 5.140424e-06 t-CS-s-c-SC-m -0.0319412767 -0.054343049 -0.009539505 4.320409e-04 t-SC-m-c-SC-m 0.0268445091 0.005958163 0.047730855 2.549327e-03 t-SC-s-c-SC-m 0.0016619971 -0.019224349 0.022548343 9.999976e-01 t-CS-m-c-SC-s -0.0380978450 -0.059526784 -0.016668906 2.285950e-06 t-CS-s-c-SC-s -0.0339498346 -0.056858334 -0.011041335 2.017708e-04 t-SC-m-c-SC-s 0.0248359512 0.003407012 0.046264890 1.061121e-02 t-SC-s-c-SC-s -0.0003465608 -0.021775500 0.021082378 1.000000e+00 t-CS-s-t-CS-m 0.0041480104 -0.018760489 0.027056510 9.993667e-01 t-SC-m-t-CS-m 0.0629337962 0.041504857 0.084362735 0.000000e+00 t-SC-s-t-CS-m 0.0377512842 0.016322345 0.059180223 2.978223e-06 t-SC-m-t-CS-s 0.0587857858 0.035877286 0.081694285 0.000000e+00 t-SC-s-t-CS-s 0.0336032738 0.010694774 0.056511773 2.484363e-04 t-SC-s-t-SC-m -0.0251825120 -0.046611451 -0.003753573 8.922393e-03
NR2B
Total variability: 8.37
Percentage of explained variability for NR2B: 26.77%
P value for NR2B: 0
Significant ANOVA result; proceeding to Tukey HSD test for NR2B diff lwr upr p adj c-CS-s-c-CS-m -0.037537101 -0.064781532 -0.010292671 8.097154e-04 c-SC-m-c-CS-m -0.017941899 -0.044459680 0.008575883 4.453300e-01 c-SC-s-c-CS-m 0.003514339 -0.023730092 0.030758770 9.999343e-01 t-CS-m-c-CS-m -0.087018627 -0.114263058 -0.059774197 0.000000e+00 t-CS-s-c-CS-m -0.123576702 -0.152797874 -0.094355530 0.000000e+00 t-SC-m-c-CS-m 0.034503509 0.007259078 0.061747940 3.186088e-03 t-SC-s-c-CS-m -0.022036403 -0.049280834 0.005208027 2.156276e-01 c-SC-m-c-CS-s 0.019595203 -0.007649228 0.046839633 3.620729e-01 c-SC-s-c-CS-s 0.041051440 0.013099244 0.069003636 2.424457e-04 t-CS-m-c-CS-s -0.049481526 -0.077433722 -0.021529330 2.591361e-06 t-CS-s-c-CS-s -0.086039601 -0.115921755 -0.056157446 0.000000e+00 t-SC-m-c-CS-s 0.072040610 0.044088414 0.099992806 0.000000e+00 t-SC-s-c-CS-s 0.015500698 -0.012451498 0.043452894 6.976997e-01 c-SC-s-c-SC-m 0.021456238 -0.005788193 0.048700668 2.463599e-01 t-CS-m-c-SC-m -0.069076729 -0.096321159 -0.041832298 3.615996e-13 t-CS-s-c-SC-m -0.105634804 -0.134855976 -0.076413632 0.000000e+00 t-SC-m-c-SC-m 0.052445408 0.025200977 0.079689838 1.861877e-07 t-SC-s-c-SC-m -0.004094505 -0.031338935 0.023149926 9.998161e-01 t-CS-m-c-SC-s -0.090532966 -0.118485162 -0.062580770 0.000000e+00 t-CS-s-c-SC-s -0.127091041 -0.156973196 -0.097208887 0.000000e+00 t-SC-m-c-SC-s 0.030989170 0.003036974 0.058941366 1.787518e-02 t-SC-s-c-SC-s -0.025550742 -0.053502938 0.002401454 1.021374e-01 t-CS-s-t-CS-m -0.036558075 -0.066440230 -0.006675920 5.233269e-03 t-SC-m-t-CS-m 0.121522136 0.093569940 0.149474332 0.000000e+00 t-SC-s-t-CS-m 0.064982224 0.037030028 0.092934420 8.306655e-11 t-SC-m-t-CS-s 0.158080211 0.128198057 0.187962366 0.000000e+00 t-SC-s-t-CS-s 0.101540299 0.071658144 0.131422453 0.000000e+00 t-SC-s-t-SC-m -0.056539912 -0.084492108 -0.028587716 3.186325e-08
pNUMB
Total variability: 4.27
Percentage of explained variability for pNUMB: 30.42%
P value for pNUMB: 0
Significant ANOVA result; proceeding to Tukey HSD test for pNUMB diff lwr upr p adj c-CS-s-c-CS-m -0.013763461 -0.0327400086 0.005213086 3.508570e-01 c-SC-m-c-CS-m -0.077611127 -0.0960815422 -0.059140712 0.000000e+00 c-SC-s-c-CS-m -0.115221949 -0.1341984960 -0.096245401 0.000000e+00 t-CS-m-c-CS-m -0.073091393 -0.0920679408 -0.054114846 0.000000e+00 t-CS-s-c-CS-m -0.047316777 -0.0676701832 -0.026963371 8.307177e-11 t-SC-m-c-CS-m -0.052077539 -0.0710540870 -0.033100992 0.000000e+00 t-SC-s-c-CS-m -0.053143682 -0.0721202300 -0.034167135 0.000000e+00 c-SC-m-c-CS-s -0.063847666 -0.0828242136 -0.044871119 0.000000e+00 c-SC-s-c-CS-s -0.101458487 -0.1209280144 -0.081988960 0.000000e+00 t-CS-m-c-CS-s -0.059327932 -0.0787974592 -0.039858405 0.000000e+00 t-CS-s-c-CS-s -0.033553316 -0.0543671159 -0.012739516 3.094493e-05 t-SC-m-c-CS-s -0.038314078 -0.0577836054 -0.018844551 8.661962e-08 t-SC-s-c-CS-s -0.039380221 -0.0588497483 -0.019910694 3.190834e-08 c-SC-s-c-SC-m -0.037610821 -0.0565873689 -0.018634274 6.718124e-08 t-CS-m-c-SC-m 0.004519734 -0.0144568137 0.023496281 9.963142e-01 t-CS-s-c-SC-m 0.030294350 0.0099409439 0.050647756 1.845476e-04 t-SC-m-c-SC-m 0.025533588 0.0065570401 0.044510135 1.219274e-03 t-SC-s-c-SC-m 0.024467445 0.0054908971 0.043443992 2.427744e-03 t-CS-m-c-SC-s 0.042130555 0.0226610283 0.061600082 2.168088e-09 t-CS-s-c-SC-s 0.067905171 0.0470913716 0.088718971 0.000000e+00 t-SC-m-c-SC-s 0.063144409 0.0436748821 0.082613936 0.000000e+00 t-SC-s-c-SC-s 0.062078266 0.0426087391 0.081547793 0.000000e+00 t-CS-s-t-CS-m 0.025774616 0.0049608163 0.046588416 4.414835e-03 t-SC-m-t-CS-m 0.021013854 0.0015443268 0.040483381 2.391130e-02 t-SC-s-t-CS-m 0.019947711 0.0004781839 0.039417238 4.010219e-02 t-SC-m-t-CS-s -0.004760762 -0.0255745622 0.016053037 9.971420e-01 t-SC-s-t-CS-s -0.005826905 -0.0266407051 0.014986894 9.900712e-01 t-SC-s-t-SC-m -0.001066143 -0.0205356699 0.018403384 9.999998e-01
RAPTOR
Total variability: 3.16
Percentage of explained variability for RAPTOR: 20.79%
P value for RAPTOR: 0
Significant ANOVA result; proceeding to Tukey HSD test for RAPTOR diff lwr upr p adj c-CS-s-c-CS-m -0.0056832449 -0.023084151 0.011717661 9.756198e-01 c-SC-m-c-CS-m -0.0035997972 -0.020536595 0.013337001 9.982083e-01 c-SC-s-c-CS-m -0.0204592817 -0.037860187 -0.003058376 8.865116e-03 t-CS-m-c-CS-m -0.0484820093 -0.065882915 -0.031081104 0.000000e+00 t-CS-s-c-CS-m -0.0554131524 -0.074076595 -0.036749710 0.000000e+00 t-SC-m-c-CS-m 0.0278416309 0.010440725 0.045242537 3.705447e-05 t-SC-s-c-CS-m -0.0007154107 -0.018116316 0.016685495 1.000000e+00 c-SC-m-c-CS-s 0.0020834477 -0.015317458 0.019484353 9.999604e-01 c-SC-s-c-CS-s -0.0147760368 -0.032628989 0.003076916 1.907058e-01 t-CS-m-c-CS-s -0.0427987644 -0.060651717 -0.024945812 1.749489e-11 t-CS-s-c-CS-s -0.0497299075 -0.068815517 -0.030644299 0.000000e+00 t-SC-m-c-CS-s 0.0335248758 0.015671923 0.051377828 4.242581e-07 t-SC-s-c-CS-s 0.0049678342 -0.012885118 0.022820787 9.904252e-01 c-SC-s-c-SC-m -0.0168594846 -0.034260390 0.000541421 6.544098e-02 t-CS-m-c-SC-m -0.0448822121 -0.062283118 -0.027481306 0.000000e+00 t-CS-s-c-SC-m -0.0518133553 -0.070476797 -0.033149913 0.000000e+00 t-SC-m-c-SC-m 0.0314414281 0.014040522 0.048842334 1.414243e-06 t-SC-s-c-SC-m 0.0028843865 -0.014516519 0.020285292 9.996465e-01 t-CS-m-c-SC-s -0.0280227275 -0.045875680 -0.010169775 5.799716e-05 t-CS-s-c-SC-s -0.0349538707 -0.054039480 -0.015868262 9.369862e-07 t-SC-m-c-SC-s 0.0483009126 0.030447960 0.066153865 0.000000e+00 t-SC-s-c-SC-s 0.0197438711 0.001890919 0.037596824 1.837378e-02 t-CS-s-t-CS-m -0.0069311432 -0.026016752 0.012154466 9.562591e-01 t-SC-m-t-CS-m 0.0763236402 0.058470688 0.094176593 0.000000e+00 t-SC-s-t-CS-m 0.0477665986 0.029913646 0.065619551 0.000000e+00 t-SC-m-t-CS-s 0.0832547833 0.064169174 0.102340392 0.000000e+00 t-SC-s-t-CS-s 0.0546977418 0.035612133 0.073783351 0.000000e+00 t-SC-s-t-SC-m -0.0285570415 -0.046409994 -0.010704089 3.729837e-05
TIAM1
Total variability: 4.87
Percentage of explained variability for TIAM1: 15.42%
P value for TIAM1: 0
Significant ANOVA result; proceeding to Tukey HSD test for TIAM1 diff lwr upr p adj c-CS-s-c-CS-m 0.004952778 -0.017390836 0.027296393 9.976573e-01 c-SC-m-c-CS-m -0.019735863 -0.041483540 0.002011814 1.074857e-01 c-SC-s-c-CS-m -0.032166179 -0.054509793 -0.009822564 3.593816e-04 t-CS-m-c-CS-m -0.033814462 -0.056158076 -0.011470848 1.301220e-04 t-CS-s-c-CS-m -0.014816829 -0.038781602 0.009147944 5.666773e-01 t-SC-m-c-CS-m 0.044579971 0.022236357 0.066923586 5.281138e-08 t-SC-s-c-CS-m 0.028810835 0.006467221 0.051154449 2.425068e-03 c-SC-m-c-CS-s -0.024688641 -0.047032256 -0.002345027 1.855250e-02 c-SC-s-c-CS-s -0.037118957 -0.060043022 -0.014194892 2.779590e-05 t-CS-m-c-CS-s -0.038767240 -0.061691305 -0.015843176 9.204569e-06 t-CS-s-c-CS-s -0.019769607 -0.044276463 0.004737249 2.186004e-01 t-SC-m-c-CS-s 0.039627193 0.016703128 0.062551258 5.079939e-06 t-SC-s-c-CS-s 0.023858057 0.000933992 0.046782121 3.454362e-02 c-SC-s-c-SC-m -0.012430316 -0.034773930 0.009913299 6.941884e-01 t-CS-m-c-SC-m -0.014078599 -0.036422213 0.008265015 5.417973e-01 t-CS-s-c-SC-m 0.004919034 -0.019045739 0.028883807 9.985678e-01 t-SC-m-c-SC-m 0.064315835 0.041972220 0.086659449 0.000000e+00 t-SC-s-c-SC-m 0.048546698 0.026203084 0.070890313 1.823558e-09 t-CS-m-c-SC-s -0.001648283 -0.024572348 0.021275781 9.999988e-01 t-CS-s-c-SC-s 0.017349350 -0.007157506 0.041856206 3.834507e-01 t-SC-m-c-SC-s 0.076746150 0.053822085 0.099670215 0.000000e+00 t-SC-s-c-SC-s 0.060977014 0.038052949 0.083901078 0.000000e+00 t-CS-s-t-CS-m 0.018997633 -0.005509223 0.043504489 2.653937e-01 t-SC-m-t-CS-m 0.078394433 0.055470369 0.101318498 0.000000e+00 t-SC-s-t-CS-m 0.062625297 0.039701232 0.085549362 0.000000e+00 t-SC-m-t-CS-s 0.059396800 0.034889944 0.083903656 9.685475e-12 t-SC-s-t-CS-s 0.043627664 0.019120808 0.068134520 2.199197e-06 t-SC-s-t-SC-m -0.015769136 -0.038693201 0.007154928 4.226533e-01
pP70S6
Total variability: 26.35
Percentage of explained variability for pP70S6: 27.7%
P value for pP70S6: 0
Significant ANOVA result; proceeding to Tukey HSD test for pP70S6 diff lwr upr p adj c-CS-s-c-CS-m 0.02746704 -0.020560420 0.075494507 6.629998e-01 c-SC-m-c-CS-m 0.09845898 0.051712475 0.145205476 6.629813e-09 c-SC-s-c-CS-m 0.05662646 0.008598996 0.104653923 8.555430e-03 t-CS-m-c-CS-m 0.06932086 0.021293399 0.117348326 3.417316e-04 t-CS-s-c-CS-m -0.04064710 -0.092159238 0.010865031 2.440595e-01 t-SC-m-c-CS-m 0.08616120 0.038133739 0.134188666 1.751945e-06 t-SC-s-c-CS-m 0.25969516 0.211667699 0.307722626 0.000000e+00 c-SC-m-c-CS-s 0.07099193 0.022964468 0.119019396 2.127045e-04 c-SC-s-c-CS-s 0.02915942 -0.020115722 0.078434554 6.221909e-01 t-CS-m-c-CS-s 0.04185382 -0.007421319 0.091128956 1.644985e-01 t-CS-s-c-CS-s -0.06811415 -0.120791486 -0.015436809 2.322519e-03 t-SC-m-c-CS-s 0.05869416 0.009419021 0.107969297 7.496711e-03 t-SC-s-c-CS-s 0.23222812 0.182952981 0.281503256 0.000000e+00 c-SC-s-c-SC-m -0.04183252 -0.089859980 0.006194947 1.411272e-01 t-CS-m-c-SC-m -0.02913811 -0.077165577 0.018889350 5.910136e-01 t-CS-s-c-SC-m -0.13910608 -0.190618214 -0.087593945 0.000000e+00 t-SC-m-c-SC-m -0.01229777 -0.060325237 0.035729690 9.942241e-01 t-SC-s-c-SC-m 0.16123619 0.113208723 0.209263650 0.000000e+00 t-CS-m-c-SC-s 0.01269440 -0.036580735 0.061969541 9.940036e-01 t-CS-s-c-SC-s -0.09727356 -0.149950902 -0.044596225 7.246658e-07 t-SC-m-c-SC-s 0.02953474 -0.019740395 0.078809881 6.063235e-01 t-SC-s-c-SC-s 0.20306870 0.153793565 0.252343841 0.000000e+00 t-CS-s-t-CS-m -0.10996797 -0.162645304 -0.057290628 9.461687e-09 t-SC-m-t-CS-m 0.01684034 -0.032434798 0.066115478 9.685802e-01 t-SC-s-t-CS-m 0.19037430 0.141099162 0.239649438 0.000000e+00 t-SC-m-t-CS-s 0.12680831 0.074130968 0.179485645 1.402223e-11 t-SC-s-t-CS-s 0.30034227 0.247664928 0.353019604 0.000000e+00 t-SC-s-t-SC-m 0.17353396 0.124258822 0.222809098 0.000000e+00
NUMB
Total variability: 0.93
Percentage of explained variability for NUMB: 17.07%
P value for NUMB: 0
Significant ANOVA result; proceeding to Tukey HSD test for NUMB diff lwr upr p adj c-CS-s-c-CS-m 0.006296342 -0.0033470343 0.0159397183 4.939987e-01 c-SC-m-c-CS-m -0.020941215 -0.0303273880 -0.0115550415 5.705386e-10 c-SC-s-c-CS-m -0.009952158 -0.0195955340 -0.0003087814 3.745088e-02 t-CS-m-c-CS-m -0.008830464 -0.0184738401 0.0008129125 1.008599e-01 t-CS-s-c-CS-m 0.023559255 0.0132161959 0.0339023142 2.204571e-10 t-SC-m-c-CS-m -0.011191823 -0.0208351992 -0.0015484466 1.043432e-02 t-SC-s-c-CS-m 0.001465354 -0.0081780224 0.0111087302 9.998020e-01 c-SC-m-c-CS-s -0.027237557 -0.0368809331 -0.0175941805 0.000000e+00 c-SC-s-c-CS-s -0.016248500 -0.0261423951 -0.0063546044 1.959609e-05 t-CS-m-c-CS-s -0.015126806 -0.0250207011 -0.0052329105 1.044185e-04 t-CS-s-c-CS-s 0.017262913 0.0066858941 0.0278399321 2.287187e-05 t-SC-m-c-CS-s -0.017488165 -0.0273820602 -0.0075942696 2.706035e-06 t-SC-s-c-CS-s -0.004830988 -0.0147248834 0.0050629072 8.166988e-01 c-SC-s-c-SC-m 0.010989057 0.0013456808 0.0206324334 1.302188e-02 t-CS-m-c-SC-m 0.012110751 0.0024673747 0.0217541273 3.605832e-03 t-CS-s-c-SC-m 0.044500470 0.0341574107 0.0548435290 0.000000e+00 t-SC-m-c-SC-m 0.009749392 0.0001060156 0.0193927682 4.533884e-02 t-SC-s-c-SC-m 0.022406569 0.0127631924 0.0320499450 8.526480e-11 t-CS-m-c-SC-s 0.001121694 -0.0087722014 0.0110155893 9.999727e-01 t-CS-s-c-SC-s 0.033511413 0.0229343938 0.0440884318 0.000000e+00 t-SC-m-c-SC-s -0.001239665 -0.0111335605 0.0086542302 9.999461e-01 t-SC-s-c-SC-s 0.011417512 0.0015236163 0.0213114070 1.118854e-02 t-CS-s-t-CS-m 0.032389719 0.0218126999 0.0429667379 0.000000e+00 t-SC-m-t-CS-m -0.002361359 -0.0122552544 0.0075325362 9.962662e-01 t-SC-s-t-CS-m 0.010295818 0.0004019224 0.0201897130 3.458211e-02 t-SC-m-t-CS-s -0.034751078 -0.0453280970 -0.0241740590 0.000000e+00 t-SC-s-t-CS-s -0.022093901 -0.0326709202 -0.0115168822 9.233957e-09 t-SC-s-t-SC-m 0.012657177 0.0027632815 0.0225510721 2.737328e-03
P70S6
Total variability: 32.23
Percentage of explained variability for P70S6: 5.57%
P value for P70S6: 0
Significant ANOVA result; proceeding to Tukey HSD test for P70S6 diff lwr upr p adj c-CS-s-c-CS-m -0.0099426594 -0.070651733 0.050766414 9.996737e-01 c-SC-m-c-CS-m 0.0586231101 -0.000466763 0.117712983 5.359463e-02 c-SC-s-c-CS-m -0.0111792219 -0.071888295 0.049529852 9.992928e-01 t-CS-m-c-CS-m -0.0145858079 -0.075294881 0.046123266 9.961080e-01 t-CS-s-c-CS-m 0.0799159976 0.014802129 0.145029866 5.005994e-03 t-SC-m-c-CS-m 0.0590156287 -0.001693445 0.119724702 6.367796e-02 t-SC-s-c-CS-m -0.0446237929 -0.105332866 0.016085281 3.331387e-01 c-SC-m-c-CS-s 0.0685657695 0.007856696 0.129274843 1.446365e-02 c-SC-s-c-CS-s -0.0012365624 -0.063522758 0.061049633 1.000000e+00 t-CS-m-c-CS-s -0.0046431484 -0.066929344 0.057643047 9.999985e-01 t-CS-s-c-CS-s 0.0898586570 0.023271913 0.156445401 1.160089e-03 t-SC-m-c-CS-s 0.0689582881 0.006672093 0.131244483 1.815265e-02 t-SC-s-c-CS-s -0.0346811334 -0.096967329 0.027605062 6.932451e-01 c-SC-s-c-SC-m -0.0698023320 -0.130511405 -0.009093258 1.169714e-02 t-CS-m-c-SC-m -0.0732089180 -0.133917991 -0.012499844 6.369380e-03 t-CS-s-c-SC-m 0.0212928875 -0.043820981 0.086406756 9.754491e-01 t-SC-m-c-SC-m 0.0003925186 -0.060316555 0.061101592 1.000000e+00 t-SC-s-c-SC-m -0.1032469030 -0.163955976 -0.042537829 7.918875e-06 t-CS-m-c-SC-s -0.0034065860 -0.065692781 0.058879609 9.999998e-01 t-CS-s-c-SC-s 0.0910952194 0.024508476 0.157681963 9.169972e-04 t-SC-m-c-SC-s 0.0701948505 0.007908655 0.132481046 1.483211e-02 t-SC-s-c-SC-s -0.0334445710 -0.095730766 0.028841624 7.316275e-01 t-CS-s-t-CS-m 0.0945018054 0.027915062 0.161088549 4.716396e-04 t-SC-m-t-CS-m 0.0736014366 0.011315241 0.135887632 8.315253e-03 t-SC-s-t-CS-m -0.0300379850 -0.092324180 0.032248210 8.261562e-01 t-SC-m-t-CS-s -0.0209003689 -0.087487112 0.045686375 9.805613e-01 t-SC-s-t-CS-s -0.1245397904 -0.191126534 -0.057953047 4.827584e-07 t-SC-s-t-SC-m -0.1036394215 -0.165925617 -0.041353226 1.405490e-05
pGSK3B
Total variability: 0.4
Percentage of explained variability for pGSK3B: 36.13%
P value for pGSK3B: 0
Significant ANOVA result; proceeding to Tukey HSD test for pGSK3B diff lwr upr p adj c-CS-s-c-CS-m 0.0115393640 0.005961758 0.0171169700 1.347696e-08 c-SC-m-c-CS-m -0.0222798244 -0.027708667 -0.0168509813 0.000000e+00 c-SC-s-c-CS-m -0.0181945061 -0.023772112 -0.0126169001 0.000000e+00 t-CS-m-c-CS-m 0.0017166276 -0.003860978 0.0072942336 9.826459e-01 t-CS-s-c-CS-m 0.0047180484 -0.001264245 0.0107003420 2.446728e-01 t-SC-m-c-CS-m -0.0155763599 -0.021153966 -0.0099987539 0.000000e+00 t-SC-s-c-CS-m 0.0012330283 -0.004344578 0.0068106343 9.976971e-01 c-SC-m-c-CS-s -0.0338191883 -0.039396794 -0.0282415823 0.000000e+00 c-SC-s-c-CS-s -0.0297338701 -0.035456373 -0.0240113671 0.000000e+00 t-CS-m-c-CS-s -0.0098227364 -0.015545239 -0.0041002334 6.163447e-06 t-CS-s-c-CS-s -0.0068213156 -0.012938929 -0.0007037026 1.675766e-02 t-SC-m-c-CS-s -0.0271157239 -0.032838227 -0.0213932209 0.000000e+00 t-SC-s-c-CS-s -0.0103063356 -0.016028839 -0.0045838326 1.559309e-06 c-SC-s-c-SC-m 0.0040853182 -0.001492288 0.0096629242 3.378035e-01 t-CS-m-c-SC-m 0.0239964519 0.018418846 0.0295740579 0.000000e+00 t-CS-s-c-SC-m 0.0269978727 0.021015579 0.0329801664 0.000000e+00 t-SC-m-c-SC-m 0.0067034645 0.001125858 0.0122810705 6.662015e-03 t-SC-s-c-SC-m 0.0235128527 0.017935247 0.0290904587 0.000000e+00 t-CS-m-c-SC-s 0.0199111337 0.014188631 0.0256336367 0.000000e+00 t-CS-s-c-SC-s 0.0229125545 0.016794941 0.0290301676 0.000000e+00 t-SC-m-c-SC-s 0.0026181462 -0.003104357 0.0083406492 8.622126e-01 t-SC-s-c-SC-s 0.0194275345 0.013705031 0.0251500375 0.000000e+00 t-CS-s-t-CS-m 0.0030014208 -0.003116192 0.0091190338 8.129551e-01 t-SC-m-t-CS-m -0.0172929875 -0.023015490 -0.0115704845 0.000000e+00 t-SC-s-t-CS-m -0.0004835992 -0.006206102 0.0052389038 9.999964e-01 t-SC-m-t-CS-s -0.0202944083 -0.026412021 -0.0141767952 0.000000e+00 t-SC-s-t-CS-s -0.0034850200 -0.009602633 0.0026325930 6.675208e-01 t-SC-s-t-SC-m 0.0168093883 0.011086885 0.0225318913 0.000000e+00
pPKCG
Total variability: 361.03
Percentage of explained variability for pPKCG: 24.94%
P value for pPKCG: 0
Significant ANOVA result; proceeding to Tukey HSD test for pPKCG diff lwr upr p adj c-CS-s-c-CS-m 0.22791858 0.046772070 0.409065089 3.508897e-03 c-SC-m-c-CS-m 0.16261353 -0.013701530 0.338928600 9.578121e-02 c-SC-s-c-CS-m -0.11039157 -0.291538077 0.070754941 5.853299e-01 t-CS-m-c-CS-m 0.24322739 0.062080885 0.424373903 1.263139e-03 t-CS-s-c-CS-m 0.35070513 0.156415390 0.544994867 1.457842e-06 t-SC-m-c-CS-m 0.05125916 -0.129887352 0.232405667 9.894140e-01 t-SC-s-c-CS-m 0.89668470 0.715538187 1.077831206 0.000000e+00 c-SC-m-c-CS-s -0.06530505 -0.246451555 0.115841464 9.579469e-01 c-SC-s-c-CS-s -0.33831015 -0.524162545 -0.152457751 1.129643e-06 t-CS-m-c-CS-s 0.01530881 -0.170543583 0.201161211 9.999970e-01 t-CS-s-c-CS-s 0.12278655 -0.075898021 0.321471119 5.672623e-01 t-SC-m-c-CS-s -0.17665942 -0.362511819 0.009192975 7.627574e-02 t-SC-s-c-CS-s 0.66876612 0.482913720 0.854618514 0.000000e+00 c-SC-s-c-SC-m -0.27300510 -0.454151612 -0.091858593 1.421690e-04 t-CS-m-c-SC-m 0.08061386 -0.100532650 0.261760369 8.786479e-01 t-CS-s-c-SC-m 0.18809159 -0.006198145 0.382381333 6.587798e-02 t-SC-m-c-SC-m -0.11135438 -0.292500886 0.069792132 5.741583e-01 t-SC-s-c-SC-m 0.73407116 0.552924653 0.915217671 0.000000e+00 t-CS-m-c-SC-s 0.35361896 0.167766565 0.539471359 2.755115e-07 t-CS-s-c-SC-s 0.46109670 0.262412127 0.659781266 9.037004e-11 t-SC-m-c-SC-s 0.16165073 -0.024201672 0.347503123 1.423885e-01 t-SC-s-c-SC-s 1.00707626 0.821223867 1.192928662 0.000000e+00 t-CS-s-t-CS-m 0.10747773 -0.091206835 0.306162304 7.240450e-01 t-SC-m-t-CS-m -0.19196824 -0.377820633 -0.006115839 3.714593e-02 t-SC-s-t-CS-m 0.65345730 0.467604906 0.839309700 0.000000e+00 t-SC-m-t-CS-s -0.29944597 -0.498130541 -0.100761401 1.420751e-04 t-SC-s-t-CS-s 0.54597957 0.347294998 0.744664138 0.000000e+00 t-SC-s-t-SC-m 0.84542554 0.659573142 1.031277936 0.000000e+00
CDK5
Total variability: 1.51
Percentage of explained variability for CDK5: 16.67%
P value for CDK5: 0
Significant ANOVA result; proceeding to Tukey HSD test for CDK5 diff lwr upr p adj c-CS-s-c-CS-m 0.006761891 -0.0055719979 0.0190957807 7.100202e-01 c-SC-m-c-CS-m -0.034087413 -0.0460923391 -0.0220824866 0.000000e+00 c-SC-s-c-CS-m -0.027217968 -0.0395518573 -0.0148840787 9.290168e-10 t-CS-m-c-CS-m -0.012563336 -0.0248972251 -0.0002294465 4.233412e-02 t-CS-s-c-CS-m 0.011114476 -0.0021143081 0.0243432608 1.752734e-01 t-SC-m-c-CS-m -0.021560111 -0.0338940001 -0.0092262215 3.717334e-06 t-SC-s-c-CS-m -0.003129561 -0.0154634504 0.0092043282 9.945388e-01 c-SC-m-c-CS-s -0.040849304 -0.0531831935 -0.0285154150 0.000000e+00 c-SC-s-c-CS-s -0.033979859 -0.0466341628 -0.0213255560 0.000000e+00 t-CS-m-c-CS-s -0.019325227 -0.0319795306 -0.0066709238 1.070333e-04 t-CS-s-c-CS-s 0.004352585 -0.0091754344 0.0178806044 9.776067e-01 t-SC-m-c-CS-s -0.028322002 -0.0409763056 -0.0156676988 4.947381e-10 t-SC-s-c-CS-s -0.009891452 -0.0225457559 0.0027628509 2.553111e-01 c-SC-s-c-SC-m 0.006869445 -0.0054644444 0.0192033341 6.929408e-01 t-CS-m-c-SC-m 0.021524077 0.0091901878 0.0338579663 3.897045e-06 t-CS-s-c-SC-m 0.045201889 0.0319731048 0.0584306737 0.000000e+00 t-SC-m-c-SC-m 0.012527302 0.0001934128 0.0248611913 4.346696e-02 t-SC-s-c-SC-m 0.030957852 0.0186239625 0.0432917410 1.021294e-12 t-CS-m-c-SC-s 0.014654632 0.0020003288 0.0273089356 1.071503e-02 t-CS-s-c-SC-s 0.038332444 0.0248044250 0.0518604638 0.000000e+00 t-SC-m-c-SC-s 0.005657857 -0.0069964462 0.0183121606 8.759856e-01 t-SC-s-c-SC-s 0.024088407 0.0114341035 0.0367427103 2.712724e-07 t-CS-s-t-CS-m 0.023677812 0.0101497928 0.0372058316 3.584944e-06 t-SC-m-t-CS-m -0.008996775 -0.0216510784 0.0036575284 3.776695e-01 t-SC-s-t-CS-m 0.009433775 -0.0032205287 0.0220880781 3.146711e-01 t-SC-m-t-CS-s -0.032674587 -0.0462026065 -0.0191465678 1.170364e-11 t-SC-s-t-CS-s -0.014244037 -0.0277720568 -0.0007160181 3.081069e-02 t-SC-s-t-SC-m 0.018430550 0.0057762463 0.0310848531 2.862174e-04
S6
Total variability: 20.38
Percentage of explained variability for S6: 39.03%
P value for S6: 0
Significant ANOVA result; proceeding to Tukey HSD test for S6 diff lwr upr p adj c-CS-s-c-CS-m -0.02177683 -0.060566412 0.01701275 6.841038e-01 c-SC-m-c-CS-m -0.15781185 -0.195566856 -0.12005684 0.000000e+00 c-SC-s-c-CS-m -0.12272915 -0.161518731 -0.08393957 0.000000e+00 t-CS-m-c-CS-m 0.01905086 -0.019738720 0.05784044 8.121278e-01 t-CS-s-c-CS-m 0.12473875 0.083134756 0.16634274 0.000000e+00 t-SC-m-c-CS-m -0.09354795 -0.132337530 -0.05475837 1.270428e-11 t-SC-s-c-CS-m 0.04783414 0.009044561 0.08662372 4.683922e-03 c-SC-m-c-CS-s -0.13603502 -0.174824601 -0.09724544 0.000000e+00 c-SC-s-c-CS-s -0.10095232 -0.140749590 -0.06115505 3.378409e-13 t-CS-m-c-CS-s 0.04082769 0.001030421 0.08062496 3.961756e-02 t-CS-s-c-CS-s 0.14651558 0.103970505 0.18906065 0.000000e+00 t-SC-m-c-CS-s -0.07177112 -0.111568389 -0.03197385 1.498308e-06 t-SC-s-c-CS-s 0.06961097 0.029813702 0.10940824 3.651707e-06 c-SC-s-c-SC-m 0.03508270 -0.003706881 0.07387228 1.100384e-01 t-CS-m-c-SC-m 0.17686271 0.138073130 0.21565229 0.000000e+00 t-CS-s-c-SC-m 0.28255060 0.240946606 0.32415459 0.000000e+00 t-SC-m-c-SC-m 0.06426390 0.025474319 0.10305348 1.570285e-05 t-SC-s-c-SC-m 0.20564599 0.166856410 0.24443557 0.000000e+00 t-CS-m-c-SC-s 0.14178001 0.101982740 0.18157728 0.000000e+00 t-CS-s-c-SC-s 0.24746790 0.204922824 0.29001297 0.000000e+00 t-SC-m-c-SC-s 0.02918120 -0.010616070 0.06897847 3.363678e-01 t-SC-s-c-SC-s 0.17056329 0.130766021 0.21036056 0.000000e+00 t-CS-s-t-CS-m 0.10568789 0.063142813 0.14823296 2.204792e-12 t-SC-m-t-CS-m -0.11259881 -0.152396082 -0.07280154 0.000000e+00 t-SC-s-t-CS-m 0.02878328 -0.011013991 0.06858055 3.546201e-01 t-SC-m-t-CS-s -0.21828670 -0.260831768 -0.17574162 0.000000e+00 t-SC-s-t-CS-s -0.07690460 -0.119449677 -0.03435953 1.397400e-06 t-SC-s-t-SC-m 0.14138209 0.101584820 0.18117936 0.000000e+00
ADARB1
Total variability: 141.2
Percentage of explained variability for ADARB1: 13.49%
P value for ADARB1: 0
Significant ANOVA result; proceeding to Tukey HSD test for ADARB1 diff lwr upr p adj c-CS-s-c-CS-m 0.015689866 -0.10592423 0.13730397 9.999343e-01 c-SC-m-c-CS-m -0.321412911 -0.43978338 -0.20304244 0.000000e+00 c-SC-s-c-CS-m -0.178699218 -0.30031332 -0.05708512 2.399164e-04 t-CS-m-c-CS-m -0.326193964 -0.44780806 -0.20457986 0.000000e+00 t-CS-s-c-CS-m -0.077345364 -0.20778327 0.05309254 6.196984e-01 t-SC-m-c-CS-m -0.073085014 -0.19469912 0.04852909 6.030334e-01 t-SC-s-c-CS-m -0.270110629 -0.39172473 -0.14849653 6.979987e-10 c-SC-m-c-CS-s -0.337102778 -0.45871688 -0.21548868 0.000000e+00 c-SC-s-c-CS-s -0.194389084 -0.31916252 -0.06961565 6.877662e-05 t-CS-m-c-CS-s -0.341883830 -0.46665727 -0.21711040 0.000000e+00 t-CS-s-c-CS-s -0.093035231 -0.22642364 0.04035318 4.037169e-01 t-SC-m-c-CS-s -0.088774880 -0.21354832 0.03599855 3.766746e-01 t-SC-s-c-CS-s -0.285800496 -0.41057393 -0.16102706 1.694259e-10 c-SC-s-c-SC-m 0.142713694 0.02109959 0.26432779 9.084466e-03 t-CS-m-c-SC-m -0.004781053 -0.12639515 0.11683305 1.000000e+00 t-CS-s-c-SC-m 0.244067547 0.11362964 0.37450546 4.761535e-07 t-SC-m-c-SC-m 0.248327897 0.12671380 0.36994200 2.232101e-08 t-SC-s-c-SC-m 0.051302282 -0.07031182 0.17291638 9.058707e-01 t-CS-m-c-SC-s -0.147494747 -0.27226818 -0.02272131 8.275984e-03 t-CS-s-c-SC-s 0.101353853 -0.03203456 0.23474227 2.902719e-01 t-SC-m-c-SC-s 0.105614203 -0.01915923 0.23038764 1.678849e-01 t-SC-s-c-SC-s -0.091411412 -0.21618485 0.03336202 3.374984e-01 t-CS-s-t-CS-m 0.248848600 0.11546019 0.38223701 5.237748e-07 t-SC-m-t-CS-m 0.253108950 0.12833552 0.37788238 2.861718e-08 t-SC-s-t-CS-m 0.056083335 -0.06869010 0.18085677 8.729211e-01 t-SC-m-t-CS-s 0.004260350 -0.12912806 0.13764876 1.000000e+00 t-SC-s-t-CS-s -0.192765265 -0.32615368 -0.05937685 3.336169e-04 t-SC-s-t-SC-m -0.197025615 -0.32179905 -0.07225218 5.051256e-05
AcetylH3K9
Total variability: 37.05
Percentage of explained variability for AcetylH3K9: 12.93%
P value for AcetylH3K9: 0
Significant ANOVA result; proceeding to Tukey HSD test for AcetylH3K9 diff lwr upr p adj c-CS-s-c-CS-m 0.009946169 -0.0525560819 0.07244842 9.997305e-01 c-SC-m-c-CS-m 0.005895013 -0.0549402110 0.06673024 9.999907e-01 c-SC-s-c-CS-m 0.086358068 0.0238558167 0.14886032 7.701996e-04 t-CS-m-c-CS-m 0.042110648 -0.0203916032 0.10461290 4.511212e-01 t-CS-s-c-CS-m 0.065886907 -0.0011502447 0.13292406 5.808317e-02 t-SC-m-c-CS-m 0.150369611 0.0878673597 0.21287186 1.447886e-11 t-SC-s-c-CS-m 0.190036254 0.1275340034 0.25253851 0.000000e+00 c-SC-m-c-CS-s -0.004051156 -0.0665534074 0.05845109 9.999994e-01 c-SC-s-c-CS-s 0.076411899 0.0122859420 0.14053786 7.460658e-03 t-CS-m-c-CS-s 0.032164479 -0.0319614779 0.09629044 7.949156e-01 t-CS-s-c-CS-s 0.055940738 -0.0126127933 0.12449427 2.058756e-01 t-SC-m-c-CS-s 0.140423442 0.0762974850 0.20454940 1.301598e-09 t-SC-s-c-CS-s 0.180090085 0.1159641287 0.24421604 0.000000e+00 c-SC-s-c-SC-m 0.080463055 0.0179608038 0.14296531 2.486248e-03 t-CS-m-c-SC-m 0.036215635 -0.0262866161 0.09871789 6.476535e-01 t-CS-s-c-SC-m 0.059991894 -0.0070452576 0.12702905 1.183031e-01 t-SC-m-c-SC-m 0.144474598 0.0819723467 0.20697685 1.096340e-10 t-SC-s-c-SC-m 0.184141242 0.1216389905 0.24664349 0.000000e+00 t-CS-m-c-SC-s -0.044247420 -0.1083733764 0.01987854 4.184352e-01 t-CS-s-c-SC-s -0.020471161 -0.0890246919 0.04808237 9.854459e-01 t-SC-m-c-SC-s 0.064011543 -0.0001144136 0.12813750 5.079355e-02 t-SC-s-c-SC-s 0.103678187 0.0395522301 0.16780414 2.882829e-05 t-CS-s-t-CS-m 0.023776259 -0.0447772720 0.09232979 9.659253e-01 t-SC-m-t-CS-m 0.108258963 0.0441330063 0.17238492 9.631278e-06 t-SC-s-t-CS-m 0.147925607 0.0837996500 0.21205156 1.209536e-10 t-SC-m-t-CS-s 0.084482704 0.0159291725 0.15303623 4.727334e-03 t-SC-s-t-CS-s 0.124149347 0.0555958162 0.19270288 1.320722e-06 t-SC-s-t-SC-m 0.039666644 -0.0244593128 0.10379260 5.660489e-01
RRP1
Total variability: 1.1
Percentage of explained variability for RRP1: 3.15%
P value for RRP1: 1e-05
Significant ANOVA result; proceeding to Tukey HSD test for RRP1 diff lwr upr p adj c-CS-s-c-CS-m 0.0046905452 -6.655408e-03 0.0160364987 9.147241e-01 c-SC-m-c-CS-m 0.0008046396 -1.023870e-02 0.0118479798 9.999987e-01 c-SC-s-c-CS-m -0.0045955865 -1.594154e-02 0.0067503670 9.229597e-01 t-CS-m-c-CS-m -0.0061586763 -1.750463e-02 0.0051872771 7.204869e-01 t-CS-s-c-CS-m 0.0063830197 -5.786148e-03 0.0185521879 7.546810e-01 t-SC-m-c-CS-m 0.0060308244 -5.315129e-03 0.0173767778 7.417650e-01 t-SC-s-c-CS-m 0.0120909202 7.449668e-04 0.0234368737 2.729120e-02 c-SC-m-c-CS-s -0.0038859056 -1.523186e-02 0.0074600479 9.682067e-01 c-SC-s-c-CS-s -0.0092861317 -2.092683e-02 0.0023545709 2.313304e-01 t-CS-m-c-CS-s -0.0108492215 -2.248992e-02 0.0007914811 8.866338e-02 t-CS-s-c-CS-s 0.0016924745 -1.075196e-02 0.0141369091 9.999061e-01 t-SC-m-c-CS-s 0.0013402792 -1.030042e-02 0.0129809818 9.999697e-01 t-SC-s-c-CS-s 0.0074003750 -4.240328e-03 0.0190410776 5.299447e-01 c-SC-s-c-SC-m -0.0054002261 -1.674618e-02 0.0059457273 8.357661e-01 t-CS-m-c-SC-m -0.0069633160 -1.830927e-02 0.0043826375 5.762471e-01 t-CS-s-c-SC-m 0.0055783801 -6.590788e-03 0.0177475482 8.610026e-01 t-SC-m-c-SC-m 0.0052261847 -6.119769e-03 0.0165721382 8.579434e-01 t-SC-s-c-SC-m 0.0112862806 -5.967288e-05 0.0226322340 5.236983e-02 t-CS-m-c-SC-s -0.0015630898 -1.320379e-02 0.0100776128 9.999138e-01 t-CS-s-c-SC-s 0.0109786062 -1.465828e-03 0.0234230408 1.300478e-01 t-SC-m-c-SC-s 0.0106264108 -1.014292e-03 0.0222671135 1.031110e-01 t-SC-s-c-SC-s 0.0166865067 5.045804e-03 0.0283272093 3.902651e-04 t-CS-s-t-CS-m 0.0125416960 9.726147e-05 0.0249861306 4.664658e-02 t-SC-m-t-CS-m 0.0121895007 5.487981e-04 0.0238302033 3.253626e-02 t-SC-s-t-CS-m 0.0182495965 6.608894e-03 0.0298902992 5.963028e-05 t-SC-m-t-CS-s -0.0003521954 -1.279663e-02 0.0120922392 1.000000e+00 t-SC-s-t-CS-s 0.0057079005 -6.736534e-03 0.0181523351 8.606348e-01 t-SC-s-t-SC-m 0.0060600958 -5.580607e-03 0.0177007985 7.617944e-01
BAX
Total variability: 0.38
Percentage of explained variability for BAX: 6.89%
P value for BAX: 0
Significant ANOVA result; proceeding to Tukey HSD test for BAX diff lwr upr p adj c-CS-s-c-CS-m 0.0152936533 0.0087274542 0.021859853 7.574652e-11 c-SC-m-c-CS-m 0.0042576159 -0.0021334530 0.010648685 4.665804e-01 c-SC-s-c-CS-m 0.0047327498 -0.0018334493 0.011298949 3.592069e-01 t-CS-m-c-CS-m 0.0010405946 -0.0055256046 0.007606794 9.997378e-01 t-CS-s-c-CS-m 0.0104187243 0.0033761093 0.017461339 2.091261e-04 t-SC-m-c-CS-m 0.0106150667 0.0040488675 0.017181266 2.890076e-05 t-SC-s-c-CS-m 0.0084200062 0.0018538070 0.014986205 2.640296e-03 c-SC-m-c-CS-s -0.0110360374 -0.0176022366 -0.004469838 1.082700e-05 c-SC-s-c-CS-s -0.0105609035 -0.0172976817 -0.003824125 5.970968e-05 t-CS-m-c-CS-s -0.0142530587 -0.0209898370 -0.007516281 5.527997e-09 t-CS-s-c-CS-s -0.0048749290 -0.0120768479 0.002326990 4.447338e-01 t-SC-m-c-CS-s -0.0046785867 -0.0114153649 0.002058192 4.095891e-01 t-SC-s-c-CS-s -0.0068736472 -0.0136104254 -0.000136869 4.168145e-02 c-SC-s-c-SC-m 0.0004751339 -0.0060910653 0.007041333 9.999988e-01 t-CS-m-c-SC-m -0.0032170213 -0.0097832205 0.003349178 8.140518e-01 t-CS-s-c-SC-m 0.0061611084 -0.0008815066 0.013203723 1.372704e-01 t-SC-m-c-SC-m 0.0063574507 -0.0002087484 0.012923650 6.581665e-02 t-SC-s-c-SC-m 0.0041623902 -0.0024038090 0.010728589 5.337711e-01 t-CS-m-c-SC-s -0.0036921553 -0.0104289335 0.003044623 7.103640e-01 t-CS-s-c-SC-s 0.0056859745 -0.0015159444 0.012887893 2.434164e-01 t-SC-m-c-SC-s 0.0058823168 -0.0008544614 0.012619095 1.389444e-01 t-SC-s-c-SC-s 0.0036872563 -0.0030495219 0.010424035 7.117732e-01 t-CS-s-t-CS-m 0.0093781297 0.0021762109 0.016580049 2.080406e-03 t-SC-m-t-CS-m 0.0095744721 0.0028376939 0.016311250 4.593334e-04 t-SC-s-t-CS-m 0.0073794116 0.0006426333 0.014116190 2.041179e-02 t-SC-m-t-CS-s 0.0001963423 -0.0070055765 0.007398261 1.000000e+00 t-SC-s-t-CS-s -0.0019987182 -0.0092006370 0.005203201 9.905767e-01 t-SC-s-t-SC-m -0.0021950605 -0.0089318387 0.004541718 9.759447e-01
ARC
Total variability: 0.22
Percentage of explained variability for ARC: 47.56%
P value for ARC: 0
Significant ANOVA result; proceeding to Tukey HSD test for ARC diff lwr upr p adj c-CS-s-c-CS-m -0.0072694325 -0.0110062759 -0.003532589 1.297725e-07 c-SC-m-c-CS-m 0.0083261831 0.0046890069 0.011963359 1.742800e-10 c-SC-s-c-CS-m 0.0131474328 0.0094105894 0.016884276 0.000000e+00 t-CS-m-c-CS-m -0.0115856259 -0.0153224692 -0.007848782 0.000000e+00 t-CS-s-c-CS-m -0.0084278957 -0.0124358687 -0.004419923 7.081986e-09 t-SC-m-c-CS-m 0.0175053275 0.0137684841 0.021242171 0.000000e+00 t-SC-s-c-CS-m -0.0005803353 -0.0043171787 0.003156508 9.997710e-01 c-SC-m-c-CS-s 0.0155956156 0.0118587722 0.019332459 0.000000e+00 c-SC-s-c-CS-s 0.0204168653 0.0165829449 0.024250786 0.000000e+00 t-CS-m-c-CS-s -0.0043161934 -0.0081501138 -0.000482273 1.501337e-02 t-CS-s-c-CS-s -0.0011584632 -0.0052570965 0.002940170 9.894863e-01 t-SC-m-c-CS-s 0.0247747600 0.0209408396 0.028608680 0.000000e+00 t-SC-s-c-CS-s 0.0066890971 0.0028551767 0.010523018 3.922428e-06 c-SC-s-c-SC-m 0.0048212497 0.0010844063 0.008558093 2.403386e-03 t-CS-m-c-SC-m -0.0199118090 -0.0236486524 -0.016174966 0.000000e+00 t-CS-s-c-SC-m -0.0167540788 -0.0207620518 -0.012746106 0.000000e+00 t-SC-m-c-SC-m 0.0091791444 0.0054423010 0.012915988 4.489853e-12 t-SC-s-c-SC-m -0.0089065185 -0.0126433618 -0.005169675 2.370937e-11 t-CS-m-c-SC-s -0.0247330587 -0.0285669791 -0.020899138 0.000000e+00 t-CS-s-c-SC-s -0.0215753284 -0.0256739618 -0.017476695 0.000000e+00 t-SC-m-c-SC-s 0.0043578947 0.0005239743 0.008191815 1.341758e-02 t-SC-s-c-SC-s -0.0137277681 -0.0175616885 -0.009893848 0.000000e+00 t-CS-s-t-CS-m 0.0031577302 -0.0009409031 0.007256364 2.729663e-01 t-SC-m-t-CS-m 0.0290909534 0.0252570329 0.032924874 0.000000e+00 t-SC-s-t-CS-m 0.0110052905 0.0071713701 0.014839211 0.000000e+00 t-SC-m-t-CS-s 0.0259332232 0.0218345898 0.030031856 0.000000e+00 t-SC-s-t-CS-s 0.0078475603 0.0037489270 0.011946194 2.233008e-07 t-SC-s-t-SC-m -0.0180856628 -0.0219195832 -0.014251742 0.000000e+00
ERBB4
Total variability: 0.25
Percentage of explained variability for ERBB4: 19.2%
P value for ERBB4: 0
Significant ANOVA result; proceeding to Tukey HSD test for ERBB4 diff lwr upr p adj c-CS-s-c-CS-m -0.0093450383 -0.0142416790 -0.0044483976 2.490451e-07 c-SC-m-c-CS-m -0.0027599492 -0.0075259893 0.0020060909 6.483560e-01 c-SC-s-c-CS-m 0.0041649212 -0.0007317195 0.0090615619 1.631580e-01 t-CS-m-c-CS-m -0.0103617336 -0.0152583743 -0.0054650929 5.487585e-09 t-CS-s-c-CS-m -0.0060543466 -0.0113062669 -0.0008024262 1.133239e-02 t-SC-m-c-CS-m 0.0109504871 0.0060538464 0.0158471278 5.131250e-10 t-SC-s-c-CS-m -0.0004792213 -0.0053758620 0.0044174194 9.999900e-01 c-SC-m-c-CS-s 0.0065850891 0.0016884484 0.0114817298 1.230265e-03 c-SC-s-c-CS-s 0.0135099595 0.0084861121 0.0185338069 0.000000e+00 t-CS-m-c-CS-s -0.0010166953 -0.0060405427 0.0040071521 9.986929e-01 t-CS-s-c-CS-s 0.0032906918 -0.0020800270 0.0086614105 5.783856e-01 t-SC-m-c-CS-s 0.0202955254 0.0152716780 0.0253193728 0.000000e+00 t-SC-s-c-CS-s 0.0088658170 0.0038419696 0.0138896644 2.833759e-06 c-SC-s-c-SC-m 0.0069248704 0.0020282297 0.0118215111 5.039903e-04 t-CS-m-c-SC-m -0.0076017844 -0.0124984251 -0.0027051437 7.446761e-05 t-CS-s-c-SC-m -0.0032943973 -0.0085463177 0.0019575231 5.477320e-01 t-SC-m-c-SC-m 0.0137104363 0.0088137956 0.0186070770 0.000000e+00 t-SC-s-c-SC-m 0.0022807279 -0.0026159128 0.0071773686 8.506916e-01 t-CS-m-c-SC-s -0.0145266548 -0.0195505022 -0.0095028074 0.000000e+00 t-CS-s-c-SC-s -0.0102192677 -0.0155899865 -0.0048485490 2.750902e-07 t-SC-m-c-SC-s 0.0067855659 0.0017617185 0.0118094133 1.143092e-03 t-SC-s-c-SC-s -0.0046441425 -0.0096679899 0.0003797049 9.418328e-02 t-CS-s-t-CS-m 0.0043073871 -0.0010633317 0.0096781058 2.251902e-01 t-SC-m-t-CS-m 0.0213122207 0.0162883733 0.0263360681 0.000000e+00 t-SC-s-t-CS-m 0.0098825123 0.0048586649 0.0149063597 8.784415e-08 t-SC-m-t-CS-s 0.0170048336 0.0116341149 0.0223755524 0.000000e+00 t-SC-s-t-CS-s 0.0055751252 0.0002044065 0.0109458440 3.541643e-02 t-SC-s-t-SC-m -0.0114297084 -0.0164535558 -0.0064058610 2.330002e-10
nNOS
Total variability: 0.67
Percentage of explained variability for nNOS: 19.54%
P value for nNOS: 0
Significant ANOVA result; proceeding to Tukey HSD test for nNOS diff lwr upr p adj c-CS-s-c-CS-m -0.0198103190 -0.0278897122 -0.011730926 4.999445e-12 c-SC-m-c-CS-m 0.0023582128 -0.0055056912 0.010222117 9.850820e-01 c-SC-s-c-CS-m 0.0108570117 0.0027776184 0.018936405 1.246192e-03 t-CS-m-c-CS-m -0.0040677083 -0.0121471016 0.004011685 7.917345e-01 t-CS-s-c-CS-m -0.0193268228 -0.0279924228 -0.010661223 5.795564e-10 t-SC-m-c-CS-m 0.0112822906 0.0032028973 0.019361684 6.362634e-04 t-SC-s-c-CS-m 0.0053412944 -0.0027380989 0.013420688 4.770421e-01 c-SC-m-c-CS-s 0.0221685318 0.0140891385 0.030247925 0.000000e+00 c-SC-s-c-CS-s 0.0306673307 0.0223780481 0.038956613 0.000000e+00 t-CS-m-c-CS-s 0.0157426107 0.0074533281 0.024031893 2.930497e-07 t-CS-s-c-CS-s 0.0004834962 -0.0083781196 0.009345112 9.999998e-01 t-SC-m-c-CS-s 0.0310926096 0.0228033270 0.039381892 0.000000e+00 t-SC-s-c-CS-s 0.0251516134 0.0168623308 0.033440896 0.000000e+00 c-SC-s-c-SC-m 0.0084987989 0.0004194057 0.016578192 3.110849e-02 t-CS-m-c-SC-m -0.0064259211 -0.0145053143 0.001653472 2.347921e-01 t-CS-s-c-SC-m -0.0216850355 -0.0303506356 -0.013019435 1.302292e-12 t-SC-m-c-SC-m 0.0089240778 0.0008446846 0.017003471 1.862807e-02 t-SC-s-c-SC-m 0.0029830816 -0.0050963116 0.011062475 9.522217e-01 t-CS-m-c-SC-s -0.0149247200 -0.0232140025 -0.006635437 1.573233e-06 t-CS-s-c-SC-s -0.0301838344 -0.0390454502 -0.021322219 0.000000e+00 t-SC-m-c-SC-s 0.0004252789 -0.0078640037 0.008714561 9.999999e-01 t-SC-s-c-SC-s -0.0055157173 -0.0138049999 0.002773565 4.681799e-01 t-CS-s-t-CS-m -0.0152591144 -0.0241207303 -0.006397499 5.653464e-06 t-SC-m-t-CS-m 0.0153499989 0.0070607163 0.023639281 6.633011e-07 t-SC-s-t-CS-m 0.0094090027 0.0011197201 0.017698285 1.364056e-02 t-SC-m-t-CS-s 0.0306091133 0.0217474975 0.039470729 0.000000e+00 t-SC-s-t-CS-s 0.0246681171 0.0158065013 0.033529733 0.000000e+00 t-SC-s-t-SC-m -0.0059409962 -0.0142302788 0.002348286 3.668095e-01
Tau
Total variability: 5.14
Percentage of explained variability for Tau: 17.92%
P value for Tau: 0
Significant ANOVA result; proceeding to Tukey HSD test for Tau diff lwr upr p adj c-CS-s-c-CS-m -0.0180980656 -0.0406966240 0.004500493 2.268462e-01 c-SC-m-c-CS-m -0.0100728359 -0.0320686574 0.011922986 8.616317e-01 c-SC-s-c-CS-m 0.0229510521 0.0003524937 0.045549611 4.349966e-02 t-CS-m-c-CS-m -0.0006214006 -0.0232199590 0.021977158 1.000000e+00 t-CS-s-c-CS-m 0.0287665575 0.0045283427 0.053004772 7.860327e-03 t-SC-m-c-CS-m 0.0377055615 0.0151070031 0.060304120 1.309545e-05 t-SC-s-c-CS-m 0.0768032814 0.0542047230 0.099401840 0.000000e+00 c-SC-m-c-CS-s 0.0080252297 -0.0145733287 0.030623788 9.612332e-01 c-SC-s-c-CS-s 0.0410491177 0.0178634860 0.064234749 2.581400e-06 t-CS-m-c-CS-s 0.0174766650 -0.0057089667 0.040662297 3.004626e-01 t-CS-s-c-CS-s 0.0468646231 0.0220781402 0.071651106 3.393109e-07 t-SC-m-c-CS-s 0.0558036271 0.0326179954 0.078989259 1.416234e-11 t-SC-s-c-CS-s 0.0949013470 0.0717157153 0.118086979 0.000000e+00 c-SC-s-c-SC-m 0.0330238880 0.0104253296 0.055622446 2.678908e-04 t-CS-m-c-SC-m 0.0094514353 -0.0131471231 0.032049994 9.097322e-01 t-CS-s-c-SC-m 0.0388393934 0.0146011785 0.063077608 3.575690e-05 t-SC-m-c-SC-m 0.0477783974 0.0251798390 0.070376956 5.688003e-09 t-SC-s-c-SC-m 0.0868761173 0.0642775589 0.109474676 0.000000e+00 t-CS-m-c-SC-s -0.0235724527 -0.0467580844 -0.000386821 4.307545e-02 t-CS-s-c-SC-s 0.0058155054 -0.0189709775 0.030601988 9.966455e-01 t-SC-m-c-SC-s 0.0147545093 -0.0084311224 0.037940141 5.286179e-01 t-SC-s-c-SC-s 0.0538522293 0.0306665975 0.077037861 8.682488e-11 t-CS-s-t-CS-m 0.0293879581 0.0046014752 0.054174441 7.962464e-03 t-SC-m-t-CS-m 0.0383269621 0.0151413304 0.061512594 1.661732e-05 t-SC-s-t-CS-m 0.0774246820 0.0542390503 0.100610314 0.000000e+00 t-SC-m-t-CS-s 0.0089390040 -0.0158474789 0.033725487 9.578647e-01 t-SC-s-t-CS-s 0.0480367239 0.0232502410 0.072823207 1.478271e-07 t-SC-s-t-SC-m 0.0390977199 0.0159120882 0.062283352 9.927067e-06
GFAP
Total variability: 0.19
Percentage of explained variability for GFAP: 14.18%
P value for GFAP: 0
Significant ANOVA result; proceeding to Tukey HSD test for GFAP diff lwr upr p adj c-CS-s-c-CS-m 0.0033033784 -0.0011277443 0.0077345011 3.146792e-01 c-SC-m-c-CS-m -0.0098887037 -0.0142016418 -0.0055757655 1.617412e-10 c-SC-s-c-CS-m -0.0070993515 -0.0115304742 -0.0026682288 3.588872e-05 t-CS-m-c-CS-m -0.0056235159 -0.0100546386 -0.0011923931 3.088211e-03 t-CS-s-c-CS-m 0.0056020612 0.0008494348 0.0103546876 8.584589e-03 t-SC-m-c-CS-m -0.0060300765 -0.0104611993 -0.0015989538 1.005208e-03 t-SC-s-c-CS-m -0.0005845948 -0.0050157175 0.0038465279 9.999235e-01 c-SC-m-c-CS-s -0.0131920821 -0.0176232048 -0.0087609593 0.000000e+00 c-SC-s-c-CS-s -0.0104027299 -0.0149489659 -0.0058564939 1.778498e-10 t-CS-m-c-CS-s -0.0089268943 -0.0134731303 -0.0043806582 9.362294e-08 t-CS-s-c-CS-s 0.0022986828 -0.0025614479 0.0071588135 8.402322e-01 t-SC-m-c-CS-s -0.0093334549 -0.0138796910 -0.0047872189 1.815331e-08 t-SC-s-c-CS-s -0.0038879732 -0.0084342092 0.0006582628 1.579503e-01 c-SC-s-c-SC-m 0.0027893521 -0.0016417706 0.0072204749 5.430679e-01 t-CS-m-c-SC-m 0.0042651878 -0.0001659349 0.0086963105 6.902660e-02 t-CS-s-c-SC-m 0.0154907648 0.0107381384 0.0202433912 0.000000e+00 t-SC-m-c-SC-m 0.0038586271 -0.0005724956 0.0082897498 1.413428e-01 t-SC-s-c-SC-m 0.0093041089 0.0048729861 0.0137352316 7.508873e-09 t-CS-m-c-SC-s 0.0014758357 -0.0030704003 0.0060220717 9.764437e-01 t-CS-s-c-SC-s 0.0127014127 0.0078412820 0.0175615434 0.000000e+00 t-SC-m-c-SC-s 0.0010692750 -0.0034769610 0.0056155110 9.965934e-01 t-SC-s-c-SC-s 0.0065147567 0.0019685207 0.0110609927 3.926835e-04 t-CS-s-t-CS-m 0.0112255770 0.0063654463 0.0160857077 1.137891e-10 t-SC-m-t-CS-m -0.0004065607 -0.0049527967 0.0041396753 9.999946e-01 t-SC-s-t-CS-m 0.0050389211 0.0004926851 0.0095851571 1.792512e-02 t-SC-m-t-CS-s -0.0116321377 -0.0164922684 -0.0067720070 1.907041e-11 t-SC-s-t-CS-s -0.0061866560 -0.0110467867 -0.0013265252 2.951259e-03 t-SC-s-t-SC-m 0.0054454818 0.0008992458 0.0099917178 6.967608e-03
GluR3
Total variability: 1.31
Percentage of explained variability for GluR3: 10.97%
P value for GluR3: 0
Significant ANOVA result; proceeding to Tukey HSD test for GluR3 diff lwr upr p adj c-CS-s-c-CS-m -1.993981e-03 -0.013891775 0.0099038136 9.996198e-01 c-SC-m-c-CS-m 3.824574e-03 -0.007755889 0.0154050364 9.740416e-01 c-SC-s-c-CS-m 9.571146e-06 -0.011888223 0.0119073656 1.000000e+00 t-CS-m-c-CS-m -4.191432e-03 -0.016089227 0.0077063625 9.628863e-01 t-CS-s-c-CS-m -3.331989e-02 -0.046080940 -0.0205588427 0.000000e+00 t-SC-m-c-CS-m -1.475736e-02 -0.026655153 -0.0028595636 4.314605e-03 t-SC-s-c-CS-m -2.148130e-02 -0.033379094 -0.0095835046 1.447599e-06 c-SC-m-c-CS-s 5.818555e-03 -0.006079240 0.0177163490 8.154788e-01 c-SC-s-c-CS-s 2.003552e-03 -0.010203328 0.0142104316 9.996689e-01 t-CS-m-c-CS-s -2.197451e-03 -0.014404331 0.0100094285 9.993905e-01 t-CS-s-c-CS-s -3.132591e-02 -0.044375613 -0.0182762070 1.629497e-11 t-SC-m-c-CS-s -1.276338e-02 -0.024970257 -0.0005564975 3.301457e-02 t-SC-s-c-CS-s -1.948732e-02 -0.031694198 -0.0072804386 3.908613e-05 c-SC-s-c-SC-m -3.815002e-03 -0.015712797 0.0080827920 9.780382e-01 t-CS-m-c-SC-m -8.016006e-03 -0.019913800 0.0038817889 4.511360e-01 t-CS-s-c-SC-m -3.714446e-02 -0.049905513 -0.0243834162 0.000000e+00 t-SC-m-c-SC-m -1.858193e-02 -0.030479726 -0.0066841371 6.502574e-05 t-SC-s-c-SC-m -2.530587e-02 -0.037203667 -0.0134080782 4.452687e-09 t-CS-m-c-SC-s -4.201003e-03 -0.016407883 0.0080058764 9.673478e-01 t-CS-s-c-SC-s -3.332946e-02 -0.046379165 -0.0202797591 7.160939e-14 t-SC-m-c-SC-s -1.476693e-02 -0.026973809 -0.0025600496 6.103521e-03 t-SC-s-c-SC-s -2.149087e-02 -0.033697750 -0.0092839907 3.034145e-06 t-CS-s-t-CS-m -2.912846e-02 -0.042178162 -0.0160787559 5.586315e-10 t-SC-m-t-CS-m -1.056593e-02 -0.022772806 0.0016409536 1.467602e-01 t-SC-s-t-CS-m -1.728987e-02 -0.029496747 -0.0050829875 4.895944e-04 t-SC-m-t-CS-s 1.856253e-02 0.005512830 0.0316122363 4.519336e-04 t-SC-s-t-CS-s 1.183859e-02 -0.001211111 0.0248882952 1.077346e-01 t-SC-s-t-SC-m -6.723941e-03 -0.018930821 0.0054829385 7.049700e-01
GluR4
Total variability: 0.78
Percentage of explained variability for GluR4: 2.08%
P value for GluR4: 0.00204
Significant ANOVA result; proceeding to Tukey HSD test for GluR4 diff lwr upr p adj c-CS-s-c-CS-m 0.0037480960 -0.0058681679 0.0133643598 0.9366016332 c-SC-m-c-CS-m 0.0040839557 -0.0052758282 0.0134437397 0.8893534942 c-SC-s-c-CS-m 0.0036356157 -0.0059806482 0.0132518796 0.9458674591 t-CS-m-c-CS-m 0.0014333760 -0.0081828879 0.0110496398 0.9998259438 t-CS-s-c-CS-m -0.0057889914 -0.0161029709 0.0045249882 0.6843689552 t-SC-m-c-CS-m 0.0019901174 -0.0076261465 0.0116063812 0.9984900756 t-SC-s-c-CS-m 0.0097530017 0.0001367378 0.0193692656 0.0440435260 c-SC-m-c-CS-s 0.0003358598 -0.0092804041 0.0099521236 0.9999999922 c-SC-s-c-CS-s -0.0001124803 -0.0099785588 0.0097535983 1.0000000000 t-CS-m-c-CS-s -0.0023147200 -0.0121807986 0.0075513586 0.9966463866 t-CS-s-c-CS-s -0.0095370873 -0.0200843690 0.0010101943 0.1102187940 t-SC-m-c-CS-s -0.0017579786 -0.0116240572 0.0081081000 0.9994301663 t-SC-s-c-CS-s 0.0060049057 -0.0038611729 0.0158709843 0.5869326168 c-SC-s-c-SC-m -0.0004483400 -0.0100646039 0.0091679239 0.9999999417 t-CS-m-c-SC-m -0.0026505798 -0.0122668436 0.0069656841 0.9909562680 t-CS-s-c-SC-m -0.0098729471 -0.0201869267 0.0004410325 0.0721585237 t-SC-m-c-SC-m -0.0020938384 -0.0117101022 0.0075224255 0.9979091715 t-SC-s-c-SC-m 0.0056690460 -0.0039472179 0.0152853098 0.6268388887 t-CS-m-c-SC-s -0.0022022398 -0.0120683183 0.0076638388 0.9975513887 t-CS-s-c-SC-s -0.0094246071 -0.0199718887 0.0011226746 0.1195091738 t-SC-m-c-SC-s -0.0016454984 -0.0115115769 0.0082205802 0.9996318015 t-SC-s-c-SC-s 0.0061173860 -0.0037486926 0.0159834645 0.5629580110 t-CS-s-t-CS-m -0.0072223673 -0.0177696490 0.0033249143 0.4288912309 t-SC-m-t-CS-m 0.0005567414 -0.0093093372 0.0104228200 0.9999997796 t-SC-s-t-CS-m 0.0083196257 -0.0015464529 0.0181857043 0.1716155810 t-SC-m-t-CS-s 0.0077791087 -0.0027681729 0.0183263904 0.3286673756 t-SC-s-t-CS-s 0.0155419930 0.0049947114 0.0260892747 0.0002266047 t-SC-s-t-SC-m 0.0077628843 -0.0021031942 0.0176289629 0.2474455707
IL1B
Total variability: 7.27
Percentage of explained variability for IL1B: 31.7%
P value for IL1B: 0
Significant ANOVA result; proceeding to Tukey HSD test for IL1B diff lwr upr p adj c-CS-s-c-CS-m -0.068216383 -0.092728708 -0.043704059 0.000000e+00 c-SC-m-c-CS-m 0.061141210 0.037282665 0.084999755 0.000000e+00 c-SC-s-c-CS-m 0.064389159 0.039876834 0.088901484 0.000000e+00 t-CS-m-c-CS-m -0.022331979 -0.046844303 0.002180346 1.045732e-01 t-CS-s-c-CS-m -0.036883911 -0.063174747 -0.010593075 5.845721e-04 t-SC-m-c-CS-m 0.051762288 0.027249964 0.076274613 5.972093e-09 t-SC-s-c-CS-m -0.013943997 -0.038456322 0.010568328 6.691637e-01 c-SC-m-c-CS-s 0.129357593 0.104845268 0.153869918 0.000000e+00 c-SC-s-c-CS-s 0.132605543 0.107456428 0.157754657 0.000000e+00 t-CS-m-c-CS-s 0.045884405 0.020735290 0.071033520 1.053068e-06 t-CS-s-c-CS-s 0.031332473 0.004446938 0.058218007 9.909794e-03 t-SC-m-c-CS-s 0.119978672 0.094829557 0.145127787 0.000000e+00 t-SC-s-c-CS-s 0.054272386 0.029123272 0.079421501 2.433611e-09 c-SC-s-c-SC-m 0.003247949 -0.021264376 0.027760274 9.999212e-01 t-CS-m-c-SC-m -0.083473188 -0.107985513 -0.058960864 0.000000e+00 t-CS-s-c-SC-m -0.098025121 -0.124315957 -0.071734285 0.000000e+00 t-SC-m-c-SC-m -0.009378921 -0.033891246 0.015133403 9.423812e-01 t-SC-s-c-SC-m -0.075085207 -0.099597532 -0.050572882 0.000000e+00 t-CS-m-c-SC-s -0.086721138 -0.111870252 -0.061572023 0.000000e+00 t-CS-s-c-SC-s -0.101273070 -0.128158605 -0.074387536 0.000000e+00 t-SC-m-c-SC-s -0.012626871 -0.037775985 0.012522244 7.940783e-01 t-SC-s-c-SC-s -0.078333156 -0.103482271 -0.053184042 0.000000e+00 t-CS-s-t-CS-m -0.014551932 -0.041437467 0.012333602 7.234565e-01 t-SC-m-t-CS-m 0.074094267 0.048945152 0.099243382 0.000000e+00 t-SC-s-t-CS-m 0.008387981 -0.016761133 0.033537096 9.725668e-01 t-SC-m-t-CS-s 0.088646199 0.061760665 0.115531734 0.000000e+00 t-SC-s-t-CS-s 0.022939914 -0.003945621 0.049825448 1.601388e-01 t-SC-s-t-SC-m -0.065706286 -0.090855400 -0.040557171 0.000000e+00
P3525
Total variability: 0.97
Percentage of explained variability for P3525: 14.4%
P value for P3525: 0
Significant ANOVA result; proceeding to Tukey HSD test for P3525 diff lwr upr p adj c-CS-s-c-CS-m -0.010287430 -0.0203249655 -0.0002498951 3.997959e-02 c-SC-m-c-CS-m -0.021094364 -0.0308641832 -0.0113245445 2.381248e-09 c-SC-s-c-CS-m -0.007851847 -0.0178893824 0.0021856880 2.544169e-01 t-CS-m-c-CS-m -0.018381286 -0.0284188207 -0.0083437503 9.396878e-07 t-CS-s-c-CS-m 0.001326565 -0.0094392513 0.0120923818 9.999519e-01 t-SC-m-c-CS-m -0.013267319 -0.0233048545 -0.0032297842 1.637791e-03 t-SC-s-c-CS-m 0.015968878 0.0059313431 0.0260064134 4.241086e-05 c-SC-m-c-CS-s -0.010806934 -0.0208444688 -0.0007693984 2.454085e-02 c-SC-s-c-CS-s 0.002435583 -0.0078627107 0.0127338769 9.964733e-01 t-CS-m-c-CS-s -0.008093855 -0.0183921490 0.0022044386 2.487830e-01 t-CS-s-c-CS-s 0.011613996 0.0006046564 0.0226233347 3.023467e-02 t-SC-m-c-CS-s -0.002979889 -0.0132781829 0.0073184047 9.879111e-01 t-SC-s-c-CS-s 0.026256309 0.0159580147 0.0365546023 1.322276e-13 c-SC-s-c-SC-m 0.013242517 0.0032049815 0.0232800518 1.688289e-03 t-CS-m-c-SC-m 0.002713078 -0.0073244568 0.0127506135 9.919642e-01 t-CS-s-c-SC-m 0.022420929 0.0116551125 0.0331867457 1.039765e-08 t-SC-m-c-SC-m 0.007827045 -0.0022104907 0.0178645797 2.582307e-01 t-SC-s-c-SC-m 0.037063242 0.0270257069 0.0471007773 0.000000e+00 t-CS-m-c-SC-s -0.010529438 -0.0208277321 -0.0002311445 4.088294e-02 t-CS-s-c-SC-s 0.009178412 -0.0018309267 0.0201877516 1.831456e-01 t-SC-m-c-SC-s -0.005415472 -0.0157137660 0.0048828217 7.522399e-01 t-SC-s-c-SC-s 0.023820725 0.0135224316 0.0341190192 1.061100e-10 t-CS-s-t-CS-m 0.019707851 0.0086985116 0.0307171899 1.868594e-06 t-SC-m-t-CS-m 0.005113966 -0.0051843276 0.0154122600 8.032419e-01 t-SC-s-t-CS-m 0.034350164 0.0240518699 0.0446484576 0.000000e+00 t-SC-m-t-CS-s -0.014593885 -0.0256032238 -0.0035845454 1.562482e-03 t-SC-s-t-CS-s 0.014642313 0.0036329738 0.0256516522 1.479793e-03 t-SC-s-t-SC-m 0.029236198 0.0189379038 0.0395344914 0.000000e+00
pCASP9
Total variability: 66.43
Percentage of explained variability for pCASP9: 7.78%
P value for pCASP9: 0
Significant ANOVA result; proceeding to Tukey HSD test for pCASP9 diff lwr upr p adj c-CS-s-c-CS-m -0.016141503 -0.102269774 0.06998677 9.992065e-01 c-SC-m-c-CS-m 0.114862493 0.031031389 0.19869360 8.927800e-04 c-SC-s-c-CS-m 0.008345173 -0.077783099 0.09447344 9.999907e-01 t-CS-m-c-CS-m -0.065088378 -0.151216650 0.02103989 2.971780e-01 t-CS-s-c-CS-m -0.031907573 -0.124284951 0.06046980 9.666869e-01 t-SC-m-c-CS-m 0.151280678 0.065152407 0.23740895 3.243132e-06 t-SC-s-c-CS-m 0.016429366 -0.069698905 0.10255764 9.991095e-01 c-SC-m-c-CS-s 0.131003995 0.044875724 0.21713227 1.167773e-04 c-SC-s-c-CS-s 0.024486676 -0.063879067 0.11285242 9.906621e-01 t-CS-m-c-CS-s -0.048946875 -0.137312618 0.03941887 6.989394e-01 t-CS-s-c-CS-s -0.015766071 -0.110233023 0.07870088 9.996302e-01 t-SC-m-c-CS-s 0.167422181 0.079056439 0.25578792 3.169657e-07 t-SC-s-c-CS-s 0.032570869 -0.055794873 0.12093661 9.526528e-01 c-SC-s-c-SC-m -0.106517320 -0.192645591 -0.02038905 4.497214e-03 t-CS-m-c-SC-m -0.179950871 -0.266079142 -0.09382260 9.150693e-09 t-CS-s-c-SC-m -0.146770066 -0.239147443 -0.05439269 4.375370e-05 t-SC-m-c-SC-m 0.036418186 -0.049710086 0.12254646 9.047928e-01 t-SC-s-c-SC-m -0.098433126 -0.184561398 -0.01230485 1.257799e-02 t-CS-m-c-SC-s -0.073433551 -0.161799293 0.01493219 1.864668e-01 t-CS-s-c-SC-s -0.040252746 -0.134719699 0.05421421 9.011864e-01 t-SC-m-c-SC-s 0.142935505 0.054569763 0.23130125 2.850299e-05 t-SC-s-c-SC-s 0.008084193 -0.080281549 0.09644994 9.999937e-01 t-CS-s-t-CS-m 0.033180805 -0.061286147 0.12764776 9.634820e-01 t-SC-m-t-CS-m 0.216369056 0.128003314 0.30473480 5.423550e-12 t-SC-s-t-CS-m 0.081517744 -0.006847998 0.16988349 9.561938e-02 t-SC-m-t-CS-s 0.183188252 0.088721300 0.27765520 1.448181e-07 t-SC-s-t-CS-s 0.048336940 -0.046130013 0.14280389 7.776017e-01 t-SC-s-t-SC-m -0.134851312 -0.223217054 -0.04648557 1.087337e-04
PSD95
Total variability: 69.83
Percentage of explained variability for PSD95: 17.68%
P value for PSD95: 0
Significant ANOVA result; proceeding to Tukey HSD test for PSD95 diff lwr upr p adj c-CS-s-c-CS-m -0.065252014 -0.148680490 0.01817646 2.545972e-01 c-SC-m-c-CS-m 0.206541221 0.125337906 0.28774454 2.254863e-13 c-SC-s-c-CS-m 0.215801658 0.132373182 0.29923013 0.000000e+00 t-CS-m-c-CS-m 0.077094975 -0.006333501 0.16052345 9.443306e-02 t-CS-s-c-CS-m 0.020912776 -0.068568919 0.11039447 9.967267e-01 t-SC-m-c-CS-m 0.235897288 0.152468812 0.31932576 0.000000e+00 t-SC-s-c-CS-m 0.041184442 -0.042244035 0.12461292 8.080507e-01 c-SC-m-c-CS-s 0.271793235 0.188364759 0.35522171 0.000000e+00 c-SC-s-c-CS-s 0.281053672 0.195457862 0.36664948 0.000000e+00 t-CS-m-c-CS-s 0.142346989 0.056751178 0.22794280 1.425366e-05 t-CS-s-c-CS-s 0.086164790 -0.005340980 0.17767056 8.203980e-02 t-SC-m-c-CS-s 0.301149302 0.215553492 0.38674511 0.000000e+00 t-SC-s-c-CS-s 0.106436455 0.020840645 0.19203227 4.161889e-03 c-SC-s-c-SC-m 0.009260437 -0.074168039 0.09268891 9.999764e-01 t-CS-m-c-SC-m -0.129446246 -0.212874723 -0.04601777 7.540524e-05 t-CS-s-c-SC-m -0.185628445 -0.275110141 -0.09614675 1.212358e-08 t-SC-m-c-SC-m 0.029356067 -0.054072409 0.11278454 9.631242e-01 t-SC-s-c-SC-m -0.165356780 -0.248785256 -0.08192830 6.711414e-08 t-CS-m-c-SC-s -0.138706683 -0.224302494 -0.05311087 2.726889e-05 t-CS-s-c-SC-s -0.194888882 -0.286394652 -0.10338311 4.213268e-09 t-SC-m-c-SC-s 0.020095630 -0.065500180 0.10569144 9.966320e-01 t-SC-s-c-SC-s -0.174617217 -0.260213027 -0.08902141 2.312993e-08 t-CS-s-t-CS-m -0.056182199 -0.147687969 0.03532357 5.757265e-01 t-SC-m-t-CS-m 0.158802314 0.073206503 0.24439812 6.251723e-07 t-SC-s-t-CS-m -0.035910533 -0.121506344 0.04968528 9.083500e-01 t-SC-m-t-CS-s 0.214984512 0.123478742 0.30649028 4.932577e-11 t-SC-s-t-CS-s 0.020271665 -0.071234105 0.11177744 9.976660e-01 t-SC-s-t-SC-m -0.194712847 -0.280308657 -0.10911704 2.344233e-10
SNCA
Total variability: 0.63
Percentage of explained variability for SNCA: 33.4%
P value for SNCA: 0
Significant ANOVA result; proceeding to Tukey HSD test for SNCA diff lwr upr p adj c-CS-s-c-CS-m -0.0058412431 -0.0129652508 0.001282765 2.006730e-01 c-SC-m-c-CS-m 0.0246609352 0.0177269353 0.031594935 0.000000e+00 c-SC-s-c-CS-m 0.0207542156 0.0136302079 0.027878223 0.000000e+00 t-CS-m-c-CS-m -0.0143361719 -0.0214601796 -0.007212164 3.856349e-08 t-CS-s-c-CS-m 0.0011346509 -0.0065062448 0.008775547 9.998303e-01 t-SC-m-c-CS-m 0.0248335355 0.0177095278 0.031957543 0.000000e+00 t-SC-s-c-CS-m 0.0053369221 -0.0017870856 0.012460930 3.083628e-01 c-SC-m-c-CS-s 0.0305021782 0.0233781706 0.037626186 0.000000e+00 c-SC-s-c-CS-s 0.0265954587 0.0192863810 0.033904536 0.000000e+00 t-CS-m-c-CS-s -0.0084949288 -0.0158040065 -0.001185851 1.024996e-02 t-CS-s-c-CS-s 0.0069758940 -0.0008378387 0.014789627 1.202157e-01 t-SC-m-c-CS-s 0.0306747786 0.0233657009 0.037983856 0.000000e+00 t-SC-s-c-CS-s 0.0111781652 0.0038690875 0.018487243 1.037498e-04 c-SC-s-c-SC-m -0.0039067196 -0.0110307273 0.003217288 7.097269e-01 t-CS-m-c-SC-m -0.0389971070 -0.0461211147 -0.031873099 0.000000e+00 t-CS-s-c-SC-m -0.0235262842 -0.0311671800 -0.015885388 0.000000e+00 t-SC-m-c-SC-m 0.0001726003 -0.0069514073 0.007296608 1.000000e+00 t-SC-s-c-SC-m -0.0193240131 -0.0264480208 -0.012200005 0.000000e+00 t-CS-m-c-SC-s -0.0350903874 -0.0423994651 -0.027781310 0.000000e+00 t-CS-s-c-SC-s -0.0196195646 -0.0274332973 -0.011805832 9.900969e-13 t-SC-m-c-SC-s 0.0040793199 -0.0032297577 0.011388398 6.906456e-01 t-SC-s-c-SC-s -0.0154172935 -0.0227263711 -0.008108216 6.247263e-09 t-CS-s-t-CS-m 0.0154708228 0.0076570901 0.023284555 6.967367e-08 t-SC-m-t-CS-m 0.0391697074 0.0318606297 0.046478785 0.000000e+00 t-SC-s-t-CS-m 0.0196730940 0.0123640163 0.026982172 0.000000e+00 t-SC-m-t-CS-s 0.0236988846 0.0158851519 0.031512617 0.000000e+00 t-SC-s-t-CS-s 0.0042022712 -0.0036114615 0.012016004 7.300103e-01 t-SC-s-t-SC-m -0.0194966134 -0.0268056911 -0.012187536 0.000000e+00
Ubiquitin
Total variability: 32.51
Percentage of explained variability for Ubiquitin: 51.28%
P value for Ubiquitin: 0
Significant ANOVA result; proceeding to Tukey HSD test for Ubiquitin diff lwr upr p adj c-CS-s-c-CS-m -0.113634668 -0.15742982 -0.06983952 0.000000e+00 c-SC-m-c-CS-m 0.225718059 0.18309099 0.26834513 0.000000e+00 c-SC-s-c-CS-m 0.094070720 0.05027557 0.13786587 2.961209e-09 t-CS-m-c-CS-m -0.091038903 -0.13483405 -0.04724375 1.118594e-08 t-CS-s-c-CS-m 0.015852424 -0.03112032 0.06282517 9.707026e-01 t-SC-m-c-CS-m 0.238091055 0.19429591 0.28188620 0.000000e+00 t-SC-s-c-CS-m 0.100346896 0.05655175 0.14414205 1.669110e-10 c-SC-m-c-CS-s 0.339352728 0.29555758 0.38314788 0.000000e+00 c-SC-s-c-CS-s 0.207705389 0.16277251 0.25263826 0.000000e+00 t-CS-m-c-CS-s 0.022595765 -0.02233711 0.06752864 7.927311e-01 t-CS-s-c-CS-s 0.129487092 0.08145183 0.17752236 0.000000e+00 t-SC-m-c-CS-s 0.351725724 0.30679285 0.39665860 0.000000e+00 t-SC-s-c-CS-s 0.213981565 0.16904869 0.25891444 0.000000e+00 c-SC-s-c-SC-m -0.131647339 -0.17544249 -0.08785219 0.000000e+00 t-CS-m-c-SC-m -0.316756962 -0.36055211 -0.27296181 0.000000e+00 t-CS-s-c-SC-m -0.209865635 -0.25683838 -0.16289289 0.000000e+00 t-SC-m-c-SC-m 0.012372996 -0.03142215 0.05616815 9.895143e-01 t-SC-s-c-SC-m -0.125371163 -0.16916631 -0.08157601 0.000000e+00 t-CS-m-c-SC-s -0.185109623 -0.23004250 -0.14017675 0.000000e+00 t-CS-s-c-SC-s -0.078218296 -0.12625356 -0.03018303 2.421417e-05 t-SC-m-c-SC-s 0.144020335 0.09908746 0.18895321 0.000000e+00 t-SC-s-c-SC-s 0.006276176 -0.03865670 0.05120905 9.998875e-01 t-CS-s-t-CS-m 0.106891327 0.05885606 0.15492659 6.412447e-10 t-SC-m-t-CS-m 0.329129959 0.28419708 0.37406283 0.000000e+00 t-SC-s-t-CS-m 0.191385799 0.14645292 0.23631867 0.000000e+00 t-SC-m-t-CS-s 0.222238631 0.17420337 0.27027390 0.000000e+00 t-SC-s-t-CS-s 0.084494472 0.03645921 0.13252974 3.111381e-06 t-SC-s-t-SC-m -0.137744159 -0.18267703 -0.09281128 0.000000e+00
pGSK3B_Tyr216
Total variability: 9.6
Percentage of explained variability for pGSK3B_Tyr216: 6.82%
P value for pGSK3B_Tyr216: 0
Significant ANOVA result; proceeding to Tukey HSD test for pGSK3B_Tyr216 diff lwr upr p adj c-CS-s-c-CS-m -1.895049e-02 -0.0518572294 0.0139562525 6.549007e-01 c-SC-m-c-CS-m -4.120976e-02 -0.0732388327 -0.0091806934 2.507932e-03 c-SC-s-c-CS-m -5.532904e-02 -0.0882357794 -0.0224222975 1.071701e-05 t-CS-m-c-CS-m 1.528272e-02 -0.0176240190 0.0481894629 8.526092e-01 t-CS-s-c-CS-m -2.755362e-02 -0.0628479391 0.0077406925 2.568312e-01 t-SC-m-c-CS-m -3.245339e-02 -0.0653601334 0.0004533485 5.640864e-02 t-SC-s-c-CS-m 1.526139e-02 -0.0176453500 0.0481681319 8.535260e-01 c-SC-m-c-CS-s -2.225927e-02 -0.0551660155 0.0106474664 4.456616e-01 c-SC-s-c-CS-s -3.637855e-02 -0.0701401538 -0.0026169461 2.433627e-02 t-CS-m-c-CS-s 3.423321e-02 0.0004716066 0.0679948143 4.414305e-02 t-CS-s-c-CS-s -8.603135e-03 -0.0446958075 0.0274895379 9.962960e-01 t-SC-m-c-CS-s -1.350290e-02 -0.0472645078 0.0202586999 9.277060e-01 t-SC-s-c-CS-s 3.421188e-02 0.0004502756 0.0679734832 4.439472e-02 c-SC-s-c-SC-m -1.411928e-02 -0.0470260164 0.0187874655 8.978403e-01 t-CS-m-c-SC-m 5.649248e-02 0.0235857441 0.0893992259 6.140496e-06 t-CS-s-c-SC-m 1.365614e-02 -0.0216381761 0.0489504555 9.389476e-01 t-SC-m-c-SC-m 8.756371e-03 -0.0241503703 0.0416631116 9.926923e-01 t-SC-s-c-SC-m 5.647115e-02 0.0235644130 0.0893778949 6.204119e-06 t-CS-m-c-SC-s 7.061176e-02 0.0368501566 0.1043733643 8.784926e-09 t-CS-s-c-SC-s 2.777542e-02 -0.0083172575 0.0638680878 2.743743e-01 t-SC-m-c-SC-s 2.287565e-02 -0.0108859578 0.0566372499 4.433758e-01 t-SC-s-c-SC-s 7.059043e-02 0.0368288255 0.1043520332 8.891125e-09 t-CS-s-t-CS-m -4.283635e-02 -0.0789290180 -0.0067436726 7.858894e-03 t-SC-m-t-CS-m -4.773611e-02 -0.0814977182 -0.0139745105 5.059294e-04 t-SC-s-t-CS-m -2.133104e-05 -0.0337829349 0.0337402728 1.000000e+00 t-SC-m-t-CS-s -4.899769e-03 -0.0409924418 0.0311929036 9.999072e-01 t-SC-s-t-CS-s 4.281501e-02 0.0067223415 0.0789076869 7.909803e-03 t-SC-s-t-SC-m 4.771478e-02 0.0139531795 0.0814763872 5.101619e-04
SHH
Total variability: 0.91
Percentage of explained variability for SHH: 8.48%
P value for SHH: 0
Significant ANOVA result; proceeding to Tukey HSD test for SHH diff lwr upr p adj c-CS-s-c-CS-m -0.012092102 -0.0221161293 -2.068074e-03 6.340083e-03 c-SC-m-c-CS-m -0.002440886 -0.0121975581 7.315786e-03 9.949952e-01 c-SC-s-c-CS-m 0.014942096 0.0049180683 2.496612e-02 1.789648e-04 t-CS-m-c-CS-m -0.009976979 -0.0200010062 4.704922e-05 5.211043e-02 t-CS-s-c-CS-m -0.004766536 -0.0155178649 5.984793e-03 8.807594e-01 t-SC-m-c-CS-m 0.003756882 -0.0062671455 1.378091e-02 9.482888e-01 t-SC-s-c-CS-m 0.007917010 -0.0021070182 1.794104e-02 2.429760e-01 c-SC-m-c-CS-s 0.009651216 -0.0003728121 1.967524e-02 6.887871e-02 c-SC-s-c-CS-s 0.027034198 0.0167497621 3.731863e-02 0.000000e+00 t-CS-m-c-CS-s 0.002115123 -0.0081693124 1.239956e-02 9.985497e-01 t-CS-s-c-CS-s 0.007325566 -0.0036689582 1.832009e-02 4.663544e-01 t-SC-m-c-CS-s 0.015848984 0.0055645483 2.613342e-02 8.774397e-05 t-SC-s-c-CS-s 0.020009111 0.0097246756 3.029355e-02 1.292375e-07 c-SC-s-c-SC-m 0.017382982 0.0073589542 2.740701e-02 4.651026e-06 t-CS-m-c-SC-m -0.007536093 -0.0175601203 2.487935e-03 3.038110e-01 t-CS-s-c-SC-m -0.002325650 -0.0130769789 8.425679e-03 9.979951e-01 t-SC-m-c-SC-m 0.006197768 -0.0038262596 1.622180e-02 5.666440e-01 t-SC-s-c-SC-m 0.010357895 0.0003338677 2.038192e-02 3.700918e-02 t-CS-m-c-SC-s -0.024919074 -0.0352035099 -1.463464e-02 9.838907e-12 t-CS-s-c-SC-s -0.019708632 -0.0307031558 -8.714108e-03 1.793398e-06 t-SC-m-c-SC-s -0.011185214 -0.0214696492 -9.007783e-04 2.205025e-02 t-SC-s-c-SC-s -0.007025086 -0.0173095219 3.259349e-03 4.322612e-01 t-CS-s-t-CS-m 0.005210443 -0.0057840813 1.620497e-02 8.388290e-01 t-SC-m-t-CS-m 0.013733861 0.0034494253 2.401830e-02 1.383674e-03 t-SC-s-t-CS-m 0.017893988 0.0076095526 2.817842e-02 4.238398e-06 t-SC-m-t-CS-s 0.008523418 -0.0024711060 1.951794e-02 2.653220e-01 t-SC-s-t-CS-s 0.012683545 0.0016890213 2.367807e-02 1.123261e-02 t-SC-s-t-SC-m 0.004160127 -0.0061243081 1.444456e-02 9.234674e-01
BAD
Total variability: 0.77
Percentage of explained variability for BAD: 12.45%
P value for BAD: 0
Significant ANOVA result; proceeding to Tukey HSD test for BAD diff lwr upr p adj c-CS-s-c-CS-m -0.0122119822 -0.0212574822 -0.003166482 1.151892e-03 c-SC-m-c-CS-m 0.0124125350 0.0036082918 0.021216778 5.338694e-04 c-SC-s-c-CS-m -0.0007606309 -0.0098061309 0.008284869 9.999965e-01 t-CS-m-c-CS-m -0.0063095628 -0.0153550628 0.002735937 4.035994e-01 t-CS-s-c-CS-m -0.0059976862 -0.0156994897 0.003704117 5.668291e-01 t-SC-m-c-CS-m -0.0031842029 -0.0122297029 0.005861297 9.630386e-01 t-SC-s-c-CS-m 0.0177666210 0.0087211210 0.026812121 9.268500e-08 c-SC-m-c-CS-s 0.0246245172 0.0155790172 0.033670017 0.000000e+00 c-SC-s-c-CS-s 0.0114513513 0.0021708641 0.020731839 4.644142e-03 t-CS-m-c-CS-s 0.0059024194 -0.0033780677 0.015182907 5.293765e-01 t-CS-s-c-CS-s 0.0062142960 -0.0037069621 0.016135554 5.496540e-01 t-SC-m-c-CS-s 0.0090277793 -0.0002527079 0.018308266 6.331915e-02 t-SC-s-c-CS-s 0.0299786032 0.0206981160 0.039259090 0.000000e+00 c-SC-s-c-SC-m -0.0131731659 -0.0222186659 -0.004127666 2.867717e-04 t-CS-m-c-SC-m -0.0187220978 -0.0277675978 -0.009676598 1.325153e-08 t-CS-s-c-SC-m -0.0184102212 -0.0281120247 -0.008708418 3.010483e-07 t-SC-m-c-SC-m -0.0155967379 -0.0246422379 -0.006551238 5.447960e-06 t-SC-s-c-SC-m 0.0053540860 -0.0036914140 0.014399586 6.219028e-01 t-CS-m-c-SC-s -0.0055489319 -0.0148294191 0.003731555 6.093938e-01 t-CS-s-c-SC-s -0.0052370553 -0.0151583135 0.004684203 7.485688e-01 t-SC-m-c-SC-s -0.0024235720 -0.0117040592 0.006856915 9.934831e-01 t-SC-s-c-SC-s 0.0185272518 0.0092467647 0.027807739 5.169935e-08 t-CS-s-t-CS-m 0.0003118766 -0.0096093816 0.010233135 1.000000e+00 t-SC-m-t-CS-m 0.0031253599 -0.0061551273 0.012405847 9.710465e-01 t-SC-s-t-CS-m 0.0240761837 0.0147956965 0.033356671 0.000000e+00 t-SC-m-t-CS-s 0.0028134833 -0.0071077748 0.012734741 9.892769e-01 t-SC-s-t-CS-s 0.0237643072 0.0138430490 0.033685565 1.828449e-11 t-SC-s-t-SC-m 0.0209508239 0.0116703367 0.030231311 3.338253e-10
BCL2
Total variability: 0.63
Percentage of explained variability for BCL2: 12.8%
P value for BCL2: 0
Significant ANOVA result; proceeding to Tukey HSD test for BCL2 diff lwr upr p adj c-CS-s-c-CS-m -0.0059498004 -0.014119639 0.002220038 3.454030e-01 c-SC-m-c-CS-m 0.0234403705 0.015488433 0.031392308 0.000000e+00 c-SC-s-c-CS-m 0.0005428727 -0.007626966 0.008712711 9.999993e-01 t-CS-m-c-CS-m -0.0005340433 -0.008703882 0.007635796 9.999994e-01 t-CS-s-c-CS-m -0.0023529756 -0.011115584 0.006409632 9.922777e-01 t-SC-m-c-CS-m 0.0049271247 -0.003242714 0.013096963 5.985790e-01 t-SC-s-c-CS-m 0.0045425743 -0.003627264 0.012712413 6.947953e-01 c-SC-m-c-CS-s 0.0293901709 0.021220332 0.037560010 0.000000e+00 c-SC-s-c-CS-s 0.0064926731 -0.001889405 0.014874751 2.663514e-01 t-CS-m-c-CS-s 0.0054157572 -0.002966321 0.013797835 5.081927e-01 t-CS-s-c-CS-s 0.0035968248 -0.005363993 0.012557643 9.263787e-01 t-SC-m-c-CS-s 0.0108769251 0.002494847 0.019259003 2.197487e-03 t-SC-s-c-CS-s 0.0104923747 0.002110297 0.018874452 3.781776e-03 c-SC-s-c-SC-m -0.0228974978 -0.031067337 -0.014727659 0.000000e+00 t-CS-m-c-SC-m -0.0239744138 -0.032144253 -0.015804575 0.000000e+00 t-CS-s-c-SC-m -0.0257933462 -0.034555954 -0.017030738 0.000000e+00 t-SC-m-c-SC-m -0.0185132458 -0.026683085 -0.010343407 2.804407e-10 t-SC-s-c-SC-m -0.0188977962 -0.027067635 -0.010727957 1.060163e-10 t-CS-m-c-SC-s -0.0010769160 -0.009458994 0.007305162 9.999361e-01 t-CS-s-c-SC-s -0.0028958483 -0.011856666 0.006064970 9.770384e-01 t-SC-m-c-SC-s 0.0043842520 -0.003997826 0.012766330 7.573587e-01 t-SC-s-c-SC-s 0.0039997016 -0.004382376 0.012381779 8.339382e-01 t-CS-s-t-CS-m -0.0018189324 -0.010779750 0.007141886 9.986671e-01 t-SC-m-t-CS-m 0.0054611680 -0.002920910 0.013843246 4.968906e-01 t-SC-s-t-CS-m 0.0050766176 -0.003305460 0.013458695 5.932061e-01 t-SC-m-t-CS-s 0.0072801003 -0.001680718 0.016240918 2.107013e-01 t-SC-s-t-CS-s 0.0068955499 -0.002065268 0.015856368 2.744321e-01 t-SC-s-t-SC-m -0.0003845504 -0.008766628 0.007997527 9.999999e-01
pS6
Total variability: 0.22
Percentage of explained variability for pS6: 47.56%
P value for pS6: 0
Significant ANOVA result; proceeding to Tukey HSD test for pS6 diff lwr upr p adj c-CS-s-c-CS-m -0.0072694325 -0.0110062759 -0.003532589 1.297725e-07 c-SC-m-c-CS-m 0.0083261831 0.0046890069 0.011963359 1.742800e-10 c-SC-s-c-CS-m 0.0131474328 0.0094105894 0.016884276 0.000000e+00 t-CS-m-c-CS-m -0.0115856259 -0.0153224692 -0.007848782 0.000000e+00 t-CS-s-c-CS-m -0.0084278957 -0.0124358687 -0.004419923 7.081986e-09 t-SC-m-c-CS-m 0.0175053275 0.0137684841 0.021242171 0.000000e+00 t-SC-s-c-CS-m -0.0005803353 -0.0043171787 0.003156508 9.997710e-01 c-SC-m-c-CS-s 0.0155956156 0.0118587722 0.019332459 0.000000e+00 c-SC-s-c-CS-s 0.0204168653 0.0165829449 0.024250786 0.000000e+00 t-CS-m-c-CS-s -0.0043161934 -0.0081501138 -0.000482273 1.501337e-02 t-CS-s-c-CS-s -0.0011584632 -0.0052570965 0.002940170 9.894863e-01 t-SC-m-c-CS-s 0.0247747600 0.0209408396 0.028608680 0.000000e+00 t-SC-s-c-CS-s 0.0066890971 0.0028551767 0.010523018 3.922428e-06 c-SC-s-c-SC-m 0.0048212497 0.0010844063 0.008558093 2.403386e-03 t-CS-m-c-SC-m -0.0199118090 -0.0236486524 -0.016174966 0.000000e+00 t-CS-s-c-SC-m -0.0167540788 -0.0207620518 -0.012746106 0.000000e+00 t-SC-m-c-SC-m 0.0091791444 0.0054423010 0.012915988 4.489853e-12 t-SC-s-c-SC-m -0.0089065185 -0.0126433618 -0.005169675 2.370937e-11 t-CS-m-c-SC-s -0.0247330587 -0.0285669791 -0.020899138 0.000000e+00 t-CS-s-c-SC-s -0.0215753284 -0.0256739618 -0.017476695 0.000000e+00 t-SC-m-c-SC-s 0.0043578947 0.0005239743 0.008191815 1.341758e-02 t-SC-s-c-SC-s -0.0137277681 -0.0175616885 -0.009893848 0.000000e+00 t-CS-s-t-CS-m 0.0031577302 -0.0009409031 0.007256364 2.729663e-01 t-SC-m-t-CS-m 0.0290909534 0.0252570329 0.032924874 0.000000e+00 t-SC-s-t-CS-m 0.0110052905 0.0071713701 0.014839211 0.000000e+00 t-SC-m-t-CS-s 0.0259332232 0.0218345898 0.030031856 0.000000e+00 t-SC-s-t-CS-s 0.0078475603 0.0037489270 0.011946194 2.233008e-07 t-SC-s-t-SC-m -0.0180856628 -0.0219195832 -0.014251742 0.000000e+00
pCFOS
Total variability: 0.57
Percentage of explained variability for pCFOS: 8.12%
P value for pCFOS: 0
Significant ANOVA result; proceeding to Tukey HSD test for pCFOS diff lwr upr p adj c-CS-s-c-CS-m 0.0030244531 -0.0049708511 0.0110197572 9.457105e-01 c-SC-m-c-CS-m 0.0196844838 0.0119024262 0.0274665414 4.861667e-13 c-SC-s-c-CS-m 0.0110774834 0.0030821793 0.0190727875 7.331696e-04 t-CS-m-c-CS-m 0.0038327077 -0.0041625964 0.0118280118 8.305989e-01 t-CS-s-c-CS-m -0.0019584186 -0.0105338284 0.0066169912 9.971699e-01 t-SC-m-c-CS-m 0.0063048202 -0.0016904839 0.0143001244 2.448278e-01 t-SC-s-c-CS-m 0.0097340567 0.0017387526 0.0177293609 5.595705e-03 c-SC-m-c-CS-s 0.0166600307 0.0086647266 0.0246553349 1.017862e-08 c-SC-s-c-CS-s 0.0080530303 -0.0001499786 0.0162560393 5.864944e-02 t-CS-m-c-CS-s 0.0008082546 -0.0073947543 0.0090112636 9.999896e-01 t-CS-s-c-CS-s -0.0049828717 -0.0137522571 0.0037865138 6.704638e-01 t-SC-m-c-CS-s 0.0032803672 -0.0049226418 0.0114833761 9.277521e-01 t-SC-s-c-CS-s 0.0067096037 -0.0014934053 0.0149126126 2.033059e-01 c-SC-s-c-SC-m -0.0086070004 -0.0166023045 -0.0006116962 2.457553e-02 t-CS-m-c-SC-m -0.0158517761 -0.0238470802 -0.0078564719 6.636714e-08 t-CS-s-c-SC-m -0.0216429024 -0.0302183122 -0.0130674926 6.198375e-13 t-SC-m-c-SC-m -0.0133796636 -0.0213749677 -0.0053843594 1.212848e-05 t-SC-s-c-SC-m -0.0099504270 -0.0179457312 -0.0019551229 4.111532e-03 t-CS-m-c-SC-s -0.0072447757 -0.0154477847 0.0009582333 1.291154e-01 t-CS-s-c-SC-s -0.0130359020 -0.0218052875 -0.0042665165 1.894576e-04 t-SC-m-c-SC-s -0.0047726632 -0.0129756721 0.0034303458 6.427499e-01 t-SC-s-c-SC-s -0.0013434267 -0.0095464356 0.0068595823 9.996737e-01 t-CS-s-t-CS-m -0.0057911263 -0.0145605118 0.0029782592 4.785310e-01 t-SC-m-t-CS-m 0.0024721125 -0.0057308964 0.0106751215 9.846439e-01 t-SC-s-t-CS-m 0.0059013490 -0.0023016599 0.0141043580 3.617448e-01 t-SC-m-t-CS-s 0.0082632388 -0.0005061466 0.0170326243 8.160721e-02 t-SC-s-t-CS-s 0.0116924753 0.0029230899 0.0204618608 1.419786e-03 t-SC-s-t-SC-m 0.0034292365 -0.0047737725 0.0116322455 9.099278e-01
SYP
Total variability: 4.76
Percentage of explained variability for SYP: 7.88%
P value for SYP: 0
Significant ANOVA result; proceeding to Tukey HSD test for SYP diff lwr upr p adj c-CS-s-c-CS-m -0.0220817202 -0.045128965 0.0009655244 7.163937e-02 c-SC-m-c-CS-m -0.0105297028 -0.032962243 0.0119028378 8.454763e-01 c-SC-s-c-CS-m 0.0041087434 -0.018938501 0.0271559879 9.994283e-01 t-CS-m-c-CS-m -0.0538059158 -0.076853160 -0.0307586712 6.753287e-11 t-CS-s-c-CS-m -0.0338166536 -0.058536109 -0.0090971979 9.175899e-04 t-SC-m-c-CS-m -0.0216653715 -0.044712616 0.0013818731 8.310584e-02 t-SC-s-c-CS-m -0.0391963144 -0.062243559 -0.0161490698 7.917509e-06 c-SC-m-c-CS-s 0.0115520174 -0.011495227 0.0345992620 7.955053e-01 c-SC-s-c-CS-s 0.0261904636 0.002544490 0.0498364376 1.806371e-02 t-CS-m-c-CS-s -0.0317241956 -0.055370170 -0.0080782216 1.280291e-03 t-CS-s-c-CS-s -0.0117349334 -0.037013543 0.0135436761 8.528944e-01 t-SC-m-c-CS-s 0.0004163487 -0.023229625 0.0240623227 1.000000e+00 t-SC-s-c-CS-s -0.0171145941 -0.040760568 0.0065313799 3.536276e-01 c-SC-s-c-SC-m 0.0146384462 -0.008408798 0.0376856908 5.311698e-01 t-CS-m-c-SC-m -0.0432762130 -0.066323458 -0.0202289684 4.251107e-07 t-CS-s-c-SC-m -0.0232869508 -0.048006407 0.0014325050 8.176204e-02 t-SC-m-c-SC-m -0.0111356687 -0.034182913 0.0119115759 8.247444e-01 t-SC-s-c-SC-m -0.0286666115 -0.051713856 -0.0056193670 4.145522e-03 t-CS-m-c-SC-s -0.0579146591 -0.081560633 -0.0342686851 5.336842e-12 t-CS-s-c-SC-s -0.0379253970 -0.063204007 -0.0126467875 1.563905e-04 t-SC-m-c-SC-s -0.0257741149 -0.049420089 -0.0021281409 2.153159e-02 t-SC-s-c-SC-s -0.0433050577 -0.066951032 -0.0196590837 9.375091e-07 t-CS-s-t-CS-m 0.0199892621 -0.005289347 0.0452678716 2.415537e-01 t-SC-m-t-CS-m 0.0321405443 0.008494570 0.0557865183 1.025887e-03 t-SC-s-t-CS-m 0.0146096014 -0.009036373 0.0382555754 5.675782e-01 t-SC-m-t-CS-s 0.0121512821 -0.013127327 0.0374298916 8.285688e-01 t-SC-s-t-CS-s -0.0053796607 -0.030658270 0.0198989488 9.981935e-01 t-SC-s-t-SC-m -0.0175309428 -0.041176917 0.0061150312 3.218586e-01
H3AcK18
Total variability: 3.42
Percentage of explained variability for H3AcK18: 28.55%
P value for H3AcK18: 0
Significant ANOVA result; proceeding to Tukey HSD test for H3AcK18 diff lwr upr p adj c-CS-s-c-CS-m 0.003514650 -0.013686285 0.0207155848 9.986093e-01 c-SC-m-c-CS-m 0.043637229 0.026895068 0.0603793896 0.000000e+00 c-SC-s-c-CS-m 0.010452585 -0.006748350 0.0276535196 5.889606e-01 t-CS-m-c-CS-m 0.007511621 -0.009689314 0.0247125556 8.889119e-01 t-CS-s-c-CS-m 0.016360994 -0.002087968 0.0348099568 1.256798e-01 t-SC-m-c-CS-m 0.084170131 0.066969196 0.1013710660 0.000000e+00 t-SC-s-c-CS-m 0.066903768 0.049702833 0.0841047031 0.000000e+00 c-SC-m-c-CS-s 0.040122579 0.022921644 0.0573235139 7.046042e-11 c-SC-s-c-CS-s 0.006937935 -0.010709852 0.0245857216 9.337467e-01 t-CS-m-c-CS-s 0.003996971 -0.013650816 0.0216447575 9.973148e-01 t-CS-s-c-CS-s 0.012846344 -0.006019933 0.0317126220 4.366106e-01 t-SC-m-c-CS-s 0.080655481 0.063007694 0.0983032680 0.000000e+00 t-SC-s-c-CS-s 0.063389118 0.045741332 0.0810369051 0.000000e+00 c-SC-s-c-SC-m -0.033184644 -0.050385579 -0.0159837094 1.727455e-07 t-CS-m-c-SC-m -0.036125608 -0.053326543 -0.0189246735 7.438428e-09 t-CS-s-c-SC-m -0.027276235 -0.045725197 -0.0088272723 2.117767e-04 t-SC-m-c-SC-m 0.040532902 0.023331967 0.0577338370 4.245859e-11 t-SC-s-c-SC-m 0.023266539 0.006065604 0.0404674741 1.115207e-03 t-CS-m-c-SC-s -0.002940964 -0.020588751 0.0147068227 9.996338e-01 t-CS-s-c-SC-s 0.005908410 -0.012957868 0.0247746872 9.808123e-01 t-SC-m-c-SC-s 0.073717546 0.056069760 0.0913653331 0.000000e+00 t-SC-s-c-SC-s 0.056451183 0.038803397 0.0740989702 0.000000e+00 t-CS-s-t-CS-m 0.008849374 -0.010016904 0.0277156513 8.459651e-01 t-SC-m-t-CS-m 0.076658510 0.059010724 0.0943062972 0.000000e+00 t-SC-s-t-CS-m 0.059392148 0.041744361 0.0770399343 0.000000e+00 t-SC-m-t-CS-s 0.067809137 0.048942859 0.0866754144 0.000000e+00 t-SC-s-t-CS-s 0.050542774 0.031676496 0.0694090515 0.000000e+00 t-SC-s-t-SC-m -0.017266363 -0.034914150 0.0003814239 6.035258e-02
EGR1
Total variability: 1.51
Percentage of explained variability for EGR1: 27.19%
P value for EGR1: 0
Significant ANOVA result; proceeding to Tukey HSD test for EGR1 diff lwr upr p adj c-CS-s-c-CS-m -0.008065686 -0.019617429 0.003486056 4.022570e-01 c-SC-m-c-CS-m 0.042739652 0.031496012 0.053983293 0.000000e+00 c-SC-s-c-CS-m 0.026090517 0.014538775 0.037642260 3.266549e-10 t-CS-m-c-CS-m -0.012240064 -0.023791807 -0.000688322 2.892369e-02 t-CS-s-c-CS-m -0.016424999 -0.028814887 -0.004035110 1.560818e-03 t-SC-m-c-CS-m 0.021489292 0.009937549 0.033041034 5.738837e-07 t-SC-s-c-CS-m 0.009675290 -0.001876452 0.021227032 1.784175e-01 c-SC-m-c-CS-s 0.050805339 0.039253596 0.062357081 0.000000e+00 c-SC-s-c-CS-s 0.034156204 0.022304366 0.046008041 0.000000e+00 t-CS-m-c-CS-s -0.004174378 -0.016026216 0.007677460 9.629281e-01 t-CS-s-c-CS-s -0.008359312 -0.021029460 0.004310835 4.798030e-01 t-SC-m-c-CS-s 0.029554978 0.017703140 0.041406816 1.685874e-12 t-SC-s-c-CS-s 0.017740976 0.005889139 0.029592814 1.639992e-04 c-SC-s-c-SC-m -0.016649135 -0.028200878 -0.005097393 3.514905e-04 t-CS-m-c-SC-m -0.054979717 -0.066531459 -0.043427974 0.000000e+00 t-CS-s-c-SC-m -0.059164651 -0.071554539 -0.046774763 0.000000e+00 t-SC-m-c-SC-m -0.021250361 -0.032802103 -0.009698618 8.162686e-07 t-SC-s-c-SC-m -0.033064362 -0.044616105 -0.021512620 0.000000e+00 t-CS-m-c-SC-s -0.038330582 -0.050182419 -0.026478744 0.000000e+00 t-CS-s-c-SC-s -0.042515516 -0.055185663 -0.029845369 0.000000e+00 t-SC-m-c-SC-s -0.004601226 -0.016453063 0.007250612 9.378771e-01 t-SC-s-c-SC-s -0.016415227 -0.028267065 -0.004563390 7.375601e-04 t-CS-s-t-CS-m -0.004184934 -0.016855082 0.008485213 9.740248e-01 t-SC-m-t-CS-m 0.033729356 0.021877518 0.045581194 0.000000e+00 t-SC-s-t-CS-m 0.021915354 0.010063517 0.033767192 6.942714e-07 t-SC-m-t-CS-s 0.037914290 0.025244143 0.050584438 0.000000e+00 t-SC-s-t-CS-s 0.026100289 0.013430141 0.038770436 1.592906e-08 t-SC-s-t-SC-m -0.011814002 -0.023665839 0.000037836 5.142738e-02
H3MeK4
Total variability: 2.7
Percentage of explained variability for H3MeK4: 26.66%
P value for H3MeK4: 0
Significant ANOVA result; proceeding to Tukey HSD test for H3MeK4 diff lwr upr p adj c-CS-s-c-CS-m -0.006667915 -0.022164096 0.008828266 8.964381e-01 c-SC-m-c-CS-m 0.042149631 0.027066756 0.057232506 0.000000e+00 c-SC-s-c-CS-m 0.040444813 0.024948631 0.055940994 0.000000e+00 t-CS-m-c-CS-m 0.002245106 -0.013251075 0.017741287 9.998562e-01 t-CS-s-c-CS-m 0.012754675 -0.003865844 0.029375194 2.778509e-01 t-SC-m-c-CS-m 0.068977103 0.053480922 0.084473284 0.000000e+00 t-SC-s-c-CS-m 0.047822550 0.032326369 0.063318732 0.000000e+00 c-SC-m-c-CS-s 0.048817546 0.033321365 0.064313727 0.000000e+00 c-SC-s-c-CS-s 0.047112727 0.031213981 0.063011474 0.000000e+00 t-CS-m-c-CS-s 0.008913020 -0.006985726 0.024811767 6.856926e-01 t-CS-s-c-CS-s 0.019422589 0.002426115 0.036419064 1.259436e-02 t-SC-m-c-CS-s 0.075645017 0.059746271 0.091543764 0.000000e+00 t-SC-s-c-CS-s 0.054490465 0.038591719 0.070389212 0.000000e+00 c-SC-s-c-SC-m -0.001704819 -0.017201000 0.013791363 9.999778e-01 t-CS-m-c-SC-m -0.039904525 -0.055400707 -0.024408344 0.000000e+00 t-CS-s-c-SC-m -0.029394956 -0.046015475 -0.012774437 2.661163e-06 t-SC-m-c-SC-m 0.026827472 0.011331290 0.042323653 4.872525e-06 t-SC-s-c-SC-m 0.005672919 -0.009823262 0.021169100 9.543423e-01 t-CS-m-c-SC-s -0.038199707 -0.054098453 -0.022300960 1.552614e-11 t-CS-s-c-SC-s -0.027690138 -0.044686613 -0.010693663 2.391617e-05 t-SC-m-c-SC-s 0.028532290 0.012633544 0.044431037 1.733856e-06 t-SC-s-c-SC-s 0.007377738 -0.008521008 0.023276484 8.531470e-01 t-CS-s-t-CS-m 0.010509569 -0.006486906 0.027506044 5.665451e-01 t-SC-m-t-CS-m 0.066731997 0.050833251 0.082630743 0.000000e+00 t-SC-s-t-CS-m 0.045577445 0.029678698 0.061476191 0.000000e+00 t-SC-m-t-CS-s 0.056222428 0.039225953 0.073218903 0.000000e+00 t-SC-s-t-CS-s 0.035067876 0.018071401 0.052064351 1.498287e-08 t-SC-s-t-SC-m -0.021154552 -0.037053299 -0.005255806 1.469025e-03
CaNA
Total variability: 108.51
Percentage of explained variability for CaNA: 61.14%
P value for CaNA: 0
Significant ANOVA result; proceeding to Tukey HSD test for CaNA diff lwr upr p adj c-CS-s-c-CS-m 0.09394970 0.022496227 0.165403181 1.783187e-03 c-SC-m-c-CS-m -0.51370164 -0.583249351 -0.444153935 0.000000e+00 c-SC-s-c-CS-m -0.36602031 -0.437473790 -0.294566836 0.000000e+00 t-CS-m-c-CS-m 0.10968168 0.038228207 0.181135161 9.570144e-05 t-CS-s-c-CS-m 0.02897410 -0.047663740 0.105611942 9.458707e-01 t-SC-m-c-CS-m -0.48252480 -0.553978274 -0.411071320 0.000000e+00 t-SC-s-c-CS-m -0.29384358 -0.365297061 -0.222390107 0.000000e+00 c-SC-m-c-CS-s -0.60765135 -0.679104824 -0.536197870 0.000000e+00 c-SC-s-c-CS-s -0.45997002 -0.533279738 -0.386660296 0.000000e+00 t-CS-m-c-CS-s 0.01573198 -0.057577741 0.089041701 9.980946e-01 t-CS-s-c-CS-s -0.06497560 -0.143346991 0.013395785 1.889085e-01 t-SC-m-c-CS-s -0.57647450 -0.649784222 -0.503164780 0.000000e+00 t-SC-s-c-CS-s -0.38779329 -0.461103009 -0.314483568 0.000000e+00 c-SC-s-c-SC-m 0.14768133 0.076227853 0.219134807 1.400893e-08 t-CS-m-c-SC-m 0.62338333 0.551929850 0.694836804 0.000000e+00 t-CS-s-c-SC-m 0.54267574 0.466037903 0.619313585 0.000000e+00 t-SC-m-c-SC-m 0.03117685 -0.040276631 0.102630323 8.893612e-01 t-SC-s-c-SC-m 0.21985806 0.148404582 0.291311536 0.000000e+00 t-CS-m-c-SC-s 0.47570200 0.402392276 0.549011718 0.000000e+00 t-CS-s-c-SC-s 0.39499441 0.316623026 0.473365802 0.000000e+00 t-SC-m-c-SC-s -0.11650448 -0.189814205 -0.043194763 4.349589e-05 t-SC-s-c-SC-s 0.07217673 -0.001132992 0.145486450 5.723449e-02 t-CS-s-t-CS-m -0.08070758 -0.159078971 -0.002336195 3.822042e-02 t-SC-m-t-CS-m -0.59220648 -0.665516202 -0.518896760 0.000000e+00 t-SC-s-t-CS-m -0.40352527 -0.476834989 -0.330215547 0.000000e+00 t-SC-m-t-CS-s -0.51149890 -0.589870286 -0.433127510 0.000000e+00 t-SC-s-t-CS-s -0.32281768 -0.401189073 -0.244446297 0.000000e+00 t-SC-s-t-SC-m 0.18868121 0.115371492 0.261990934 0.000000e+00
for (i in 1:length(proteins)) {
cat("#### ", proteins[i], "\n")
# Perform ANOVA
aov_result <- aov(eval(parse(text = proteins[i])) ~ class, data = data)
# Output the ANOVA summary
print(summary(aov_result))
# Perform Tukey's HSD if ANOVA is significant
if (summary(aov_result)[[1]][["Pr(>F)"]][1] < 0.05) {
tukey_result <- TukeyHSD(aov_result)
print(tukey_result)
}
cat("\n\n")
}DYRK1A
Df Sum Sq Mean Sq F value Pr(>F) class 7 19.36 2.7660 62.33 <2e-16 *** Residuals 1072 47.57
0.0444
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.116291899 0.04039842 0.19218537 0.0000995 c-SC-m-c-CS-m -0.207253476 -0.28112276 -0.13338419 0.0000000 c-SC-s-c-CS-m -0.205633013 -0.28152649 -0.12973954 0.0000000 t-CS-m-c-CS-m 0.138837508 0.06294403 0.21473098 0.0000010 t-CS-s-c-CS-m 0.045278549 -0.03612144 0.12667854 0.6943415 t-SC-m-c-CS-m -0.150595735 -0.22648921 -0.07470226 0.0000001 t-SC-s-c-CS-m -0.142968422 -0.21886190 -0.06707495 0.0000004 c-SC-m-c-CS-s -0.323545375 -0.39943885 -0.24765190 0.0000000 c-SC-s-c-CS-s -0.321924912 -0.39978997 -0.24405985 0.0000000 t-CS-m-c-CS-s 0.022545609 -0.05531945 0.10041067 0.9878641 t-CS-s-c-CS-s -0.071013350 -0.15425460 0.01222790 0.1602967 t-SC-m-c-CS-s -0.266887634 -0.34475270 -0.18902257 0.0000000 t-SC-s-c-CS-s -0.259260321 -0.33712538 -0.18139526 0.0000000 c-SC-s-c-SC-m 0.001620463 -0.07427301 0.07751394 1.0000000 t-CS-m-c-SC-m 0.346090984 0.27019751 0.42198446 0.0000000 t-CS-s-c-SC-m 0.252532025 0.17113204 0.33393201 0.0000000 t-SC-m-c-SC-m 0.056657741 -0.01923573 0.13255122 0.3128586 t-SC-s-c-SC-m 0.064285054 -0.01160842 0.14017853 0.1671956 t-CS-m-c-SC-s 0.344470521 0.26660546 0.42233558 0.0000000 t-CS-s-c-SC-s 0.250911562 0.16767031 0.33415281 0.0000000 t-SC-m-c-SC-s 0.055037278 -0.02282778 0.13290234 0.3855795 t-SC-s-c-SC-s 0.062664591 -0.01520047 0.14052965 0.2212756 t-CS-s-t-CS-m -0.093558959 -0.17680021 -0.01031771 0.0152998 t-SC-m-t-CS-m -0.289433243 -0.36729831 -0.21156818 0.0000000 t-SC-s-t-CS-m -0.281805930 -0.35967099 -0.20394087 0.0000000 t-SC-m-t-CS-s -0.195874284 -0.27911554 -0.11263303 0.0000000 t-SC-s-t-CS-s -0.188246971 -0.27148822 -0.10500572 0.0000000 t-SC-s-t-SC-m 0.007627313 -0.07023775 0.08549238 0.9999900
ITSN1
Df Sum Sq Mean Sq F value Pr(>F) class 7 19.61 2.8015 61.87 <2e-16 *** Residuals 1072 48.54
0.0453
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.11980786 0.04314464 0.196471068 0.0000641 c-SC-m-c-CS-m -0.21622649 -0.29084499 -0.141608004 0.0000000 c-SC-s-c-CS-m -0.20323362 -0.27989683 -0.126570404 0.0000000 t-CS-m-c-CS-m 0.14441918 0.06775597 0.221082394 0.0000004 t-CS-s-c-CS-m 0.10696915 0.02474358 0.189194725 0.0021121 t-SC-m-c-CS-m -0.08580384 -0.16246705 -0.009140624 0.0160562 t-SC-s-c-CS-m -0.10353107 -0.18019428 -0.026867860 0.0011460 c-SC-m-c-CS-s -0.33603435 -0.41269756 -0.259371139 0.0000000 c-SC-s-c-CS-s -0.32304147 -0.40169627 -0.244386676 0.0000000 t-CS-m-c-CS-s 0.02461133 -0.05404347 0.103266122 0.9809073 t-CS-s-c-CS-s -0.01283870 -0.09692422 0.071246810 0.9997955 t-SC-m-c-CS-s -0.20561169 -0.28426649 -0.126956897 0.0000000 t-SC-s-c-CS-s -0.22333893 -0.30199372 -0.144684132 0.0000000 c-SC-s-c-SC-m 0.01299288 -0.06367033 0.089656091 0.9995905 t-CS-m-c-SC-m 0.36064568 0.28398247 0.437308889 0.0000000 t-CS-s-c-SC-m 0.32319565 0.24097008 0.405421220 0.0000000 t-SC-m-c-SC-m 0.13042266 0.05375945 0.207085871 0.0000078 t-SC-s-c-SC-m 0.11269542 0.03603221 0.189358635 0.0002379 t-CS-m-c-SC-s 0.34765280 0.26899800 0.426307594 0.0000000 t-CS-s-c-SC-s 0.31020277 0.22611725 0.394288282 0.0000000 t-SC-m-c-SC-s 0.11742978 0.03877498 0.196084575 0.0001732 t-SC-s-c-SC-s 0.09970254 0.02104775 0.178357340 0.0031432 t-CS-s-t-CS-m -0.03745003 -0.12153554 0.046635483 0.8781915 t-SC-m-t-CS-m -0.23022302 -0.30887781 -0.151568223 0.0000000 t-SC-s-t-CS-m -0.24795025 -0.32660505 -0.169295459 0.0000000 t-SC-m-t-CS-s -0.19277299 -0.27685850 -0.108687475 0.0000000 t-SC-s-t-CS-s -0.21050022 -0.29458574 -0.126414711 0.0000000 t-SC-s-t-SC-m -0.01772724 -0.09638203 0.060927560 0.9973967
BDNF
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.288 0.04114 18.88 <2e-16 *** Residuals 1072 2.336
0.00218
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0030979096 -0.013720984 0.0199168033 0.9992916 c-SC-m-c-CS-m -0.0482716607 -0.064641970 -0.0319013517 0.0000000 c-SC-s-c-CS-m -0.0258249025 -0.042643796 -0.0090060088 0.0000951 t-CS-m-c-CS-m -0.0264852092 -0.043304103 -0.0096663155 0.0000538 t-CS-s-c-CS-m -0.0337569838 -0.051796186 -0.0157177818 0.0000005 t-SC-m-c-CS-m -0.0181541101 -0.034973004 -0.0013352164 0.0238955 t-SC-s-c-CS-m -0.0136310252 -0.030449919 0.0031878685 0.2134012 c-SC-m-c-CS-s -0.0513695703 -0.068188464 -0.0345506766 0.0000000 c-SC-s-c-CS-s -0.0289228121 -0.046178633 -0.0116669913 0.0000116 t-CS-m-c-CS-s -0.0295831188 -0.046838940 -0.0123272979 0.0000064 t-CS-s-c-CS-s -0.0368548934 -0.055302142 -0.0184076449 0.0000001 t-SC-m-c-CS-s -0.0212520197 -0.038507841 -0.0039961989 0.0047693 t-SC-s-c-CS-s -0.0167289348 -0.033984756 0.0005268861 0.0651201 c-SC-s-c-SC-m 0.0224467582 0.005627864 0.0392656519 0.0013973 t-CS-m-c-SC-m 0.0217864515 0.004967558 0.0386053452 0.0022588 t-CS-s-c-SC-m 0.0145146769 -0.003524525 0.0325538789 0.2215086 t-SC-m-c-SC-m 0.0301175506 0.013298657 0.0469364443 0.0000019 t-SC-s-c-SC-m 0.0346406355 0.017821742 0.0514595292 0.0000000 t-CS-m-c-SC-s -0.0006603067 -0.017916128 0.0165955142 1.0000000 t-CS-s-c-SC-s -0.0079320813 -0.026379330 0.0105151672 0.8967905 t-SC-m-c-SC-s 0.0076707924 -0.009585028 0.0249266133 0.8792631 t-SC-s-c-SC-s 0.0121938774 -0.005061943 0.0294496982 0.3859175 t-CS-s-t-CS-m -0.0072717746 -0.025719023 0.0111754738 0.9328307 t-SC-m-t-CS-m 0.0083310991 -0.008924722 0.0255869199 0.8253159 t-SC-s-t-CS-m 0.0128541840 -0.004401637 0.0301100049 0.3156819 t-SC-m-t-CS-s 0.0156028737 -0.002844375 0.0340501221 0.1686252 t-SC-s-t-CS-s 0.0201259586 0.001678710 0.0385732071 0.0213198 t-SC-s-t-SC-m 0.0045230850 -0.012732736 0.0217789058 0.9933333
NR1
Df Sum Sq Mean Sq F value Pr(>F) class 7 11.98 1.7113 15.57 <2e-16 *** Residuals 1072 117.81
0.1099
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.036060168 -0.08337399 0.155494324 0.9844771 c-SC-m-c-CS-m -0.236115640 -0.35236431 -0.119866968 0.0000000 c-SC-s-c-CS-m 0.023225272 -0.09620888 0.142659429 0.9989906 t-CS-m-c-CS-m -0.185207993 -0.30464215 -0.065773836 0.0000764 t-CS-s-c-CS-m -0.197142492 -0.32524229 -0.069042694 0.0000904 t-SC-m-c-CS-m -0.002303091 -0.12173725 0.117131065 1.0000000 t-SC-s-c-CS-m -0.133007368 -0.25244152 -0.013573211 0.0169945 c-SC-m-c-CS-s -0.272175807 -0.39160996 -0.152741651 0.0000000 c-SC-s-c-CS-s -0.012834896 -0.13537175 0.109701964 0.9999841 t-CS-m-c-CS-s -0.221268161 -0.34380502 -0.098731301 0.0000014 t-CS-s-c-CS-s -0.233202659 -0.36420007 -0.102205247 0.0000022 t-SC-m-c-CS-s -0.038363259 -0.16090012 0.084173600 0.9808468 t-SC-s-c-CS-s -0.169067536 -0.29160439 -0.046530676 0.0007898 c-SC-s-c-SC-m 0.259340912 0.13990676 0.378775069 0.0000000 t-CS-m-c-SC-m 0.050907647 -0.06852651 0.170341804 0.9010342 t-CS-s-c-SC-m 0.038973148 -0.08912665 0.167072945 0.9837704 t-SC-m-c-SC-m 0.233812549 0.11437839 0.353246705 0.0000001 t-SC-s-c-SC-m 0.103108272 -0.01632588 0.222542429 0.1491539 t-CS-m-c-SC-s -0.208433265 -0.33097012 -0.085896406 0.0000079 t-CS-s-c-SC-s -0.220367764 -0.35136518 -0.089370351 0.0000106 t-SC-m-c-SC-s -0.025528363 -0.14806522 0.097008496 0.9984242 t-SC-s-c-SC-s -0.156232640 -0.27876950 -0.033695781 0.0028808 t-CS-s-t-CS-m -0.011934499 -0.14293191 0.119062914 0.9999939 t-SC-m-t-CS-m 0.182904902 0.06036804 0.305441761 0.0001740 t-SC-s-t-CS-m 0.052200625 -0.07033623 0.174737484 0.9013032 t-SC-m-t-CS-s 0.194839400 0.06384199 0.325836813 0.0001873 t-SC-s-t-CS-s 0.064135124 -0.06686229 0.195132537 0.8146058 t-SC-s-t-SC-m -0.130704277 -0.25324114 -0.008167417 0.0270320
NR2A
Df Sum Sq Mean Sq F value Pr(>F) class 7 119.3 17.038 22.33 <2e-16 *** Residuals 1072 817.8
0.763
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0284633230 -0.3431444 0.28621776 0.9999942 c-SC-m-c-CS-m -0.8491246454 -1.1554127 -0.54283657 0.0000000 c-SC-s-c-CS-m -0.3954441305 -0.7101252 -0.08076305 0.0035729 t-CS-m-c-CS-m -0.7425806907 -1.0572618 -0.42789961 0.0000000 t-CS-s-c-CS-m -0.7937019653 -1.1312150 -0.45618895 0.0000000 t-SC-m-c-CS-m -0.2523174542 -0.5669985 0.06236363 0.2254654 t-SC-s-c-CS-m -0.7434475616 -1.0581286 -0.42876648 0.0000000 c-SC-m-c-CS-s -0.8206613224 -1.1353424 -0.50598024 0.0000000 c-SC-s-c-CS-s -0.3669808075 -0.6898368 -0.04412483 0.0134173 t-CS-m-c-CS-s -0.7141173677 -1.0369733 -0.39126139 0.0000000 t-CS-s-c-CS-s -0.7652386422 -1.1103862 -0.42009109 0.0000000 t-SC-m-c-CS-s -0.2238541312 -0.5467101 0.09900185 0.4118121 t-SC-s-c-CS-s -0.7149842385 -1.0378402 -0.39212826 0.0000000 c-SC-s-c-SC-m 0.4536805149 0.1389994 0.76836160 0.0003494 t-CS-m-c-SC-m 0.1065439547 -0.2081371 0.42122504 0.9701694 t-CS-s-c-SC-m 0.0554226802 -0.2820903 0.39293570 0.9996679 t-SC-m-c-SC-m 0.5968071912 0.2821261 0.91148827 0.0000003 t-SC-s-c-SC-m 0.1056770839 -0.2090040 0.42035816 0.9714961 t-CS-m-c-SC-s -0.3471365602 -0.6699925 -0.02428058 0.0248882 t-CS-s-c-SC-s -0.3982578348 -0.7434054 -0.05311028 0.0112026 t-SC-m-c-SC-s 0.1431266763 -0.1797293 0.46598265 0.8807965 t-SC-s-c-SC-s -0.3480034311 -0.6708594 -0.02514745 0.0242468 t-CS-s-t-CS-m -0.0511212745 -0.3962688 0.29402628 0.9998332 t-SC-m-t-CS-m 0.4902632365 0.1674073 0.81311921 0.0001210 t-SC-s-t-CS-m -0.0008668708 -0.3237228 0.32198911 1.0000000 t-SC-m-t-CS-s 0.5413845110 0.1962370 0.88653207 0.0000589 t-SC-s-t-CS-s 0.0502544037 -0.2948932 0.39540196 0.9998513 t-SC-s-t-SC-m -0.4911301073 -0.8139861 -0.16827413 0.0001165
pAKT
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.3573 0.05105 36.28 <2e-16 *** Residuals 1072 1.5084
0.00141
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0175091451 -0.0310237229 -0.0039945674 0.0022529 c-SC-m-c-CS-m 0.0113209341 -0.0018331900 0.0244750582 0.1520113 c-SC-s-c-CS-m 0.0034360303 -0.0100785475 0.0169506080 0.9944709 t-CS-m-c-CS-m -0.0163106394 -0.0298252172 -0.0027960617 0.0062992 t-CS-s-c-CS-m -0.0154664111 -0.0299615499 -0.0009712724 0.0269401 t-SC-m-c-CS-m 0.0391985814 0.0256840037 0.0527131592 0.0000000 t-SC-s-c-CS-m 0.0168271454 0.0033125677 0.0303417232 0.0040843 c-SC-m-c-CS-s 0.0288300792 0.0153155015 0.0423446570 0.0000000 c-SC-s-c-CS-s 0.0209451754 0.0070795112 0.0348108396 0.0001354 t-CS-m-c-CS-s 0.0011985057 -0.0126671585 0.0150641699 0.9999958 t-CS-s-c-CS-s 0.0020427340 -0.0127802846 0.0168657526 0.9998973 t-SC-m-c-CS-s 0.0567077266 0.0428420623 0.0705733908 0.0000000 t-SC-s-c-CS-s 0.0343362906 0.0204706264 0.0482019548 0.0000000 c-SC-s-c-SC-m -0.0078849038 -0.0213994816 0.0056296739 0.6394206 t-CS-m-c-SC-m -0.0276315735 -0.0411461513 -0.0141169958 0.0000000 t-CS-s-c-SC-m -0.0267873452 -0.0412824840 -0.0122922065 0.0000007 t-SC-m-c-SC-m 0.0278776473 0.0143630696 0.0413922251 0.0000000 t-SC-s-c-SC-m 0.0055062113 -0.0080083664 0.0190207891 0.9206677 t-CS-m-c-SC-s -0.0197466697 -0.0336123339 -0.0058810055 0.0004419 t-CS-s-c-SC-s -0.0189024414 -0.0337254600 -0.0040794229 0.0028731 t-SC-m-c-SC-s 0.0357625511 0.0218968869 0.0496282154 0.0000000 t-SC-s-c-SC-s 0.0133911152 -0.0004745491 0.0272567794 0.0671821 t-CS-s-t-CS-m 0.0008442283 -0.0139787903 0.0156672469 0.9999998 t-SC-m-t-CS-m 0.0555092209 0.0416435566 0.0693748851 0.0000000 t-SC-s-t-CS-m 0.0331377849 0.0192721207 0.0470034491 0.0000000 t-SC-m-t-CS-s 0.0546649926 0.0398419740 0.0694880111 0.0000000 t-SC-s-t-CS-s 0.0322935566 0.0174705380 0.0471165752 0.0000000 t-SC-s-t-SC-m -0.0223714360 -0.0362371002 -0.0085057718 0.0000303
pBRAF
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1249 0.017847 28.9 <2e-16 *** Residuals 1072 0.6620
0.000617
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0138554603 -0.022808263 -0.0049026580 0.0000799 c-SC-m-c-CS-m 0.0073355504 -0.001378468 0.0160495683 0.1733240 c-SC-s-c-CS-m 0.0027633489 -0.006189453 0.0117161512 0.9823547 t-CS-m-c-CS-m -0.0082554502 -0.017208253 0.0006973521 0.0959184 t-CS-s-c-CS-m -0.0174163703 -0.027018750 -0.0078139903 0.0000013 t-SC-m-c-CS-m 0.0187958007 0.009842998 0.0277486030 0.0000000 t-SC-s-c-CS-m 0.0031063863 -0.005846416 0.0120591887 0.9658464 c-SC-m-c-CS-s 0.0211910107 0.012238208 0.0301438130 0.0000000 c-SC-s-c-CS-s 0.0166188092 0.007433428 0.0258041906 0.0000014 t-CS-m-c-CS-s 0.0056000101 -0.003585371 0.0147853915 0.5847826 t-CS-s-c-CS-s -0.0035609100 -0.013380496 0.0062586757 0.9565985 t-SC-m-c-CS-s 0.0326512610 0.023465880 0.0418366424 0.0000000 t-SC-s-c-CS-s 0.0169618467 0.007776465 0.0261472280 0.0000007 c-SC-s-c-SC-m -0.0045722015 -0.013525004 0.0043806009 0.7793107 t-CS-m-c-SC-m -0.0155910006 -0.024543803 -0.0066381982 0.0000041 t-CS-s-c-SC-m -0.0247519207 -0.034354301 -0.0151495406 0.0000000 t-SC-m-c-SC-m 0.0114602503 0.002507448 0.0204130526 0.0027120 t-SC-s-c-SC-m -0.0042291640 -0.013181966 0.0047236383 0.8410942 t-CS-m-c-SC-s -0.0110187991 -0.020204180 -0.0018334177 0.0068302 t-CS-s-c-SC-s -0.0201797192 -0.029999305 -0.0103601335 0.0000000 t-SC-m-c-SC-s 0.0160324518 0.006847070 0.0252178332 0.0000039 t-SC-s-c-SC-s 0.0003430374 -0.008842344 0.0095284188 1.0000000 t-CS-s-t-CS-m -0.0091609201 -0.018980506 0.0006586656 0.0880151 t-SC-m-t-CS-m 0.0270512509 0.017865869 0.0362366323 0.0000000 t-SC-s-t-CS-m 0.0113618365 0.002176455 0.0205472179 0.0044860 t-SC-m-t-CS-s 0.0362121710 0.026392585 0.0460317567 0.0000000 t-SC-s-t-CS-s 0.0205227567 0.010703171 0.0303423424 0.0000000 t-SC-s-t-SC-m -0.0156894143 -0.024874796 -0.0065040329 0.0000070
pCAMKII
Df Sum Sq Mean Sq F value Pr(>F) class 7 594.4 84.91 75.11 <2e-16 *** Residuals 1072 1211.8
1.13
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.01938951 -0.36366306 0.40244208 0.9999999 c-SC-m-c-CS-m 1.82014050 1.44730450 2.19297649 0.0000000 c-SC-s-c-CS-m 0.44510092 0.06204835 0.82815349 0.0102784 t-CS-m-c-CS-m 0.20561409 -0.17743848 0.58866666 0.7319525 t-CS-s-c-CS-m -0.42728473 -0.83812999 -0.01643947 0.0347789 t-SC-m-c-CS-m 1.36107046 0.97801789 1.74412304 0.0000000 t-SC-s-c-CS-m 1.26036848 0.87731591 1.64342105 0.0000000 c-SC-m-c-CS-s 1.80075099 1.41769841 2.18380356 0.0000000 c-SC-s-c-CS-s 0.42571141 0.03270776 0.81871506 0.0230156 t-CS-m-c-CS-s 0.18622458 -0.20677907 0.57922822 0.8389228 t-CS-s-c-CS-s -0.44667424 -0.86681281 -0.02653567 0.0279531 t-SC-m-c-CS-s 1.34168095 0.94867730 1.73468460 0.0000000 t-SC-s-c-CS-s 1.24097897 0.84797532 1.63398262 0.0000000 c-SC-s-c-SC-m -1.37503958 -1.75809215 -0.99198700 0.0000000 t-CS-m-c-SC-m -1.61452641 -1.99757898 -1.23147384 0.0000000 t-CS-s-c-SC-m -2.24742523 -2.65827048 -1.83657997 0.0000000 t-SC-m-c-SC-m -0.45907003 -0.84212261 -0.07601746 0.0069176 t-SC-s-c-SC-m -0.55977202 -0.94282459 -0.17671944 0.0002678 t-CS-m-c-SC-s -0.23948683 -0.63249048 0.15351682 0.5853914 t-CS-s-c-SC-s -0.87238565 -1.29252422 -0.45224708 0.0000000 t-SC-m-c-SC-s 0.91596954 0.52296590 1.30897319 0.0000000 t-SC-s-c-SC-s 0.81526756 0.42226391 1.20827121 0.0000000 t-CS-s-t-CS-m -0.63289882 -1.05303739 -0.21276025 0.0001436 t-SC-m-t-CS-m 1.15545637 0.76245273 1.54846002 0.0000000 t-SC-s-t-CS-m 1.05475439 0.66175074 1.44775804 0.0000000 t-SC-m-t-CS-s 1.78835519 1.36821662 2.20849376 0.0000000 t-SC-s-t-CS-s 1.68765321 1.26751464 2.10779178 0.0000000 t-SC-s-t-SC-m -0.10070198 -0.49370563 0.29230166 0.9941991
pCREB
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1264 0.018059 19.04 <2e-16 *** Residuals 1072 1.0168
0.000949
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0099551549 -0.0011409323 0.0210512421 0.1162907 c-SC-m-c-CS-m 0.0096646853 -0.0011354529 0.0204648236 0.1183373 c-SC-s-c-CS-m 0.0164647799 0.0053686927 0.0275608671 0.0001966 t-CS-m-c-CS-m 0.0049109630 -0.0061851243 0.0160070502 0.8817079 t-CS-s-c-CS-m 0.0115564533 -0.0003447194 0.0234576260 0.0642598 t-SC-m-c-CS-m 0.0333047725 0.0222086852 0.0444008597 0.0000000 t-SC-s-c-CS-m 0.0286807459 0.0175846587 0.0397768332 0.0000000 c-SC-m-c-CS-s -0.0002904696 -0.0113865568 0.0108056177 1.0000000 c-SC-s-c-CS-s 0.0065096250 -0.0048747203 0.0178939703 0.6631984 t-CS-m-c-CS-s -0.0050441919 -0.0164285372 0.0063401534 0.8810880 t-CS-s-c-CS-s 0.0016012984 -0.0105690787 0.0137716754 0.9999249 t-SC-m-c-CS-s 0.0233496176 0.0119652723 0.0347339629 0.0000000 t-SC-s-c-CS-s 0.0187255911 0.0073412458 0.0301099363 0.0000188 c-SC-s-c-SC-m 0.0068000946 -0.0042959927 0.0178961818 0.5781178 t-CS-m-c-SC-m -0.0047537224 -0.0158498096 0.0063423649 0.8985855 t-CS-s-c-SC-m 0.0018917680 -0.0100094047 0.0137929406 0.9997325 t-SC-m-c-SC-m 0.0236400872 0.0125439999 0.0347361744 0.0000000 t-SC-s-c-SC-m 0.0190160606 0.0079199734 0.0301121479 0.0000064 t-CS-m-c-SC-s -0.0115538169 -0.0229381622 -0.0001694716 0.0437797 t-CS-s-c-SC-s -0.0049083266 -0.0170787037 0.0072620504 0.9246043 t-SC-m-c-SC-s 0.0168399926 0.0054556473 0.0282243379 0.0002096 t-SC-s-c-SC-s 0.0122159660 0.0008316208 0.0236003113 0.0254141 t-CS-s-t-CS-m 0.0066454903 -0.0055248867 0.0188158674 0.7142753 t-SC-m-t-CS-m 0.0283938095 0.0170094642 0.0397781548 0.0000000 t-SC-s-t-CS-m 0.0237697830 0.0123854377 0.0351541283 0.0000000 t-SC-m-t-CS-s 0.0217483192 0.0095779422 0.0339186963 0.0000020 t-SC-s-t-CS-s 0.0171242927 0.0049539156 0.0292946697 0.0005538 t-SC-s-t-SC-m -0.0046240265 -0.0160083718 0.0067603188 0.9218774
pELK
Df Sum Sq Mean Sq F value Pr(>F) class 7 24.74 3.534 18.04 <2e-16 *** Residuals 1072 209.98
0.196
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.19452599 0.03507328 0.353978697 0.0054411 c-SC-m-c-CS-m -0.21375182 -0.36895169 -0.058551944 0.0008152 c-SC-s-c-CS-m -0.16460365 -0.32405636 -0.005150939 0.0373531 t-CS-m-c-CS-m 0.07158719 -0.08786552 0.231039903 0.8736041 t-CS-s-c-CS-m 0.02598379 -0.14503814 0.197005722 0.9998022 t-SC-m-c-CS-m -0.11080249 -0.27025520 0.048650221 0.4087860 t-SC-s-c-CS-m -0.28747859 -0.44693130 -0.128025875 0.0000015 c-SC-m-c-CS-s -0.40827780 -0.56773051 -0.248825091 0.0000000 c-SC-s-c-CS-s -0.35912964 -0.52272467 -0.195534607 0.0000000 t-CS-m-c-CS-s -0.12293879 -0.28653382 0.040656235 0.3043579 t-CS-s-c-CS-s -0.16854219 -0.34343264 0.006348249 0.0683642 t-SC-m-c-CS-s -0.30532848 -0.46892351 -0.141733447 0.0000005 t-SC-s-c-CS-s -0.48200457 -0.64559960 -0.318409543 0.0000000 c-SC-s-c-SC-m 0.04914817 -0.11030455 0.208600876 0.9824955 t-CS-m-c-SC-m 0.28533901 0.12588630 0.444791718 0.0000019 t-CS-s-c-SC-m 0.23973561 0.06871368 0.410757538 0.0005933 t-SC-m-c-SC-m 0.10294933 -0.05650338 0.262402036 0.5091747 t-SC-s-c-SC-m -0.07372677 -0.23317948 0.085725940 0.8554994 t-CS-m-c-SC-s 0.23619084 0.07259581 0.399785871 0.0003399 t-CS-s-c-SC-s 0.19058744 0.01569700 0.365477886 0.0215841 t-SC-m-c-SC-s 0.05380116 -0.10979387 0.217396190 0.9746518 t-SC-s-c-SC-s -0.12287494 -0.28646997 0.040720094 0.3050250 t-CS-s-t-CS-m -0.04560340 -0.22049384 0.129287044 0.9935428 t-SC-m-t-CS-m -0.18238968 -0.34598471 -0.018794652 0.0167821 t-SC-s-t-CS-m -0.35906578 -0.52266081 -0.195470748 0.0000000 t-SC-m-t-CS-s -0.13678628 -0.31167673 0.038104160 0.2546059 t-SC-s-t-CS-s -0.31346238 -0.48835282 -0.138571936 0.0000018 t-SC-s-t-SC-m -0.17667610 -0.34027113 -0.013081067 0.0237625
pERK
Df Sum Sq Mean Sq F value Pr(>F) class 7 46.19 6.598 86.04 <2e-16 *** Residuals 1072 82.22
0.077
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.130791433 0.031015877 0.230566989 0.0018720 c-SC-m-c-CS-m -0.336461844 -0.433576240 -0.239347449 0.0000000 c-SC-s-c-CS-m -0.365010844 -0.464786401 -0.265235288 0.0000000 t-CS-m-c-CS-m 0.109263057 0.009487501 0.209038613 0.0204734 t-CS-s-c-CS-m 0.004306835 -0.102708016 0.111321687 1.0000000 t-SC-m-c-CS-m -0.335295227 -0.435070784 -0.235519671 0.0000000 t-SC-s-c-CS-m -0.333116436 -0.432891992 -0.233340880 0.0000000 c-SC-m-c-CS-s -0.467253278 -0.567028834 -0.367477721 0.0000000 c-SC-s-c-CS-s -0.495802277 -0.598169838 -0.393434717 0.0000000 t-CS-m-c-CS-s -0.021528376 -0.123895937 0.080839185 0.9983259 t-CS-s-c-CS-s -0.126484598 -0.235920124 -0.017049072 0.0109779 t-SC-m-c-CS-s -0.466086661 -0.568454221 -0.363719100 0.0000000 t-SC-s-c-CS-s -0.463907869 -0.566275430 -0.361540308 0.0000000 c-SC-s-c-SC-m -0.028549000 -0.128324556 0.071226556 0.9886894 t-CS-m-c-SC-m 0.445724901 0.345949345 0.545500458 0.0000000 t-CS-s-c-SC-m 0.340768680 0.233753828 0.447783531 0.0000000 t-SC-m-c-SC-m 0.001166617 -0.098608939 0.100942173 1.0000000 t-SC-s-c-SC-m 0.003345408 -0.096430148 0.103120965 1.0000000 t-CS-m-c-SC-s 0.474273901 0.371906340 0.576641462 0.0000000 t-CS-s-c-SC-s 0.369317679 0.259882154 0.478753205 0.0000000 t-SC-m-c-SC-s 0.029715617 -0.072651944 0.132083178 0.9876802 t-SC-s-c-SC-s 0.031894408 -0.070473153 0.134261969 0.9813720 t-CS-s-t-CS-m -0.104956222 -0.214391748 0.004479304 0.0710670 t-SC-m-t-CS-m -0.444558284 -0.546925845 -0.342190723 0.0000000 t-SC-s-t-CS-m -0.442379493 -0.544747054 -0.340011932 0.0000000 t-SC-m-t-CS-s -0.339602062 -0.449037588 -0.230166537 0.0000000 t-SC-s-t-CS-s -0.337423271 -0.446858797 -0.227987745 0.0000000 t-SC-s-t-SC-m 0.002178791 -0.100188769 0.104546352 1.0000000
pJNK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.610 0.08715 40.67 <2e-16 *** Residuals 1072 2.297
0.00214
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.036672776 -5.335039e-02 -0.019995166 0.0000000 c-SC-m-c-CS-m 0.017754794 1.522000e-03 0.033987587 0.0207449 c-SC-s-c-CS-m -0.011133623 -2.781123e-02 0.005543987 0.4637147 t-CS-m-c-CS-m -0.043901674 -6.057928e-02 -0.027224064 0.0000000 t-CS-s-c-CS-m -0.020775500 -3.866317e-02 -0.002887832 0.0103379 t-SC-m-c-CS-m 0.029875668 1.319806e-02 0.046553279 0.0000018 t-SC-s-c-CS-m -0.002572367 -1.924998e-02 0.014105243 0.9997812 c-SC-m-c-CS-s 0.054427569 3.774996e-02 0.071105180 0.0000000 c-SC-s-c-CS-s 0.025539152 8.428285e-03 0.042650019 0.0001742 t-CS-m-c-CS-s -0.007228898 -2.433977e-02 0.009881969 0.9051877 t-CS-s-c-CS-s 0.015897276 -2.395010e-03 0.034189562 0.1431193 t-SC-m-c-CS-s 0.066548444 4.943758e-02 0.083659311 0.0000000 t-SC-s-c-CS-s 0.034100408 1.698954e-02 0.051211275 0.0000001 c-SC-s-c-SC-m -0.028888417 -4.556603e-02 -0.012210807 0.0000048 t-CS-m-c-SC-m -0.061656468 -7.833408e-02 -0.044978857 0.0000000 t-CS-s-c-SC-m -0.038530293 -5.641796e-02 -0.020642626 0.0000000 t-SC-m-c-SC-m 0.012120875 -4.556735e-03 0.028798485 0.3481262 t-SC-s-c-SC-m -0.020327161 -3.700477e-02 -0.003649551 0.0055108 t-CS-m-c-SC-s -0.032768051 -4.987892e-02 -0.015657184 0.0000002 t-CS-s-c-SC-s -0.009641876 -2.793416e-02 0.008650410 0.7499682 t-SC-m-c-SC-s 0.041009292 2.389842e-02 0.058120159 0.0000000 t-SC-s-c-SC-s 0.008561256 -8.549611e-03 0.025672123 0.7970007 t-CS-s-t-CS-m 0.023126174 4.833888e-03 0.041418460 0.0032688 t-SC-m-t-CS-m 0.073777342 5.666648e-02 0.090888209 0.0000000 t-SC-s-t-CS-m 0.041329307 2.421844e-02 0.058440173 0.0000000 t-SC-m-t-CS-s 0.050651168 3.235888e-02 0.068943454 0.0000000 t-SC-s-t-CS-s 0.018203132 -8.915372e-05 0.036495419 0.0521929 t-SC-s-t-SC-m -0.032448036 -4.955890e-02 -0.015337169 0.0000003
PKCA
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.4808 0.06869 29.99 <2e-16 *** Residuals 1072 2.4554
0.00229
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 1.272407e-02 -0.004518478 0.029966623 0.3279562 c-SC-m-c-CS-m -5.036537e-02 -0.067148040 -0.033582707 0.0000000 c-SC-s-c-CS-m -5.032391e-02 -0.067566458 -0.033081357 0.0000000 t-CS-m-c-CS-m -1.980992e-02 -0.037052471 -0.002567370 0.0118069 t-CS-s-c-CS-m -3.031678e-02 -0.048810380 -0.011823185 0.0000205 t-SC-m-c-CS-m -2.436714e-02 -0.041609687 -0.007124585 0.0005108 t-SC-s-c-CS-m -1.440948e-02 -0.031652032 0.002833069 0.1806900 c-SC-m-c-CS-s -6.308945e-02 -0.080331997 -0.045846896 0.0000000 c-SC-s-c-CS-s -6.304798e-02 -0.080738464 -0.045357496 0.0000000 t-CS-m-c-CS-s -3.253399e-02 -0.050224477 -0.014843510 0.0000008 t-CS-s-c-CS-s -4.304086e-02 -0.061952778 -0.024128933 0.0000000 t-SC-m-c-CS-s -3.709121e-02 -0.054781692 -0.019400725 0.0000000 t-SC-s-c-CS-s -2.713355e-02 -0.044824038 -0.009443070 0.0000974 c-SC-s-c-SC-m 4.146619e-05 -0.017201084 0.017284017 1.0000000 t-CS-m-c-SC-m 3.055545e-02 0.013312902 0.047798003 0.0000025 t-CS-s-c-SC-m 2.004859e-02 0.001554993 0.038542189 0.0228228 t-SC-m-c-SC-m 2.599824e-02 0.008755687 0.043240788 0.0001408 t-SC-s-c-SC-m 3.595589e-02 0.018713342 0.053198443 0.0000000 t-CS-m-c-SC-s 3.051399e-02 0.012823503 0.048204470 0.0000054 t-CS-s-c-SC-s 2.000712e-02 0.001095202 0.038919047 0.0293888 t-SC-m-c-SC-s 2.595677e-02 0.008266288 0.043647255 0.0002470 t-SC-s-c-SC-s 3.591443e-02 0.018223942 0.053604910 0.0000000 t-CS-s-t-CS-m -1.050686e-02 -0.029418784 0.008405061 0.6956816 t-SC-m-t-CS-m -4.557215e-03 -0.022247699 0.013133269 0.9940057 t-SC-s-t-CS-m 5.400440e-03 -0.012290044 0.023090923 0.9834473 t-SC-m-t-CS-s 5.949647e-03 -0.012962276 0.024861569 0.9803052 t-SC-s-t-CS-s 1.590730e-02 -0.003004621 0.034819224 0.1741377 t-SC-s-t-SC-m 9.957655e-03 -0.007732829 0.027648138 0.6811646
pMEK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.4326 0.06180 35.6 <2e-16 *** Residuals 1072 1.8611
0.00174
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -1.109995e-02 -0.026111763 0.0039118644 0.3253511 c-SC-m-c-CS-m 1.799575e-02 0.003384322 0.0326071756 0.0047673 c-SC-s-c-CS-m 8.288755e-03 -0.006723058 0.0233005691 0.7023969 t-CS-m-c-CS-m -1.634455e-02 -0.031356361 -0.0013327330 0.0217926 t-CS-s-c-CS-m -1.633464e-02 -0.032435646 -0.0002336302 0.0439283 t-SC-m-c-CS-m 4.549306e-02 0.030481243 0.0605048705 0.0000000 t-SC-s-c-CS-m 2.237013e-02 0.007358320 0.0373819479 0.0001801 c-SC-m-c-CS-s 2.909570e-02 0.014083885 0.0441075122 0.0000001 c-SC-s-c-CS-s 1.938870e-02 0.003986909 0.0347905007 0.0034820 t-CS-m-c-CS-s -5.244597e-03 -0.020646393 0.0101571985 0.9692078 t-CS-s-c-CS-s -5.234689e-03 -0.021699901 0.0112305237 0.9790818 t-SC-m-c-CS-s 5.659301e-02 0.041191210 0.0719948021 0.0000000 t-SC-s-c-CS-s 3.347008e-02 0.018068288 0.0488718795 0.0000000 c-SC-s-c-SC-m -9.706994e-03 -0.024718807 0.0053048201 0.5071226 t-CS-m-c-SC-m -3.434030e-02 -0.049352110 -0.0193284820 0.0000000 t-CS-s-c-SC-m -3.433039e-02 -0.050431395 -0.0182293793 0.0000000 t-SC-m-c-SC-m 2.749731e-02 0.012485494 0.0425091215 0.0000009 t-SC-s-c-SC-m 4.374385e-03 -0.010637429 0.0193861989 0.9873983 t-CS-m-c-SC-s -2.463330e-02 -0.040035098 -0.0092315062 0.0000374 t-CS-s-c-SC-s -2.462339e-02 -0.041088606 -0.0081581810 0.0001673 t-SC-m-c-SC-s 3.720430e-02 0.021802505 0.0526060974 0.0000000 t-SC-s-c-SC-s 1.408138e-02 -0.001320417 0.0294831748 0.1019933 t-CS-s-t-CS-m 9.908642e-06 -0.016455304 0.0164751211 1.0000000 t-SC-m-t-CS-m 6.183760e-02 0.046435808 0.0772393995 0.0000000 t-SC-s-t-CS-m 3.871468e-02 0.023312885 0.0541164769 0.0000000 t-SC-m-t-CS-s 6.182769e-02 0.045362482 0.0782929073 0.0000000 t-SC-s-t-CS-s 3.870477e-02 0.022239560 0.0551699847 0.0000000 t-SC-s-t-SC-m -2.312292e-02 -0.038524719 -0.0077211267 0.0001542
pNR1
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.706 0.24373 19.69 <2e-16 *** Residuals 1072 13.270
0.01238
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.004068007 -0.044152403 0.03601639 0.9999872 c-SC-m-c-CS-m -0.059088473 -0.098103759 -0.02007319 0.0001281 c-SC-s-c-CS-m 0.010562449 -0.029521948 0.05064684 0.9931152 t-CS-m-c-CS-m -0.088918928 -0.129003324 -0.04883453 0.0000000 t-CS-s-c-CS-m -0.095850334 -0.138843086 -0.05285758 0.0000000 t-SC-m-c-CS-m 0.001624814 -0.038459582 0.04170921 1.0000000 t-SC-s-c-CS-m -0.056705802 -0.096790198 -0.01662141 0.0005010 c-SC-m-c-CS-s -0.055020466 -0.095104862 -0.01493607 0.0008653 c-SC-s-c-CS-s 0.014630455 -0.026495267 0.05575618 0.9608599 t-CS-m-c-CS-s -0.084850921 -0.125976643 -0.04372520 0.0000000 t-CS-s-c-CS-s -0.091782327 -0.135747574 -0.04781708 0.0000000 t-SC-m-c-CS-s 0.005692821 -0.035432901 0.04681854 0.9998942 t-SC-s-c-CS-s -0.052637795 -0.093763518 -0.01151207 0.0027168 c-SC-s-c-SC-m 0.069650921 0.029566525 0.10973532 0.0000044 t-CS-m-c-SC-m -0.029830455 -0.069914851 0.01025394 0.3169510 t-CS-s-c-SC-m -0.036761861 -0.079754613 0.00623089 0.1581011 t-SC-m-c-SC-m 0.060713287 0.020628891 0.10079768 0.0001278 t-SC-s-c-SC-m 0.002382670 -0.037701726 0.04246707 0.9999997 t-CS-m-c-SC-s -0.099481376 -0.140607099 -0.05835565 0.0000000 t-CS-s-c-SC-s -0.106412783 -0.150378029 -0.06244754 0.0000000 t-SC-m-c-SC-s -0.008937634 -0.050063357 0.03218809 0.9979344 t-SC-s-c-SC-s -0.067268251 -0.108393974 -0.02614253 0.0000217 t-CS-s-t-CS-m -0.006931406 -0.050896653 0.03703384 0.9997467 t-SC-m-t-CS-m 0.090543742 0.049418019 0.13166946 0.0000000 t-SC-s-t-CS-m 0.032213125 -0.008912597 0.07333885 0.2528290 t-SC-m-t-CS-s 0.097475148 0.053509901 0.14144040 0.0000000 t-SC-s-t-CS-s 0.039144532 -0.004820715 0.08310978 0.1224177 t-SC-s-t-SC-m -0.058330617 -0.099456339 -0.01720489 0.0004772
pNR2A
Df Sum Sq Mean Sq F value Pr(>F) class 7 11.79 1.6836 68.73 <2e-16 *** Residuals 1072 26.26
0.0245
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.02107107 -0.035316806 0.077458937 0.9490882 c-SC-m-c-CS-m 0.21982010 0.164936181 0.274704028 0.0000000 c-SC-s-c-CS-m 0.09470608 0.038318210 0.151093953 0.0000110 t-CS-m-c-CS-m -0.12039976 -0.176787631 -0.064011888 0.0000000 t-CS-s-c-CS-m -0.03786356 -0.098342694 0.022615583 0.5502896 t-SC-m-c-CS-m 0.15623982 0.099851947 0.212627690 0.0000000 t-SC-s-c-CS-m -0.00953174 -0.065919612 0.046856131 0.9995975 c-SC-m-c-CS-s 0.19874904 0.142361168 0.255136911 0.0000000 c-SC-s-c-CS-s 0.07363502 0.015782281 0.131487752 0.0029561 t-CS-m-c-CS-s -0.14147083 -0.199323561 -0.083618090 0.0000000 t-CS-s-c-CS-s -0.05893462 -0.120781797 0.002912555 0.0747979 t-SC-m-c-CS-s 0.13516875 0.077316017 0.193021488 0.0000000 t-SC-s-c-CS-s -0.03060281 -0.088455541 0.027249930 0.7465124 c-SC-s-c-SC-m -0.12511402 -0.181501894 -0.068726151 0.0000000 t-CS-m-c-SC-m -0.34021986 -0.396607736 -0.283831993 0.0000000 t-CS-s-c-SC-m -0.25768366 -0.318162798 -0.197204521 0.0000000 t-SC-m-c-SC-m -0.06358029 -0.119968158 -0.007192415 0.0147439 t-SC-s-c-SC-m -0.22935184 -0.285739716 -0.172963973 0.0000000 t-CS-m-c-SC-s -0.21510584 -0.272958577 -0.157253106 0.0000000 t-CS-s-c-SC-s -0.13256964 -0.194416813 -0.070722462 0.0000000 t-SC-m-c-SC-s 0.06153374 0.003681001 0.119386472 0.0278282 t-SC-s-c-SC-s -0.10423782 -0.162090557 -0.046385086 0.0000015 t-CS-s-t-CS-m 0.08253620 0.020689029 0.144383380 0.0013990 t-SC-m-t-CS-m 0.27663958 0.218786843 0.334492313 0.0000000 t-SC-s-t-CS-m 0.11086802 0.053015284 0.168720755 0.0000002 t-SC-m-t-CS-s 0.19410337 0.132256198 0.255950549 0.0000000 t-SC-s-t-CS-s 0.02833182 -0.033515360 0.090178991 0.8614255 t-SC-s-t-SC-m -0.16577156 -0.223624294 -0.107918823 0.0000000
pNR2B
Df Sum Sq Mean Sq F value Pr(>F) class 7 8.23 1.1759 17.83 <2e-16 *** Residuals 1072 70.69
0.0659
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.006862988 -0.08565196 0.099377932 0.9999985 c-SC-m-c-CS-m -0.046950090 -0.13699752 0.043097344 0.7603575 c-SC-s-c-CS-m 0.056261590 -0.03625335 0.148776534 0.5879957 t-CS-m-c-CS-m -0.144393545 -0.23690849 -0.051878601 0.0000660 t-CS-s-c-CS-m -0.072903906 -0.17213135 0.026323534 0.3337270 t-SC-m-c-CS-m 0.113034035 0.02051909 0.205548979 0.0053297 t-SC-s-c-CS-m -0.156024999 -0.24853994 -0.063510055 0.0000099 c-SC-m-c-CS-s -0.053813078 -0.14632802 0.038701866 0.6430573 c-SC-s-c-CS-s 0.049398602 -0.04551973 0.144316932 0.7620871 t-CS-m-c-CS-s -0.151256533 -0.24617486 -0.056338203 0.0000408 t-CS-s-c-CS-s -0.079766894 -0.18123886 0.021705069 0.2485460 t-SC-m-c-CS-s 0.106171047 0.01125272 0.201089377 0.0161678 t-SC-s-c-CS-s -0.162887987 -0.25780632 -0.067969657 0.0000062 c-SC-s-c-SC-m 0.103211680 0.01069674 0.195726624 0.0166571 t-CS-m-c-SC-m -0.097443455 -0.18995840 -0.004928511 0.0307106 t-CS-s-c-SC-m -0.025953815 -0.12518126 0.073273624 0.9934200 t-SC-m-c-SC-m 0.159984125 0.06746918 0.252499069 0.0000050 t-SC-s-c-SC-m -0.109074909 -0.20158985 -0.016559965 0.0085597 t-CS-m-c-SC-s -0.200655135 -0.29557346 -0.105736805 0.0000000 t-CS-s-c-SC-s -0.129165496 -0.23063746 -0.027693533 0.0029520 t-SC-m-c-SC-s 0.056772445 -0.03814589 0.151690775 0.6089659 t-SC-s-c-SC-s -0.212286589 -0.30720492 -0.117368259 0.0000000 t-CS-s-t-CS-m 0.071489639 -0.02998232 0.172961602 0.3900134 t-SC-m-t-CS-m 0.257427580 0.16250925 0.352345910 0.0000000 t-SC-s-t-CS-m -0.011631454 -0.10654978 0.083286876 0.9999536 t-SC-m-t-CS-s 0.185937941 0.08446598 0.287409904 0.0000009 t-SC-s-t-CS-s -0.083121094 -0.18459306 0.018350869 0.2017062 t-SC-s-t-SC-m -0.269059034 -0.36397736 -0.174140704 0.0000000
pPKCAB
Df Sum Sq Mean Sq F value Pr(>F) class 7 96.36 13.766 96.21 <2e-16 *** Residuals 1072 153.39
0.143
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.333081925 0.19679965 0.46936420 0.0000000 c-SC-m-c-CS-m -0.539738074 -0.67238550 -0.40709065 0.0000000 c-SC-s-c-CS-m -0.492337023 -0.62861930 -0.35605475 0.0000000 t-CS-m-c-CS-m -0.005945668 -0.14222794 0.13033660 1.0000000 t-CS-s-c-CS-m 0.063666382 -0.08250396 0.20983672 0.8902700 t-SC-m-c-CS-m -0.491298156 -0.62758043 -0.35501588 0.0000000 t-SC-s-c-CS-m -0.155769812 -0.29205209 -0.01948754 0.0125612 c-SC-m-c-CS-s -0.872819999 -1.00910227 -0.73653773 0.0000000 c-SC-s-c-CS-s -0.825418948 -0.96524161 -0.68559629 0.0000000 t-CS-m-c-CS-s -0.339027593 -0.47885026 -0.19920493 0.0000000 t-CS-s-c-CS-s -0.269415542 -0.41889226 -0.11993883 0.0000015 t-SC-m-c-CS-s -0.824380081 -0.96420274 -0.68455742 0.0000000 t-SC-s-c-CS-s -0.488851737 -0.62867440 -0.34902907 0.0000000 c-SC-s-c-SC-m 0.047401051 -0.08888122 0.18368332 0.9653893 t-CS-m-c-SC-m 0.533792406 0.39751013 0.67007468 0.0000000 t-CS-s-c-SC-m 0.603404457 0.45723411 0.74957480 0.0000000 t-SC-m-c-SC-m 0.048439918 -0.08784235 0.18472219 0.9610453 t-SC-s-c-SC-m 0.383968262 0.24768599 0.52025054 0.0000000 t-CS-m-c-SC-s 0.486391355 0.34656869 0.62621402 0.0000000 t-CS-s-c-SC-s 0.556003405 0.40652669 0.70548012 0.0000000 t-SC-m-c-SC-s 0.001038867 -0.13878379 0.14086153 1.0000000 t-SC-s-c-SC-s 0.336567211 0.19674455 0.47638987 0.0000000 t-CS-s-t-CS-m 0.069612051 -0.07986466 0.21908876 0.8507901 t-SC-m-t-CS-m -0.485352488 -0.62517515 -0.34552983 0.0000000 t-SC-s-t-CS-m -0.149824144 -0.28964681 -0.01000148 0.0257905 t-SC-m-t-CS-s -0.554964538 -0.70444125 -0.40548783 0.0000000 t-SC-s-t-CS-s -0.219436195 -0.36891291 -0.06995948 0.0002444 t-SC-s-t-SC-m 0.335528344 0.19570568 0.47535101 0.0000000
pRSK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.372 0.05315 12.9 5.3e-16 *** Residuals 1072 4.415
0.00412
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.003444149 -0.0265661779 0.019677881 0.9998267 c-SC-m-c-CS-m -0.006230826 -0.0287361569 0.016274504 0.9907118 c-SC-s-c-CS-m -0.015792320 -0.0389143495 0.007329709 0.4324229 t-CS-m-c-CS-m 0.020685264 -0.0024367652 0.043807293 0.1185640 t-CS-s-c-CS-m -0.022415992 -0.0472156585 0.002383675 0.1105056 t-SC-m-c-CS-m 0.004849815 -0.0182722146 0.027971844 0.9983541 t-SC-s-c-CS-m 0.040919561 0.0177975316 0.064041590 0.0000026 c-SC-m-c-CS-s -0.002786678 -0.0259087068 0.020335352 0.9999586 c-SC-s-c-CS-s -0.012348172 -0.0360708731 0.011374530 0.7619277 t-CS-m-c-CS-s 0.024129413 0.0004067113 0.047852114 0.0428965 t-CS-s-c-CS-s -0.018971843 -0.0443324779 0.006388791 0.3101956 t-SC-m-c-CS-s 0.008293963 -0.0154287381 0.032016665 0.9643934 t-SC-s-c-CS-s 0.044363710 0.0206410081 0.068086411 0.0000005 c-SC-s-c-SC-m -0.009561494 -0.0326835233 0.013560535 0.9146103 t-CS-m-c-SC-m 0.026916090 0.0037940610 0.050038120 0.0100500 t-CS-s-c-SC-m -0.016185166 -0.0409848323 0.008614501 0.4945862 t-SC-m-c-SC-m 0.011080641 -0.0120413883 0.034202670 0.8308211 t-SC-s-c-SC-m 0.047150387 0.0240283578 0.070272416 0.0000000 t-CS-m-c-SC-s 0.036477584 0.0127548828 0.060200286 0.0000921 t-CS-s-c-SC-s -0.006623672 -0.0319843064 0.018736963 0.9934782 t-SC-m-c-SC-s 0.020642135 -0.0030805665 0.044364836 0.1420166 t-SC-s-c-SC-s 0.056711881 0.0329891796 0.080434583 0.0000000 t-CS-s-t-CS-m -0.043101256 -0.0684618907 -0.017740621 0.0000081 t-SC-m-t-CS-m -0.015835449 -0.0395581508 0.007887252 0.4638295 t-SC-s-t-CS-m 0.020234297 -0.0034884047 0.043956998 0.1604672 t-SC-m-t-CS-s 0.027265807 0.0019051720 0.052626441 0.0249082 t-SC-s-t-CS-s 0.063335553 0.0379749182 0.088696188 0.0000000 t-SC-s-t-SC-m 0.036069746 0.0123470447 0.059792448 0.0001177
AKT
Df Sum Sq Mean Sq F value Pr(>F) class 7 4.044 0.5777 46.11 <2e-16 *** Residuals 1072 13.430
0.0125
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.056301088 -0.0966270688 -0.01597511 0.0006386 c-SC-m-c-CS-m -0.050194737 -0.0894451648 -0.01094431 0.0027523 c-SC-s-c-CS-m 0.078827086 0.0385011058 0.11915307 0.0000001 t-CS-m-c-CS-m -0.115583586 -0.1559095670 -0.07525761 0.0000000 t-CS-s-c-CS-m -0.060162322 -0.1034141868 -0.01691046 0.0006830 t-SC-m-c-CS-m 0.063360206 0.0230342251 0.10368619 0.0000567 t-SC-s-c-CS-m -0.009368667 -0.0496946480 0.03095731 0.9968470 c-SC-m-c-CS-s 0.006106351 -0.0342196299 0.04643233 0.9998066 c-SC-s-c-CS-s 0.135128175 0.0937545914 0.17650176 0.0000000 t-CS-m-c-CS-s -0.059282498 -0.1006560814 -0.01790892 0.0003934 t-CS-s-c-CS-s -0.003861234 -0.0480914552 0.04036899 0.9999955 t-SC-m-c-CS-s 0.119661294 0.0782877108 0.16103488 0.0000000 t-SC-s-c-CS-s 0.046932421 0.0055588376 0.08830600 0.0137433 c-SC-s-c-SC-m 0.129021824 0.0886958432 0.16934780 0.0000000 t-CS-m-c-SC-m -0.065388849 -0.1057148296 -0.02506287 0.0000269 t-CS-s-c-SC-m -0.009967585 -0.0532194493 0.03328428 0.9970034 t-SC-m-c-SC-m 0.113554943 0.0732289626 0.15388092 0.0000000 t-SC-s-c-SC-m 0.040826070 0.0005000894 0.08115205 0.0447697 t-CS-m-c-SC-s -0.194410673 -0.2357842560 -0.15303709 0.0000000 t-CS-s-c-SC-s -0.138989409 -0.1832196297 -0.09475919 0.0000000 t-SC-m-c-SC-s -0.015466881 -0.0568404638 0.02590670 0.9489776 t-SC-s-c-SC-s -0.088195754 -0.1295693370 -0.04682217 0.0000000 t-CS-s-t-CS-m 0.055421264 0.0111910431 0.09965148 0.0037271 t-SC-m-t-CS-m 0.178943792 0.1375702090 0.22031738 0.0000000 t-SC-s-t-CS-m 0.106214919 0.0648413358 0.14758850 0.0000000 t-SC-m-t-CS-s 0.123522528 0.0792923074 0.16775275 0.0000000 t-SC-s-t-CS-s 0.050793655 0.0065634342 0.09502388 0.0118697 t-SC-s-t-SC-m -0.072728873 -0.1141024563 -0.03135529 0.0000032
BRAF
Df Sum Sq Mean Sq F value Pr(>F) class 7 12.97 1.8534 53.08 <2e-16 *** Residuals 1072 37.43
0.0349
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.105757548 0.03843302 0.17308208 0.0000570 c-SC-m-c-CS-m -0.161484566 -0.22701345 -0.09595568 0.0000000 c-SC-s-c-CS-m -0.158289138 -0.22561367 -0.09096461 0.0000000 t-CS-m-c-CS-m 0.111968574 0.04464405 0.17929310 0.0000142 t-CS-s-c-CS-m 0.010770197 -0.06143912 0.08297951 0.9998252 t-SC-m-c-CS-m -0.130655793 -0.19798032 -0.06333126 0.0000001 t-SC-s-c-CS-m -0.139224748 -0.20654928 -0.07190022 0.0000000 c-SC-m-c-CS-s -0.267242114 -0.33456664 -0.19991759 0.0000000 c-SC-s-c-CS-s -0.264046685 -0.33312019 -0.19497318 0.0000000 t-CS-m-c-CS-s 0.006211026 -0.06286248 0.07528453 0.9999944 t-CS-s-c-CS-s -0.094987351 -0.16883004 -0.02114466 0.0025166 t-SC-m-c-CS-s -0.236413340 -0.30548685 -0.16733983 0.0000000 t-SC-s-c-CS-s -0.244982296 -0.31405580 -0.17590879 0.0000000 c-SC-s-c-SC-m 0.003195428 -0.06412910 0.07051996 0.9999999 t-CS-m-c-SC-m 0.273453140 0.20612861 0.34077767 0.0000000 t-CS-s-c-SC-m 0.172254763 0.10004545 0.24446408 0.0000000 t-SC-m-c-SC-m 0.030828773 -0.03649575 0.09815330 0.8616730 t-SC-s-c-SC-m 0.022259817 -0.04506471 0.08958435 0.9738760 t-CS-m-c-SC-s 0.270257711 0.20118420 0.33933122 0.0000000 t-CS-s-c-SC-s 0.169059334 0.09521665 0.24290202 0.0000000 t-SC-m-c-SC-s 0.027633345 -0.04144016 0.09670685 0.9276070 t-SC-s-c-SC-s 0.019064389 -0.05000912 0.08813790 0.9908837 t-CS-s-t-CS-m -0.101198377 -0.17504106 -0.02735569 0.0008894 t-SC-m-t-CS-m -0.242624367 -0.31169787 -0.17355086 0.0000000 t-SC-s-t-CS-m -0.251193322 -0.32026683 -0.18211981 0.0000000 t-SC-m-t-CS-s -0.141425990 -0.21526868 -0.06758330 0.0000002 t-SC-s-t-CS-s -0.149994945 -0.22383763 -0.07615226 0.0000000 t-SC-s-t-SC-m -0.008568956 -0.07764246 0.06050455 0.9999496
CAMKII
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.4352 0.06218 26.51 <2e-16 *** Residuals 1072 2.5139
0.00235
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0009424752 -0.0165043544 0.0183893048 0.9999998 c-SC-m-c-CS-m -0.0081085317 -0.0250900287 0.0088729652 0.8334553 c-SC-s-c-CS-m 0.0056703807 -0.0117764489 0.0231172103 0.9762866 t-CS-m-c-CS-m -0.0381089786 -0.0555558082 -0.0206621490 0.0000000 t-CS-s-c-CS-m -0.0193513616 -0.0380640598 -0.0006386633 0.0367290 t-SC-m-c-CS-m 0.0370547095 0.0196078799 0.0545015391 0.0000000 t-SC-s-c-CS-m -0.0102200004 -0.0276668300 0.0072268292 0.6345898 c-SC-m-c-CS-s -0.0090510069 -0.0264978365 0.0083958227 0.7650577 c-SC-s-c-CS-s 0.0047279055 -0.0131721640 0.0226279750 0.9930154 t-CS-m-c-CS-s -0.0390514538 -0.0569515233 -0.0211513844 0.0000000 t-CS-s-c-CS-s -0.0202938368 -0.0394298160 -0.0011578576 0.0286708 t-SC-m-c-CS-s 0.0361122343 0.0182121648 0.0540123038 0.0000000 t-SC-s-c-CS-s -0.0111624756 -0.0290625451 0.0067375938 0.5554689 c-SC-s-c-SC-m 0.0137789124 -0.0036679172 0.0312257420 0.2430316 t-CS-m-c-SC-m -0.0300004469 -0.0474472765 -0.0125536173 0.0000059 t-CS-s-c-SC-m -0.0112428299 -0.0299555281 0.0074698684 0.6033377 t-SC-m-c-SC-m 0.0451632412 0.0277164116 0.0626100708 0.0000000 t-SC-s-c-SC-m -0.0021114687 -0.0195582983 0.0153353609 0.9999574 t-CS-m-c-SC-s -0.0437793593 -0.0616794288 -0.0258792899 0.0000000 t-CS-s-c-SC-s -0.0250217423 -0.0441577215 -0.0058857631 0.0019483 t-SC-m-c-SC-s 0.0313843288 0.0134842593 0.0492843983 0.0000034 t-SC-s-c-SC-s -0.0158903812 -0.0337904506 0.0020096883 0.1248386 t-CS-s-t-CS-m 0.0187576171 -0.0003783621 0.0378935963 0.0594060 t-SC-m-t-CS-m 0.0751636881 0.0572636187 0.0930637576 0.0000000 t-SC-s-t-CS-m 0.0278889782 0.0099889087 0.0457890477 0.0000687 t-SC-m-t-CS-s 0.0564060711 0.0372700919 0.0755420503 0.0000000 t-SC-s-t-CS-s 0.0091313611 -0.0100046181 0.0282673403 0.8339233 t-SC-s-t-SC-m -0.0472747099 -0.0651747794 -0.0293746405 0.0000000
CREB
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0670 0.009578 15.07 <2e-16 *** Residuals 1072 0.6813
0.000636
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 4.622018e-04 -0.0086204748 0.009544878 0.9999999 c-SC-m-c-CS-m 6.954003e-03 -0.0018864254 0.015794431 0.2477657 c-SC-s-c-CS-m -5.926622e-05 -0.0091419428 0.009023410 1.0000000 t-CS-m-c-CS-m 7.143905e-04 -0.0083682861 0.009797067 0.9999978 t-CS-s-c-CS-m -1.229340e-02 -0.0220350790 -0.002551724 0.0033589 t-SC-m-c-CS-m 1.799864e-02 0.0089159612 0.027081314 0.0000001 t-SC-s-c-CS-m 9.508210e-03 0.0004255337 0.018590887 0.0326261 c-SC-m-c-CS-s 6.491801e-03 -0.0025908756 0.015574478 0.3705054 c-SC-s-c-CS-s -5.214680e-04 -0.0098400975 0.008797162 0.9999998 t-CS-m-c-CS-s 2.521887e-04 -0.0090664408 0.009570818 1.0000000 t-CS-s-c-CS-s -1.275560e-02 -0.0227176374 -0.002793569 0.0027008 t-SC-m-c-CS-s 1.753644e-02 0.0082178065 0.026855065 0.0000004 t-SC-s-c-CS-s 9.046008e-03 -0.0002726210 0.018364638 0.0644183 c-SC-s-c-SC-m -7.013269e-03 -0.0160959455 0.002069408 0.2702099 t-CS-m-c-SC-m -6.239612e-03 -0.0153222888 0.002843064 0.4244592 t-CS-s-c-SC-m -1.924740e-02 -0.0289890818 -0.009505727 0.0000001 t-SC-m-c-SC-m 1.104463e-02 0.0019619584 0.020127312 0.0056883 t-SC-s-c-SC-m 2.554208e-03 -0.0065284690 0.011636884 0.9897999 t-CS-m-c-SC-s 7.736567e-04 -0.0085449728 0.010092286 0.9999968 t-CS-s-c-SC-s -1.223414e-02 -0.0221961694 -0.002272101 0.0049636 t-SC-m-c-SC-s 1.805790e-02 0.0087392744 0.027376533 0.0000001 t-SC-s-c-SC-s 9.567476e-03 0.0002488469 0.018886106 0.0393242 t-CS-s-t-CS-m -1.300779e-02 -0.0229698261 -0.003045758 0.0019924 t-SC-m-t-CS-m 1.728425e-02 0.0079656177 0.026602877 0.0000006 t-SC-s-t-CS-m 8.793820e-03 -0.0005248097 0.018112449 0.0806827 t-SC-m-t-CS-s 3.029204e-02 0.0203300054 0.040254073 0.0000000 t-SC-s-t-CS-s 2.180161e-02 0.0118395779 0.031763646 0.0000000 t-SC-s-t-SC-m -8.490427e-03 -0.0178090570 0.000828202 0.1045141
ELK
Df Sum Sq Mean Sq F value Pr(>F) class 7 7.98 1.1406 10.93 2.2e-13 *** Residuals 1072 111.86
0.1043
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.050182185 -0.066196910 0.16656128 0.8953980 c-SC-m-c-CS-m -0.205755775 -0.319030868 -0.09248068 0.0000012 c-SC-s-c-CS-m -0.012202350 -0.128581445 0.10417674 0.9999840 t-CS-m-c-CS-m -0.179942152 -0.296321247 -0.06356306 0.0000815 t-CS-s-c-CS-m -0.007058299 -0.131881372 0.11776477 0.9999998 t-SC-m-c-CS-m -0.084909525 -0.201288620 0.03146957 0.3429789 t-SC-s-c-CS-m -0.079558483 -0.195937578 0.03682061 0.4311872 c-SC-m-c-CS-s -0.255937960 -0.372317055 -0.13955887 0.0000000 c-SC-s-c-CS-s -0.062384536 -0.181786968 0.05701790 0.7584057 t-CS-m-c-CS-s -0.230124337 -0.349526769 -0.11072191 0.0000002 t-CS-s-c-CS-s -0.057240485 -0.184887054 0.07040608 0.8742855 t-SC-m-c-CS-s -0.135091711 -0.254494143 -0.01568928 0.0141706 t-SC-s-c-CS-s -0.129740669 -0.249143101 -0.01033824 0.0222691 c-SC-s-c-SC-m 0.193553424 0.077174329 0.30993252 0.0000142 t-CS-m-c-SC-m 0.025813623 -0.090565472 0.14219272 0.9976478 t-CS-s-c-SC-m 0.198697475 0.073874402 0.32352055 0.0000418 t-SC-m-c-SC-m 0.120846249 0.004467154 0.23722534 0.0353097 t-SC-s-c-SC-m 0.126197291 0.009818196 0.24257639 0.0227600 t-CS-m-c-SC-s -0.167739802 -0.287142234 -0.04833737 0.0005701 t-CS-s-c-SC-s 0.005144051 -0.122502518 0.13279062 1.0000000 t-SC-m-c-SC-s -0.072707175 -0.192109607 0.04669526 0.5863367 t-SC-s-c-SC-s -0.067356133 -0.186758565 0.05204630 0.6787075 t-CS-s-t-CS-m 0.172883853 0.045237284 0.30053042 0.0010907 t-SC-m-t-CS-m 0.095032626 -0.024369806 0.21443506 0.2339828 t-SC-s-t-CS-m 0.100383669 -0.019018763 0.21978610 0.1746244 t-SC-m-t-CS-s -0.077851226 -0.205497795 0.04979534 0.5842969 t-SC-s-t-CS-s -0.072500184 -0.200146753 0.05514639 0.6709400 t-SC-s-t-SC-m 0.005351042 -0.114051390 0.12475347 1.0000000
ERK
Df Sum Sq Mean Sq F value Pr(>F) class 7 85.6 12.224 35.05 <2e-16 *** Residuals 1072 373.8
0.349
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0074006715 -0.20535786 0.22015921 1.0000000 c-SC-m-c-CS-m -0.8192690436 -1.02635299 -0.61218509 0.0000000 c-SC-s-c-CS-m -0.4964427910 -0.70920132 -0.28368426 0.0000000 t-CS-m-c-CS-m -0.5635592382 -0.77631777 -0.35080070 0.0000000 t-CS-s-c-CS-m -0.1591802852 -0.38737568 0.06901511 0.4035501 t-SC-m-c-CS-m -0.4891840092 -0.70194254 -0.27642548 0.0000000 t-SC-s-c-CS-m -0.4890135143 -0.70177205 -0.27625498 0.0000000 c-SC-m-c-CS-s -0.8266697151 -1.03942825 -0.61391118 0.0000000 c-SC-s-c-CS-s -0.5038434626 -0.72212911 -0.28555781 0.0000000 t-CS-m-c-CS-s -0.5709599098 -0.78924556 -0.35267426 0.0000000 t-CS-s-c-CS-s -0.1665809567 -0.39993813 0.06677622 0.3722055 t-SC-m-c-CS-s -0.4965846808 -0.71487033 -0.27829903 0.0000000 t-SC-s-c-CS-s -0.4964141858 -0.71469984 -0.27812854 0.0000000 c-SC-s-c-SC-m 0.3228262526 0.11006772 0.53558479 0.0001231 t-CS-m-c-SC-m 0.2557098054 0.04295127 0.46846834 0.0066602 t-CS-s-c-SC-m 0.6600887584 0.43189336 0.88828416 0.0000000 t-SC-m-c-SC-m 0.3300850344 0.11732650 0.54284357 0.0000755 t-SC-s-c-SC-m 0.3302555293 0.11749700 0.54301406 0.0000747 t-CS-m-c-SC-s -0.0671164472 -0.28540210 0.15116920 0.9827439 t-CS-s-c-SC-s 0.3372625059 0.10390533 0.57061968 0.0003331 t-SC-m-c-SC-s 0.0072587818 -0.21102687 0.22554443 1.0000000 t-SC-s-c-SC-s 0.0074292767 -0.21085637 0.22571493 1.0000000 t-CS-s-t-CS-m 0.4043789531 0.17102178 0.63773613 0.0000047 t-SC-m-t-CS-m 0.0743752290 -0.14391042 0.29266088 0.9691045 t-SC-s-t-CS-m 0.0745457239 -0.14373993 0.29283137 0.9687103 t-SC-m-t-CS-s -0.3300037241 -0.56336090 -0.09664655 0.0005043 t-SC-s-t-CS-s -0.3298332291 -0.56319040 -0.09647605 0.0005092 t-SC-s-t-SC-m 0.0001704949 -0.21811515 0.21845614 1.0000000
GSK3B
Df Sum Sq Mean Sq F value Pr(>F) class 7 16.62 2.3742 53.19 <2e-16 *** Residuals 1072 47.85
0.0446
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.066470266 -0.009644733 0.142585265 0.1388207 c-SC-m-c-CS-m -0.275125136 -0.349210036 -0.201040236 0.0000000 c-SC-s-c-CS-m -0.272903341 -0.349018340 -0.196788342 0.0000000 t-CS-m-c-CS-m -0.008004564 -0.084119563 0.068110436 0.9999837 t-CS-s-c-CS-m -0.053359874 -0.134997457 0.028277710 0.4925430 t-SC-m-c-CS-m -0.181319727 -0.257434727 -0.105204728 0.0000000 t-SC-s-c-CS-m -0.172086495 -0.248201494 -0.095971496 0.0000000 c-SC-m-c-CS-s -0.341595402 -0.417710401 -0.265480403 0.0000000 c-SC-s-c-CS-s -0.339373607 -0.417465949 -0.261281266 0.0000000 t-CS-m-c-CS-s -0.074474830 -0.152567171 0.003617512 0.0743235 t-CS-s-c-CS-s -0.119830140 -0.203314364 -0.036345915 0.0003805 t-SC-m-c-CS-s -0.247789994 -0.325882335 -0.169697652 0.0000000 t-SC-s-c-CS-s -0.238556761 -0.316649102 -0.160464419 0.0000000 c-SC-s-c-SC-m 0.002221795 -0.073893204 0.078336794 1.0000000 t-CS-m-c-SC-m 0.267120573 0.191005573 0.343235572 0.0000000 t-CS-s-c-SC-m 0.221765263 0.140127679 0.303402846 0.0000000 t-SC-m-c-SC-m 0.093805409 0.017690409 0.169920408 0.0047243 t-SC-s-c-SC-m 0.103038641 0.026923642 0.179153641 0.0011000 t-CS-m-c-SC-s 0.264898778 0.186806436 0.342991119 0.0000000 t-CS-s-c-SC-s 0.219543468 0.136059243 0.303027692 0.0000000 t-SC-m-c-SC-s 0.091583614 0.013491272 0.169675955 0.0091568 t-SC-s-c-SC-s 0.100816846 0.022724505 0.178909188 0.0023804 t-CS-s-t-CS-m -0.045355310 -0.128839535 0.038128915 0.7195825 t-SC-m-t-CS-m -0.173315164 -0.251407506 -0.095222822 0.0000000 t-SC-s-t-CS-m -0.164081931 -0.242174273 -0.085989590 0.0000000 t-SC-m-t-CS-s -0.127959854 -0.211444079 -0.044475629 0.0000989 t-SC-s-t-CS-s -0.118726621 -0.202210846 -0.035242397 0.0004538 t-SC-s-t-SC-m 0.009233233 -0.068859109 0.087325574 0.9999637
JNK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0683 0.009758 8.953 9.3e-11 *** Residuals 1072 1.1683
0.001090
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.015883445 -0.0277773238 -0.0039895660 0.0013832 c-SC-m-c-CS-m -0.023632947 -0.0352095983 -0.0120562950 0.0000000 c-SC-s-c-CS-m -0.013602452 -0.0254963305 -0.0017085727 0.0124751 t-CS-m-c-CS-m -0.012475656 -0.0243695352 -0.0005817774 0.0319997 t-CS-s-c-CS-m -0.021383193 -0.0341400417 -0.0086263442 0.0000116 t-SC-m-c-CS-m -0.001598405 -0.0134922835 0.0102954743 0.9999133 t-SC-s-c-CS-m -0.010870904 -0.0227647832 0.0010229746 0.1022135 c-SC-m-c-CS-s -0.007749502 -0.0196433806 0.0041443772 0.4968394 c-SC-s-c-CS-s 0.002280993 -0.0099218690 0.0144838556 0.9992200 t-CS-m-c-CS-s 0.003407789 -0.0087950737 0.0156106509 0.9902175 t-CS-s-c-CS-s -0.005499748 -0.0185451566 0.0075456604 0.9061519 t-SC-m-c-CS-s 0.014285040 0.0020821780 0.0264879025 0.0093693 t-SC-s-c-CS-s 0.005012541 -0.0071903217 0.0172154029 0.9173845 c-SC-s-c-SC-m 0.010030495 -0.0018633838 0.0219243740 0.1715249 t-CS-m-c-SC-m 0.011157290 -0.0007365885 0.0230511693 0.0844429 t-CS-s-c-SC-m 0.002249754 -0.0105070951 0.0150066025 0.9994676 t-SC-m-c-SC-m 0.022034542 0.0101406631 0.0339284209 0.0000007 t-SC-s-c-SC-m 0.012762042 0.0008681634 0.0246559212 0.0254281 t-CS-m-c-SC-s 0.001126795 -0.0110760670 0.0133296576 0.9999933 t-CS-s-c-SC-s -0.007780741 -0.0208261499 0.0052646671 0.6124779 t-SC-m-c-SC-s 0.012004047 -0.0001988153 0.0242069092 0.0576505 t-SC-s-c-SC-s 0.002731547 -0.0094713150 0.0149344095 0.9975071 t-CS-s-t-CS-m -0.008907537 -0.0219529452 0.0041378718 0.4328019 t-SC-m-t-CS-m 0.010877252 -0.0013256106 0.0230801139 0.1214891 t-SC-s-t-CS-m 0.001604752 -0.0105981103 0.0138076142 0.9999252 t-SC-m-t-CS-s 0.019784788 0.0067393798 0.0328301968 0.0001243 t-SC-s-t-CS-s 0.010512289 -0.0025331199 0.0235576972 0.2198204 t-SC-s-t-SC-m -0.009272500 -0.0214753619 0.0029303626 0.2902342
MEK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1298 0.018540 11.83 1.4e-14 *** Residuals 1072 1.6797
0.001567
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.006449933 -0.0078112465 0.0207111130 0.8692595 c-SC-m-c-CS-m -0.010163236 -0.0240440495 0.0037175767 0.3382936 c-SC-s-c-CS-m 0.001289523 -0.0129716570 0.0155507025 0.9999942 t-CS-m-c-CS-m -0.012230834 -0.0264920133 0.0020303462 0.1552784 t-CS-s-c-CS-m -0.008353993 -0.0236499044 0.0069419177 0.7140427 t-SC-m-c-CS-m 0.018538508 0.0042773284 0.0327996879 0.0021376 t-SC-s-c-CS-m 0.016627914 0.0023667344 0.0308890940 0.0098512 c-SC-m-c-CS-s -0.016613170 -0.0308743494 -0.0023519899 0.0099608 c-SC-s-c-CS-s -0.005160411 -0.0197920722 0.0094712512 0.9626553 t-CS-m-c-CS-s -0.018680767 -0.0333124286 -0.0040491051 0.0028216 t-CS-s-c-CS-s -0.014803927 -0.0304458310 0.0008379777 0.0788931 t-SC-m-c-CS-s 0.012088575 -0.0025430868 0.0267202366 0.1925644 t-SC-s-c-CS-s 0.010177981 -0.0044536808 0.0248096427 0.4073689 c-SC-s-c-SC-m 0.011452759 -0.0028084206 0.0257139389 0.2236887 t-CS-m-c-SC-m -0.002067597 -0.0163287770 0.0121935826 0.9998555 t-CS-s-c-SC-m 0.001809243 -0.0134866680 0.0171051541 0.9999636 t-SC-m-c-SC-m 0.028701745 0.0144405648 0.0429629243 0.0000000 t-SC-s-c-SC-m 0.026791151 0.0125299708 0.0410523304 0.0000004 t-CS-m-c-SC-s -0.013520356 -0.0281520181 0.0011113054 0.0944605 t-CS-s-c-SC-s -0.009643516 -0.0252854205 0.0059983882 0.5703756 t-SC-m-c-SC-s 0.017248985 0.0026173237 0.0318806471 0.0085705 t-SC-s-c-SC-s 0.015338391 0.0007067297 0.0299700532 0.0321846 t-CS-s-t-CS-m 0.003876840 -0.0117650641 0.0195187445 0.9952765 t-SC-m-t-CS-m 0.030769342 0.0161376800 0.0454010035 0.0000000 t-SC-s-t-CS-m 0.028858748 0.0142270861 0.0434904095 0.0000001 t-SC-m-t-CS-s 0.026892502 0.0112505972 0.0425344059 0.0000059 t-SC-s-t-CS-s 0.024981908 0.0093400032 0.0406238119 0.0000387 t-SC-s-t-SC-m -0.001910594 -0.0165422557 0.0127210678 0.9999287
TRKA
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.183 0.16906 12.48 1.95e-15 *** Residuals 1072 14.525
0.01355
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.020444568 -0.062381945 0.0214928097 0.8179340 c-SC-m-c-CS-m -0.107354214 -0.148173060 -0.0665353686 0.0000000 c-SC-s-c-CS-m -0.042676179 -0.084613557 -0.0007388018 0.0427136 t-CS-m-c-CS-m -0.036760204 -0.078697581 0.0051771737 0.1355626 t-CS-s-c-CS-m -0.018498102 -0.063478280 0.0264820748 0.9169030 t-SC-m-c-CS-m -0.002329355 -0.044266733 0.0396080220 0.9999998 t-SC-s-c-CS-m -0.026379632 -0.068317010 0.0155577453 0.5440499 c-SC-m-c-CS-s -0.086909647 -0.128847024 -0.0449722692 0.0000000 c-SC-s-c-CS-s -0.022231612 -0.065258453 0.0207952299 0.7687748 t-CS-m-c-CS-s -0.016315636 -0.059342477 0.0267112054 0.9450180 t-CS-s-c-CS-s 0.001946465 -0.044051163 0.0479440935 1.0000000 t-SC-m-c-CS-s 0.018115212 -0.024911629 0.0611420537 0.9067600 t-SC-s-c-CS-s -0.005935064 -0.048961906 0.0370917770 0.9998967 c-SC-s-c-SC-m 0.064678035 0.022740658 0.1066154126 0.0000863 t-CS-m-c-SC-m 0.070594011 0.028656633 0.1125313881 0.0000104 t-CS-s-c-SC-m 0.088856112 0.043875935 0.1338362893 0.0000001 t-SC-m-c-SC-m 0.105024859 0.063087482 0.1469622365 0.0000000 t-SC-s-c-SC-m 0.080974582 0.039037205 0.1229119597 0.0000002 t-CS-m-c-SC-s 0.005915976 -0.037110866 0.0489428169 0.9998989 t-CS-s-c-SC-s 0.024178077 -0.021819551 0.0701757051 0.7526488 t-SC-m-c-SC-s 0.040346824 -0.002680018 0.0833736653 0.0846869 t-SC-s-c-SC-s 0.016296547 -0.026730294 0.0593233885 0.9453534 t-CS-s-t-CS-m 0.018262101 -0.027735527 0.0642597295 0.9303426 t-SC-m-t-CS-m 0.034430848 -0.008595993 0.0774576897 0.2277504 t-SC-s-t-CS-m 0.010380572 -0.032646270 0.0534074130 0.9960057 t-SC-m-t-CS-s 0.016168747 -0.029828881 0.0621663754 0.9633285 t-SC-s-t-CS-s -0.007881530 -0.053879158 0.0381160986 0.9995598 t-SC-s-t-SC-m -0.024050277 -0.067077118 0.0189765647 0.6889746
RSK
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0441 0.006304 8.366 5.58e-10 *** Residuals 1072 0.8078
0.000754
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0018248440 -0.0080650212 1.171471e-02 0.9992834 c-SC-m-c-CS-m 0.0027439149 -0.0068821729 1.237000e-02 0.9889417 c-SC-s-c-CS-m 0.0036499936 -0.0062398715 1.353986e-02 0.9523295 t-CS-m-c-CS-m -0.0050431291 -0.0149329942 4.846736e-03 0.7806517 t-CS-s-c-CS-m -0.0071646890 -0.0177721212 3.442743e-03 0.4476787 t-SC-m-c-CS-m 0.0161769525 0.0062870874 2.606682e-02 0.0000217 t-SC-s-c-CS-m 0.0039079849 -0.0059818802 1.379785e-02 0.9319956 c-SC-m-c-CS-s 0.0009190709 -0.0089707942 1.080894e-02 0.9999930 c-SC-s-c-CS-s 0.0018251497 -0.0083216378 1.197194e-02 0.9993937 t-CS-m-c-CS-s -0.0068679731 -0.0170147606 3.278814e-03 0.4447971 t-CS-s-c-CS-s -0.0089895330 -0.0198369051 1.857839e-03 0.1893425 t-SC-m-c-CS-s 0.0143521086 0.0042053211 2.449890e-02 0.0005024 t-SC-s-c-CS-s 0.0020831409 -0.0080636466 1.222993e-02 0.9985661 c-SC-s-c-SC-m 0.0009060788 -0.0089837864 1.079594e-02 0.9999937 t-CS-m-c-SC-m -0.0077870440 -0.0176769091 2.102821e-03 0.2466154 t-CS-s-c-SC-m -0.0099086039 -0.0205160361 6.988283e-04 0.0871745 t-SC-m-c-SC-m 0.0134330376 0.0035431725 2.332290e-02 0.0010387 t-SC-s-c-SC-m 0.0011640700 -0.0087257951 1.105394e-02 0.9999648 t-CS-m-c-SC-s -0.0086931227 -0.0188399103 1.453665e-03 0.1562608 t-CS-s-c-SC-s -0.0108146827 -0.0216620548 3.268947e-05 0.0513465 t-SC-m-c-SC-s 0.0125269589 0.0023801714 2.267375e-02 0.0046094 t-SC-s-c-SC-s 0.0002579912 -0.0098887963 1.040478e-02 1.0000000 t-CS-s-t-CS-m -0.0021215599 -0.0129689320 8.725812e-03 0.9989522 t-SC-m-t-CS-m 0.0212200816 0.0110732941 3.136687e-02 0.0000000 t-SC-s-t-CS-m 0.0089511140 -0.0011956735 1.909790e-02 0.1300936 t-SC-m-t-CS-s 0.0233416415 0.0124942694 3.418901e-02 0.0000000 t-SC-s-t-CS-s 0.0110726739 0.0002253018 2.192005e-02 0.0415102 t-SC-s-t-SC-m -0.0122689677 -0.0224157552 -2.122180e-03 0.0061428
APP
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.325 0.18933 75.03 <2e-16 *** Residuals 1072 2.705
0.00252
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0067320974 -0.024829755 0.01136556 0.9502946 c-SC-m-c-CS-m -0.0457832199 -0.063398186 -0.02816825 0.0000000 c-SC-s-c-CS-m -0.0354673940 -0.053565052 -0.01736974 0.0000001 t-CS-m-c-CS-m 0.0376120935 0.019514436 0.05570975 0.0000000 t-CS-s-c-CS-m 0.0448638756 0.025453128 0.06427462 0.0000000 t-SC-m-c-CS-m 0.0431192100 0.025021552 0.06121687 0.0000000 t-SC-s-c-CS-m 0.0434798746 0.025382217 0.06157753 0.0000000 c-SC-m-c-CS-s -0.0390511225 -0.057148780 -0.02095346 0.0000000 c-SC-s-c-CS-s -0.0287352966 -0.047303102 -0.01016749 0.0000799 t-CS-m-c-CS-s 0.0443441909 0.025776386 0.06291200 0.0000000 t-CS-s-c-CS-s 0.0515959729 0.031746154 0.07144579 0.0000000 t-SC-m-c-CS-s 0.0498513074 0.031283502 0.06841911 0.0000000 t-SC-s-c-CS-s 0.0502119720 0.031644167 0.06877978 0.0000000 c-SC-s-c-SC-m 0.0103158259 -0.007781832 0.02841348 0.6668355 t-CS-m-c-SC-m 0.0833953133 0.065297656 0.10149297 0.0000000 t-CS-s-c-SC-m 0.0906470954 0.071236348 0.11005784 0.0000000 t-SC-m-c-SC-m 0.0889024299 0.070804772 0.10700009 0.0000000 t-SC-s-c-SC-m 0.0892630945 0.071165437 0.10736075 0.0000000 t-CS-m-c-SC-s 0.0730794874 0.054511682 0.09164729 0.0000000 t-CS-s-c-SC-s 0.0803312695 0.060481451 0.10018109 0.0000000 t-SC-m-c-SC-s 0.0785866039 0.060018799 0.09715441 0.0000000 t-SC-s-c-SC-s 0.0789472686 0.060379463 0.09751507 0.0000000 t-CS-s-t-CS-m 0.0072517821 -0.012598037 0.02710160 0.9548412 t-SC-m-t-CS-m 0.0055071165 -0.013060689 0.02407492 0.9860143 t-SC-s-t-CS-m 0.0058677812 -0.012700024 0.02443559 0.9797892 t-SC-m-t-CS-s -0.0017446656 -0.021594484 0.01810515 0.9999952 t-SC-s-t-CS-s -0.0013840009 -0.021233820 0.01846582 0.9999990 t-SC-s-t-SC-m 0.0003606647 -0.018207140 0.01892847 1.0000000
Bcatenin
Df Sum Sq Mean Sq F value Pr(>F) class 7 15.24 2.1764 12.52 1.73e-15 *** Residuals 1072 186.42
0.1739
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.078734926 -0.071505517 0.228975368 0.7555265 c-SC-m-c-CS-m -0.179207372 -0.325440680 -0.032974063 0.0051114 c-SC-s-c-CS-m 0.105545793 -0.044694650 0.255786236 0.3939075 t-CS-m-c-CS-m -0.112739980 -0.262980423 0.037500462 0.3062148 t-CS-s-c-CS-m -0.153105273 -0.314246531 0.008035985 0.0765308 t-SC-m-c-CS-m 0.146492489 -0.003747954 0.296732932 0.0620987 t-SC-s-c-CS-m 0.086318302 -0.063922141 0.236558745 0.6576524 c-SC-m-c-CS-s -0.257942297 -0.408182740 -0.107701854 0.0000061 c-SC-s-c-CS-s 0.026810868 -0.127332574 0.180954309 0.9995140 t-CS-m-c-CS-s -0.191474906 -0.345618348 -0.037331464 0.0042242 t-CS-s-c-CS-s -0.231840199 -0.396626469 -0.067053928 0.0005548 t-SC-m-c-CS-s 0.067757563 -0.086385878 0.221901005 0.8854261 t-SC-s-c-CS-s 0.007583376 -0.146560066 0.161726818 0.9999999 c-SC-s-c-SC-m 0.284753165 0.134512722 0.434993607 0.0000003 t-CS-m-c-SC-m 0.066467391 -0.083773052 0.216707834 0.8819301 t-CS-s-c-SC-m 0.026102098 -0.135039159 0.187243356 0.9996967 t-SC-m-c-SC-m 0.325699861 0.175459418 0.475940303 0.0000000 t-SC-s-c-SC-m 0.265525673 0.115285231 0.415766116 0.0000027 t-CS-m-c-SC-s -0.218285774 -0.372429215 -0.064142332 0.0004914 t-CS-s-c-SC-s -0.258651066 -0.423437337 -0.093864795 0.0000580 t-SC-m-c-SC-s 0.040946696 -0.113196746 0.195090138 0.9927682 t-SC-s-c-SC-s -0.019227491 -0.173370933 0.134915951 0.9999477 t-CS-s-t-CS-m -0.040365293 -0.205151563 0.124420978 0.9956088 t-SC-m-t-CS-m 0.259232470 0.105089028 0.413375911 0.0000107 t-SC-s-t-CS-m 0.199058282 0.044914841 0.353201724 0.0023693 t-SC-m-t-CS-s 0.299597762 0.134811491 0.464384033 0.0000012 t-SC-s-t-CS-s 0.239423575 0.074637304 0.404209846 0.0003003 t-SC-s-t-SC-m -0.060174187 -0.214317629 0.093969255 0.9360894
SOD1
Df Sum Sq Mean Sq F value Pr(>F) class 7 55.8 7.971 294.7 <2e-16 *** Residuals 1072 29.0
0.027
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.005945404 -0.06519928 0.05330847 0.9999882 c-SC-m-c-CS-m 0.290087365 0.23241388 0.34776085 0.0000000 c-SC-s-c-CS-m 0.525298263 0.46604439 0.58455213 0.0000000 t-CS-m-c-CS-m -0.022966264 -0.08222014 0.03628761 0.9384011 t-CS-s-c-CS-m -0.014990698 -0.07854378 0.04856239 0.9965315 t-SC-m-c-CS-m 0.501427053 0.44217318 0.56068092 0.0000000 t-SC-s-c-CS-m 0.390645082 0.33139121 0.44989895 0.0000000 c-SC-m-c-CS-s 0.296032769 0.23677890 0.35528664 0.0000000 c-SC-s-c-CS-s 0.531243667 0.47045048 0.59203686 0.0000000 t-CS-m-c-CS-s -0.017020860 -0.07781405 0.04377233 0.9900657 t-CS-s-c-CS-s -0.009045294 -0.07403595 0.05594536 0.9998902 t-SC-m-c-CS-s 0.507372457 0.44657927 0.56816565 0.0000000 t-SC-s-c-CS-s 0.396590486 0.33579730 0.45738368 0.0000000 c-SC-s-c-SC-m 0.235210898 0.17595703 0.29446477 0.0000000 t-CS-m-c-SC-m -0.313053629 -0.37230750 -0.25379976 0.0000000 t-CS-s-c-SC-m -0.305078063 -0.36863115 -0.24152498 0.0000000 t-SC-m-c-SC-m 0.211339688 0.15208582 0.27059356 0.0000000 t-SC-s-c-SC-m 0.100557717 0.04130384 0.15981159 0.0000084 t-CS-m-c-SC-s -0.548264527 -0.60905772 -0.48747134 0.0000000 t-CS-s-c-SC-s -0.540288961 -0.60527961 -0.47529831 0.0000000 t-SC-m-c-SC-s -0.023871210 -0.08466440 0.03692198 0.9341510 t-SC-s-c-SC-s -0.134653181 -0.19544637 -0.07385999 0.0000000 t-CS-s-t-CS-m 0.007975566 -0.05701509 0.07296622 0.9999532 t-SC-m-t-CS-m 0.524393317 0.46360013 0.58518651 0.0000000 t-SC-s-t-CS-m 0.413611346 0.35281816 0.47440454 0.0000000 t-SC-m-t-CS-s 0.516417751 0.45142710 0.58140840 0.0000000 t-SC-s-t-CS-s 0.405635779 0.34064513 0.47062643 0.0000000 t-SC-s-t-SC-m -0.110781971 -0.17157516 -0.04998878 0.0000011
MTOR
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.262 0.18030 57.65 <2e-16 *** Residuals 1072 3.353
0.00313
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0333711243 -0.053519718 -0.0132225309 0.0000158 c-SC-m-c-CS-m -0.0165677598 -0.036178960 0.0030434410 0.1697903 c-SC-s-c-CS-m 0.0047095725 -0.015439021 0.0248581659 0.9967239 t-CS-m-c-CS-m -0.0794342510 -0.099582844 -0.0592856576 0.0000000 t-CS-s-c-CS-m -0.0893044815 -0.110914972 -0.0676939908 0.0000000 t-SC-m-c-CS-m 0.0120027520 -0.008145841 0.0321513454 0.6139859 t-SC-s-c-CS-m -0.0163747363 -0.036523330 0.0037738570 0.2103458 c-SC-m-c-CS-s 0.0168033645 -0.003345229 0.0369519579 0.1828018 c-SC-s-c-CS-s 0.0380806968 0.017408676 0.0587527174 0.0000008 t-CS-m-c-CS-s -0.0460631267 -0.066735147 -0.0253911061 0.0000000 t-CS-s-c-CS-s -0.0559333572 -0.078032677 -0.0338340376 0.0000000 t-SC-m-c-CS-s 0.0453738763 0.024701856 0.0660458969 0.0000000 t-SC-s-c-CS-s 0.0169963879 -0.003675633 0.0376684086 0.1977231 c-SC-s-c-SC-m 0.0212773322 0.001128739 0.0414259256 0.0299213 t-CS-m-c-SC-m -0.0628664912 -0.083015085 -0.0427178978 0.0000000 t-CS-s-c-SC-m -0.0727367217 -0.094347212 -0.0511262311 0.0000000 t-SC-m-c-SC-m 0.0285705117 0.008421918 0.0487191051 0.0004794 t-SC-s-c-SC-m 0.0001930234 -0.019955570 0.0203416168 1.0000000 t-CS-m-c-SC-s -0.0841438235 -0.104815844 -0.0634718028 0.0000000 t-CS-s-c-SC-s -0.0940140540 -0.116113374 -0.0719147343 0.0000000 t-SC-m-c-SC-s 0.0072931795 -0.013378841 0.0279652001 0.9625881 t-SC-s-c-SC-s -0.0210843088 -0.041756329 -0.0004122882 0.0418225 t-CS-s-t-CS-m -0.0098702305 -0.031969550 0.0122290891 0.8765988 t-SC-m-t-CS-m 0.0914370030 0.070764982 0.1121090236 0.0000000 t-SC-s-t-CS-m 0.0630595146 0.042387494 0.0837315353 0.0000000 t-SC-m-t-CS-s 0.1013072335 0.079207914 0.1234065531 0.0000000 t-SC-s-t-CS-s 0.0729297451 0.050830426 0.0950290648 0.0000000 t-SC-s-t-SC-m -0.0283774883 -0.049049509 -0.0077054677 0.0008638
P38
Df Sum Sq Mean Sq F value Pr(>F) class 7 4.017 0.5738 134.8 <2e-16 *** Residuals 1072 4.562
0.0043
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.03751654 -0.061020264 -0.014012813 0.0000392 c-SC-m-c-CS-m 0.07899054 0.056113695 0.101867388 0.0000000 c-SC-s-c-CS-m 0.05995953 0.036455807 0.083463257 0.0000000 t-CS-m-c-CS-m -0.05643761 -0.079941331 -0.032933881 0.0000000 t-CS-s-c-CS-m -0.09484918 -0.120058238 -0.069640124 0.0000000 t-SC-m-c-CS-m 0.09071735 0.067213622 0.114221073 0.0000000 t-SC-s-c-CS-m 0.02178110 -0.001722627 0.045284823 0.0924900 c-SC-m-c-CS-s 0.11650708 0.093003354 0.140010805 0.0000000 c-SC-s-c-CS-s 0.09747607 0.073361757 0.121590384 0.0000000 t-CS-m-c-CS-s -0.01892107 -0.043035381 0.005193246 0.2507586 t-CS-s-c-CS-s -0.05733264 -0.083111928 -0.031553358 0.0000000 t-SC-m-c-CS-s 0.12823389 0.104119572 0.152348199 0.0000000 t-SC-s-c-CS-s 0.05929764 0.035183323 0.083411950 0.0000000 c-SC-s-c-SC-m -0.01903101 -0.042534735 0.004472716 0.2144410 t-CS-m-c-SC-m -0.13542815 -0.158931873 -0.111924422 0.0000000 t-CS-s-c-SC-m -0.17383972 -0.199048780 -0.148630666 0.0000000 t-SC-m-c-SC-m 0.01172681 -0.011776920 0.035230531 0.7993483 t-SC-s-c-SC-m -0.05720944 -0.080713169 -0.033705718 0.0000000 t-CS-m-c-SC-s -0.11639714 -0.140511451 -0.092282825 0.0000000 t-CS-s-c-SC-s -0.15480871 -0.180587999 -0.129029428 0.0000000 t-SC-m-c-SC-s 0.03075782 0.006643502 0.054872128 0.0028632 t-SC-s-c-SC-s -0.03817843 -0.062292747 -0.014064121 0.0000475 t-CS-s-t-CS-m -0.03841158 -0.064190861 -0.012632290 0.0001805 t-SC-m-t-CS-m 0.14715495 0.123040640 0.171269266 0.0000000 t-SC-s-t-CS-m 0.07821870 0.054104391 0.102333017 0.0000000 t-SC-m-t-CS-s 0.18556653 0.159787243 0.211345814 0.0000000 t-SC-s-t-CS-s 0.11663028 0.090850994 0.142409565 0.0000000 t-SC-s-t-SC-m -0.06893625 -0.093050563 -0.044821936 0.0000000
pMTOR
Df Sum Sq Mean Sq F value Pr(>F) class 7 5.776 0.8251 85.4 <2e-16 *** Residuals 1072 10.358
0.0097
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.02635155 -0.061766004 0.009062898 0.3171270 c-SC-m-c-CS-m 0.06750119 0.033031291 0.101971082 0.0000001 c-SC-s-c-CS-m 0.02820844 -0.007206013 0.063622889 0.2330787 t-CS-m-c-CS-m -0.09746945 -0.132883899 -0.062054996 0.0000000 t-CS-s-c-CS-m -0.12123091 -0.159214881 -0.083246930 0.0000000 t-SC-m-c-CS-m 0.12166942 0.086254972 0.157083875 0.0000000 t-SC-s-c-CS-m -0.02301008 -0.058424535 0.012404368 0.5006244 c-SC-m-c-CS-s 0.09385274 0.058438288 0.129267191 0.0000000 c-SC-s-c-CS-s 0.05455999 0.018225531 0.090894451 0.0001536 t-CS-m-c-CS-s -0.07111789 -0.107452355 -0.034783434 0.0000001 t-CS-s-c-CS-s -0.09487935 -0.133722525 -0.056036181 0.0000000 t-SC-m-c-CS-s 0.14802098 0.111686516 0.184355437 0.0000000 t-SC-s-c-CS-s 0.00334147 -0.032992991 0.039675930 0.9999935 c-SC-s-c-SC-m -0.03929275 -0.074707200 -0.003878297 0.0177203 t-CS-m-c-SC-m -0.16497063 -0.200385085 -0.129556183 0.0000000 t-CS-s-c-SC-m -0.18873209 -0.226716067 -0.150748117 0.0000000 t-SC-m-c-SC-m 0.05416824 0.018753785 0.089582688 0.0001035 t-SC-s-c-SC-m -0.09051127 -0.125925721 -0.055096819 0.0000000 t-CS-m-c-SC-s -0.12567789 -0.162012346 -0.089343425 0.0000000 t-CS-s-c-SC-s -0.14943934 -0.188282516 -0.110596172 0.0000000 t-SC-m-c-SC-s 0.09346099 0.057126525 0.129795446 0.0000000 t-SC-s-c-SC-s -0.05121852 -0.087552982 -0.014884061 0.0005352 t-CS-s-t-CS-m -0.02376146 -0.062604630 0.015081714 0.5804492 t-SC-m-t-CS-m 0.21913887 0.182804411 0.255473331 0.0000000 t-SC-s-t-CS-m 0.07445936 0.038124904 0.110793824 0.0000000 t-SC-m-t-CS-s 0.24290033 0.204057157 0.281743501 0.0000000 t-SC-s-t-CS-s 0.09822082 0.059377650 0.137063994 0.0000000 t-SC-s-t-SC-m -0.14467951 -0.181013967 -0.108345046 0.0000000
DSCR1
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.257 0.17950 19.98 <2e-16 *** Residuals 1072 9.633
0.00899
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0218913743 -0.056044521 0.0122617727 0.5189403 c-SC-m-c-CS-m 0.0004473917 -0.032794841 0.0336896240 1.0000000 c-SC-s-c-CS-m -0.0345936738 -0.068746821 -0.0004405267 0.0445700 t-CS-m-c-CS-m -0.0480886402 -0.082241787 -0.0139354932 0.0005467 t-CS-s-c-CS-m -0.0466905049 -0.083321661 -0.0100593491 0.0028935 t-SC-m-c-CS-m 0.0662664150 0.032113268 0.1004195620 0.0000001 t-SC-s-c-CS-m -0.0061790738 -0.040332221 0.0279740732 0.9993701 c-SC-m-c-CS-s 0.0223387660 -0.011814381 0.0564919130 0.4915924 c-SC-s-c-CS-s -0.0127022995 -0.047742689 0.0223380900 0.9566812 t-CS-m-c-CS-s -0.0261972659 -0.061237655 0.0088431236 0.3109759 t-CS-s-c-CS-s -0.0247991307 -0.062258883 0.0126606214 0.4751442 t-SC-m-c-CS-s 0.0881577893 0.053117400 0.1231981788 0.0000000 t-SC-s-c-CS-s 0.0157123005 -0.019328089 0.0507526900 0.8743166 c-SC-s-c-SC-m -0.0350410655 -0.069194212 -0.0008879184 0.0395790 t-CS-m-c-SC-m -0.0485360319 -0.082689179 -0.0143828848 0.0004599 t-CS-s-c-SC-m -0.0471378966 -0.083769052 -0.0105067408 0.0025023 t-SC-m-c-SC-m 0.0658190233 0.031665876 0.0999721703 0.0000002 t-SC-s-c-SC-m -0.0066264655 -0.040779613 0.0275266815 0.9990054 t-CS-m-c-SC-s -0.0134949664 -0.048535356 0.0215454231 0.9403977 t-CS-s-c-SC-s -0.0120968312 -0.049556583 0.0253629209 0.9771347 t-SC-m-c-SC-s 0.1008600888 0.065819699 0.1359004783 0.0000000 t-SC-s-c-SC-s 0.0284145999 -0.006625790 0.0634549894 0.2127838 t-CS-s-t-CS-m 0.0013981352 -0.036061617 0.0388578873 1.0000000 t-SC-m-t-CS-m 0.1143550552 0.079314666 0.1493954447 0.0000000 t-SC-s-t-CS-m 0.0419095663 0.006869177 0.0769499558 0.0071046 t-SC-m-t-CS-s 0.1129569199 0.075497168 0.1504166720 0.0000000 t-SC-s-t-CS-s 0.0405114311 0.003051679 0.0779711832 0.0234155 t-SC-s-t-SC-m -0.0724454888 -0.107485878 -0.0374050993 0.0000000
AMPKA
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.612 0.08737 26 <2e-16 *** Residuals 1072 3.603
0.00336
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0003345053 -0.021220852 0.020551841 1.0000000 c-SC-m-c-CS-m -0.0296262865 -0.049955563 -0.009297010 0.0002829 c-SC-s-c-CS-m -0.0276177285 -0.048504075 -0.006731382 0.0016274 t-CS-m-c-CS-m -0.0657155736 -0.086601920 -0.044829227 0.0000000 t-CS-s-c-CS-m -0.0615675632 -0.083969335 -0.039165791 0.0000000 t-SC-m-c-CS-m -0.0027817774 -0.023668124 0.018104569 0.9999184 t-SC-s-c-CS-m -0.0279642894 -0.048850636 -0.007077943 0.0013251 c-SC-m-c-CS-s -0.0292917812 -0.050178127 -0.008405435 0.0005883 c-SC-s-c-CS-s -0.0272832232 -0.048712162 -0.005854284 0.0029424 t-CS-m-c-CS-s -0.0653810682 -0.086810007 -0.043952129 0.0000000 t-CS-s-c-CS-s -0.0612330578 -0.084141557 -0.038324558 0.0000000 t-SC-m-c-CS-s -0.0024472720 -0.023876211 0.018981667 0.9999713 t-SC-s-c-CS-s -0.0276297840 -0.049058723 -0.006200845 0.0024273 c-SC-s-c-SC-m 0.0020085579 -0.018877788 0.022894904 0.9999912 t-CS-m-c-SC-m -0.0360892871 -0.056975633 -0.015202941 0.0000051 t-CS-s-c-SC-m -0.0319412767 -0.054343049 -0.009539505 0.0004320 t-SC-m-c-SC-m 0.0268445091 0.005958163 0.047730855 0.0025493 t-SC-s-c-SC-m 0.0016619971 -0.019224349 0.022548343 0.9999976 t-CS-m-c-SC-s -0.0380978450 -0.059526784 -0.016668906 0.0000023 t-CS-s-c-SC-s -0.0339498346 -0.056858334 -0.011041335 0.0002018 t-SC-m-c-SC-s 0.0248359512 0.003407012 0.046264890 0.0106112 t-SC-s-c-SC-s -0.0003465608 -0.021775500 0.021082378 1.0000000 t-CS-s-t-CS-m 0.0041480104 -0.018760489 0.027056510 0.9993667 t-SC-m-t-CS-m 0.0629337962 0.041504857 0.084362735 0.0000000 t-SC-s-t-CS-m 0.0377512842 0.016322345 0.059180223 0.0000030 t-SC-m-t-CS-s 0.0587857858 0.035877286 0.081694285 0.0000000 t-SC-s-t-CS-s 0.0336032738 0.010694774 0.056511773 0.0002484 t-SC-s-t-SC-m -0.0251825120 -0.046611451 -0.003753573 0.0089224
NR2B
Df Sum Sq Mean Sq F value Pr(>F) class 7 2.241 0.3201 55.98 <2e-16 *** Residuals 1072 6.130
0.0057
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.037537101 -0.064781532 -0.010292671 0.0008097 c-SC-m-c-CS-m -0.017941899 -0.044459680 0.008575883 0.4453300 c-SC-s-c-CS-m 0.003514339 -0.023730092 0.030758770 0.9999343 t-CS-m-c-CS-m -0.087018627 -0.114263058 -0.059774197 0.0000000 t-CS-s-c-CS-m -0.123576702 -0.152797874 -0.094355530 0.0000000 t-SC-m-c-CS-m 0.034503509 0.007259078 0.061747940 0.0031861 t-SC-s-c-CS-m -0.022036403 -0.049280834 0.005208027 0.2156276 c-SC-m-c-CS-s 0.019595203 -0.007649228 0.046839633 0.3620729 c-SC-s-c-CS-s 0.041051440 0.013099244 0.069003636 0.0002424 t-CS-m-c-CS-s -0.049481526 -0.077433722 -0.021529330 0.0000026 t-CS-s-c-CS-s -0.086039601 -0.115921755 -0.056157446 0.0000000 t-SC-m-c-CS-s 0.072040610 0.044088414 0.099992806 0.0000000 t-SC-s-c-CS-s 0.015500698 -0.012451498 0.043452894 0.6976997 c-SC-s-c-SC-m 0.021456238 -0.005788193 0.048700668 0.2463599 t-CS-m-c-SC-m -0.069076729 -0.096321159 -0.041832298 0.0000000 t-CS-s-c-SC-m -0.105634804 -0.134855976 -0.076413632 0.0000000 t-SC-m-c-SC-m 0.052445408 0.025200977 0.079689838 0.0000002 t-SC-s-c-SC-m -0.004094505 -0.031338935 0.023149926 0.9998161 t-CS-m-c-SC-s -0.090532966 -0.118485162 -0.062580770 0.0000000 t-CS-s-c-SC-s -0.127091041 -0.156973196 -0.097208887 0.0000000 t-SC-m-c-SC-s 0.030989170 0.003036974 0.058941366 0.0178752 t-SC-s-c-SC-s -0.025550742 -0.053502938 0.002401454 0.1021374 t-CS-s-t-CS-m -0.036558075 -0.066440230 -0.006675920 0.0052333 t-SC-m-t-CS-m 0.121522136 0.093569940 0.149474332 0.0000000 t-SC-s-t-CS-m 0.064982224 0.037030028 0.092934420 0.0000000 t-SC-m-t-CS-s 0.158080211 0.128198057 0.187962366 0.0000000 t-SC-s-t-CS-s 0.101540299 0.071658144 0.131422453 0.0000000 t-SC-s-t-SC-m -0.056539912 -0.084492108 -0.028587716 0.0000000
pNUMB
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.300 0.18572 66.94 <2e-16 *** Residuals 1072 2.974
0.00277
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.013763461 -0.0327400086 0.005213086 0.3508570 c-SC-m-c-CS-m -0.077611127 -0.0960815422 -0.059140712 0.0000000 c-SC-s-c-CS-m -0.115221949 -0.1341984960 -0.096245401 0.0000000 t-CS-m-c-CS-m -0.073091393 -0.0920679408 -0.054114846 0.0000000 t-CS-s-c-CS-m -0.047316777 -0.0676701832 -0.026963371 0.0000000 t-SC-m-c-CS-m -0.052077539 -0.0710540870 -0.033100992 0.0000000 t-SC-s-c-CS-m -0.053143682 -0.0721202300 -0.034167135 0.0000000 c-SC-m-c-CS-s -0.063847666 -0.0828242136 -0.044871119 0.0000000 c-SC-s-c-CS-s -0.101458487 -0.1209280144 -0.081988960 0.0000000 t-CS-m-c-CS-s -0.059327932 -0.0787974592 -0.039858405 0.0000000 t-CS-s-c-CS-s -0.033553316 -0.0543671159 -0.012739516 0.0000309 t-SC-m-c-CS-s -0.038314078 -0.0577836054 -0.018844551 0.0000001 t-SC-s-c-CS-s -0.039380221 -0.0588497483 -0.019910694 0.0000000 c-SC-s-c-SC-m -0.037610821 -0.0565873689 -0.018634274 0.0000001 t-CS-m-c-SC-m 0.004519734 -0.0144568137 0.023496281 0.9963142 t-CS-s-c-SC-m 0.030294350 0.0099409439 0.050647756 0.0001845 t-SC-m-c-SC-m 0.025533588 0.0065570401 0.044510135 0.0012193 t-SC-s-c-SC-m 0.024467445 0.0054908971 0.043443992 0.0024277 t-CS-m-c-SC-s 0.042130555 0.0226610283 0.061600082 0.0000000 t-CS-s-c-SC-s 0.067905171 0.0470913716 0.088718971 0.0000000 t-SC-m-c-SC-s 0.063144409 0.0436748821 0.082613936 0.0000000 t-SC-s-c-SC-s 0.062078266 0.0426087391 0.081547793 0.0000000 t-CS-s-t-CS-m 0.025774616 0.0049608163 0.046588416 0.0044148 t-SC-m-t-CS-m 0.021013854 0.0015443268 0.040483381 0.0239113 t-SC-s-t-CS-m 0.019947711 0.0004781839 0.039417238 0.0401022 t-SC-m-t-CS-s -0.004760762 -0.0255745622 0.016053037 0.9971420 t-SC-s-t-CS-s -0.005826905 -0.0266407051 0.014986894 0.9900712 t-SC-s-t-SC-m -0.001066143 -0.0205356699 0.018403384 0.9999998
RAPTOR
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.6563 0.09375 40.19 <2e-16 *** Residuals 1072 2.5007
0.00233
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0056832449 -0.023084151 0.011717661 0.9756198 c-SC-m-c-CS-m -0.0035997972 -0.020536595 0.013337001 0.9982083 c-SC-s-c-CS-m -0.0204592817 -0.037860187 -0.003058376 0.0088651 t-CS-m-c-CS-m -0.0484820093 -0.065882915 -0.031081104 0.0000000 t-CS-s-c-CS-m -0.0554131524 -0.074076595 -0.036749710 0.0000000 t-SC-m-c-CS-m 0.0278416309 0.010440725 0.045242537 0.0000371 t-SC-s-c-CS-m -0.0007154107 -0.018116316 0.016685495 1.0000000 c-SC-m-c-CS-s 0.0020834477 -0.015317458 0.019484353 0.9999604 c-SC-s-c-CS-s -0.0147760368 -0.032628989 0.003076916 0.1907058 t-CS-m-c-CS-s -0.0427987644 -0.060651717 -0.024945812 0.0000000 t-CS-s-c-CS-s -0.0497299075 -0.068815517 -0.030644299 0.0000000 t-SC-m-c-CS-s 0.0335248758 0.015671923 0.051377828 0.0000004 t-SC-s-c-CS-s 0.0049678342 -0.012885118 0.022820787 0.9904252 c-SC-s-c-SC-m -0.0168594846 -0.034260390 0.000541421 0.0654410 t-CS-m-c-SC-m -0.0448822121 -0.062283118 -0.027481306 0.0000000 t-CS-s-c-SC-m -0.0518133553 -0.070476797 -0.033149913 0.0000000 t-SC-m-c-SC-m 0.0314414281 0.014040522 0.048842334 0.0000014 t-SC-s-c-SC-m 0.0028843865 -0.014516519 0.020285292 0.9996465 t-CS-m-c-SC-s -0.0280227275 -0.045875680 -0.010169775 0.0000580 t-CS-s-c-SC-s -0.0349538707 -0.054039480 -0.015868262 0.0000009 t-SC-m-c-SC-s 0.0483009126 0.030447960 0.066153865 0.0000000 t-SC-s-c-SC-s 0.0197438711 0.001890919 0.037596824 0.0183738 t-CS-s-t-CS-m -0.0069311432 -0.026016752 0.012154466 0.9562591 t-SC-m-t-CS-m 0.0763236402 0.058470688 0.094176593 0.0000000 t-SC-s-t-CS-m 0.0477665986 0.029913646 0.065619551 0.0000000 t-SC-m-t-CS-s 0.0832547833 0.064169174 0.102340392 0.0000000 t-SC-s-t-CS-s 0.0546977418 0.035612133 0.073783351 0.0000000 t-SC-s-t-SC-m -0.0285570415 -0.046409994 -0.010704089 0.0000373
TIAM1
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.752 0.10738 27.92 <2e-16 *** Residuals 1072 4.123
0.00385
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.004952778 -0.017390836 0.027296393 0.9976573 c-SC-m-c-CS-m -0.019735863 -0.041483540 0.002011814 0.1074857 c-SC-s-c-CS-m -0.032166179 -0.054509793 -0.009822564 0.0003594 t-CS-m-c-CS-m -0.033814462 -0.056158076 -0.011470848 0.0001301 t-CS-s-c-CS-m -0.014816829 -0.038781602 0.009147944 0.5666773 t-SC-m-c-CS-m 0.044579971 0.022236357 0.066923586 0.0000001 t-SC-s-c-CS-m 0.028810835 0.006467221 0.051154449 0.0024251 c-SC-m-c-CS-s -0.024688641 -0.047032256 -0.002345027 0.0185525 c-SC-s-c-CS-s -0.037118957 -0.060043022 -0.014194892 0.0000278 t-CS-m-c-CS-s -0.038767240 -0.061691305 -0.015843176 0.0000092 t-CS-s-c-CS-s -0.019769607 -0.044276463 0.004737249 0.2186004 t-SC-m-c-CS-s 0.039627193 0.016703128 0.062551258 0.0000051 t-SC-s-c-CS-s 0.023858057 0.000933992 0.046782121 0.0345436 c-SC-s-c-SC-m -0.012430316 -0.034773930 0.009913299 0.6941884 t-CS-m-c-SC-m -0.014078599 -0.036422213 0.008265015 0.5417973 t-CS-s-c-SC-m 0.004919034 -0.019045739 0.028883807 0.9985678 t-SC-m-c-SC-m 0.064315835 0.041972220 0.086659449 0.0000000 t-SC-s-c-SC-m 0.048546698 0.026203084 0.070890313 0.0000000 t-CS-m-c-SC-s -0.001648283 -0.024572348 0.021275781 0.9999988 t-CS-s-c-SC-s 0.017349350 -0.007157506 0.041856206 0.3834507 t-SC-m-c-SC-s 0.076746150 0.053822085 0.099670215 0.0000000 t-SC-s-c-SC-s 0.060977014 0.038052949 0.083901078 0.0000000 t-CS-s-t-CS-m 0.018997633 -0.005509223 0.043504489 0.2653937 t-SC-m-t-CS-m 0.078394433 0.055470369 0.101318498 0.0000000 t-SC-s-t-CS-m 0.062625297 0.039701232 0.085549362 0.0000000 t-SC-m-t-CS-s 0.059396800 0.034889944 0.083903656 0.0000000 t-SC-s-t-CS-s 0.043627664 0.019120808 0.068134520 0.0000022 t-SC-s-t-SC-m -0.015769136 -0.038693201 0.007154928 0.4226533
pP70S6
Df Sum Sq Mean Sq F value Pr(>F) class 7 7.299 1.0427 58.67 <2e-16 *** Residuals 1072 19.050
0.0178
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.02746704 -0.020560420 0.075494507 0.6629998 c-SC-m-c-CS-m 0.09845898 0.051712475 0.145205476 0.0000000 c-SC-s-c-CS-m 0.05662646 0.008598996 0.104653923 0.0085554 t-CS-m-c-CS-m 0.06932086 0.021293399 0.117348326 0.0003417 t-CS-s-c-CS-m -0.04064710 -0.092159238 0.010865031 0.2440595 t-SC-m-c-CS-m 0.08616120 0.038133739 0.134188666 0.0000018 t-SC-s-c-CS-m 0.25969516 0.211667699 0.307722626 0.0000000 c-SC-m-c-CS-s 0.07099193 0.022964468 0.119019396 0.0002127 c-SC-s-c-CS-s 0.02915942 -0.020115722 0.078434554 0.6221909 t-CS-m-c-CS-s 0.04185382 -0.007421319 0.091128956 0.1644985 t-CS-s-c-CS-s -0.06811415 -0.120791486 -0.015436809 0.0023225 t-SC-m-c-CS-s 0.05869416 0.009419021 0.107969297 0.0074967 t-SC-s-c-CS-s 0.23222812 0.182952981 0.281503256 0.0000000 c-SC-s-c-SC-m -0.04183252 -0.089859980 0.006194947 0.1411272 t-CS-m-c-SC-m -0.02913811 -0.077165577 0.018889350 0.5910136 t-CS-s-c-SC-m -0.13910608 -0.190618214 -0.087593945 0.0000000 t-SC-m-c-SC-m -0.01229777 -0.060325237 0.035729690 0.9942241 t-SC-s-c-SC-m 0.16123619 0.113208723 0.209263650 0.0000000 t-CS-m-c-SC-s 0.01269440 -0.036580735 0.061969541 0.9940036 t-CS-s-c-SC-s -0.09727356 -0.149950902 -0.044596225 0.0000007 t-SC-m-c-SC-s 0.02953474 -0.019740395 0.078809881 0.6063235 t-SC-s-c-SC-s 0.20306870 0.153793565 0.252343841 0.0000000 t-CS-s-t-CS-m -0.10996797 -0.162645304 -0.057290628 0.0000000 t-SC-m-t-CS-m 0.01684034 -0.032434798 0.066115478 0.9685802 t-SC-s-t-CS-m 0.19037430 0.141099162 0.239649438 0.0000000 t-SC-m-t-CS-s 0.12680831 0.074130968 0.179485645 0.0000000 t-SC-s-t-CS-s 0.30034227 0.247664928 0.353019604 0.0000000 t-SC-s-t-SC-m 0.17353396 0.124258822 0.222809098 0.0000000
NUMB
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1581 0.022580 31.52 <2e-16 *** Residuals 1072 0.7680
0.000716
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.006296342 -0.0033470343 0.0159397183 0.4939987 c-SC-m-c-CS-m -0.020941215 -0.0303273880 -0.0115550415 0.0000000 c-SC-s-c-CS-m -0.009952158 -0.0195955340 -0.0003087814 0.0374509 t-CS-m-c-CS-m -0.008830464 -0.0184738401 0.0008129125 0.1008599 t-CS-s-c-CS-m 0.023559255 0.0132161959 0.0339023142 0.0000000 t-SC-m-c-CS-m -0.011191823 -0.0208351992 -0.0015484466 0.0104343 t-SC-s-c-CS-m 0.001465354 -0.0081780224 0.0111087302 0.9998020 c-SC-m-c-CS-s -0.027237557 -0.0368809331 -0.0175941805 0.0000000 c-SC-s-c-CS-s -0.016248500 -0.0261423951 -0.0063546044 0.0000196 t-CS-m-c-CS-s -0.015126806 -0.0250207011 -0.0052329105 0.0001044 t-CS-s-c-CS-s 0.017262913 0.0066858941 0.0278399321 0.0000229 t-SC-m-c-CS-s -0.017488165 -0.0273820602 -0.0075942696 0.0000027 t-SC-s-c-CS-s -0.004830988 -0.0147248834 0.0050629072 0.8166988 c-SC-s-c-SC-m 0.010989057 0.0013456808 0.0206324334 0.0130219 t-CS-m-c-SC-m 0.012110751 0.0024673747 0.0217541273 0.0036058 t-CS-s-c-SC-m 0.044500470 0.0341574107 0.0548435290 0.0000000 t-SC-m-c-SC-m 0.009749392 0.0001060156 0.0193927682 0.0453388 t-SC-s-c-SC-m 0.022406569 0.0127631924 0.0320499450 0.0000000 t-CS-m-c-SC-s 0.001121694 -0.0087722014 0.0110155893 0.9999727 t-CS-s-c-SC-s 0.033511413 0.0229343938 0.0440884318 0.0000000 t-SC-m-c-SC-s -0.001239665 -0.0111335605 0.0086542302 0.9999461 t-SC-s-c-SC-s 0.011417512 0.0015236163 0.0213114070 0.0111885 t-CS-s-t-CS-m 0.032389719 0.0218126999 0.0429667379 0.0000000 t-SC-m-t-CS-m -0.002361359 -0.0122552544 0.0075325362 0.9962662 t-SC-s-t-CS-m 0.010295818 0.0004019224 0.0201897130 0.0345821 t-SC-m-t-CS-s -0.034751078 -0.0453280970 -0.0241740590 0.0000000 t-SC-s-t-CS-s -0.022093901 -0.0326709202 -0.0115168822 0.0000000 t-SC-s-t-SC-m 0.012657177 0.0027632815 0.0225510721 0.0027373
P70S6
Df Sum Sq Mean Sq F value Pr(>F) class 7 1.795 0.25636 9.029 7.4e-11 *** Residuals 1072 30.438
0.02839
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0099426594 -0.070651733 0.050766414 0.9996737 c-SC-m-c-CS-m 0.0586231101 -0.000466763 0.117712983 0.0535946 c-SC-s-c-CS-m -0.0111792219 -0.071888295 0.049529852 0.9992928 t-CS-m-c-CS-m -0.0145858079 -0.075294881 0.046123266 0.9961080 t-CS-s-c-CS-m 0.0799159976 0.014802129 0.145029866 0.0050060 t-SC-m-c-CS-m 0.0590156287 -0.001693445 0.119724702 0.0636780 t-SC-s-c-CS-m -0.0446237929 -0.105332866 0.016085281 0.3331387 c-SC-m-c-CS-s 0.0685657695 0.007856696 0.129274843 0.0144637 c-SC-s-c-CS-s -0.0012365624 -0.063522758 0.061049633 1.0000000 t-CS-m-c-CS-s -0.0046431484 -0.066929344 0.057643047 0.9999985 t-CS-s-c-CS-s 0.0898586570 0.023271913 0.156445401 0.0011601 t-SC-m-c-CS-s 0.0689582881 0.006672093 0.131244483 0.0181527 t-SC-s-c-CS-s -0.0346811334 -0.096967329 0.027605062 0.6932451 c-SC-s-c-SC-m -0.0698023320 -0.130511405 -0.009093258 0.0116971 t-CS-m-c-SC-m -0.0732089180 -0.133917991 -0.012499844 0.0063694 t-CS-s-c-SC-m 0.0212928875 -0.043820981 0.086406756 0.9754491 t-SC-m-c-SC-m 0.0003925186 -0.060316555 0.061101592 1.0000000 t-SC-s-c-SC-m -0.1032469030 -0.163955976 -0.042537829 0.0000079 t-CS-m-c-SC-s -0.0034065860 -0.065692781 0.058879609 0.9999998 t-CS-s-c-SC-s 0.0910952194 0.024508476 0.157681963 0.0009170 t-SC-m-c-SC-s 0.0701948505 0.007908655 0.132481046 0.0148321 t-SC-s-c-SC-s -0.0334445710 -0.095730766 0.028841624 0.7316275 t-CS-s-t-CS-m 0.0945018054 0.027915062 0.161088549 0.0004716 t-SC-m-t-CS-m 0.0736014366 0.011315241 0.135887632 0.0083153 t-SC-s-t-CS-m -0.0300379850 -0.092324180 0.032248210 0.8261562 t-SC-m-t-CS-s -0.0209003689 -0.087487112 0.045686375 0.9805613 t-SC-s-t-CS-s -0.1245397904 -0.191126534 -0.057953047 0.0000005 t-SC-s-t-SC-m -0.1036394215 -0.165925617 -0.041353226 0.0000141
pGSK3B
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1453 0.02076 86.62 <2e-16 *** Residuals 1072 0.2569
0.00024
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0115393640 0.005961758 0.0171169700 0.0000000 c-SC-m-c-CS-m -0.0222798244 -0.027708667 -0.0168509813 0.0000000 c-SC-s-c-CS-m -0.0181945061 -0.023772112 -0.0126169001 0.0000000 t-CS-m-c-CS-m 0.0017166276 -0.003860978 0.0072942336 0.9826459 t-CS-s-c-CS-m 0.0047180484 -0.001264245 0.0107003420 0.2446728 t-SC-m-c-CS-m -0.0155763599 -0.021153966 -0.0099987539 0.0000000 t-SC-s-c-CS-m 0.0012330283 -0.004344578 0.0068106343 0.9976971 c-SC-m-c-CS-s -0.0338191883 -0.039396794 -0.0282415823 0.0000000 c-SC-s-c-CS-s -0.0297338701 -0.035456373 -0.0240113671 0.0000000 t-CS-m-c-CS-s -0.0098227364 -0.015545239 -0.0041002334 0.0000062 t-CS-s-c-CS-s -0.0068213156 -0.012938929 -0.0007037026 0.0167577 t-SC-m-c-CS-s -0.0271157239 -0.032838227 -0.0213932209 0.0000000 t-SC-s-c-CS-s -0.0103063356 -0.016028839 -0.0045838326 0.0000016 c-SC-s-c-SC-m 0.0040853182 -0.001492288 0.0096629242 0.3378035 t-CS-m-c-SC-m 0.0239964519 0.018418846 0.0295740579 0.0000000 t-CS-s-c-SC-m 0.0269978727 0.021015579 0.0329801664 0.0000000 t-SC-m-c-SC-m 0.0067034645 0.001125858 0.0122810705 0.0066620 t-SC-s-c-SC-m 0.0235128527 0.017935247 0.0290904587 0.0000000 t-CS-m-c-SC-s 0.0199111337 0.014188631 0.0256336367 0.0000000 t-CS-s-c-SC-s 0.0229125545 0.016794941 0.0290301676 0.0000000 t-SC-m-c-SC-s 0.0026181462 -0.003104357 0.0083406492 0.8622126 t-SC-s-c-SC-s 0.0194275345 0.013705031 0.0251500375 0.0000000 t-CS-s-t-CS-m 0.0030014208 -0.003116192 0.0091190338 0.8129551 t-SC-m-t-CS-m -0.0172929875 -0.023015490 -0.0115704845 0.0000000 t-SC-s-t-CS-m -0.0004835992 -0.006206102 0.0052389038 0.9999964 t-SC-m-t-CS-s -0.0202944083 -0.026412021 -0.0141767952 0.0000000 t-SC-s-t-CS-s -0.0034850200 -0.009602633 0.0026325930 0.6675208 t-SC-s-t-SC-m 0.0168093883 0.011086885 0.0225318913 0.0000000
pPKCG
Df Sum Sq Mean Sq F value Pr(>F) class 7 90.03 12.861 50.87 <2e-16 *** Residuals 1072 271.00
0.253
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.22791858 0.046772070 0.409065089 0.0035089 c-SC-m-c-CS-m 0.16261353 -0.013701530 0.338928600 0.0957812 c-SC-s-c-CS-m -0.11039157 -0.291538077 0.070754941 0.5853299 t-CS-m-c-CS-m 0.24322739 0.062080885 0.424373903 0.0012631 t-CS-s-c-CS-m 0.35070513 0.156415390 0.544994867 0.0000015 t-SC-m-c-CS-m 0.05125916 -0.129887352 0.232405667 0.9894140 t-SC-s-c-CS-m 0.89668470 0.715538187 1.077831206 0.0000000 c-SC-m-c-CS-s -0.06530505 -0.246451555 0.115841464 0.9579469 c-SC-s-c-CS-s -0.33831015 -0.524162545 -0.152457751 0.0000011 t-CS-m-c-CS-s 0.01530881 -0.170543583 0.201161211 0.9999970 t-CS-s-c-CS-s 0.12278655 -0.075898021 0.321471119 0.5672623 t-SC-m-c-CS-s -0.17665942 -0.362511819 0.009192975 0.0762757 t-SC-s-c-CS-s 0.66876612 0.482913720 0.854618514 0.0000000 c-SC-s-c-SC-m -0.27300510 -0.454151612 -0.091858593 0.0001422 t-CS-m-c-SC-m 0.08061386 -0.100532650 0.261760369 0.8786479 t-CS-s-c-SC-m 0.18809159 -0.006198145 0.382381333 0.0658780 t-SC-m-c-SC-m -0.11135438 -0.292500886 0.069792132 0.5741583 t-SC-s-c-SC-m 0.73407116 0.552924653 0.915217671 0.0000000 t-CS-m-c-SC-s 0.35361896 0.167766565 0.539471359 0.0000003 t-CS-s-c-SC-s 0.46109670 0.262412127 0.659781266 0.0000000 t-SC-m-c-SC-s 0.16165073 -0.024201672 0.347503123 0.1423885 t-SC-s-c-SC-s 1.00707626 0.821223867 1.192928662 0.0000000 t-CS-s-t-CS-m 0.10747773 -0.091206835 0.306162304 0.7240450 t-SC-m-t-CS-m -0.19196824 -0.377820633 -0.006115839 0.0371459 t-SC-s-t-CS-m 0.65345730 0.467604906 0.839309700 0.0000000 t-SC-m-t-CS-s -0.29944597 -0.498130541 -0.100761401 0.0001421 t-SC-s-t-CS-s 0.54597957 0.347294998 0.744664138 0.0000000 t-SC-s-t-SC-m 0.84542554 0.659573142 1.031277936 0.0000000
CDK5
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.2513 0.03590 30.63 <2e-16 *** Residuals 1072 1.2564
0.00117
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.006761891 -0.0055719979 0.0190957807 0.7100202 c-SC-m-c-CS-m -0.034087413 -0.0460923391 -0.0220824866 0.0000000 c-SC-s-c-CS-m -0.027217968 -0.0395518573 -0.0148840787 0.0000000 t-CS-m-c-CS-m -0.012563336 -0.0248972251 -0.0002294465 0.0423341 t-CS-s-c-CS-m 0.011114476 -0.0021143081 0.0243432608 0.1752734 t-SC-m-c-CS-m -0.021560111 -0.0338940001 -0.0092262215 0.0000037 t-SC-s-c-CS-m -0.003129561 -0.0154634504 0.0092043282 0.9945388 c-SC-m-c-CS-s -0.040849304 -0.0531831935 -0.0285154150 0.0000000 c-SC-s-c-CS-s -0.033979859 -0.0466341628 -0.0213255560 0.0000000 t-CS-m-c-CS-s -0.019325227 -0.0319795306 -0.0066709238 0.0001070 t-CS-s-c-CS-s 0.004352585 -0.0091754344 0.0178806044 0.9776067 t-SC-m-c-CS-s -0.028322002 -0.0409763056 -0.0156676988 0.0000000 t-SC-s-c-CS-s -0.009891452 -0.0225457559 0.0027628509 0.2553111 c-SC-s-c-SC-m 0.006869445 -0.0054644444 0.0192033341 0.6929408 t-CS-m-c-SC-m 0.021524077 0.0091901878 0.0338579663 0.0000039 t-CS-s-c-SC-m 0.045201889 0.0319731048 0.0584306737 0.0000000 t-SC-m-c-SC-m 0.012527302 0.0001934128 0.0248611913 0.0434670 t-SC-s-c-SC-m 0.030957852 0.0186239625 0.0432917410 0.0000000 t-CS-m-c-SC-s 0.014654632 0.0020003288 0.0273089356 0.0107150 t-CS-s-c-SC-s 0.038332444 0.0248044250 0.0518604638 0.0000000 t-SC-m-c-SC-s 0.005657857 -0.0069964462 0.0183121606 0.8759856 t-SC-s-c-SC-s 0.024088407 0.0114341035 0.0367427103 0.0000003 t-CS-s-t-CS-m 0.023677812 0.0101497928 0.0372058316 0.0000036 t-SC-m-t-CS-m -0.008996775 -0.0216510784 0.0036575284 0.3776695 t-SC-s-t-CS-m 0.009433775 -0.0032205287 0.0220880781 0.3146711 t-SC-m-t-CS-s -0.032674587 -0.0462026065 -0.0191465678 0.0000000 t-SC-s-t-CS-s -0.014244037 -0.0277720568 -0.0007160181 0.0308107 t-SC-s-t-SC-m 0.018430550 0.0057762463 0.0310848531 0.0002862
S6
Df Sum Sq Mean Sq F value Pr(>F) class 7 7.956 1.1365 98.05 <2e-16 *** Residuals 1072 12.426
0.0116
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.02177683 -0.060566412 0.01701275 0.6841038 c-SC-m-c-CS-m -0.15781185 -0.195566856 -0.12005684 0.0000000 c-SC-s-c-CS-m -0.12272915 -0.161518731 -0.08393957 0.0000000 t-CS-m-c-CS-m 0.01905086 -0.019738720 0.05784044 0.8121278 t-CS-s-c-CS-m 0.12473875 0.083134756 0.16634274 0.0000000 t-SC-m-c-CS-m -0.09354795 -0.132337530 -0.05475837 0.0000000 t-SC-s-c-CS-m 0.04783414 0.009044561 0.08662372 0.0046839 c-SC-m-c-CS-s -0.13603502 -0.174824601 -0.09724544 0.0000000 c-SC-s-c-CS-s -0.10095232 -0.140749590 -0.06115505 0.0000000 t-CS-m-c-CS-s 0.04082769 0.001030421 0.08062496 0.0396176 t-CS-s-c-CS-s 0.14651558 0.103970505 0.18906065 0.0000000 t-SC-m-c-CS-s -0.07177112 -0.111568389 -0.03197385 0.0000015 t-SC-s-c-CS-s 0.06961097 0.029813702 0.10940824 0.0000037 c-SC-s-c-SC-m 0.03508270 -0.003706881 0.07387228 0.1100384 t-CS-m-c-SC-m 0.17686271 0.138073130 0.21565229 0.0000000 t-CS-s-c-SC-m 0.28255060 0.240946606 0.32415459 0.0000000 t-SC-m-c-SC-m 0.06426390 0.025474319 0.10305348 0.0000157 t-SC-s-c-SC-m 0.20564599 0.166856410 0.24443557 0.0000000 t-CS-m-c-SC-s 0.14178001 0.101982740 0.18157728 0.0000000 t-CS-s-c-SC-s 0.24746790 0.204922824 0.29001297 0.0000000 t-SC-m-c-SC-s 0.02918120 -0.010616070 0.06897847 0.3363678 t-SC-s-c-SC-s 0.17056329 0.130766021 0.21036056 0.0000000 t-CS-s-t-CS-m 0.10568789 0.063142813 0.14823296 0.0000000 t-SC-m-t-CS-m -0.11259881 -0.152396082 -0.07280154 0.0000000 t-SC-s-t-CS-m 0.02878328 -0.011013991 0.06858055 0.3546201 t-SC-m-t-CS-s -0.21828670 -0.260831768 -0.17574162 0.0000000 t-SC-s-t-CS-s -0.07690460 -0.119449677 -0.03435953 0.0000014 t-SC-s-t-SC-m 0.14138209 0.101584820 0.18117936 0.0000000
ADARB1
Df Sum Sq Mean Sq F value Pr(>F) class 7 19.05 2.7214 23.88 <2e-16 *** Residuals 1072 122.15
0.1139
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.015689866 -0.10592423 0.13730397 0.9999343 c-SC-m-c-CS-m -0.321412911 -0.43978338 -0.20304244 0.0000000 c-SC-s-c-CS-m -0.178699218 -0.30031332 -0.05708512 0.0002399 t-CS-m-c-CS-m -0.326193964 -0.44780806 -0.20457986 0.0000000 t-CS-s-c-CS-m -0.077345364 -0.20778327 0.05309254 0.6196984 t-SC-m-c-CS-m -0.073085014 -0.19469912 0.04852909 0.6030334 t-SC-s-c-CS-m -0.270110629 -0.39172473 -0.14849653 0.0000000 c-SC-m-c-CS-s -0.337102778 -0.45871688 -0.21548868 0.0000000 c-SC-s-c-CS-s -0.194389084 -0.31916252 -0.06961565 0.0000688 t-CS-m-c-CS-s -0.341883830 -0.46665727 -0.21711040 0.0000000 t-CS-s-c-CS-s -0.093035231 -0.22642364 0.04035318 0.4037169 t-SC-m-c-CS-s -0.088774880 -0.21354832 0.03599855 0.3766746 t-SC-s-c-CS-s -0.285800496 -0.41057393 -0.16102706 0.0000000 c-SC-s-c-SC-m 0.142713694 0.02109959 0.26432779 0.0090845 t-CS-m-c-SC-m -0.004781053 -0.12639515 0.11683305 1.0000000 t-CS-s-c-SC-m 0.244067547 0.11362964 0.37450546 0.0000005 t-SC-m-c-SC-m 0.248327897 0.12671380 0.36994200 0.0000000 t-SC-s-c-SC-m 0.051302282 -0.07031182 0.17291638 0.9058707 t-CS-m-c-SC-s -0.147494747 -0.27226818 -0.02272131 0.0082760 t-CS-s-c-SC-s 0.101353853 -0.03203456 0.23474227 0.2902719 t-SC-m-c-SC-s 0.105614203 -0.01915923 0.23038764 0.1678849 t-SC-s-c-SC-s -0.091411412 -0.21618485 0.03336202 0.3374984 t-CS-s-t-CS-m 0.248848600 0.11546019 0.38223701 0.0000005 t-SC-m-t-CS-m 0.253108950 0.12833552 0.37788238 0.0000000 t-SC-s-t-CS-m 0.056083335 -0.06869010 0.18085677 0.8729211 t-SC-m-t-CS-s 0.004260350 -0.12912806 0.13764876 1.0000000 t-SC-s-t-CS-s -0.192765265 -0.32615368 -0.05937685 0.0003336 t-SC-s-t-SC-m -0.197025615 -0.32179905 -0.07225218 0.0000505
AcetylH3K9
Df Sum Sq Mean Sq F value Pr(>F) class 7 4.79 0.6842 22.73 <2e-16 *** Residuals 1072 32.26
0.0301
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.009946169 -0.0525560819 0.07244842 0.9997305 c-SC-m-c-CS-m 0.005895013 -0.0549402110 0.06673024 0.9999907 c-SC-s-c-CS-m 0.086358068 0.0238558167 0.14886032 0.0007702 t-CS-m-c-CS-m 0.042110648 -0.0203916032 0.10461290 0.4511212 t-CS-s-c-CS-m 0.065886907 -0.0011502447 0.13292406 0.0580832 t-SC-m-c-CS-m 0.150369611 0.0878673597 0.21287186 0.0000000 t-SC-s-c-CS-m 0.190036254 0.1275340034 0.25253851 0.0000000 c-SC-m-c-CS-s -0.004051156 -0.0665534074 0.05845109 0.9999994 c-SC-s-c-CS-s 0.076411899 0.0122859420 0.14053786 0.0074607 t-CS-m-c-CS-s 0.032164479 -0.0319614779 0.09629044 0.7949156 t-CS-s-c-CS-s 0.055940738 -0.0126127933 0.12449427 0.2058756 t-SC-m-c-CS-s 0.140423442 0.0762974850 0.20454940 0.0000000 t-SC-s-c-CS-s 0.180090085 0.1159641287 0.24421604 0.0000000 c-SC-s-c-SC-m 0.080463055 0.0179608038 0.14296531 0.0024862 t-CS-m-c-SC-m 0.036215635 -0.0262866161 0.09871789 0.6476535 t-CS-s-c-SC-m 0.059991894 -0.0070452576 0.12702905 0.1183031 t-SC-m-c-SC-m 0.144474598 0.0819723467 0.20697685 0.0000000 t-SC-s-c-SC-m 0.184141242 0.1216389905 0.24664349 0.0000000 t-CS-m-c-SC-s -0.044247420 -0.1083733764 0.01987854 0.4184352 t-CS-s-c-SC-s -0.020471161 -0.0890246919 0.04808237 0.9854459 t-SC-m-c-SC-s 0.064011543 -0.0001144136 0.12813750 0.0507935 t-SC-s-c-SC-s 0.103678187 0.0395522301 0.16780414 0.0000288 t-CS-s-t-CS-m 0.023776259 -0.0447772720 0.09232979 0.9659253 t-SC-m-t-CS-m 0.108258963 0.0441330063 0.17238492 0.0000096 t-SC-s-t-CS-m 0.147925607 0.0837996500 0.21205156 0.0000000 t-SC-m-t-CS-s 0.084482704 0.0159291725 0.15303623 0.0047273 t-SC-s-t-CS-s 0.124149347 0.0555958162 0.19270288 0.0000013 t-SC-s-t-SC-m 0.039666644 -0.0244593128 0.10379260 0.5660489
RRP1
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0345 0.004935 4.976 1.48e-05 *** Residuals 1072 1.0632
0.000992
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0046905452 -6.655408e-03 0.0160364987 0.9147241 c-SC-m-c-CS-m 0.0008046396 -1.023870e-02 0.0118479798 0.9999987 c-SC-s-c-CS-m -0.0045955865 -1.594154e-02 0.0067503670 0.9229597 t-CS-m-c-CS-m -0.0061586763 -1.750463e-02 0.0051872771 0.7204869 t-CS-s-c-CS-m 0.0063830197 -5.786148e-03 0.0185521879 0.7546810 t-SC-m-c-CS-m 0.0060308244 -5.315129e-03 0.0173767778 0.7417650 t-SC-s-c-CS-m 0.0120909202 7.449668e-04 0.0234368737 0.0272912 c-SC-m-c-CS-s -0.0038859056 -1.523186e-02 0.0074600479 0.9682067 c-SC-s-c-CS-s -0.0092861317 -2.092683e-02 0.0023545709 0.2313304 t-CS-m-c-CS-s -0.0108492215 -2.248992e-02 0.0007914811 0.0886634 t-CS-s-c-CS-s 0.0016924745 -1.075196e-02 0.0141369091 0.9999061 t-SC-m-c-CS-s 0.0013402792 -1.030042e-02 0.0129809818 0.9999697 t-SC-s-c-CS-s 0.0074003750 -4.240328e-03 0.0190410776 0.5299447 c-SC-s-c-SC-m -0.0054002261 -1.674618e-02 0.0059457273 0.8357661 t-CS-m-c-SC-m -0.0069633160 -1.830927e-02 0.0043826375 0.5762471 t-CS-s-c-SC-m 0.0055783801 -6.590788e-03 0.0177475482 0.8610026 t-SC-m-c-SC-m 0.0052261847 -6.119769e-03 0.0165721382 0.8579434 t-SC-s-c-SC-m 0.0112862806 -5.967288e-05 0.0226322340 0.0523698 t-CS-m-c-SC-s -0.0015630898 -1.320379e-02 0.0100776128 0.9999138 t-CS-s-c-SC-s 0.0109786062 -1.465828e-03 0.0234230408 0.1300478 t-SC-m-c-SC-s 0.0106264108 -1.014292e-03 0.0222671135 0.1031110 t-SC-s-c-SC-s 0.0166865067 5.045804e-03 0.0283272093 0.0003903 t-CS-s-t-CS-m 0.0125416960 9.726147e-05 0.0249861306 0.0466466 t-SC-m-t-CS-m 0.0121895007 5.487981e-04 0.0238302033 0.0325363 t-SC-s-t-CS-m 0.0182495965 6.608894e-03 0.0298902992 0.0000596 t-SC-m-t-CS-s -0.0003521954 -1.279663e-02 0.0120922392 1.0000000 t-SC-s-t-CS-s 0.0057079005 -6.736534e-03 0.0181523351 0.8606348 t-SC-s-t-SC-m 0.0060600958 -5.580607e-03 0.0177007985 0.7617944
BAX
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0264 0.003765 11.34 6.38e-14 *** Residuals 1072 0.3561
0.000332
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0152936533 0.0087274542 0.021859853 0.0000000 c-SC-m-c-CS-m 0.0042576159 -0.0021334530 0.010648685 0.4665804 c-SC-s-c-CS-m 0.0047327498 -0.0018334493 0.011298949 0.3592069 t-CS-m-c-CS-m 0.0010405946 -0.0055256046 0.007606794 0.9997378 t-CS-s-c-CS-m 0.0104187243 0.0033761093 0.017461339 0.0002091 t-SC-m-c-CS-m 0.0106150667 0.0040488675 0.017181266 0.0000289 t-SC-s-c-CS-m 0.0084200062 0.0018538070 0.014986205 0.0026403 c-SC-m-c-CS-s -0.0110360374 -0.0176022366 -0.004469838 0.0000108 c-SC-s-c-CS-s -0.0105609035 -0.0172976817 -0.003824125 0.0000597 t-CS-m-c-CS-s -0.0142530587 -0.0209898370 -0.007516281 0.0000000 t-CS-s-c-CS-s -0.0048749290 -0.0120768479 0.002326990 0.4447338 t-SC-m-c-CS-s -0.0046785867 -0.0114153649 0.002058192 0.4095891 t-SC-s-c-CS-s -0.0068736472 -0.0136104254 -0.000136869 0.0416814 c-SC-s-c-SC-m 0.0004751339 -0.0060910653 0.007041333 0.9999988 t-CS-m-c-SC-m -0.0032170213 -0.0097832205 0.003349178 0.8140518 t-CS-s-c-SC-m 0.0061611084 -0.0008815066 0.013203723 0.1372704 t-SC-m-c-SC-m 0.0063574507 -0.0002087484 0.012923650 0.0658167 t-SC-s-c-SC-m 0.0041623902 -0.0024038090 0.010728589 0.5337711 t-CS-m-c-SC-s -0.0036921553 -0.0104289335 0.003044623 0.7103640 t-CS-s-c-SC-s 0.0056859745 -0.0015159444 0.012887893 0.2434164 t-SC-m-c-SC-s 0.0058823168 -0.0008544614 0.012619095 0.1389444 t-SC-s-c-SC-s 0.0036872563 -0.0030495219 0.010424035 0.7117732 t-CS-s-t-CS-m 0.0093781297 0.0021762109 0.016580049 0.0020804 t-SC-m-t-CS-m 0.0095744721 0.0028376939 0.016311250 0.0004593 t-SC-s-t-CS-m 0.0073794116 0.0006426333 0.014116190 0.0204118 t-SC-m-t-CS-s 0.0001963423 -0.0070055765 0.007398261 1.0000000 t-SC-s-t-CS-s -0.0019987182 -0.0092006370 0.005203201 0.9905767 t-SC-s-t-SC-m -0.0021950605 -0.0089318387 0.004541718 0.9759447
ARC
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1046 0.014942 138.9 <2e-16 *** Residuals 1072 0.1153
0.000108
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0072694325 -0.0110062759 -0.003532589 0.0000001 c-SC-m-c-CS-m 0.0083261831 0.0046890069 0.011963359 0.0000000 c-SC-s-c-CS-m 0.0131474328 0.0094105894 0.016884276 0.0000000 t-CS-m-c-CS-m -0.0115856259 -0.0153224692 -0.007848782 0.0000000 t-CS-s-c-CS-m -0.0084278957 -0.0124358687 -0.004419923 0.0000000 t-SC-m-c-CS-m 0.0175053275 0.0137684841 0.021242171 0.0000000 t-SC-s-c-CS-m -0.0005803353 -0.0043171787 0.003156508 0.9997710 c-SC-m-c-CS-s 0.0155956156 0.0118587722 0.019332459 0.0000000 c-SC-s-c-CS-s 0.0204168653 0.0165829449 0.024250786 0.0000000 t-CS-m-c-CS-s -0.0043161934 -0.0081501138 -0.000482273 0.0150134 t-CS-s-c-CS-s -0.0011584632 -0.0052570965 0.002940170 0.9894863 t-SC-m-c-CS-s 0.0247747600 0.0209408396 0.028608680 0.0000000 t-SC-s-c-CS-s 0.0066890971 0.0028551767 0.010523018 0.0000039 c-SC-s-c-SC-m 0.0048212497 0.0010844063 0.008558093 0.0024034 t-CS-m-c-SC-m -0.0199118090 -0.0236486524 -0.016174966 0.0000000 t-CS-s-c-SC-m -0.0167540788 -0.0207620518 -0.012746106 0.0000000 t-SC-m-c-SC-m 0.0091791444 0.0054423010 0.012915988 0.0000000 t-SC-s-c-SC-m -0.0089065185 -0.0126433618 -0.005169675 0.0000000 t-CS-m-c-SC-s -0.0247330587 -0.0285669791 -0.020899138 0.0000000 t-CS-s-c-SC-s -0.0215753284 -0.0256739618 -0.017476695 0.0000000 t-SC-m-c-SC-s 0.0043578947 0.0005239743 0.008191815 0.0134176 t-SC-s-c-SC-s -0.0137277681 -0.0175616885 -0.009893848 0.0000000 t-CS-s-t-CS-m 0.0031577302 -0.0009409031 0.007256364 0.2729663 t-SC-m-t-CS-m 0.0290909534 0.0252570329 0.032924874 0.0000000 t-SC-s-t-CS-m 0.0110052905 0.0071713701 0.014839211 0.0000000 t-SC-m-t-CS-s 0.0259332232 0.0218345898 0.030031856 0.0000000 t-SC-s-t-CS-s 0.0078475603 0.0037489270 0.011946194 0.0000002 t-SC-s-t-SC-m -0.0180856628 -0.0219195832 -0.014251742 0.0000000
ERBB4
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.04705 0.006722 36.39 <2e-16 *** Residuals 1072 0.19802
0.000185
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0093450383 -0.0142416790 -0.0044483976 0.0000002 c-SC-m-c-CS-m -0.0027599492 -0.0075259893 0.0020060909 0.6483560 c-SC-s-c-CS-m 0.0041649212 -0.0007317195 0.0090615619 0.1631580 t-CS-m-c-CS-m -0.0103617336 -0.0152583743 -0.0054650929 0.0000000 t-CS-s-c-CS-m -0.0060543466 -0.0113062669 -0.0008024262 0.0113324 t-SC-m-c-CS-m 0.0109504871 0.0060538464 0.0158471278 0.0000000 t-SC-s-c-CS-m -0.0004792213 -0.0053758620 0.0044174194 0.9999900 c-SC-m-c-CS-s 0.0065850891 0.0016884484 0.0114817298 0.0012303 c-SC-s-c-CS-s 0.0135099595 0.0084861121 0.0185338069 0.0000000 t-CS-m-c-CS-s -0.0010166953 -0.0060405427 0.0040071521 0.9986929 t-CS-s-c-CS-s 0.0032906918 -0.0020800270 0.0086614105 0.5783856 t-SC-m-c-CS-s 0.0202955254 0.0152716780 0.0253193728 0.0000000 t-SC-s-c-CS-s 0.0088658170 0.0038419696 0.0138896644 0.0000028 c-SC-s-c-SC-m 0.0069248704 0.0020282297 0.0118215111 0.0005040 t-CS-m-c-SC-m -0.0076017844 -0.0124984251 -0.0027051437 0.0000745 t-CS-s-c-SC-m -0.0032943973 -0.0085463177 0.0019575231 0.5477320 t-SC-m-c-SC-m 0.0137104363 0.0088137956 0.0186070770 0.0000000 t-SC-s-c-SC-m 0.0022807279 -0.0026159128 0.0071773686 0.8506916 t-CS-m-c-SC-s -0.0145266548 -0.0195505022 -0.0095028074 0.0000000 t-CS-s-c-SC-s -0.0102192677 -0.0155899865 -0.0048485490 0.0000003 t-SC-m-c-SC-s 0.0067855659 0.0017617185 0.0118094133 0.0011431 t-SC-s-c-SC-s -0.0046441425 -0.0096679899 0.0003797049 0.0941833 t-CS-s-t-CS-m 0.0043073871 -0.0010633317 0.0096781058 0.2251902 t-SC-m-t-CS-m 0.0213122207 0.0162883733 0.0263360681 0.0000000 t-SC-s-t-CS-m 0.0098825123 0.0048586649 0.0149063597 0.0000001 t-SC-m-t-CS-s 0.0170048336 0.0116341149 0.0223755524 0.0000000 t-SC-s-t-CS-s 0.0055751252 0.0002044065 0.0109458440 0.0354164 t-SC-s-t-SC-m -0.0114297084 -0.0164535558 -0.0064058610 0.0000000
nNOS
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1309 0.018701 37.19 <2e-16 *** Residuals 1072 0.5391
0.000503
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0198103190 -0.0278897122 -0.011730926 0.0000000 c-SC-m-c-CS-m 0.0023582128 -0.0055056912 0.010222117 0.9850820 c-SC-s-c-CS-m 0.0108570117 0.0027776184 0.018936405 0.0012462 t-CS-m-c-CS-m -0.0040677083 -0.0121471016 0.004011685 0.7917345 t-CS-s-c-CS-m -0.0193268228 -0.0279924228 -0.010661223 0.0000000 t-SC-m-c-CS-m 0.0112822906 0.0032028973 0.019361684 0.0006363 t-SC-s-c-CS-m 0.0053412944 -0.0027380989 0.013420688 0.4770421 c-SC-m-c-CS-s 0.0221685318 0.0140891385 0.030247925 0.0000000 c-SC-s-c-CS-s 0.0306673307 0.0223780481 0.038956613 0.0000000 t-CS-m-c-CS-s 0.0157426107 0.0074533281 0.024031893 0.0000003 t-CS-s-c-CS-s 0.0004834962 -0.0083781196 0.009345112 0.9999998 t-SC-m-c-CS-s 0.0310926096 0.0228033270 0.039381892 0.0000000 t-SC-s-c-CS-s 0.0251516134 0.0168623308 0.033440896 0.0000000 c-SC-s-c-SC-m 0.0084987989 0.0004194057 0.016578192 0.0311085 t-CS-m-c-SC-m -0.0064259211 -0.0145053143 0.001653472 0.2347921 t-CS-s-c-SC-m -0.0216850355 -0.0303506356 -0.013019435 0.0000000 t-SC-m-c-SC-m 0.0089240778 0.0008446846 0.017003471 0.0186281 t-SC-s-c-SC-m 0.0029830816 -0.0050963116 0.011062475 0.9522217 t-CS-m-c-SC-s -0.0149247200 -0.0232140025 -0.006635437 0.0000016 t-CS-s-c-SC-s -0.0301838344 -0.0390454502 -0.021322219 0.0000000 t-SC-m-c-SC-s 0.0004252789 -0.0078640037 0.008714561 0.9999999 t-SC-s-c-SC-s -0.0055157173 -0.0138049999 0.002773565 0.4681799 t-CS-s-t-CS-m -0.0152591144 -0.0241207303 -0.006397499 0.0000057 t-SC-m-t-CS-m 0.0153499989 0.0070607163 0.023639281 0.0000007 t-SC-s-t-CS-m 0.0094090027 0.0011197201 0.017698285 0.0136406 t-SC-m-t-CS-s 0.0306091133 0.0217474975 0.039470729 0.0000000 t-SC-s-t-CS-s 0.0246681171 0.0158065013 0.033529733 0.0000000 t-SC-s-t-SC-m -0.0059409962 -0.0142302788 0.002348286 0.3668095
Tau
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.921 0.13156 33.44 <2e-16 *** Residuals 1072 4.218
0.00393
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0180980656 -0.0406966240 0.004500493 0.2268462 c-SC-m-c-CS-m -0.0100728359 -0.0320686574 0.011922986 0.8616317 c-SC-s-c-CS-m 0.0229510521 0.0003524937 0.045549611 0.0434997 t-CS-m-c-CS-m -0.0006214006 -0.0232199590 0.021977158 1.0000000 t-CS-s-c-CS-m 0.0287665575 0.0045283427 0.053004772 0.0078603 t-SC-m-c-CS-m 0.0377055615 0.0151070031 0.060304120 0.0000131 t-SC-s-c-CS-m 0.0768032814 0.0542047230 0.099401840 0.0000000 c-SC-m-c-CS-s 0.0080252297 -0.0145733287 0.030623788 0.9612332 c-SC-s-c-CS-s 0.0410491177 0.0178634860 0.064234749 0.0000026 t-CS-m-c-CS-s 0.0174766650 -0.0057089667 0.040662297 0.3004626 t-CS-s-c-CS-s 0.0468646231 0.0220781402 0.071651106 0.0000003 t-SC-m-c-CS-s 0.0558036271 0.0326179954 0.078989259 0.0000000 t-SC-s-c-CS-s 0.0949013470 0.0717157153 0.118086979 0.0000000 c-SC-s-c-SC-m 0.0330238880 0.0104253296 0.055622446 0.0002679 t-CS-m-c-SC-m 0.0094514353 -0.0131471231 0.032049994 0.9097322 t-CS-s-c-SC-m 0.0388393934 0.0146011785 0.063077608 0.0000358 t-SC-m-c-SC-m 0.0477783974 0.0251798390 0.070376956 0.0000000 t-SC-s-c-SC-m 0.0868761173 0.0642775589 0.109474676 0.0000000 t-CS-m-c-SC-s -0.0235724527 -0.0467580844 -0.000386821 0.0430755 t-CS-s-c-SC-s 0.0058155054 -0.0189709775 0.030601988 0.9966455 t-SC-m-c-SC-s 0.0147545093 -0.0084311224 0.037940141 0.5286179 t-SC-s-c-SC-s 0.0538522293 0.0306665975 0.077037861 0.0000000 t-CS-s-t-CS-m 0.0293879581 0.0046014752 0.054174441 0.0079625 t-SC-m-t-CS-m 0.0383269621 0.0151413304 0.061512594 0.0000166 t-SC-s-t-CS-m 0.0774246820 0.0542390503 0.100610314 0.0000000 t-SC-m-t-CS-s 0.0089390040 -0.0158474789 0.033725487 0.9578647 t-SC-s-t-CS-s 0.0480367239 0.0232502410 0.072823207 0.0000001 t-SC-s-t-SC-m 0.0390977199 0.0159120882 0.062283352 0.0000099
GFAP
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0268 0.003828 25.31 <2e-16 *** Residuals 1072 0.1622
0.000151
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0033033784 -0.0011277443 0.0077345011 0.3146792 c-SC-m-c-CS-m -0.0098887037 -0.0142016418 -0.0055757655 0.0000000 c-SC-s-c-CS-m -0.0070993515 -0.0115304742 -0.0026682288 0.0000359 t-CS-m-c-CS-m -0.0056235159 -0.0100546386 -0.0011923931 0.0030882 t-CS-s-c-CS-m 0.0056020612 0.0008494348 0.0103546876 0.0085846 t-SC-m-c-CS-m -0.0060300765 -0.0104611993 -0.0015989538 0.0010052 t-SC-s-c-CS-m -0.0005845948 -0.0050157175 0.0038465279 0.9999235 c-SC-m-c-CS-s -0.0131920821 -0.0176232048 -0.0087609593 0.0000000 c-SC-s-c-CS-s -0.0104027299 -0.0149489659 -0.0058564939 0.0000000 t-CS-m-c-CS-s -0.0089268943 -0.0134731303 -0.0043806582 0.0000001 t-CS-s-c-CS-s 0.0022986828 -0.0025614479 0.0071588135 0.8402322 t-SC-m-c-CS-s -0.0093334549 -0.0138796910 -0.0047872189 0.0000000 t-SC-s-c-CS-s -0.0038879732 -0.0084342092 0.0006582628 0.1579503 c-SC-s-c-SC-m 0.0027893521 -0.0016417706 0.0072204749 0.5430679 t-CS-m-c-SC-m 0.0042651878 -0.0001659349 0.0086963105 0.0690266 t-CS-s-c-SC-m 0.0154907648 0.0107381384 0.0202433912 0.0000000 t-SC-m-c-SC-m 0.0038586271 -0.0005724956 0.0082897498 0.1413428 t-SC-s-c-SC-m 0.0093041089 0.0048729861 0.0137352316 0.0000000 t-CS-m-c-SC-s 0.0014758357 -0.0030704003 0.0060220717 0.9764437 t-CS-s-c-SC-s 0.0127014127 0.0078412820 0.0175615434 0.0000000 t-SC-m-c-SC-s 0.0010692750 -0.0034769610 0.0056155110 0.9965934 t-SC-s-c-SC-s 0.0065147567 0.0019685207 0.0110609927 0.0003927 t-CS-s-t-CS-m 0.0112255770 0.0063654463 0.0160857077 0.0000000 t-SC-m-t-CS-m -0.0004065607 -0.0049527967 0.0041396753 0.9999946 t-SC-s-t-CS-m 0.0050389211 0.0004926851 0.0095851571 0.0179251 t-SC-m-t-CS-s -0.0116321377 -0.0164922684 -0.0067720070 0.0000000 t-SC-s-t-CS-s -0.0061866560 -0.0110467867 -0.0013265252 0.0029513 t-SC-s-t-SC-m 0.0054454818 0.0008992458 0.0099917178 0.0069676
GluR3
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1441 0.020582 18.87 <2e-16 *** Residuals 1072 1.1691
0.001091
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -1.993981e-03 -0.013891775 0.0099038136 0.9996198 c-SC-m-c-CS-m 3.824574e-03 -0.007755889 0.0154050364 0.9740416 c-SC-s-c-CS-m 9.571146e-06 -0.011888223 0.0119073656 1.0000000 t-CS-m-c-CS-m -4.191432e-03 -0.016089227 0.0077063625 0.9628863 t-CS-s-c-CS-m -3.331989e-02 -0.046080940 -0.0205588427 0.0000000 t-SC-m-c-CS-m -1.475736e-02 -0.026655153 -0.0028595636 0.0043146 t-SC-s-c-CS-m -2.148130e-02 -0.033379094 -0.0095835046 0.0000014 c-SC-m-c-CS-s 5.818555e-03 -0.006079240 0.0177163490 0.8154788 c-SC-s-c-CS-s 2.003552e-03 -0.010203328 0.0142104316 0.9996689 t-CS-m-c-CS-s -2.197451e-03 -0.014404331 0.0100094285 0.9993905 t-CS-s-c-CS-s -3.132591e-02 -0.044375613 -0.0182762070 0.0000000 t-SC-m-c-CS-s -1.276338e-02 -0.024970257 -0.0005564975 0.0330146 t-SC-s-c-CS-s -1.948732e-02 -0.031694198 -0.0072804386 0.0000391 c-SC-s-c-SC-m -3.815002e-03 -0.015712797 0.0080827920 0.9780382 t-CS-m-c-SC-m -8.016006e-03 -0.019913800 0.0038817889 0.4511360 t-CS-s-c-SC-m -3.714446e-02 -0.049905513 -0.0243834162 0.0000000 t-SC-m-c-SC-m -1.858193e-02 -0.030479726 -0.0066841371 0.0000650 t-SC-s-c-SC-m -2.530587e-02 -0.037203667 -0.0134080782 0.0000000 t-CS-m-c-SC-s -4.201003e-03 -0.016407883 0.0080058764 0.9673478 t-CS-s-c-SC-s -3.332946e-02 -0.046379165 -0.0202797591 0.0000000 t-SC-m-c-SC-s -1.476693e-02 -0.026973809 -0.0025600496 0.0061035 t-SC-s-c-SC-s -2.149087e-02 -0.033697750 -0.0092839907 0.0000030 t-CS-s-t-CS-m -2.912846e-02 -0.042178162 -0.0160787559 0.0000000 t-SC-m-t-CS-m -1.056593e-02 -0.022772806 0.0016409536 0.1467602 t-SC-s-t-CS-m -1.728987e-02 -0.029496747 -0.0050829875 0.0004896 t-SC-m-t-CS-s 1.856253e-02 0.005512830 0.0316122363 0.0004519 t-SC-s-t-CS-s 1.183859e-02 -0.001211111 0.0248882952 0.1077346 t-SC-s-t-SC-m -6.723941e-03 -0.018930821 0.0054829385 0.7049700
GluR4
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0162 0.0023139 3.248 0.00204 ** Residuals 1072 0.7637
0.0007124
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0037480960 -0.0058681679 0.0133643598 0.9366016 c-SC-m-c-CS-m 0.0040839557 -0.0052758282 0.0134437397 0.8893535 c-SC-s-c-CS-m 0.0036356157 -0.0059806482 0.0132518796 0.9458675 t-CS-m-c-CS-m 0.0014333760 -0.0081828879 0.0110496398 0.9998259 t-CS-s-c-CS-m -0.0057889914 -0.0161029709 0.0045249882 0.6843690 t-SC-m-c-CS-m 0.0019901174 -0.0076261465 0.0116063812 0.9984901 t-SC-s-c-CS-m 0.0097530017 0.0001367378 0.0193692656 0.0440435 c-SC-m-c-CS-s 0.0003358598 -0.0092804041 0.0099521236 1.0000000 c-SC-s-c-CS-s -0.0001124803 -0.0099785588 0.0097535983 1.0000000 t-CS-m-c-CS-s -0.0023147200 -0.0121807986 0.0075513586 0.9966464 t-CS-s-c-CS-s -0.0095370873 -0.0200843690 0.0010101943 0.1102188 t-SC-m-c-CS-s -0.0017579786 -0.0116240572 0.0081081000 0.9994302 t-SC-s-c-CS-s 0.0060049057 -0.0038611729 0.0158709843 0.5869326 c-SC-s-c-SC-m -0.0004483400 -0.0100646039 0.0091679239 0.9999999 t-CS-m-c-SC-m -0.0026505798 -0.0122668436 0.0069656841 0.9909563 t-CS-s-c-SC-m -0.0098729471 -0.0201869267 0.0004410325 0.0721585 t-SC-m-c-SC-m -0.0020938384 -0.0117101022 0.0075224255 0.9979092 t-SC-s-c-SC-m 0.0056690460 -0.0039472179 0.0152853098 0.6268389 t-CS-m-c-SC-s -0.0022022398 -0.0120683183 0.0076638388 0.9975514 t-CS-s-c-SC-s -0.0094246071 -0.0199718887 0.0011226746 0.1195092 t-SC-m-c-SC-s -0.0016454984 -0.0115115769 0.0082205802 0.9996318 t-SC-s-c-SC-s 0.0061173860 -0.0037486926 0.0159834645 0.5629580 t-CS-s-t-CS-m -0.0072223673 -0.0177696490 0.0033249143 0.4288912 t-SC-m-t-CS-m 0.0005567414 -0.0093093372 0.0104228200 0.9999998 t-SC-s-t-CS-m 0.0083196257 -0.0015464529 0.0181857043 0.1716156 t-SC-m-t-CS-s 0.0077791087 -0.0027681729 0.0183263904 0.3286674 t-SC-s-t-CS-s 0.0155419930 0.0049947114 0.0260892747 0.0002266 t-SC-s-t-SC-m 0.0077628843 -0.0021031942 0.0176289629 0.2474456
IL1B
Df Sum Sq Mean Sq F value Pr(>F) class 7 2.303 0.3290 71.08 <2e-16 *** Residuals 1072 4.962
0.0046
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.068216383 -0.092728708 -0.043704059 0.0000000 c-SC-m-c-CS-m 0.061141210 0.037282665 0.084999755 0.0000000 c-SC-s-c-CS-m 0.064389159 0.039876834 0.088901484 0.0000000 t-CS-m-c-CS-m -0.022331979 -0.046844303 0.002180346 0.1045732 t-CS-s-c-CS-m -0.036883911 -0.063174747 -0.010593075 0.0005846 t-SC-m-c-CS-m 0.051762288 0.027249964 0.076274613 0.0000000 t-SC-s-c-CS-m -0.013943997 -0.038456322 0.010568328 0.6691637 c-SC-m-c-CS-s 0.129357593 0.104845268 0.153869918 0.0000000 c-SC-s-c-CS-s 0.132605543 0.107456428 0.157754657 0.0000000 t-CS-m-c-CS-s 0.045884405 0.020735290 0.071033520 0.0000011 t-CS-s-c-CS-s 0.031332473 0.004446938 0.058218007 0.0099098 t-SC-m-c-CS-s 0.119978672 0.094829557 0.145127787 0.0000000 t-SC-s-c-CS-s 0.054272386 0.029123272 0.079421501 0.0000000 c-SC-s-c-SC-m 0.003247949 -0.021264376 0.027760274 0.9999212 t-CS-m-c-SC-m -0.083473188 -0.107985513 -0.058960864 0.0000000 t-CS-s-c-SC-m -0.098025121 -0.124315957 -0.071734285 0.0000000 t-SC-m-c-SC-m -0.009378921 -0.033891246 0.015133403 0.9423812 t-SC-s-c-SC-m -0.075085207 -0.099597532 -0.050572882 0.0000000 t-CS-m-c-SC-s -0.086721138 -0.111870252 -0.061572023 0.0000000 t-CS-s-c-SC-s -0.101273070 -0.128158605 -0.074387536 0.0000000 t-SC-m-c-SC-s -0.012626871 -0.037775985 0.012522244 0.7940783 t-SC-s-c-SC-s -0.078333156 -0.103482271 -0.053184042 0.0000000 t-CS-s-t-CS-m -0.014551932 -0.041437467 0.012333602 0.7234565 t-SC-m-t-CS-m 0.074094267 0.048945152 0.099243382 0.0000000 t-SC-s-t-CS-m 0.008387981 -0.016761133 0.033537096 0.9725668 t-SC-m-t-CS-s 0.088646199 0.061760665 0.115531734 0.0000000 t-SC-s-t-CS-s 0.022939914 -0.003945621 0.049825448 0.1601388 t-SC-s-t-SC-m -0.065706286 -0.090855400 -0.040557171 0.0000000
P3525
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1400 0.019999 25.77 <2e-16 *** Residuals 1072 0.8321
0.000776
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.010287430 -0.0203249655 -0.0002498951 0.0399796 c-SC-m-c-CS-m -0.021094364 -0.0308641832 -0.0113245445 0.0000000 c-SC-s-c-CS-m -0.007851847 -0.0178893824 0.0021856880 0.2544169 t-CS-m-c-CS-m -0.018381286 -0.0284188207 -0.0083437503 0.0000009 t-CS-s-c-CS-m 0.001326565 -0.0094392513 0.0120923818 0.9999519 t-SC-m-c-CS-m -0.013267319 -0.0233048545 -0.0032297842 0.0016378 t-SC-s-c-CS-m 0.015968878 0.0059313431 0.0260064134 0.0000424 c-SC-m-c-CS-s -0.010806934 -0.0208444688 -0.0007693984 0.0245409 c-SC-s-c-CS-s 0.002435583 -0.0078627107 0.0127338769 0.9964733 t-CS-m-c-CS-s -0.008093855 -0.0183921490 0.0022044386 0.2487830 t-CS-s-c-CS-s 0.011613996 0.0006046564 0.0226233347 0.0302347 t-SC-m-c-CS-s -0.002979889 -0.0132781829 0.0073184047 0.9879111 t-SC-s-c-CS-s 0.026256309 0.0159580147 0.0365546023 0.0000000 c-SC-s-c-SC-m 0.013242517 0.0032049815 0.0232800518 0.0016883 t-CS-m-c-SC-m 0.002713078 -0.0073244568 0.0127506135 0.9919642 t-CS-s-c-SC-m 0.022420929 0.0116551125 0.0331867457 0.0000000 t-SC-m-c-SC-m 0.007827045 -0.0022104907 0.0178645797 0.2582307 t-SC-s-c-SC-m 0.037063242 0.0270257069 0.0471007773 0.0000000 t-CS-m-c-SC-s -0.010529438 -0.0208277321 -0.0002311445 0.0408829 t-CS-s-c-SC-s 0.009178412 -0.0018309267 0.0201877516 0.1831456 t-SC-m-c-SC-s -0.005415472 -0.0157137660 0.0048828217 0.7522399 t-SC-s-c-SC-s 0.023820725 0.0135224316 0.0341190192 0.0000000 t-CS-s-t-CS-m 0.019707851 0.0086985116 0.0307171899 0.0000019 t-SC-m-t-CS-m 0.005113966 -0.0051843276 0.0154122600 0.8032419 t-SC-s-t-CS-m 0.034350164 0.0240518699 0.0446484576 0.0000000 t-SC-m-t-CS-s -0.014593885 -0.0256032238 -0.0035845454 0.0015625 t-SC-s-t-CS-s 0.014642313 0.0036329738 0.0256516522 0.0014798 t-SC-s-t-SC-m 0.029236198 0.0189379038 0.0395344914 0.0000000
pCASP9
Df Sum Sq Mean Sq F value Pr(>F) class 7 5.17 0.7385 12.92 5.01e-16 *** Residuals 1072 61.26
0.0571
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.016141503 -0.102269774 0.06998677 0.9992065 c-SC-m-c-CS-m 0.114862493 0.031031389 0.19869360 0.0008928 c-SC-s-c-CS-m 0.008345173 -0.077783099 0.09447344 0.9999907 t-CS-m-c-CS-m -0.065088378 -0.151216650 0.02103989 0.2971780 t-CS-s-c-CS-m -0.031907573 -0.124284951 0.06046980 0.9666869 t-SC-m-c-CS-m 0.151280678 0.065152407 0.23740895 0.0000032 t-SC-s-c-CS-m 0.016429366 -0.069698905 0.10255764 0.9991095 c-SC-m-c-CS-s 0.131003995 0.044875724 0.21713227 0.0001168 c-SC-s-c-CS-s 0.024486676 -0.063879067 0.11285242 0.9906621 t-CS-m-c-CS-s -0.048946875 -0.137312618 0.03941887 0.6989394 t-CS-s-c-CS-s -0.015766071 -0.110233023 0.07870088 0.9996302 t-SC-m-c-CS-s 0.167422181 0.079056439 0.25578792 0.0000003 t-SC-s-c-CS-s 0.032570869 -0.055794873 0.12093661 0.9526528 c-SC-s-c-SC-m -0.106517320 -0.192645591 -0.02038905 0.0044972 t-CS-m-c-SC-m -0.179950871 -0.266079142 -0.09382260 0.0000000 t-CS-s-c-SC-m -0.146770066 -0.239147443 -0.05439269 0.0000438 t-SC-m-c-SC-m 0.036418186 -0.049710086 0.12254646 0.9047928 t-SC-s-c-SC-m -0.098433126 -0.184561398 -0.01230485 0.0125780 t-CS-m-c-SC-s -0.073433551 -0.161799293 0.01493219 0.1864668 t-CS-s-c-SC-s -0.040252746 -0.134719699 0.05421421 0.9011864 t-SC-m-c-SC-s 0.142935505 0.054569763 0.23130125 0.0000285 t-SC-s-c-SC-s 0.008084193 -0.080281549 0.09644994 0.9999937 t-CS-s-t-CS-m 0.033180805 -0.061286147 0.12764776 0.9634820 t-SC-m-t-CS-m 0.216369056 0.128003314 0.30473480 0.0000000 t-SC-s-t-CS-m 0.081517744 -0.006847998 0.16988349 0.0956194 t-SC-m-t-CS-s 0.183188252 0.088721300 0.27765520 0.0000001 t-SC-s-t-CS-s 0.048336940 -0.046130013 0.14280389 0.7776017 t-SC-s-t-SC-m -0.134851312 -0.223217054 -0.04648557 0.0001087
PSD95
Df Sum Sq Mean Sq F value Pr(>F) class 7 12.35 1.7637 32.89 <2e-16 *** Residuals 1072 57.48
0.0536
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.065252014 -0.148680490 0.01817646 0.2545972 c-SC-m-c-CS-m 0.206541221 0.125337906 0.28774454 0.0000000 c-SC-s-c-CS-m 0.215801658 0.132373182 0.29923013 0.0000000 t-CS-m-c-CS-m 0.077094975 -0.006333501 0.16052345 0.0944331 t-CS-s-c-CS-m 0.020912776 -0.068568919 0.11039447 0.9967267 t-SC-m-c-CS-m 0.235897288 0.152468812 0.31932576 0.0000000 t-SC-s-c-CS-m 0.041184442 -0.042244035 0.12461292 0.8080507 c-SC-m-c-CS-s 0.271793235 0.188364759 0.35522171 0.0000000 c-SC-s-c-CS-s 0.281053672 0.195457862 0.36664948 0.0000000 t-CS-m-c-CS-s 0.142346989 0.056751178 0.22794280 0.0000143 t-CS-s-c-CS-s 0.086164790 -0.005340980 0.17767056 0.0820398 t-SC-m-c-CS-s 0.301149302 0.215553492 0.38674511 0.0000000 t-SC-s-c-CS-s 0.106436455 0.020840645 0.19203227 0.0041619 c-SC-s-c-SC-m 0.009260437 -0.074168039 0.09268891 0.9999764 t-CS-m-c-SC-m -0.129446246 -0.212874723 -0.04601777 0.0000754 t-CS-s-c-SC-m -0.185628445 -0.275110141 -0.09614675 0.0000000 t-SC-m-c-SC-m 0.029356067 -0.054072409 0.11278454 0.9631242 t-SC-s-c-SC-m -0.165356780 -0.248785256 -0.08192830 0.0000001 t-CS-m-c-SC-s -0.138706683 -0.224302494 -0.05311087 0.0000273 t-CS-s-c-SC-s -0.194888882 -0.286394652 -0.10338311 0.0000000 t-SC-m-c-SC-s 0.020095630 -0.065500180 0.10569144 0.9966320 t-SC-s-c-SC-s -0.174617217 -0.260213027 -0.08902141 0.0000000 t-CS-s-t-CS-m -0.056182199 -0.147687969 0.03532357 0.5757265 t-SC-m-t-CS-m 0.158802314 0.073206503 0.24439812 0.0000006 t-SC-s-t-CS-m -0.035910533 -0.121506344 0.04968528 0.9083500 t-SC-m-t-CS-s 0.214984512 0.123478742 0.30649028 0.0000000 t-SC-s-t-CS-s 0.020271665 -0.071234105 0.11177744 0.9976660 t-SC-s-t-SC-m -0.194712847 -0.280308657 -0.10911704 0.0000000
SNCA
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.2102 0.030023 76.79 <2e-16 *** Residuals 1072 0.4191
0.000391
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0058412431 -0.0129652508 0.001282765 0.2006730 c-SC-m-c-CS-m 0.0246609352 0.0177269353 0.031594935 0.0000000 c-SC-s-c-CS-m 0.0207542156 0.0136302079 0.027878223 0.0000000 t-CS-m-c-CS-m -0.0143361719 -0.0214601796 -0.007212164 0.0000000 t-CS-s-c-CS-m 0.0011346509 -0.0065062448 0.008775547 0.9998303 t-SC-m-c-CS-m 0.0248335355 0.0177095278 0.031957543 0.0000000 t-SC-s-c-CS-m 0.0053369221 -0.0017870856 0.012460930 0.3083628 c-SC-m-c-CS-s 0.0305021782 0.0233781706 0.037626186 0.0000000 c-SC-s-c-CS-s 0.0265954587 0.0192863810 0.033904536 0.0000000 t-CS-m-c-CS-s -0.0084949288 -0.0158040065 -0.001185851 0.0102500 t-CS-s-c-CS-s 0.0069758940 -0.0008378387 0.014789627 0.1202157 t-SC-m-c-CS-s 0.0306747786 0.0233657009 0.037983856 0.0000000 t-SC-s-c-CS-s 0.0111781652 0.0038690875 0.018487243 0.0001037 c-SC-s-c-SC-m -0.0039067196 -0.0110307273 0.003217288 0.7097269 t-CS-m-c-SC-m -0.0389971070 -0.0461211147 -0.031873099 0.0000000 t-CS-s-c-SC-m -0.0235262842 -0.0311671800 -0.015885388 0.0000000 t-SC-m-c-SC-m 0.0001726003 -0.0069514073 0.007296608 1.0000000 t-SC-s-c-SC-m -0.0193240131 -0.0264480208 -0.012200005 0.0000000 t-CS-m-c-SC-s -0.0350903874 -0.0423994651 -0.027781310 0.0000000 t-CS-s-c-SC-s -0.0196195646 -0.0274332973 -0.011805832 0.0000000 t-SC-m-c-SC-s 0.0040793199 -0.0032297577 0.011388398 0.6906456 t-SC-s-c-SC-s -0.0154172935 -0.0227263711 -0.008108216 0.0000000 t-CS-s-t-CS-m 0.0154708228 0.0076570901 0.023284555 0.0000001 t-SC-m-t-CS-m 0.0391697074 0.0318606297 0.046478785 0.0000000 t-SC-s-t-CS-m 0.0196730940 0.0123640163 0.026982172 0.0000000 t-SC-m-t-CS-s 0.0236988846 0.0158851519 0.031512617 0.0000000 t-SC-s-t-CS-s 0.0042022712 -0.0036114615 0.012016004 0.7300103 t-SC-s-t-SC-m -0.0194966134 -0.0268056911 -0.012187536 0.0000000
Ubiquitin
Df Sum Sq Mean Sq F value Pr(>F) class 7 16.67 2.3814 161.2 <2e-16 *** Residuals 1072 15.84
0.0148
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.113634668 -0.15742982 -0.06983952 0.0000000 c-SC-m-c-CS-m 0.225718059 0.18309099 0.26834513 0.0000000 c-SC-s-c-CS-m 0.094070720 0.05027557 0.13786587 0.0000000 t-CS-m-c-CS-m -0.091038903 -0.13483405 -0.04724375 0.0000000 t-CS-s-c-CS-m 0.015852424 -0.03112032 0.06282517 0.9707026 t-SC-m-c-CS-m 0.238091055 0.19429591 0.28188620 0.0000000 t-SC-s-c-CS-m 0.100346896 0.05655175 0.14414205 0.0000000 c-SC-m-c-CS-s 0.339352728 0.29555758 0.38314788 0.0000000 c-SC-s-c-CS-s 0.207705389 0.16277251 0.25263826 0.0000000 t-CS-m-c-CS-s 0.022595765 -0.02233711 0.06752864 0.7927311 t-CS-s-c-CS-s 0.129487092 0.08145183 0.17752236 0.0000000 t-SC-m-c-CS-s 0.351725724 0.30679285 0.39665860 0.0000000 t-SC-s-c-CS-s 0.213981565 0.16904869 0.25891444 0.0000000 c-SC-s-c-SC-m -0.131647339 -0.17544249 -0.08785219 0.0000000 t-CS-m-c-SC-m -0.316756962 -0.36055211 -0.27296181 0.0000000 t-CS-s-c-SC-m -0.209865635 -0.25683838 -0.16289289 0.0000000 t-SC-m-c-SC-m 0.012372996 -0.03142215 0.05616815 0.9895143 t-SC-s-c-SC-m -0.125371163 -0.16916631 -0.08157601 0.0000000 t-CS-m-c-SC-s -0.185109623 -0.23004250 -0.14017675 0.0000000 t-CS-s-c-SC-s -0.078218296 -0.12625356 -0.03018303 0.0000242 t-SC-m-c-SC-s 0.144020335 0.09908746 0.18895321 0.0000000 t-SC-s-c-SC-s 0.006276176 -0.03865670 0.05120905 0.9998875 t-CS-s-t-CS-m 0.106891327 0.05885606 0.15492659 0.0000000 t-SC-m-t-CS-m 0.329129959 0.28419708 0.37406283 0.0000000 t-SC-s-t-CS-m 0.191385799 0.14645292 0.23631867 0.0000000 t-SC-m-t-CS-s 0.222238631 0.17420337 0.27027390 0.0000000 t-SC-s-t-CS-s 0.084494472 0.03645921 0.13252974 0.0000031 t-SC-s-t-SC-m -0.137744159 -0.18267703 -0.09281128 0.0000000
pGSK3B_Tyr216
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.654 0.09347 11.2 9.54e-14 *** Residuals 1072 8.943
0.00834
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -1.895049e-02 -0.0518572294 0.0139562525 0.6549007 c-SC-m-c-CS-m -4.120976e-02 -0.0732388327 -0.0091806934 0.0025079 c-SC-s-c-CS-m -5.532904e-02 -0.0882357794 -0.0224222975 0.0000107 t-CS-m-c-CS-m 1.528272e-02 -0.0176240190 0.0481894629 0.8526092 t-CS-s-c-CS-m -2.755362e-02 -0.0628479391 0.0077406925 0.2568312 t-SC-m-c-CS-m -3.245339e-02 -0.0653601334 0.0004533485 0.0564086 t-SC-s-c-CS-m 1.526139e-02 -0.0176453500 0.0481681319 0.8535260 c-SC-m-c-CS-s -2.225927e-02 -0.0551660155 0.0106474664 0.4456616 c-SC-s-c-CS-s -3.637855e-02 -0.0701401538 -0.0026169461 0.0243363 t-CS-m-c-CS-s 3.423321e-02 0.0004716066 0.0679948143 0.0441430 t-CS-s-c-CS-s -8.603135e-03 -0.0446958075 0.0274895379 0.9962960 t-SC-m-c-CS-s -1.350290e-02 -0.0472645078 0.0202586999 0.9277060 t-SC-s-c-CS-s 3.421188e-02 0.0004502756 0.0679734832 0.0443947 c-SC-s-c-SC-m -1.411928e-02 -0.0470260164 0.0187874655 0.8978403 t-CS-m-c-SC-m 5.649248e-02 0.0235857441 0.0893992259 0.0000061 t-CS-s-c-SC-m 1.365614e-02 -0.0216381761 0.0489504555 0.9389476 t-SC-m-c-SC-m 8.756371e-03 -0.0241503703 0.0416631116 0.9926923 t-SC-s-c-SC-m 5.647115e-02 0.0235644130 0.0893778949 0.0000062 t-CS-m-c-SC-s 7.061176e-02 0.0368501566 0.1043733643 0.0000000 t-CS-s-c-SC-s 2.777542e-02 -0.0083172575 0.0638680878 0.2743743 t-SC-m-c-SC-s 2.287565e-02 -0.0108859578 0.0566372499 0.4433758 t-SC-s-c-SC-s 7.059043e-02 0.0368288255 0.1043520332 0.0000000 t-CS-s-t-CS-m -4.283635e-02 -0.0789290180 -0.0067436726 0.0078589 t-SC-m-t-CS-m -4.773611e-02 -0.0814977182 -0.0139745105 0.0005059 t-SC-s-t-CS-m -2.133104e-05 -0.0337829349 0.0337402728 1.0000000 t-SC-m-t-CS-s -4.899769e-03 -0.0409924418 0.0311929036 0.9999072 t-SC-s-t-CS-s 4.281501e-02 0.0067223415 0.0789076869 0.0079098 t-SC-s-t-SC-m 4.771478e-02 0.0139531795 0.0814763872 0.0005102
SHH
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0769 0.010987 14.19 <2e-16 *** Residuals 1072 0.8298
0.000774
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.012092102 -0.0221161293 -2.068074e-03 0.0063401 c-SC-m-c-CS-m -0.002440886 -0.0121975581 7.315786e-03 0.9949952 c-SC-s-c-CS-m 0.014942096 0.0049180683 2.496612e-02 0.0001790 t-CS-m-c-CS-m -0.009976979 -0.0200010062 4.704922e-05 0.0521104 t-CS-s-c-CS-m -0.004766536 -0.0155178649 5.984793e-03 0.8807594 t-SC-m-c-CS-m 0.003756882 -0.0062671455 1.378091e-02 0.9482888 t-SC-s-c-CS-m 0.007917010 -0.0021070182 1.794104e-02 0.2429760 c-SC-m-c-CS-s 0.009651216 -0.0003728121 1.967524e-02 0.0688787 c-SC-s-c-CS-s 0.027034198 0.0167497621 3.731863e-02 0.0000000 t-CS-m-c-CS-s 0.002115123 -0.0081693124 1.239956e-02 0.9985497 t-CS-s-c-CS-s 0.007325566 -0.0036689582 1.832009e-02 0.4663544 t-SC-m-c-CS-s 0.015848984 0.0055645483 2.613342e-02 0.0000877 t-SC-s-c-CS-s 0.020009111 0.0097246756 3.029355e-02 0.0000001 c-SC-s-c-SC-m 0.017382982 0.0073589542 2.740701e-02 0.0000047 t-CS-m-c-SC-m -0.007536093 -0.0175601203 2.487935e-03 0.3038110 t-CS-s-c-SC-m -0.002325650 -0.0130769789 8.425679e-03 0.9979951 t-SC-m-c-SC-m 0.006197768 -0.0038262596 1.622180e-02 0.5666440 t-SC-s-c-SC-m 0.010357895 0.0003338677 2.038192e-02 0.0370092 t-CS-m-c-SC-s -0.024919074 -0.0352035099 -1.463464e-02 0.0000000 t-CS-s-c-SC-s -0.019708632 -0.0307031558 -8.714108e-03 0.0000018 t-SC-m-c-SC-s -0.011185214 -0.0214696492 -9.007783e-04 0.0220502 t-SC-s-c-SC-s -0.007025086 -0.0173095219 3.259349e-03 0.4322612 t-CS-s-t-CS-m 0.005210443 -0.0057840813 1.620497e-02 0.8388290 t-SC-m-t-CS-m 0.013733861 0.0034494253 2.401830e-02 0.0013837 t-SC-s-t-CS-m 0.017893988 0.0076095526 2.817842e-02 0.0000042 t-SC-m-t-CS-s 0.008523418 -0.0024711060 1.951794e-02 0.2653220 t-SC-s-t-CS-s 0.012683545 0.0016890213 2.367807e-02 0.0112326 t-SC-s-t-SC-m 0.004160127 -0.0061243081 1.444456e-02 0.9234674
BAD
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0961 0.01373 21.79 <2e-16 *** Residuals 1072 0.6757
0.00063
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0122119822 -0.0212574822 -0.003166482 0.0011519 c-SC-m-c-CS-m 0.0124125350 0.0036082918 0.021216778 0.0005339 c-SC-s-c-CS-m -0.0007606309 -0.0098061309 0.008284869 0.9999965 t-CS-m-c-CS-m -0.0063095628 -0.0153550628 0.002735937 0.4035994 t-CS-s-c-CS-m -0.0059976862 -0.0156994897 0.003704117 0.5668291 t-SC-m-c-CS-m -0.0031842029 -0.0122297029 0.005861297 0.9630386 t-SC-s-c-CS-m 0.0177666210 0.0087211210 0.026812121 0.0000001 c-SC-m-c-CS-s 0.0246245172 0.0155790172 0.033670017 0.0000000 c-SC-s-c-CS-s 0.0114513513 0.0021708641 0.020731839 0.0046441 t-CS-m-c-CS-s 0.0059024194 -0.0033780677 0.015182907 0.5293765 t-CS-s-c-CS-s 0.0062142960 -0.0037069621 0.016135554 0.5496540 t-SC-m-c-CS-s 0.0090277793 -0.0002527079 0.018308266 0.0633192 t-SC-s-c-CS-s 0.0299786032 0.0206981160 0.039259090 0.0000000 c-SC-s-c-SC-m -0.0131731659 -0.0222186659 -0.004127666 0.0002868 t-CS-m-c-SC-m -0.0187220978 -0.0277675978 -0.009676598 0.0000000 t-CS-s-c-SC-m -0.0184102212 -0.0281120247 -0.008708418 0.0000003 t-SC-m-c-SC-m -0.0155967379 -0.0246422379 -0.006551238 0.0000054 t-SC-s-c-SC-m 0.0053540860 -0.0036914140 0.014399586 0.6219028 t-CS-m-c-SC-s -0.0055489319 -0.0148294191 0.003731555 0.6093938 t-CS-s-c-SC-s -0.0052370553 -0.0151583135 0.004684203 0.7485688 t-SC-m-c-SC-s -0.0024235720 -0.0117040592 0.006856915 0.9934831 t-SC-s-c-SC-s 0.0185272518 0.0092467647 0.027807739 0.0000001 t-CS-s-t-CS-m 0.0003118766 -0.0096093816 0.010233135 1.0000000 t-SC-m-t-CS-m 0.0031253599 -0.0061551273 0.012405847 0.9710465 t-SC-s-t-CS-m 0.0240761837 0.0147956965 0.033356671 0.0000000 t-SC-m-t-CS-s 0.0028134833 -0.0071077748 0.012734741 0.9892769 t-SC-s-t-CS-s 0.0237643072 0.0138430490 0.033685565 0.0000000 t-SC-s-t-SC-m 0.0209508239 0.0116703367 0.030231311 0.0000000
BCL2
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0809 0.011562 22.48 <2e-16 *** Residuals 1072 0.5512
0.000514
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0059498004 -0.014119639 0.002220038 0.3454030 c-SC-m-c-CS-m 0.0234403705 0.015488433 0.031392308 0.0000000 c-SC-s-c-CS-m 0.0005428727 -0.007626966 0.008712711 0.9999993 t-CS-m-c-CS-m -0.0005340433 -0.008703882 0.007635796 0.9999994 t-CS-s-c-CS-m -0.0023529756 -0.011115584 0.006409632 0.9922777 t-SC-m-c-CS-m 0.0049271247 -0.003242714 0.013096963 0.5985790 t-SC-s-c-CS-m 0.0045425743 -0.003627264 0.012712413 0.6947953 c-SC-m-c-CS-s 0.0293901709 0.021220332 0.037560010 0.0000000 c-SC-s-c-CS-s 0.0064926731 -0.001889405 0.014874751 0.2663514 t-CS-m-c-CS-s 0.0054157572 -0.002966321 0.013797835 0.5081927 t-CS-s-c-CS-s 0.0035968248 -0.005363993 0.012557643 0.9263787 t-SC-m-c-CS-s 0.0108769251 0.002494847 0.019259003 0.0021975 t-SC-s-c-CS-s 0.0104923747 0.002110297 0.018874452 0.0037818 c-SC-s-c-SC-m -0.0228974978 -0.031067337 -0.014727659 0.0000000 t-CS-m-c-SC-m -0.0239744138 -0.032144253 -0.015804575 0.0000000 t-CS-s-c-SC-m -0.0257933462 -0.034555954 -0.017030738 0.0000000 t-SC-m-c-SC-m -0.0185132458 -0.026683085 -0.010343407 0.0000000 t-SC-s-c-SC-m -0.0188977962 -0.027067635 -0.010727957 0.0000000 t-CS-m-c-SC-s -0.0010769160 -0.009458994 0.007305162 0.9999361 t-CS-s-c-SC-s -0.0028958483 -0.011856666 0.006064970 0.9770384 t-SC-m-c-SC-s 0.0043842520 -0.003997826 0.012766330 0.7573587 t-SC-s-c-SC-s 0.0039997016 -0.004382376 0.012381779 0.8339382 t-CS-s-t-CS-m -0.0018189324 -0.010779750 0.007141886 0.9986671 t-SC-m-t-CS-m 0.0054611680 -0.002920910 0.013843246 0.4968906 t-SC-s-t-CS-m 0.0050766176 -0.003305460 0.013458695 0.5932061 t-SC-m-t-CS-s 0.0072801003 -0.001680718 0.016240918 0.2107013 t-SC-s-t-CS-s 0.0068955499 -0.002065268 0.015856368 0.2744321 t-SC-s-t-SC-m -0.0003845504 -0.008766628 0.007997527 0.9999999
pS6
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.1046 0.014942 138.9 <2e-16 *** Residuals 1072 0.1153
0.000108
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0072694325 -0.0110062759 -0.003532589 0.0000001 c-SC-m-c-CS-m 0.0083261831 0.0046890069 0.011963359 0.0000000 c-SC-s-c-CS-m 0.0131474328 0.0094105894 0.016884276 0.0000000 t-CS-m-c-CS-m -0.0115856259 -0.0153224692 -0.007848782 0.0000000 t-CS-s-c-CS-m -0.0084278957 -0.0124358687 -0.004419923 0.0000000 t-SC-m-c-CS-m 0.0175053275 0.0137684841 0.021242171 0.0000000 t-SC-s-c-CS-m -0.0005803353 -0.0043171787 0.003156508 0.9997710 c-SC-m-c-CS-s 0.0155956156 0.0118587722 0.019332459 0.0000000 c-SC-s-c-CS-s 0.0204168653 0.0165829449 0.024250786 0.0000000 t-CS-m-c-CS-s -0.0043161934 -0.0081501138 -0.000482273 0.0150134 t-CS-s-c-CS-s -0.0011584632 -0.0052570965 0.002940170 0.9894863 t-SC-m-c-CS-s 0.0247747600 0.0209408396 0.028608680 0.0000000 t-SC-s-c-CS-s 0.0066890971 0.0028551767 0.010523018 0.0000039 c-SC-s-c-SC-m 0.0048212497 0.0010844063 0.008558093 0.0024034 t-CS-m-c-SC-m -0.0199118090 -0.0236486524 -0.016174966 0.0000000 t-CS-s-c-SC-m -0.0167540788 -0.0207620518 -0.012746106 0.0000000 t-SC-m-c-SC-m 0.0091791444 0.0054423010 0.012915988 0.0000000 t-SC-s-c-SC-m -0.0089065185 -0.0126433618 -0.005169675 0.0000000 t-CS-m-c-SC-s -0.0247330587 -0.0285669791 -0.020899138 0.0000000 t-CS-s-c-SC-s -0.0215753284 -0.0256739618 -0.017476695 0.0000000 t-SC-m-c-SC-s 0.0043578947 0.0005239743 0.008191815 0.0134176 t-SC-s-c-SC-s -0.0137277681 -0.0175616885 -0.009893848 0.0000000 t-CS-s-t-CS-m 0.0031577302 -0.0009409031 0.007256364 0.2729663 t-SC-m-t-CS-m 0.0290909534 0.0252570329 0.032924874 0.0000000 t-SC-s-t-CS-m 0.0110052905 0.0071713701 0.014839211 0.0000000 t-SC-m-t-CS-s 0.0259332232 0.0218345898 0.030031856 0.0000000 t-SC-s-t-CS-s 0.0078475603 0.0037489270 0.011946194 0.0000002 t-SC-s-t-SC-m -0.0180856628 -0.0219195832 -0.014251742 0.0000000
pCFOS
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.0467 0.006667 13.54 <2e-16 *** Residuals 1072 0.5279
0.000492
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.0030244531 -0.0049708511 0.0110197572 0.9457105 c-SC-m-c-CS-m 0.0196844838 0.0119024262 0.0274665414 0.0000000 c-SC-s-c-CS-m 0.0110774834 0.0030821793 0.0190727875 0.0007332 t-CS-m-c-CS-m 0.0038327077 -0.0041625964 0.0118280118 0.8305989 t-CS-s-c-CS-m -0.0019584186 -0.0105338284 0.0066169912 0.9971699 t-SC-m-c-CS-m 0.0063048202 -0.0016904839 0.0143001244 0.2448278 t-SC-s-c-CS-m 0.0097340567 0.0017387526 0.0177293609 0.0055957 c-SC-m-c-CS-s 0.0166600307 0.0086647266 0.0246553349 0.0000000 c-SC-s-c-CS-s 0.0080530303 -0.0001499786 0.0162560393 0.0586494 t-CS-m-c-CS-s 0.0008082546 -0.0073947543 0.0090112636 0.9999896 t-CS-s-c-CS-s -0.0049828717 -0.0137522571 0.0037865138 0.6704638 t-SC-m-c-CS-s 0.0032803672 -0.0049226418 0.0114833761 0.9277521 t-SC-s-c-CS-s 0.0067096037 -0.0014934053 0.0149126126 0.2033059 c-SC-s-c-SC-m -0.0086070004 -0.0166023045 -0.0006116962 0.0245755 t-CS-m-c-SC-m -0.0158517761 -0.0238470802 -0.0078564719 0.0000001 t-CS-s-c-SC-m -0.0216429024 -0.0302183122 -0.0130674926 0.0000000 t-SC-m-c-SC-m -0.0133796636 -0.0213749677 -0.0053843594 0.0000121 t-SC-s-c-SC-m -0.0099504270 -0.0179457312 -0.0019551229 0.0041115 t-CS-m-c-SC-s -0.0072447757 -0.0154477847 0.0009582333 0.1291154 t-CS-s-c-SC-s -0.0130359020 -0.0218052875 -0.0042665165 0.0001895 t-SC-m-c-SC-s -0.0047726632 -0.0129756721 0.0034303458 0.6427499 t-SC-s-c-SC-s -0.0013434267 -0.0095464356 0.0068595823 0.9996737 t-CS-s-t-CS-m -0.0057911263 -0.0145605118 0.0029782592 0.4785310 t-SC-m-t-CS-m 0.0024721125 -0.0057308964 0.0106751215 0.9846439 t-SC-s-t-CS-m 0.0059013490 -0.0023016599 0.0141043580 0.3617448 t-SC-m-t-CS-s 0.0082632388 -0.0005061466 0.0170326243 0.0816072 t-SC-s-t-CS-s 0.0116924753 0.0029230899 0.0204618608 0.0014198 t-SC-s-t-SC-m 0.0034292365 -0.0047737725 0.0116322455 0.9099278
SYP
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.375 0.05358 13.09 2.97e-16 *** Residuals 1072 4.387
0.00409
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.0220817202 -0.045128965 0.0009655244 0.0716394 c-SC-m-c-CS-m -0.0105297028 -0.032962243 0.0119028378 0.8454763 c-SC-s-c-CS-m 0.0041087434 -0.018938501 0.0271559879 0.9994283 t-CS-m-c-CS-m -0.0538059158 -0.076853160 -0.0307586712 0.0000000 t-CS-s-c-CS-m -0.0338166536 -0.058536109 -0.0090971979 0.0009176 t-SC-m-c-CS-m -0.0216653715 -0.044712616 0.0013818731 0.0831058 t-SC-s-c-CS-m -0.0391963144 -0.062243559 -0.0161490698 0.0000079 c-SC-m-c-CS-s 0.0115520174 -0.011495227 0.0345992620 0.7955053 c-SC-s-c-CS-s 0.0261904636 0.002544490 0.0498364376 0.0180637 t-CS-m-c-CS-s -0.0317241956 -0.055370170 -0.0080782216 0.0012803 t-CS-s-c-CS-s -0.0117349334 -0.037013543 0.0135436761 0.8528944 t-SC-m-c-CS-s 0.0004163487 -0.023229625 0.0240623227 1.0000000 t-SC-s-c-CS-s -0.0171145941 -0.040760568 0.0065313799 0.3536276 c-SC-s-c-SC-m 0.0146384462 -0.008408798 0.0376856908 0.5311698 t-CS-m-c-SC-m -0.0432762130 -0.066323458 -0.0202289684 0.0000004 t-CS-s-c-SC-m -0.0232869508 -0.048006407 0.0014325050 0.0817620 t-SC-m-c-SC-m -0.0111356687 -0.034182913 0.0119115759 0.8247444 t-SC-s-c-SC-m -0.0286666115 -0.051713856 -0.0056193670 0.0041455 t-CS-m-c-SC-s -0.0579146591 -0.081560633 -0.0342686851 0.0000000 t-CS-s-c-SC-s -0.0379253970 -0.063204007 -0.0126467875 0.0001564 t-SC-m-c-SC-s -0.0257741149 -0.049420089 -0.0021281409 0.0215316 t-SC-s-c-SC-s -0.0433050577 -0.066951032 -0.0196590837 0.0000009 t-CS-s-t-CS-m 0.0199892621 -0.005289347 0.0452678716 0.2415537 t-SC-m-t-CS-m 0.0321405443 0.008494570 0.0557865183 0.0010259 t-SC-s-t-CS-m 0.0146096014 -0.009036373 0.0382555754 0.5675782 t-SC-m-t-CS-s 0.0121512821 -0.013127327 0.0374298916 0.8285688 t-SC-s-t-CS-s -0.0053796607 -0.030658270 0.0198989488 0.9981935 t-SC-s-t-SC-m -0.0175309428 -0.041176917 0.0061150312 0.3218586
H3AcK18
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.9763 0.13948 61.19 <2e-16 *** Residuals 1072 2.4435
0.00228
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.003514650 -0.013686285 0.0207155848 0.9986093 c-SC-m-c-CS-m 0.043637229 0.026895068 0.0603793896 0.0000000 c-SC-s-c-CS-m 0.010452585 -0.006748350 0.0276535196 0.5889606 t-CS-m-c-CS-m 0.007511621 -0.009689314 0.0247125556 0.8889119 t-CS-s-c-CS-m 0.016360994 -0.002087968 0.0348099568 0.1256798 t-SC-m-c-CS-m 0.084170131 0.066969196 0.1013710660 0.0000000 t-SC-s-c-CS-m 0.066903768 0.049702833 0.0841047031 0.0000000 c-SC-m-c-CS-s 0.040122579 0.022921644 0.0573235139 0.0000000 c-SC-s-c-CS-s 0.006937935 -0.010709852 0.0245857216 0.9337467 t-CS-m-c-CS-s 0.003996971 -0.013650816 0.0216447575 0.9973148 t-CS-s-c-CS-s 0.012846344 -0.006019933 0.0317126220 0.4366106 t-SC-m-c-CS-s 0.080655481 0.063007694 0.0983032680 0.0000000 t-SC-s-c-CS-s 0.063389118 0.045741332 0.0810369051 0.0000000 c-SC-s-c-SC-m -0.033184644 -0.050385579 -0.0159837094 0.0000002 t-CS-m-c-SC-m -0.036125608 -0.053326543 -0.0189246735 0.0000000 t-CS-s-c-SC-m -0.027276235 -0.045725197 -0.0088272723 0.0002118 t-SC-m-c-SC-m 0.040532902 0.023331967 0.0577338370 0.0000000 t-SC-s-c-SC-m 0.023266539 0.006065604 0.0404674741 0.0011152 t-CS-m-c-SC-s -0.002940964 -0.020588751 0.0147068227 0.9996338 t-CS-s-c-SC-s 0.005908410 -0.012957868 0.0247746872 0.9808123 t-SC-m-c-SC-s 0.073717546 0.056069760 0.0913653331 0.0000000 t-SC-s-c-SC-s 0.056451183 0.038803397 0.0740989702 0.0000000 t-CS-s-t-CS-m 0.008849374 -0.010016904 0.0277156513 0.8459651 t-SC-m-t-CS-m 0.076658510 0.059010724 0.0943062972 0.0000000 t-SC-s-t-CS-m 0.059392148 0.041744361 0.0770399343 0.0000000 t-SC-m-t-CS-s 0.067809137 0.048942859 0.0866754144 0.0000000 t-SC-s-t-CS-s 0.050542774 0.031676496 0.0694090515 0.0000000 t-SC-s-t-SC-m -0.017266363 -0.034914150 0.0003814239 0.0603526
EGR1
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.4115 0.05879 57.19 <2e-16 *** Residuals 1072 1.1021
0.00103
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.008065686 -0.019617429 0.003486056 0.4022570 c-SC-m-c-CS-m 0.042739652 0.031496012 0.053983293 0.0000000 c-SC-s-c-CS-m 0.026090517 0.014538775 0.037642260 0.0000000 t-CS-m-c-CS-m -0.012240064 -0.023791807 -0.000688322 0.0289237 t-CS-s-c-CS-m -0.016424999 -0.028814887 -0.004035110 0.0015608 t-SC-m-c-CS-m 0.021489292 0.009937549 0.033041034 0.0000006 t-SC-s-c-CS-m 0.009675290 -0.001876452 0.021227032 0.1784175 c-SC-m-c-CS-s 0.050805339 0.039253596 0.062357081 0.0000000 c-SC-s-c-CS-s 0.034156204 0.022304366 0.046008041 0.0000000 t-CS-m-c-CS-s -0.004174378 -0.016026216 0.007677460 0.9629281 t-CS-s-c-CS-s -0.008359312 -0.021029460 0.004310835 0.4798030 t-SC-m-c-CS-s 0.029554978 0.017703140 0.041406816 0.0000000 t-SC-s-c-CS-s 0.017740976 0.005889139 0.029592814 0.0001640 c-SC-s-c-SC-m -0.016649135 -0.028200878 -0.005097393 0.0003515 t-CS-m-c-SC-m -0.054979717 -0.066531459 -0.043427974 0.0000000 t-CS-s-c-SC-m -0.059164651 -0.071554539 -0.046774763 0.0000000 t-SC-m-c-SC-m -0.021250361 -0.032802103 -0.009698618 0.0000008 t-SC-s-c-SC-m -0.033064362 -0.044616105 -0.021512620 0.0000000 t-CS-m-c-SC-s -0.038330582 -0.050182419 -0.026478744 0.0000000 t-CS-s-c-SC-s -0.042515516 -0.055185663 -0.029845369 0.0000000 t-SC-m-c-SC-s -0.004601226 -0.016453063 0.007250612 0.9378771 t-SC-s-c-SC-s -0.016415227 -0.028267065 -0.004563390 0.0007376 t-CS-s-t-CS-m -0.004184934 -0.016855082 0.008485213 0.9740248 t-SC-m-t-CS-m 0.033729356 0.021877518 0.045581194 0.0000000 t-SC-s-t-CS-m 0.021915354 0.010063517 0.033767192 0.0000007 t-SC-m-t-CS-s 0.037914290 0.025244143 0.050584438 0.0000000 t-SC-s-t-CS-s 0.026100289 0.013430141 0.038770436 0.0000000 t-SC-s-t-SC-m -0.011814002 -0.023665839 0.000037836 0.0514274
H3MeK4
Df Sum Sq Mean Sq F value Pr(>F) class 7 0.721 0.10299 55.67 <2e-16 *** Residuals 1072 1.983
0.00185
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m -0.006667915 -0.022164096 0.008828266 0.8964381 c-SC-m-c-CS-m 0.042149631 0.027066756 0.057232506 0.0000000 c-SC-s-c-CS-m 0.040444813 0.024948631 0.055940994 0.0000000 t-CS-m-c-CS-m 0.002245106 -0.013251075 0.017741287 0.9998562 t-CS-s-c-CS-m 0.012754675 -0.003865844 0.029375194 0.2778509 t-SC-m-c-CS-m 0.068977103 0.053480922 0.084473284 0.0000000 t-SC-s-c-CS-m 0.047822550 0.032326369 0.063318732 0.0000000 c-SC-m-c-CS-s 0.048817546 0.033321365 0.064313727 0.0000000 c-SC-s-c-CS-s 0.047112727 0.031213981 0.063011474 0.0000000 t-CS-m-c-CS-s 0.008913020 -0.006985726 0.024811767 0.6856926 t-CS-s-c-CS-s 0.019422589 0.002426115 0.036419064 0.0125944 t-SC-m-c-CS-s 0.075645017 0.059746271 0.091543764 0.0000000 t-SC-s-c-CS-s 0.054490465 0.038591719 0.070389212 0.0000000 c-SC-s-c-SC-m -0.001704819 -0.017201000 0.013791363 0.9999778 t-CS-m-c-SC-m -0.039904525 -0.055400707 -0.024408344 0.0000000 t-CS-s-c-SC-m -0.029394956 -0.046015475 -0.012774437 0.0000027 t-SC-m-c-SC-m 0.026827472 0.011331290 0.042323653 0.0000049 t-SC-s-c-SC-m 0.005672919 -0.009823262 0.021169100 0.9543423 t-CS-m-c-SC-s -0.038199707 -0.054098453 -0.022300960 0.0000000 t-CS-s-c-SC-s -0.027690138 -0.044686613 -0.010693663 0.0000239 t-SC-m-c-SC-s 0.028532290 0.012633544 0.044431037 0.0000017 t-SC-s-c-SC-s 0.007377738 -0.008521008 0.023276484 0.8531470 t-CS-s-t-CS-m 0.010509569 -0.006486906 0.027506044 0.5665451 t-SC-m-t-CS-m 0.066731997 0.050833251 0.082630743 0.0000000 t-SC-s-t-CS-m 0.045577445 0.029678698 0.061476191 0.0000000 t-SC-m-t-CS-s 0.056222428 0.039225953 0.073218903 0.0000000 t-SC-s-t-CS-s 0.035067876 0.018071401 0.052064351 0.0000000 t-SC-s-t-SC-m -0.021154552 -0.037053299 -0.005255806 0.0014690
CaNA
Df Sum Sq Mean Sq F value Pr(>F) class 7 66.35 9.478 241 <2e-16 *** Residuals 1072 42.17
0.039
— Signif. codes: 0 ‘’ 0.001 ’’ 0.01 ’’ 0.05
‘.’ 0.1 ’ ’ 1 Tukey multiple comparisons of means 95% family-wise
confidence level
Fit: aov(formula = eval(parse(text = proteins[i])) ~ class, data = data)
$class diff lwr upr p adj c-CS-s-c-CS-m 0.09394970 0.022496227 0.165403181 0.0017832 c-SC-m-c-CS-m -0.51370164 -0.583249351 -0.444153935 0.0000000 c-SC-s-c-CS-m -0.36602031 -0.437473790 -0.294566836 0.0000000 t-CS-m-c-CS-m 0.10968168 0.038228207 0.181135161 0.0000957 t-CS-s-c-CS-m 0.02897410 -0.047663740 0.105611942 0.9458707 t-SC-m-c-CS-m -0.48252480 -0.553978274 -0.411071320 0.0000000 t-SC-s-c-CS-m -0.29384358 -0.365297061 -0.222390107 0.0000000 c-SC-m-c-CS-s -0.60765135 -0.679104824 -0.536197870 0.0000000 c-SC-s-c-CS-s -0.45997002 -0.533279738 -0.386660296 0.0000000 t-CS-m-c-CS-s 0.01573198 -0.057577741 0.089041701 0.9980946 t-CS-s-c-CS-s -0.06497560 -0.143346991 0.013395785 0.1889085 t-SC-m-c-CS-s -0.57647450 -0.649784222 -0.503164780 0.0000000 t-SC-s-c-CS-s -0.38779329 -0.461103009 -0.314483568 0.0000000 c-SC-s-c-SC-m 0.14768133 0.076227853 0.219134807 0.0000000 t-CS-m-c-SC-m 0.62338333 0.551929850 0.694836804 0.0000000 t-CS-s-c-SC-m 0.54267574 0.466037903 0.619313585 0.0000000 t-SC-m-c-SC-m 0.03117685 -0.040276631 0.102630323 0.8893612 t-SC-s-c-SC-m 0.21985806 0.148404582 0.291311536 0.0000000 t-CS-m-c-SC-s 0.47570200 0.402392276 0.549011718 0.0000000 t-CS-s-c-SC-s 0.39499441 0.316623026 0.473365802 0.0000000 t-SC-m-c-SC-s -0.11650448 -0.189814205 -0.043194763 0.0000435 t-SC-s-c-SC-s 0.07217673 -0.001132992 0.145486450 0.0572345 t-CS-s-t-CS-m -0.08070758 -0.159078971 -0.002336195 0.0382204 t-SC-m-t-CS-m -0.59220648 -0.665516202 -0.518896760 0.0000000 t-SC-s-t-CS-m -0.40352527 -0.476834989 -0.330215547 0.0000000 t-SC-m-t-CS-s -0.51149890 -0.589870286 -0.433127510 0.0000000 t-SC-s-t-CS-s -0.32281768 -0.401189073 -0.244446297 0.0000000 t-SC-s-t-SC-m 0.18868121 0.115371492 0.261990934 0.0000000